双重任务训练对帕金森病患者运动功能的影响

蔺小英; 谭艳; 杨磊

doi:10.12259/j.issn.2095-610X.S20230110

双重任务训练对帕金森病患者运动功能的影响

doi: 10.12259/j.issn.2095-610X.S20230110

蔺小英¹,
谭艳¹,
杨磊^2, ,

1.
昆明医科大学第二附属医院康复医学部，云南昆明　650101
2.
昆明市第二人民医院康复医学科，云南昆明　650204

基金项目: 云南省卫生健康委员会医学后备人才培养计划基金资助项目（H-2017058）；昆明市卫生科技人才培养基金资助项目[2022-SW（带头）-27]

详细信息

作者简介:
蔺小英（1998～），女，山西临汾人，在读硕士研究生，主要从事神经系统疾病物理康复治疗工作

通讯作者:
杨磊，E-mail： leon_yang30@163.com

中图分类号: R741.05；R454.9
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出版历程
- 收稿日期: 2022-11-09
- 刊出日期: 2023-01-25

Effect of Dual-task Training on Mobility Function in Patients with Parkinson’s Disease

Xiaoying LIN¹,
Yan TAN¹,
Lei YANG^{2
, ,}

1.
Dept. of Rehabilitation Medicine，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101
2.
Dept. of Rehabilitation Medicine，The 2nd People’s Hospital of Kunming，Kunming Yunnan 650204，China

摘要

摘要: 目的检验双重任务训练对帕金森患者运动功能的影响。方法 56名帕金森患者随机分为实验组和对照组。每组患者接受为期2周，每周5次，每次60 min的训练，并比较2组患者训练前后的运动和认知功能。结果尽管2组患者完成10 m步行和起立行走计时（TUG）测试的时间变化值无显著差异（P > 0.05），但仅有实验组在双重任务状态下改善显著（ P < 0.05）。对于简易平衡评定系统测试和特定活动平衡信心量表，仅有实验组呈现出显著的时间效应。结论双重任务训练对帕金森患者步行速度和平衡功能具有改善趋势。未来的研究应该探索改善帕金森病患者运动功能的最佳训练方案，以及将获得的能力转移到其他新的双重任务场景的问题。
- 帕金森病 /
- 双重任务 /
- 步行能力 /
- 平衡功能 /
- 随机对照试验
Abstract: Objective To examine the effect of dual-task （DT） training on mobility function in patients with Parkinson’s disease （PD）. Methods 56 patients with PD were randomly divided into DT training group or single-task （ST） training group. Each group of patients received the 60 min/session training, 5 times/week, for over 2 weeks. The motor and cognitive functions of the two groups were compared before and after the training. Results Although there was no significant difference between the two groups in the change time taken to complete the 10 m walking and timed up and go （TUG） test under either DT or ST condition, only the experimental group improved significantly under DT condition （P < 0.05）. For balance function （mini-balance evaluation system test, Mini-BESTest） and balance efficiency （activity-specific balance confidence scale, ABC）, only DT training group showed the significant time effect. Conclusion Walking speed and balance function in patients with PD tend to be improved after DT training. Future research should be conducted to explore the optimized training protocol and improve DT motor function in patients with PD and the ability of transferring the acquired function to new DT scenarios.
- Parkinson’s disease /
- Dual task /
- Walking ability /
- Balance function /
- Randomized controlled trial

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图 1 筛选流程图

Figure 1. Flow chart

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图 2 干预前后2组Mini-BESTest、ABC、MoCA分数比较

Figure 2. Comparison of the scores of Mini-BESTest、ABC、MoCA between the two groups before and after intervention

A：2组受试者训练前后Mini-BESTest分数；B：2组受试者训练前后ABC分数；C：2组受试者训练前后MoCA分数。^*P < 0.05。

下载: 全尺寸图片幻灯片

表 1 人口学特征[（ $ \bar x \pm s $ ）/M（IQR）/n（%）]

Table 1. Characteristics of participants [（ $ \bar x \pm s $ ）/M（IQR）/n（%）]

项目	实验组（n = 28）	对照组（n = 28）	统计量（t/χ²/U）	P
基本人口统计数据
年龄（岁）	62.7 ± 7.2	63.2 ± 8.6	0.035	0.428
女性	10 （35.7）	12 （42.8）	0.299	0.585
身体质量指数（kg/m^2）	23.8 ± 2.6	23.3 ± 3.7	0.476	0.608
帕金森疾病的特征
发病时间（a）	6.6 ± 4.2	7.6 ± 5.0	−0.428	0.495
Hoehn-Yahr分期	2.5 （2，3）	2.5 （2，3）	14	0.510
运动状态
室内步行辅助	3 （10.7）	2 （7.1）	0.22	0.639
室外步行辅助	5 （17.9）	3 （10.7）	0.583	0.445
在过去12个月内至少有一次跌倒的受试者	11 （39.3）	6 （21.4）	2.112	0.146
^*P < 0.05。

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表 2 干预前后2组完成步行任务所需时间比较 [（ $ \bar x \pm s $ ），秒]

Table 2. Comparison of the time taken to complete the walking task between the two groups before and after treatment [（ $ \bar x \pm s $ ），s ]

项目	实验组			对照组			基线比较	2组治疗前后变化值比较
项目	训练前	训练后	变化值	训练前	训练后	变化值	t 　　　 P	t 　　　 P
10 m步行
单一任务	20.5 ± 15.1	18.6 ± 13.5	−1.9 ± 14.37^*	14.5 ± 5.4	13.3 ± 5.4	−1.2 ± 5.4	1.937　　0.102	−0.419　　0.677
+命名任务	25.7 ± 3.2	20.9 ± 2.4	−4.8 ±19.51^*	17.3 ± 3.8	15.9 ± 2.9	−1.4 ± 3.44	1.942　　0.094	−1.566　　0.123
+连续减3任务	26.3 ± 3.5	21.7 ± 2.5	−4.6 ± 21.46^*	17.9 ± 4.2	15.8 ± 3.0	−2.1 ± 3.75	1.730　　0.128	−1.151　　0.255
TUG
单一任务	24.4 ± 2.7	23.2 ± 2.4	−1.2 ± 15.94	17.7 ± 3.3	16.0 ± 3.0	−1.7 ± 3.16	1.791　　0.124	−0.574　　0.568
+命名任务	34.0 ± 4.1	25.9 ± 2.6	−8.1 ± 3.59^*	22.4 ± 5.0	19.8 ± 3.2	−2.6 ± 4.39	1.963　　0.080	−1.662　　0.102
+连续减3任务	33.8 ± 4.0	26.6 ± 2.8	−7.2 ± 3.56^*	22.1 ± 4.9	19.5 ± 3.4	−2.6 ± 4.35	1.971　　0.070	−1.130　　0.264
^*P < 0.05。

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