转移性前列腺癌细胞减灭治疗的研究进展

代龙国; 白宇

doi:10.12259/j.issn.2095-610X.S20230103

转移性前列腺癌细胞减灭治疗的研究进展

doi: 10.12259/j.issn.2095-610X.S20230103

代龙国,
白宇^,

云南省肿瘤医院泌尿外科，云南昆明　650118

基金项目: 国家自然科学基金资助项目（82160511）；国家癌症中心攀登基金资助项目（NCC201925B01）；昆明医科大学研究生教育创新基金资助项目（2022S082）

详细信息

作者简介:
代龙国（1996～），男，云南曲靖人，在读硕士研究生，主要从事泌尿生殖系统肿瘤的基础与临床研究工作

通讯作者:
白宇，E-mail：baiyuff@126.com

中图分类号: R737.25
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- 被引次数: 0
出版历程
- 收稿日期: 2022-11-15
- 网络出版日期: 2023-01-18
- 刊出日期: 2023-01-18

Research Progress of Cytoreductive Treatment for Metastatic Prostate Cancer

Longguo DAI,
Yu BAI^,

Dept. of Urinary Surgery，Yunnan Tumor Hospital，Kunming Yunnan 650118，China

摘要

摘要: 转移性前列腺癌（metastatic prostate cancer，mPCa）在单独使用全身治疗一段时间后会进展至去势抵抗状态。因此，越来越多的注意力集中在局部细胞减灭和/或转移导向治疗（metastasis-directed therapies，MDT）可能获得的生存益处上。在此背景下，已经探索了用放射治疗和根治性前列腺切除术（radical prostatectomy，RP）治疗原发肿瘤的方法，并提出了新型微创消融疗法。此外，有关MDT （主要是立体定向消融放射治疗）的潜在临床益处的证据正在积累。总结了当前mPCa患者细胞减灭治疗策略的证据基础。
- 转移性前列腺癌 /
- 细胞减灭治疗 /
- 消融治疗 /
- 放射治疗 /
- 前列腺切除术
Abstract: Metastatic prostate cancer （mPCa） will progress to castrate-resistant state after a period of androgen-deprivation therapy （ADT） alone. Therefore, increasing focus is being placed on the additional survival benefits that could potentially be achieved with local cytoreductive and/or metastasis-directed therapies （MDT）. Local treatment of the primary tumour with the established modalities of radiotherapy and radical prostatectomy has been explored in this context, and the use of novel minimally invasive ablative therapies has been proposed. In addition, evidence of the potential clinical benefits of MDT with ionizing radiation （primarily stereotactic ablative radiotherapy） is accumulating. This aticle summarizes the current evidence base for a cytoreductive strategy in patients with mPCa.
- Metastatic prostate cancer /
- Cytoreductive treatment /
- Ablative therapies /
- Radiotherapy /
- Prostatectomy

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参考文献(26)

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