HPA轴在抑郁症中的研究概述

余蕾; 武文志; 张云桥; 游旭; 曾勇

doi:10.12259/j.issn.2095-610X.S20230222

HPA轴在抑郁症中的研究概述

doi: 10.12259/j.issn.2095-610X.S20230222

余蕾¹,
武文志¹,
张云桥²,
游旭²,
曾勇^1, ,

1.
昆明医科大学第二附属医院，云南昆明　650101
2.
红河州第二人民医院，云南红河　654399

基金项目: 国家自然科学基金资助项目（81960254；82260276；82060257）

详细信息

作者简介:
余蕾（1997～），女，云南曲靖人，在读硕士研究生，主要从事精神医学研究工作

通讯作者:
曾勇，E-mail： zengyong@kmmu.edu.cn

中图分类号: R74
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- 文章访问数: 3993
- HTML全文浏览量: 3951
- PDF下载量: 179
- 被引次数: 0
出版历程
- 收稿日期: 2022-12-06
- 刊出日期: 2023-02-25

Research Overview of HPA Axis in Depression

1.
The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101
2.
The Second People's Hospital of Honghe Prefecture，Honghe Yunnan 651400，China

摘要

摘要: 抑郁症临床上的主要特点为显著而持久的心境低落，其高发病率和高致残性给个人、家庭及社会都带来了沉重的负担。近年来针对抑郁患者神经内分泌方面的研究表明，以下丘脑-垂体-肾上腺皮质轴（The hypothalamic–pituitary–adrenal axis，HPA axis）紊乱为主的失调在抑郁症的发病过程中起到了重要作用。综述近年来HPA轴与抑郁症的研究进展，以期为抑郁症的诊断与治疗提供新的思路及参考价值。
- 抑郁症 /
- 下丘脑-垂体-肾上腺轴 /
- 促肾上腺皮质激素释放激素 /
- 促肾上腺皮质激素 /
- 皮质醇
Abstract: The main clinical feature of depression is marked and persistent low mood, and its high incidence and high disability have brought a heavy burden to individuals, families and society. Recent studies on neuroendocrine in patients with depression have shown that disorders of the hypothalamic-pituitary-adrenocortical axis （HPA axis） plays an important role in the pathogenesis of depression. This article reviews the research progress of HPA axis and depression in recent years, in order to provide new ideas and reference value for the diagnosis and treatment of depression.
- Depression /
- Hypothalamic-pituitary-adrenal axis /
- Corticotropin-releasing hormone /
- Adrenocorticotrophic hormone /
- Cortisol

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参考文献(51)

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HPA轴在抑郁症中的研究概述

doi: 10.12259/j.issn.2095-610X.S20230222

作者简介:
余蕾（1997～），女，云南曲靖人，在读硕士研究生，主要从事精神医学研究工作

通讯作者:
曾勇，E-mail： zengyong@kmmu.edu.cn

计量

Research Overview of HPA Axis in Depression

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目录

[1]	行浩然, 张曦, 张盈盈, 鲍天昊. 青少年抑郁症使用抗抑郁药物的临床进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240725
[2]	段登艾, 张勇辉, 王维, 廖欣菊, 张志雄. 儿童期虐待对青少年首发抑郁症患者非自杀性自伤行为的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230304
[3]	储召松, 王欣, 和梦鑫, 许秀峰, 王娜, 沈宗霖. 抑郁症自杀相关基因的研究进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230301
[4]	王小云, 王巧云, 顾明华, 丁昱, 关雨雯, 张继兰. miR-373通过P2X7R影响抑郁症小鼠行为的作用机制, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20211030
[5]	吴丽园, 罗夙医, 顾永洁, 王旗鹏, 许家豪. 三七总黄酮抗糖皮质激素诱发骨质疏松的效应, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20201117
[6]	李仙, 季长亮, 曾淑娥, 杨蜀云, 杨皓棋, 侯亚婷. 不同严重程度抑郁症患者认知功能的比较, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20201226
[7]	刘畅, 沈宗霖, 程宇琪, 许秀峰. 精神分裂症、双相情感障碍、抑郁症静息态功能磁共振研究的异同, 昆明医科大学学报.
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[11]	李晓明. 血糖对下丘脑-垂体-性腺轴的影响, 昆明医科大学学报.
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[17]	石鑫. 促肾上腺皮质激素非依赖性肾上腺大结节样增生1例报道, 昆明医科大学学报.
[18]	闫永吉. 肾上腺醛固酮腺瘤大鼠模型的建立, 昆明医科大学学报.
[19]	王曦. 糖皮质激素对脑死亡猪心脏血流动力学的影响, 昆明医科大学学报.
[20]	. 2型糖尿病合并抑郁危险因素的临床研究, 昆明医科大学学报.

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HPA轴在抑郁症中的研究概述

doi: 10.12259/j.issn.2095-610X.S20230222

作者简介: 余蕾（1997～），女，云南曲靖人，在读硕士研究生，主要从事精神医学研究工作

通讯作者: 曾勇，E-mail： zengyong@kmmu.edu.cn

计量

出版历程

Research Overview of HPA Axis in Depression

计量

出版历程

目录

作者简介:
余蕾（1997～），女，云南曲靖人，在读硕士研究生，主要从事精神医学研究工作

通讯作者:
曾勇，E-mail： zengyong@kmmu.edu.cn