SD大鼠慢性根尖周炎动物模型的研究进展

杨镕羽; 宋飞; 黄浩; 段开文; 钱石兵; 向盈盈

doi:10.12259/j.issn.2095-610X.S20221005

SD大鼠慢性根尖周炎动物模型的研究进展

doi: 10.12259/j.issn.2095-610X.S20221005

1.
昆明医科大学附属延安医院口腔科，云南昆明　650031
2.
昆明医科大学第三附属医院微创介入科，云南昆明　650106

基金项目: 国家自然科学基金项目（31860147）；云南省高层次卫生计生技术人才培养经费资助项目（H-2018086）；昆明市卫生健康委员会卫生科研课题（2022-08-01-004）

详细信息

作者简介:
杨镕羽（1996～），女，白族，云南大理人，在读硕士研究生，主要从事口腔临床工作

通讯作者:
向盈盈，E-mail：25591394@qq.com

中图分类号: R780.1
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- 被引次数: 0
出版历程
- 收稿日期: 2022-06-17
- 网络出版日期: 2022-10-08
- 刊出日期: 2022-10-31

Research Progress on Animal Model of Chronic Periapical Periodontitis in SD Rats

1.
Dept. of Stomatology, Yan’an Hospital of Kunming City, Kunming Yunnan 650031
2.
Dept. of Minimally Invasive Intervention，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650106，China

摘要

摘要: 慢性根尖周炎是口腔内常见的一类多继发于牙髓感染的疾病，常由于根管内细菌感染而导致根尖区骨破坏。由于人类个体的特殊性，很多情况下，根尖周组织发病机理的动态变化不能被直接研究，所以选择并确立适当的动物模型十分重要。目前，常用于建立慢性根尖周炎的动物模型主要有猴、狗、鼠及小型猪等。其中，SD大鼠凭借其生长速度快、易培养、适应性强、价格低廉、易饲养等优势，常用于研究根尖周炎的发病机制。从建立SD大鼠慢性根尖周炎动物模型的依据、方法及模型建立后评价手段等方面，对国内外SD大鼠慢性根尖周炎动物模型的研究作综述，为临床研究慢性根尖周炎的发展机制及治疗提供理论基础。
- SD大鼠 /
- 慢性根尖周炎 /
- 动物模型
Abstract: Chronic periapical periodontitis is a common oral disease secondary to dental pulp infection, which often leads to bone destruction in the apical region because of bacterial infection in the root canal. Because of the particularity of human individuals, in many cases, the dynamic changes of the pathogenesis of periapical tissue can not be directly studied, it is very important to select and establish an appropriate animal model. At present, the animal models commonly used to establish chronic periapical periodontitis mainly include monkeys, dogs, rats and miniature pigs. Among them, SD rats are often used to study the pathogenesis of periapical periodontitis because of their advantages of fast growth, easy culture, strong adaptability, low price, and easy feeding. This paper reviews the research on the animal model of chronic apical periodontitis in SD rats at home and abroad from the aspects of the basis, methods and evaluation methods after the establishment of the model, so as to provide a theoretical basis for the clinical study of the development mechanism and treatment of chronic apical periodontitis.
- SD rats /
- Chronic periapical periodontitis /
- Animal model

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