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α-鹅膏毒肽诱导肝细胞毒性作用机制的研究进展

许悦,  王婵,  林纾丞,  张慧洁,  澹忆,  张树威,  曾晓锋,  李桢

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文章导航 > 昆明医科大学学报  > 2022 >  43(12): 153-158
许悦, 王婵, 林纾丞, 张慧洁, 澹忆, 张树威, 曾晓锋, 李桢. α-鹅膏毒肽诱导肝细胞毒性作用机制的研究进展[J]. 昆明医科大学学报, 2022, 43(12): 153-158. doi: 10.12259/j.issn.2095-610X.S20221228
引用本文: 许悦, 王婵, 林纾丞, 张慧洁, 澹忆, 张树威, 曾晓锋, 李桢. α-鹅膏毒肽诱导肝细胞毒性作用机制的研究进展[J]. 昆明医科大学学报, 2022, 43(12): 153-158. doi: 10.12259/j.issn.2095-610X.S20221228
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Yue XU, Chan WANG, Shucheng LIN, Huijie ZHANG, Yi TAN, Shuwei ZHANG, Xiaofeng ZENG, Zhen LI. Advances in the Mechanism of Hepatotoxic Effects Induced by α-amanitin[J]. Journal of Kunming Medical University, 2022, 43(12): 153-158. doi: 10.12259/j.issn.2095-610X.S20221228
Citation: Yue XU, Chan WANG, Shucheng LIN, Huijie ZHANG, Yi TAN, Shuwei ZHANG, Xiaofeng ZENG, Zhen LI. Advances in the Mechanism of Hepatotoxic Effects Induced by α-amanitin[J]. Journal of Kunming Medical University, 2022, 43(12): 153-158. doi: 10.12259/j.issn.2095-610X.S20221228
shu

α-鹅膏毒肽诱导肝细胞毒性作用机制的研究进展

doi: 10.12259/j.issn.2095-610X.S20221228

  • 昆明医科大学法医学院，云南 昆明　650500

基金项目: 国家自然科学基金资助项目（81960340）
详细信息
    作者简介:

    许悦（1995～），女，贵州盘州人，医学硕士，主要从事法医毒理学研究工作

    通讯作者:

    曾晓锋，E-mail：zxf2004033@163.com

    李桢，E-mail：lizhenlaura@126.com

  • 中图分类号: R89

Advances in the Mechanism of Hepatotoxic Effects Induced by α-amanitin

  • School of Forensic Science，Kunming Medical University，Kunming Yunnan 650500，China

    摘要
  • 摘要: 鹅膏菌是一类可引起急性中毒的蘑菇种属，90％以上野生菌中毒死亡事件均由鹅膏毒肽引发，α-鹅膏毒肽（α-amanitin、α-AMA）是其中毒性最强的成分，肝脏是其毒性靶器官。RNA聚合酶Ⅱ（RNA pol Ⅱ）转录抑制是α-鹅膏毒肽导致肝细胞损伤的公认机制，但其他可能的毒理学机制尚待阐明。主要从α-鹅膏毒肽诱导肝细胞凋亡、自噬、炎症、氧化应激等毒性机制，中毒后临床治疗等方面进行综述，旨在为鹅膏毒肽中毒研究以及防治提供新的思路。
    Abstract: Amanita is a genus of mushrooms that can cause acute poisoning, and more than 90% of wild mushroom poisoning deaths are caused by its toxins. α-amanitin （α-AMA） is the most toxic component, and the liver is the major target of its toxicity. Transcriptional inhibition of RNA polymerase Ⅱ （RNA polⅡ） is a recognized mechanism of α-amanita toxin-induced hepatocyte injury, but other possible toxicological mechanisms are yet to be identified. The article reviews the toxic mechanisms of α-amanitin induced apoptosis, autophagy, inflammation and oxidative stress in hepatocytes, and the clinical treatment after poisoning, aiming to provide new directions for the research and prevention of Amanita poisoning.
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  • 收稿日期:  2022-04-19
  • 网络出版日期:  2022-12-06
  • 刊出日期:  2022-12-25

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