抑郁症自杀相关基因的研究进展

储召松; 王欣; 和梦鑫; 许秀峰; 王娜; 沈宗霖

doi:10.12259/j.issn.2095-610X.S20230301

抑郁症自杀相关基因的研究进展

doi: 10.12259/j.issn.2095-610X.S20230301

昆明医科大学第一附属医院精神科，云南省精神心理疾病临床医学研究中心，云南昆明　650032

基金项目: 国家自然科学基金资助项目（81660237）；云南省高层次卫生计生技术人才培养项目（H-2018090）；云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2019FE001（-144） ]

详细信息

作者简介:
储召松（1994～），男，陕西旬阳人，在读博士研究生，住院医师，主要从事精神疾病相关工作

通讯作者:
沈宗霖，E-mail：shenzl1987@163.com

中图分类号: R749.4
计量
- 文章访问数: 3887
- HTML全文浏览量: 2107
- PDF下载量: 59
- 被引次数: 0
出版历程
- 收稿日期: 2022-06-24
- 网络出版日期: 2023-03-02
- 刊出日期: 2023-03-25

Research Progress on Gene Related to Suicide in Major Depressive Disorder：A Review

Dept. of Psychiatry，The 1st Affiliated Hospital of Kunming Medical University，Yunnan Province Clinical Research Center for Mental Health，Kunming Yunnan 650032，China

摘要

摘要: 自杀是全球重大的公共卫生问题，在全球范围内都是主要的死亡原因之一，给人类造成巨大的社会经济损失和心理伤害。抑郁症是自杀死亡的首要原因，探究抑郁症自杀的病理生理机制对于预防和减少自杀具有重要意义。抑郁症自杀与遗传、环境、社会、心理以及生物学因素关系密切。随着基因组学技术的发展，越来越多的研究者对抑郁症自杀相关基因进行探究。对近年来抑郁症自杀相关基因的研究进行综述，以期为其病理机制研究提供思路。
- 抑郁症 /
- 自杀 /
- 基因
Abstract: Suicide is a major global public health concern and is one of the leading causes of death worldwide, causing enormous socioeconomic losses and psychological damage to human beings. Major depressive disorder is the leading cause of death of suicide, and it is crucial to investigate the pathophysiological mechanisms of suicide by depression to prevent and reduce suicide. Suicide by depression is closely related to genetic, environmental, social, psychological, and biological factors. With the development of genomics technology, more and more researchers explore the genes related to suicide in depression. This study reviews recent genetic researches on suicide by depression to provide references for the study of its pathological mechanisms.
- Major depressive disorder /
- Suicide /
- Gene

HTML全文

参考文献(48)

[1]	Bachmann S. Epidemiology of suicide and the psychiatric perspective[J]. Int J Environ Res Public Health,2018,15(7):1425. doi: 10.3390/ijerph15071425
[2]	Cai H,Jin Y,Liu S,et al. Prevalence of suicidal ideation and planning in patients with major depressive disorder: A meta-analysis of observation studies[J]. J Affect Disord,2021,293:148-158. doi: 10.1016/j.jad.2021.05.115
[3]	Dong M,Zeng L N,Lu L,et al. Prevalence of suicide attempt in individuals with major depressive disorder: A meta-analysis of observational surveys[J]. Psychol Med,2019,49(10):1691-1704. doi: 10.1017/S0033291718002301
[4]	Orsolini L,Latini R,Pompili M,et al. Understanding the complex of suicide in depression: From research to clinics[J]. Psychiatry Investig,2020,17(3):207-221. doi: 10.30773/pi.2019.0171
[5]	Mcguffin P,Perroud N,Uher R,et al. The genetics of affective disorder and suicide[J]. Eur Psychiatry,2010,25(5):275-277. doi: 10.1016/j.eurpsy.2009.12.012
[6]	Martinez-Levy G A,Campos A I,Rabinowitz J A,et al. Suicidal ideation and planning among Mexican adolescents are associated with depression polygenic risk scores[J]. Am J Med Genet B Neuropsychiatr Genet,2021,186(8):476-484. doi: 10.1002/ajmg.b.32864
[7]	Mullins N,Bigdeli T B,Børglum A D,et al. GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores[J]. Am J Psychiatry,2019,176(8):651-660. doi: 10.1176/appi.ajp.2019.18080957
[8]	Mann J J,Rizk M M. A brain-centric model of suicidal behavior[J]. Am J Psychiatry,2020,177(10):902-916. doi: 10.1176/appi.ajp.2020.20081224
[9]	Mann J J. The serotonergic system in mood disorders and suicidal behaviour[J]. Philos Trans R Soc Lond B Biol Sci,2013,368(1615):20120537. doi: 10.1098/rstb.2012.0537
[10]	Turecki G,Brière R,Dewar K,et al. Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide[J]. Am J Psychiatry,1999,156(9):1456-1458. doi: 10.1176/ajp.156.9.1456
[11]	Ghasemi A,Seifi M,Baybordi F,et al. Association between serotonin 2A receptor genetic variations,stressful life events and suicide[J]. Gene,2018,658:191-197. doi: 10.1016/j.gene.2018.03.023
[12]	李卓文,马靖松,戚东,等. 5-羟色胺受体相关基因的交互作用与抑郁症自杀行为的关联研究[J]. 中华行为医学与脑科学杂志,2017,26(7):610-614.
[13]	Höfer P,Schosser A,Calati R,et al. The impact of serotonin receptor 1A and 2A gene polymorphisms and interactions on suicide attempt and suicide risk in depressed patients with insufficient response to treatment-a European multicentre study[J]. Int Clin Psychopharmacol,2016,31(1):1-7. doi: 10.1097/YIC.0000000000000101
[14]	Fratelli C,Siqueira J,Silva C,et al. 5HTTLPR genetic variant and major depressive disorder: A review[J]. Genes (Basel),2020,11(11):1260. doi: 10.3390/genes11111260
[15]	Alshaya D S. Genetic and epigenetic factors associated with depression: An updated overview[J]. Saudi journal of biological sciences,2022,29(8):103311. doi: 10.1016/j.sjbs.2022.103311
[16]	Sarmiento-Hernández E I,Ulloa-Flores R E,Camarena-Medellín B,et al. Association between 5-HTTLPR polymorphism,suicide attempt and comorbidity in Mexican adolescents with major depressive disorder[J]. Actas Esp Psiquiatr,2019,47(1):1-6.
[17]	赵蓓,章皎洁,李国海,等. 5-HTT基因多态性与抑郁症患者自杀的关联性研究[J]. 临床心身疾病杂志,2019,25(2):6-8.
[18]	Fanelli G,Serretti A. The influence of the serotonin transporter gene 5-HTTLPR polymorphism on suicidal behaviors: A meta-analysis[J]. Prog Neuropsychopharmacol Biol Psychiatry,2019,88:375-387. doi: 10.1016/j.pnpbp.2018.08.007
[19]	Ran L,Ai M,Wang W,et al. Rare variants in SLC6A4 cause susceptibility to major depressive disorder with suicidal ideation in Han Chinese adolescents and young adults[J]. Gene,2020,726:144147. doi: 10.1016/j.gene.2019.144147
[20]	Consoloni J L,Ibrahim E C,Lefebvre M N,et al. Serotonin transporter gene expression predicts the worsening of suicidal ideation and suicide attempts along a long-term follow-up of a major depressive episode[J]. Eur Neuropsychopharmacol,2018,28(3):401-414. doi: 10.1016/j.euroneuro.2017.12.015
[21]	Walther D J,Peter J U,Bashammakh S,et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform[J]. Science,2003,299(5603):76-76. doi: 10.1126/science.1078197
[22]	Lim J E,Pinsonneault J,Sadee W,et al. Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons[J]. Mol Psychiatry,2007,12(5):491-501. doi: 10.1038/sj.mp.4001923
[23]	郭建雄,刘国雄,刘恩益,等. 色氨酸羟化酶2基因多态性与抑郁症及自杀企图的关系[J]. 广东医学,2014,35(24):3879-3882.
[24]	张玉琦,袁国桢,李桂林,等. TPH2基因rs7305115单核苷酸多态性与抑郁症自杀未遂的关联研究[J]. 中国神经精神疾病杂志,2007,33(2):103-105.
[25]	Zhang Y,Chang Z,Chen J,et al. Methylation of the tryptophan hydroxylase-2 gene is associated with mRNA expression in patients with major depression with suicide attempts[J]. Mol Med Rep,2015,12(2):3184-3190. doi: 10.3892/mmr.2015.3748
[26]	Duman R S,Sanacora G,Krystal J H. Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments[J]. Neuron,2019,102(1):75-90. doi: 10.1016/j.neuron.2019.03.013
[27]	Sarawagi A,Soni N D,Patel A B. Glutamate and GABA homeostasis and neurometabolism in major depressive disorder[J]. Front Psychiatry,2021,12:637863. doi: 10.3389/fpsyt.2021.637863
[28]	Yin H,Pantazatos S P,Galfalvy H,et al. A pilot integrative genomics study of GABA and glutamate neurotransmitter systems in suicide,suicidal behavior,and major depressive disorder[J]. Am J Med Genet B Neuropsychiatr Genet,2016,171b(3):414-426.
[29]	尹红蕾. GABA-谷氨酸系统、糖皮质激素受体相关基因与自杀行为的关联研究[D]. 广州: 南方医科大学, 2017.
[30]	Yin H,Galfalvy H,Zhang B,et al. Interactions of the GABRG2 polymorphisms and childhood trauma on suicide attempt and related traits in depressed patients[J]. J Affect Disord,2020,266:447-455. doi: 10.1016/j.jad.2020.01.126
[31]	Zhao J,Verwer R W H,Gao S F,et al. Prefrontal alterations in GABAergic and glutamatergic gene expression in relation to depression and suicide[J]. J Psychiatr Res,2018,102:261-274. doi: 10.1016/j.jpsychires.2018.04.020
[32]	Berardelli I,Serafini G,Cortese N,et al. The involvement of hypothalamus-pituitary-adrenal (HPA) axis in suicide risk[J]. Brain Sci,2020,10(9):563.
[33]	Figaro-Drumond F V,Pereira S C,Menezes I C,et al. Association of 11β-hydroxysteroid dehydrogenase type1 (HSD11b1) gene polymorphisms with outcome of antidepressant therapy and suicide attempts[J]. Behav Brain Res,2020,381:112343. doi: 10.1016/j.bbr.2019.112343
[34]	Juruena M F. Early-life stress and HPA axis trigger recurrent adulthood depression[J]. Epilepsy Behav,2014,38:148-159. doi: 10.1016/j.yebeh.2013.10.020
[35]	Yin H,Galfalvy H,Pantazatos S P,et al. Glucocorticoid receptor‐related genes: Genotype and brain gene expression relationships to suicide and major depressive disorder[J]. Depress Anxiety,2016,33(6):531-540. doi: 10.1002/da.22499
[36]	Jokinen J,Boström A E,Dadfar A,et al. Epigenetic changes in the CRH gene are related to severity of suicide attempt and a general psychiatric risk score in adolescents[J]. EBioMedicine,2018,27:123-133. doi: 10.1016/j.ebiom.2017.12.018
[37]	O'connor D B,Branley-Bell D,Green J A,et al. Effects of childhood trauma,daily stress,and emotions on daily cortisol levels in individuals vulnerable to suicide[J]. J Abnorm Psychol,2020,129(1):92-107. doi: 10.1037/abn0000482
[38]	O'connor D B,Gartland N,O'connor R C. Stress,cortisol and suicide risk[J]. Int Rev Neurobiol,2020,152:101-130. doi: 10.1016/bs.irn.2019.11.006
[39]	Sanabrais-Jiménez M A,Sotelo-Ramirez C E,Ordoñez-Martinez B,et al. Effect of CRHR1 and CRHR2 gene polymorphisms and childhood trauma in suicide attempt[J]. J Neural Transm (Vienna),2019,126(5):637-644. doi: 10.1007/s00702-019-01991-4
[40]	邱小英,瞿铭,张琳娜,等. 下丘脑-垂体-肾上腺轴相关基因多态性与环境因素对抑郁症患者自杀未遂行为的交互作用[J]. 中华行为医学与脑科学杂志,2021,30(8):694-700.
[41]	Beurel E,Toups M,Nemeroff C B. The bidirectional relationship of depression and inflammation: double trouble[J]. Neuron,2020,107(2):234-256. doi: 10.1016/j.neuron.2020.06.002
[42]	Wiebenga J X M,Heering H D,Eikelenboom M,et al. Associations of three major physiological stress systems with suicidal ideation and suicide attempts in patients with a depressive and/or anxiety disorder[J]. Brain,behavior,and immunity,2022,102:195-205. doi: 10.1016/j.bbi.2022.02.021
[43]	Troubat R,Barone P,Leman S,et al. Neuroinflammation and depression: A review[J]. Eur J Neurosci,2021,53(1):151-171. doi: 10.1111/ejn.14720
[44]	Pandey G N,Rizavi H S,Bhaumik R,et al. Chemokines gene expression in the prefrontal cortex of depressed suicide victims and normal control subjects[J]. Brain Behav Immun,2021,94:266-273. doi: 10.1016/j.bbi.2021.01.033
[45]	Schiweck C,Claes S,Van Oudenhove L,et al. Childhood trauma,suicide risk and inflammatory phenotypes of depression: insights from monocyte gene expression[J]. Transl Psychiatry,2020,10(1):1-12. doi: 10.1038/s41398-019-0665-5
[46]	González-Castro T B,Hernández-Díaz Y,Juárez-Rojop I E,et al. The role of COMT gene Val108/158Met polymorphism in suicidal behavior: systematic review and updated meta-analysis[J]. Neuropsychiatr Dis Treat,2018,14:2485-2496. doi: 10.2147/NDT.S172243
[47]	谢诗意,俞佳,胡燕,等. 催产素及受体基因与抑郁症相关性的研究进展[J]. 现代预防医学,2020,47(10):1880-1883.
[48]	Parris M S,Grunebaum M F,Galfalvy H C,et al. Attempted suicide and oxytocin-related gene polymorphisms[J]. J Affect Disord,2018,238:62-68. doi: 10.1016/j.jad.2018.05.022

计量

文章访问数: 3887
HTML全文浏览量: 2107
PDF下载量: 59
被引次数: 0

姓名
邮箱
手机号码
标题
留言内容
验证码

留言板

抑郁症自杀相关基因的研究进展

doi: 10.12259/j.issn.2095-610X.S20230301

作者简介:
储召松（1994～），男，陕西旬阳人，在读博士研究生，住院医师，主要从事精神疾病相关工作

通讯作者:
沈宗霖，E-mail：shenzl1987@163.com

计量

Research Progress on Gene Related to Suicide in Major Depressive Disorder：A Review

计量

目录

[1]	赵冬艳, 杨润许. 双相情感障碍的遗传学研究进展, 昆明医科大学学报.
[2]	行浩然, 张曦, 张盈盈, 鲍天昊. 青少年抑郁症使用抗抑郁药物的临床进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240725
[3]	余蕾, 武文志, 张云桥, 游旭, 曾勇. HPA轴在抑郁症中的研究概述, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230222
[4]	段登艾, 张勇辉, 王维, 廖欣菊, 张志雄. 儿童期虐待对青少年首发抑郁症患者非自杀性自伤行为的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230304
[5]	戴微微, 冯伟伟, 李德富, 林钐, 秦苇. 风湿免疫病住院患者的抑郁与自杀风险分析, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220302
[6]	徐莉, 赵锦涵, 金于雄, 付会佐, 元静, 王新, 杨建中. 青少年抑郁症患者非自杀性自伤的相关因素, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220529
[7]	赵云欣, 孟繁媛, 刘巍, 吴会东, 罗长良, 李彬, 敖丽娟, 陈茉弦. 单核苷酸多态性与青少年特发性脊柱侧凸的研究进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20221121
[8]	王小云, 王巧云, 顾明华, 丁昱, 关雨雯, 张继兰. miR-373通过P2X7R影响抑郁症小鼠行为的作用机制, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20211030
[9]	马国玉, 熊庆, 蒋国庆, 杨家甜, 木云珍. 基于生物信息学方法识别肺腺癌预后相关基因, 昆明医科大学学报.
[10]	李仙, 季长亮, 曾淑娥, 杨蜀云, 杨皓棋, 侯亚婷. 不同严重程度抑郁症患者认知功能的比较, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20201226
[11]	刘畅, 沈宗霖, 程宇琪, 许秀峰. 精神分裂症、双相情感障碍、抑郁症静息态功能磁共振研究的异同, 昆明医科大学学报.
[12]	倪广惠, 佟钧, 胡芝, 李娜, 陈贤露, 缪璇, 何越峰. 灯盏乙素对乳腺癌细胞中细胞周期调控分子的基因表达, 昆明医科大学学报.
[13]	喻箴. Let-7在正常乳腺组织和乳腺癌组织中的表达, 昆明医科大学学报.
[14]	安新焕. ACE和eNOS 2个基因多态性并存与糖尿病肾病的相关性, 昆明医科大学学报.
[15]	保文莉. 瑜伽运动对高校大学生抑郁症干预效果的研究, 昆明医科大学学报.
[16]	杜映荣. 血管紧张素原（AGT）基因M235T多态性与中老年高血压并抑郁症的相关性研究, 昆明医科大学学报.
[17]	孙健玮. PTEN基因与前列腺癌, 昆明医科大学学报.
[18]	刘梅. 2007年至2008年昆明地区腹泻患儿轮状病毒非结构蛋白基因特征的分析, 昆明医科大学学报.
[19]	. 2型糖尿病合并抑郁危险因素的临床研究, 昆明医科大学学报.
[20]	. 手足口病和腹泻病患儿肠道病毒71型的基因型检测和分析, 昆明医科大学学报.

留言板

抑郁症自杀相关基因的研究进展

doi: 10.12259/j.issn.2095-610X.S20230301

作者简介: 储召松（1994～），男，陕西旬阳人，在读博士研究生，住院医师，主要从事精神疾病相关工作

通讯作者: 沈宗霖，E-mail：shenzl1987@163.com

计量

出版历程

Research Progress on Gene Related to Suicide in Major Depressive Disorder：A Review

计量

出版历程

目录

作者简介:
储召松（1994～），男，陕西旬阳人，在读博士研究生，住院医师，主要从事精神疾病相关工作

通讯作者:
沈宗霖，E-mail：shenzl1987@163.com