翼状胬肉发病机制的研究进展

江华维; 刘霞; 王艳; 章敏慧; 尹维丹; 张利伟

doi:10.12259/j.issn.2095-610X.S20230125

翼状胬肉发病机制的研究进展

doi: 10.12259/j.issn.2095-610X.S20230125

云南大学附属医院/云南省第二人民医院/云南省眼科医院/昆明医科大学第四附属医院眼科，云南昆明　650021

基金项目: 国家自然科学基金资助项目（81860171）；云南省卫生健康委员会医学后备人才培养计划基金资助项目（H-2018020）；昆明医科大学研究生创新基金资助项目（2022S116）

详细信息

作者简介:
江华维（1994～），男，河南信阳人，在读硕士研究生，主要从事眼表疾病及小儿眼底病研究工作

通讯作者:
张利伟，E-mail：drzhangliwei@163.com

中图分类号: R777.33
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- 文章访问数: 4207
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- PDF下载量: 46
- 被引次数: 0
出版历程
- 收稿日期: 2022-11-19
- 网络出版日期: 2022-12-24
- 刊出日期: 2023-01-18

Research Progress on the Pathogenesis of Pterygium

Dept. of Ophthalmology，The Affiliated Hospital of Yunnan University，The 2nd People’s Hospital of Yunnan，Yunnan Eye Hospital，The 4th Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650021，China

摘要

摘要: 翼状胬肉是人群中常见的一种眼表疾病，其危险因素主要是紫外线照射，发病机制主要有氧化应激、光毒性、细胞增殖凋亡、细胞外基质重塑、炎症与免疫调控等。已发现了参与上述机制的多种重要蛋白，但它们在翼状胬肉中的调控信号通路尚不清楚，目前认为是多种机制共同作用的结果，其较完整的发病机制还有待进一步探索。就翼状胬肉的不同发病机制进行综述，以期待更好地了解翼状胬肉的发生发展，寻求新的治疗靶点和治疗方法，从而改善手术效果并减少术后复发。
- 翼状胬肉 /
- 发病机制 /
- 增殖与凋亡 /
- 炎症
Abstract: Pterygium is a common ocular surface disease in the population and its risk factors are mainly ultraviolet radiation. The pathogenesis mainly includes oxidative stress, phototoxicity, cell proliferation and apoptosis, extracellular matrix remodeling, inflammation and immune regulation. A variety of important proteins involved in the above mechanisms have been identified, but their regulatory signaling pathways in pterygium are still unclear and are currently considered to be the result of a combination of mechanisms, and their relatively complete pathogenesis needs further exploration. This paper aims to review the different pathogenesis of pterygium in order to better understand the occurrence and development of pterygium and seek new therapeutic targets and methods, so as to improve the surgical effect and reduce postoperative recurrence.
- Pterygium /
- Pathogenesis /
- Proliferation and apoptosis /
- Inflammation

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参考文献(48)

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