ACSM蛋白家族在肿瘤中的研究进展

何成禄; 李娅; 朱敏; 钟敏; 段勇

doi:10.12259/j.issn.2095-610X.S20230307

ACSM蛋白家族在肿瘤中的研究进展

doi: 10.12259/j.issn.2095-610X.S20230307

昆明医科大学第一附属医院医学检验科，云南昆明　650032

基金项目: 国家自然科学基金资助项目（82160407）；云南省科技厅科技计划项目（202201AT070288）；云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目（202001AC070613）

详细信息

作者简介:
何成禄（1981～），男，云南昆明人，博士，主管技师，主要从事肿瘤发病机制研究工作

通讯作者:
段勇，E-mail：kossy3791@sina.com

中图分类号: R730.2
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- 文章访问数: 3986
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- PDF下载量: 54
- 被引次数: 0
出版历程
- 收稿日期: 2022-07-03
- 网络出版日期: 2023-03-02
- 刊出日期: 2023-03-25

Research Progress of ACSM Protein Family in Tumor

Dept. of Clinical Laboratory，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

摘要

摘要: 酰基辅酶A合成酶中链家族（Acyl-CoA Synthetase Medium Chains，ACSMs）是一类可以活化C6～C10脂肪酸，并参与中链脂肪酸的合成与分解的酶，对于细胞的存活具有重要意义。肿瘤发生时，由于肿瘤细胞增长快速，需要高出正常细胞所需的更多的能量供给，除外糖酵解途径，脂肪酸供能也是肿瘤细胞获取能量的重要途径。研究中链脂肪酸合成与代谢的关键酶ACSMs，对于深入探究肿瘤的发生发展及预后等方面均具有重要意义。主要介绍近年来ACSMs家族成员与肿瘤发生发展的研究进展。
- ACSMs /
- 中链脂肪酸 /
- 细胞代谢 /
- 肿瘤
Abstract: Acyl-CoA Synthetase Medium Chains（ACSMs） are enzymes that can activate C6～C10 fatty acids and participate in the synthesis and decomposition of medium chain fatty acids. They are of great significance for cell survival. When tumor occurs, due to the rapid growth of tumor cells, more energy supply is required than that required by normal cells, except glycolysis, fatty acid energy supply is also an important way for tumor cells to obtain energy. The study of ACSMs, the key enzyme of medium chain fatty acid synthesis and metabolism, is of great significance to further explore the occurrence, development and prognosis of tumors. This review mainly introduces the research progress of ACSM family members and tumorigenesis and development in recent years.
- ACSMs /
- MCFAs /
- Cellular metabolism /
- Tumor

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参考文献(47)

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ACSM蛋白家族在肿瘤中的研究进展

doi: 10.12259/j.issn.2095-610X.S20230307

作者简介:
何成禄（1981～），男，云南昆明人，博士，主管技师，主要从事肿瘤发病机制研究工作

通讯作者:
段勇，E-mail：kossy3791@sina.com

计量

Research Progress of ACSM Protein Family in Tumor

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目录

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ACSM蛋白家族在肿瘤中的研究进展

doi: 10.12259/j.issn.2095-610X.S20230307

作者简介: 何成禄（1981～），男，云南昆明人，博士，主管技师，主要从事肿瘤发病机制研究工作

通讯作者: 段勇，E-mail：kossy3791@sina.com

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出版历程

Research Progress of ACSM Protein Family in Tumor

计量

出版历程

目录

作者简介:
何成禄（1981～），男，云南昆明人，博士，主管技师，主要从事肿瘤发病机制研究工作

通讯作者:
段勇，E-mail：kossy3791@sina.com