Study on ANP Level in Peripheral Blood of Patients with Hypertension in Yunnan
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摘要:
目的 观察云南原发性高血压患者外周血中ANP水平的变化，探讨其与原发性高血压发病机制之间的关系。 方法 收集2019年6月至9月在昆明市第一人民医院心内科诊断的原发性高血压患者44例，设为病例组，收集同期昆明医科大学附属甘美医院体检中心的健康体检患者44例，作为健康对照组。研究对象外周血中ANP的水平采用ELISA方法进行检测。 结果 原发性高血压患者外周血中ANP水平显著低于正常人（P < 0.05）；以高血压病发生与否为因变量，以血清ANP为自变量进行Logistic回归分析，结果显示ANP与高血压偏回归系数为0.071， P值为0.002（P < 0.05），具有统计学意义；采用Person相关性分析分别对ANP与SBP/DBP进行分析，结果显示ANP与SBP的相关系数为−0.374， P值为0.000（P < 0.05）；ANP与DBP的相关系数为−0.331， P值为0.002（P < 0.05），差异具有统计学意义，但是相对于DBP，ANP与SBP的相关性更显著。 结论 外周血中ANP浓度降低与血压升高密切相关；NPR-C配体ANP参与了原发性高血压的发病；ANP影响着SBP/DBP的水平变化，尤其对SBP的影响更为显著。 Abstract:Objective To observe the changes of ANP levels in the peripheral blood of patients with essential hypertension in Yunnan, and to explore the relationship between it and the pathogenesis of essential hypertension. Methods We selected 44 patients with essential hypertension diagnosed in the cardiology department of our hospital from June to September 2019 and set them as the case group. We also selected 44 healthy patients from the physical examination center of our hospital as the healthy control group. The ELISA method was used to detect the ANP level in the peripheral blood of the subjects. Results The level of ANP in the peripheral blood of patients with essential hypertension was significantly lower than that of normal people（P < 0.05）; the occurrence of hypertension was used as the dependent variable and the serum ANP was used as the independent variable for logistic regression analysis. The results showed that ANP The partial regression coefficient with hypertension was 0.071, and the P value was 0.002（ P < 0.05）. It was statistically significant; the person correlation analysis was used to analyze ANP and SBP/DBP, and the results showed that the correlation coefficient between ANP and SBP was -0.374. The P value is 0.000（ P < 0.05）; the correlation coefficient between ANP and DBP is -0.331, and the P value is 0.002（ P < 0.05）, both of which are statistically significant, but compared to DBP, the correlation between ANP and SBP is more significant. Conclusions The low concentration of ANP in peripheral blood is closely related to the increase of blood pressure; NPR-C ligand ANP is involved in the pathogenesis of essential hypertension; ANP affects the changes in the level of SBP/DBP, and has a more significant impact on SBP. -
Key words:
- Primary hypertension /
- NPR-C /
- ANP
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表 1 研究对象年龄、性别 、体重、身高、BMI分析结果（
$\bar x \pm s $ ）Table 1. Results of age，sex，weight，height，and BMI of the study subjects （
$\bar x \pm s $ ）组别 性别（男/女） 年龄（岁） 体重（kg） 身高（cm） BMI（kg/m2） 病例组 20/24 66.57 ± 9.35 66.48 ± 11.68 162.64 ± 7.60 25.02 ± 3.43 对照组 24/20 63.68 ± 8.41 64.39 ± 11.75 163.45 ± 8.99 23.97 ± 3.08 t/Z 0.847 1.523 0.837 −0.461 1.508 P 0.400 0.132 0.405 −0.818 0.135 
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表 2 研究对象SBP、DBP和ANP浓度水平（
$\bar x \pm s $ ）Table 2. The concentration of SBP，DBP and ANP of the study subjects （
$\bar x \pm s $ ）组别 SBP（mmHg） DBP（mmHg） ANP（ng/mL） 病例组 167.95 ± 23.96 102.57 ± 15.99 52.21（38.80，56.70） 对照组 118.34 ± 14.13 75.59 ± 8.96 65.87（57.70，74.97） t/Z 11.832 9.760 −4.978 P 0.000* 0.000* 0.000* *P < 0.05。
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[1] 中国心血管健康与疾病报告编写组. 中国心血管健康与疾病报告2019概要[J]. 心脑血管病防治,2020,20(5):437-450. doi: 10.3969/j.issn.1009-816x.2020.05.001 [2] 赵晓丽,钱净,黎海生. 高血压患者NPR-C基因A-55C位点多态性研究[J]. 昆明医科大学学报,2020,41(7):76-79. doi: 10.3969/j.issn.1003-4706.2020.07.015 [3] 中国高血压防治指南修订委员会,高血压联盟(中国,中华医学会心血管病学分会中国医师协会高血压专业委员会,中国医疗保健国际交流促进会高血压分会,中国老年医学学会高血压分会. 中国高血压防治指南(2018年修订版)[J]. 中国心血管杂志,2019,24(1):24-56. doi: 10.3969/j.issn.1007-5410.2019.01.002 [4] Kato J. Natriuretic peptides and neprilysin inhibition in hypertension and hypertensive organ damage[J]. Peptides.,2020,132:170352. doi: 10.1016/j.peptides.2020.170352 [5] Gupta D K,Wang T J. Natriuretic peptides and cardiometabolic health[J]. Circ J,2015,79:1647-1655. [6] Luis G. MELO,Mark E. Steinhelper,Stephen C. Pang. ANP in regulation of arterial pressure and fluidelectrolyte balance:lessons from genetic mouse models[J]. Physiol Genomics,2000,3:45-58. [7] Li Y,Sarkar O,Brochu M. Natriuretic peptide receptor-C attenuates hypertension in spontaneously hypertensive rats:role of nitroxidative stress and Gi proteins[J]. Hypertension,2014,63:846-855. [8] 段翔,边波,孙跃民. 高血压患者盐摄入量对尿蛋白和左心室质量指数的影响[J]. 中国慢性病预防与控制,2018,05:334-337. doi: 10.16386/j.cjpccd.issn.1004-6194.2018.05.004 [9] Kravchychyn A C P,Campos R M D S,Ferreira Y A M,et al. The Role of ANP Level Response in Interdisciplinary Weight Loss Therapy on Cardiometabolic Risk and Body Composition in Adolescents with Obesity.[J]. Arq Bras Cardiol,2022,118(1):33-40. [10] 张丰,张家留,高觉民. 重症患者并发高钠血症的临床研究[J]. 中国急救医学,2013,33(3):281-284. [11] 张扬,张涛. 高血压性脑出血患者SBP水平与血肿扩张、心肾不良事件的关系分析[J]. 贵州医药,2021,45(1):65-67. doi: 10.3969/j.issn.1000-744X.2021.01.029 [12] Vinnakota S,Chen H H. The Importance of Natriuretic Peptides in Cardiom- etabolic Diseases[J]. J Endorc Soc,2020,4(6):52. -
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