放射性<sup>125</sup>I粒子在肺腺癌EMT及临床治疗中的作用

宋飞; 车佳音; 黄明; 徐丹; 李红阳; 李定坤; 向盈盈

doi:10.12259/j.issn.2095-610X.S20230101

放射性¹²⁵I粒子在肺腺癌EMT及临床治疗中的作用

doi: 10.12259/j.issn.2095-610X.S20230101

1.
昆明医科大学第三附属医院/云南省肿瘤医院微创介入科
2.
屏边苗族自治县人民医院医学检验科，云南屏边　661200
3.
昆明医科大学第三附属医院/云南省肿瘤医院肝胆胰外科，云南昆明　650118
4.
昆明市延安医院口腔科，云南昆明　650051

基金项目: 国家自然科学基金资助项目（31860147）；昆明市卫生健康委员会卫生科研基金资助项目（2022-08-01-004）

详细信息

作者简介:
宋飞（1981～），男，云南昆明人，医学博士，副主任医师，主要从事肿瘤综合介入治疗临床工作

通讯作者:
向盈盈，E-mail： 198181981@qq.com

中图分类号: R734.2
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出版历程
- 收稿日期: 2022-10-14
- 刊出日期: 2023-01-25

The Role of Radioactive Iodine-125 Particles in EMT and Clinical Treatment of Lung Adenocarcinoma

1.
Dept. of Invasive Intervention，The 3rd Affiliated Hospital of Kunming Medical University/Yunnan Cancer Hospital，Kunming Yunnan 650118
2.
Dept. of Medical Laboratory，Pingbian Miao Autonomous County People’s Hospital，Pingbian Yunnan，661200
3.
Dept. of Hepatobiliary and Pancreatic Surgery，The 3rd Affiliated Hospital of Kunming Medical University/Yunnan Cancer Hospital，Kunming Yunnan 650118
4.
Dept. of Stomatology，Yan’an Hospital of Kunming City，Kunming Yunnan 650051，China

摘要

摘要: 肺癌是最常见的肿瘤之一，而云南省肺癌的发病率位居全国首位。许多患者确诊时已为晚期肺癌，采用多手段联合治疗，包括化学治疗、放射治疗、靶向治疗、免疫治疗以及局部治疗（消融、冷冻、¹²⁵I等）。放射性¹²⁵I粒子植入治疗作为晚期肺癌局部治疗手段之一，有其独特的优势，其放射半径小，特异性照射靶向病灶，而对周围正常组织损伤小，并且临床效果较好。研究表明上皮-间质样表型转化（epithelial-mesenchymal transformation，EMT）与肺腺癌的生长、侵袭、转移密切相关。对放射性¹²⁵I粒子在肺腺癌EMT及临床治疗中的作用进行论述。
- 肺腺癌 /
- 上皮间质转化 /
- 放射性¹²⁵I粒子
Abstract: Lung cancer is one of the most common tumors, and Yunnan has the highest incidence of lung cancer in China. Many patients are diagnosed with advanced lung cancer and are treated with a combination of chemotherapy, radiotherapy, targeted therapy, immunotherapy, and local therapy （ablation, freezing, ¹²⁵I, etc.）. As one of the local treatment methods for advanced lung cancer, radioactive ¹²⁵I seed implantation has its unique advantages, such as small radiation radius, specific irradiation targeting of the lesion, and little damage to surrounding normal tissue, and good clinical effect. Studies have shown that epithelial mesenchymaltransformation （EMT） with lung adenocarcinoma is closely related to the growth, invasion, and metastasis. This article discusses the role of radioactive ¹²⁵I particles in EMT and clinical treatment of lung adenocarcinoma
- Lung adenocarcinoma /
- Epithelial-mesenchymal transformation /
- Radioactive iodine-125 particles

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参考文献(21)

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