骨髓间充质干细胞在口腔医学中的应用

杨镕羽; 宋飞; 黄浩; 段开文; 向盈盈

doi:10.12259/j.issn.2095-610X.S20230323

骨髓间充质干细胞在口腔医学中的应用

doi: 10.12259/j.issn.2095-610X.S20230323

1.
昆明医科大学附属延安医院口腔科，云南昆明　650031
2.
昆明医科大学第三附属医院微创介入科，云南昆明　650106

基金项目: 国家自然科学基金资助项目（31860147）；昆明市卫生健康委员会卫生科研课题（2022-08-01-004）

详细信息

作者简介:
杨镕羽（1996～），女，白族，云南大理人，在读硕士研究生，住院医师，主要从事口腔科临床工作

通讯作者:
向盈盈，E- mail：25591394@qq.com

中图分类号: R780.1
计量
- 文章访问数: 3873
- HTML全文浏览量: 2163
- PDF下载量: 18
- 被引次数: 0
出版历程
- 收稿日期: 2022-08-16
- 网络出版日期: 2023-03-03
- 刊出日期: 2023-03-25

Application of Bone Marrow Mesenchymal Stem Cells in Stomatology

1.
Dept. of Stomatology，Yan’an Hospital of Kunming，Kunming Yunnan 650031
2.
Dept. of Minimally Invasive Intervention ，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650106，China

摘要

摘要: 在颌面部，由肿瘤、创伤、先天或后天性的急性引起的组织缺损使患者的容貌、正常生理功能及心理健康受到严重伤害，使患者的整体生活质量下降。寻找适当的治疗方法来恢复这些缺损的组织是至关重要的。近年来，随着组织工程的飞速发展，人们对于口腔组织再生技术十分重视。骨髓来源的间充质干细胞（ bone marrow mesenchymal stem cells ，BMSCs）由于其具有向其他细胞分化的潜力，最常被应用于再生医学。近年来，研究人员开发了许多基于BMSCs的生物支架材料，利用其卓越的性能以满足口腔颌面组织工程的需求。综述BMSCs在口腔医学的研究进展及应用，探讨其在口腔医学中的应用前景。
- 骨髓间充质干细胞 /
- 组织工程 /
- 细胞疗法
Abstract: In the maxillofacial region, tissue defects caused by tumors, trauma, congenital or acquired acute can cause serious damage to the patient’s appearance, normal physiological function and mental health, and overall quality of life of the patient. It is very important to find an appropriate treatment method to restore these defective tissues. In recent years, with the rapid development of tissue engineering, people attach great importance to oral tissue regeneration technology. Bone marrow mesenchymal stem cells （BMSCs）are most often used in regenerative medicine because of their potential to differentiate into other cells. In recent years, researchers have developed many biological scaffolds based on BMSCs to meet the needs of oral and maxillofacial tissue engineering with their excellent performance. This review introduces the research progress and application of BMSCs in stomatology, and discusses its application prospect in stomatology.
- Bone marrow mesenchymal stem cells /
- Tissue engineering /
- Cell therapy

HTML全文

参考文献(31)

[1]	Fiedler T,Rabe M,Mundkowski R G,et al. Adipose-derived mesenchymal stem cells release microvesicles with procoagulant activity[J]. Int J Biochem Cell Biol,2018,100(1):49-53.
[2]	Kishimoto N,Honda Y,Momota Y,et al. Dedifferentiated Fat (DFAT) cells: a cell source for oral and maxillofacial tissue engineering[J]. Oral Dis,2018,24(7):1161-1167. doi: 10.1111/odi.12832
[3]	Buduru Smaranda Dana,Gulei Diana,Zimta Alina-Andreea,et al. The potential of different origin stem cells in modulating oral bone regeneration processes[J]. Cells,2019,8(1):29. doi: 10.3390/cells8010029
[4]	Ansari Sahar,Seagroves Jackson T,Chen Chider,et al. Dental and orofacial mesenchymal stem cells in craniofacial regeneration: The prosthodontist’s point of view[J]. Journal of Prosthetic Dentistry,2017,118(4):455-461. doi: 10.1016/j.prosdent.2016.11.021
[5]	Hu Lifang,Yin Chong,Zhao Fan,et al. Mesenchymal stem cells:Cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment[J]. International Journal of Molecular Sciences,2018,19(2):360.
[6]	Nemeth K,Mezey E. Bone marrow stromal cells as immunomodulators. A primer for dermatologists[J]. J Dermatol Sci,2015,77(1):11-20. doi: 10.1016/j.jdermsci.2014.10.004
[7]	Deak E,Seifried E,Henschler R. Homing pathways of mesenchymal stromal cells (MSCs) and their role in clinical applications[J]. International Reviews of Immunology,2010,29(5):514-529. doi: 10.3109/08830185.2010.498931
[8]	Blanc K L,Rasmusson I,Sundberg B,et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells[J]. Lancet,2004,363(9419):1439-1441. doi: 10.1016/S0140-6736(04)16104-7
[9]	Ciccocioppo Rachele,Bernardo Maria Ester,Sgarella Adele,et al. Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn’s disease[J]. GUT,2011,60(6):788-798. doi: 10.1136/gut.2010.214841
[10]	Tan Jianming,Wu Weizhen,Xu Xiumin,et al. Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants:A randomized controlled trial[J]. Jama-Journal of The American Medical Association,2012,307(11):1169-1177. doi: 10.1001/jama.2012.316
[11]	Oh Eun Jung,Lee Ho Won,Kalimuthu Senthilkumar,et al. In vivo migration of mesenchymal stem cells to burn injury sites and their therapeutic effects in a living mouse model[J]. Journal of Controlled Releaser,2018,279(1):79-88.
[12]	Kakabadze Mariam Z,Paresishvili Teona,Mardaleishvili Konstantine,et al. Local drug delivery system for the treatment of tongue squamous cell carcinoma in rats[J]. Oncology Letters.,2022,23(1):13.
[13]	Xiao Quan,Zhao Zhe,Teng Yun,et al. BMSC-derived exosomes alleviate intervertebral disc degeneration by modulating AKT/mTOR-mediated autophagy of nucleus pulposus cells[J]. Stem Cells International,2022,7(9):9896444.
[14]	Zhou Yan,Wen Lulu,Li Yanfei,et al. Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis[J]. Neural Regeneration Research,2022,17(1):194-202. doi: 10.4103/1673-5374.314323
[15]	Kinane D F,Stathopoulou P G,Papapanou P N. Periodontal diseases[J]. Nat Rev Dis Primers.,2017,3(2):17038.
[16]	Xu Xinyue,Li Xuan,Wang Jia,et al. Concise review:Periodontal tissue regeneration using stem cells:Strategies and translational considerations[J]. Stem Cells Translational Medicine,2019,8(4):392-403. doi: 10.1002/sctm.18-0181
[17]	Sanz A R,Carrión F S,Chaparro A P. Mesenchymal stem cells from the oral cavity and their potential value in tissue engineering[J]. Periodontol,2015,67(1):251-267. doi: 10.1111/prd.12070
[18]	Baba Shunsuke,Yamada Yoichi,Komuro Akira,et al. Phase I/II trial of autologous bone marrow stem cell transplantation with a three-dimensional woven-fabric scaffold for periodontitis[J]. Stem Cells International.,2016,10(17):6205910.
[19]	Xu Mengting,Wei Xing,Fang Jie,et al. Combination of SDF-1 and bFGF promotes bone marrow stem cell-mediated periodontal ligament regeneration[J]. Bioscience Reports,2019,39(12):BSR20190785. doi: 10.1042/BSR20190785
[20]	Liu Li,Guo Shujuan,Shi Weiwei,et al. Bone marrow mesenchymal stem cell-derived small extracellular vesicles promote periodontal regeneration[J]. Tissue Engineering Part A,2021,27(13-14):962-976. doi: 10.1089/ten.tea.2020.0141
[21]	Kaku Masaru,Akiba Yosuke,Akiyama Kentaro,et al. Cell-based bone regeneration for alveolar ridge augmentation-cell source,endogenous cell recruitment and immunomodulatory function[J]. Journal of Prosthodontic Research,2015,59(2):96-112. doi: 10.1016/j.jpor.2015.02.001
[22]	Grassi Felice Roberto,Grassi Roberta,Rapone Biagio,et al. Dimensional changes of buccal bone plate in immediate implants inserted through open flap,open flap and bone grafting and flapless techniques: A cone-beam computed tomography randomized controlled clinical trial[J]. Clinical Oral Implants Research,2019,30(12):1155-1164. doi: 10.1111/clr.13528
[23]	Su Peihong,Tian Ye,Yang Chaofei,et al. Mesenchymal stem cell migration during bone formation and bone diseases therapy[J]. International Journal of Molecular Sciences,2018,19(8):2343. doi: 10.3390/ijms19082343
[24]	Jiang Yinhua,Shang Yu,Zou Duohong,et al. Effect of rat allogeneic BMSCs-Bio-Oss-bFGF compound on tooth extraction healing: a micro-CT study[J]. Shanghai Journal of Stomatology,2022,31(1):38-43.
[25]	Niu Qiannan,He Jiaojiao,Wu Minke,et al. Transplantation of bone marrow mesenchymal stem cells and fibrin glue into extraction socket in maxilla promoted bone regeneration in osteoporosis rat[J]. Life Sciencess,2022,290:119480. doi: 10.1016/j.lfs.2021.119480
[26]	Ma Dong,Wang Yuanyin,Chen Yongxiang,et al. Promoting osseointegration of dental implants in dog maxillary sinus floor augmentation using dentin matrix protein 1-transduced bone marrow stem cells[J]. Tissue Engineering and Regenerative Medicine,2020,17(5):705-715. doi: 10.1007/s13770-020-00277-1
[27]	Xu Ling,Zhang Wenjie,Lv Kaige,et al. Peri-implant bone regeneration using rhPDGF-BB,BMSCs,and β-TCP in a canine model[J]. Clinical Implant Dentistry and Related Research,2016,18(2):241-252. doi: 10.1111/cid.12259
[28]	El-Zekrid Mona H,Mahmoud Salah H,Ali Fawzy A,et al. Healing capacity of autologous bone marrow- derived mesenchymal stem cells on partially pulpotomized dogs’ teeth[J]. Journal of Endodontics,2019,45(3):287-294. doi: 10.1016/j.joen.2018.11.013
[29]	Zhang Lixia,Shen Lili,Ge Shaohua,et al. Systemic BMSC homing in the regeneration of pulp-like tissue and the enhancing effect of stromal cell-derived factor-1 on BMSC homing[J]. International Journal of Clinical and Experimental Pathology,2015,8(9):10261-10271.
[30]	Davies O G,Cooper P R,Shelton R M,et al. A comparison of the in vitro mineralisation and dentinogenic potential of mesenchymal stem cells derived from adipose tissue,bone marrow and dental pulp[J]. Journal of Bone And Mineral Metabolism,2015,33(4):371-382. doi: 10.1007/s00774-014-0601-y
[31]	Wang Sainan,Huang Guibin,Dong Yanmei. Directional migration and odontogenic differentiation of bone marrow stem cells induced by dentin coated with nanobioactive glass[J]. Journal of Endodontics,2020,46(2):216-223. doi: 10.1016/j.joen.2019.11.004

相关文章(20)

[1]	徐静逍, 刘佳, 姚姝, 张希, 李江, 崔桂琴, 易小玲, 李东云. 槲皮素对BMSCs成骨分化的影响及作用机制, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20250504
[2]	徐云容, 何飞. 材料结构对骨再生中血管生成的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20250919
[3]	沈晓霞, 冯春晖, 赵晓东. 基于外泌体STAT3蛋白转运探讨干细胞在对梗死心脏修复及心电生理的影响, 昆明医科大学学报.
[4]	张明慧, 温江涛, 辛小梅, 张宝惠. 骨髓间充质干细胞移植对脊髓损伤后神经病理性疼痛大鼠的影响以及对LPS诱导神经元细胞的作用, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20250709
[5]	蔡啸, 扆雪涛, 姚菁青, 戴昕妤, 汤忠泉, 欧婷, 赵晓敏, 李云涛. 人骨髓间充质干细胞分泌的外泌体调控恶性胶质瘤相关巨噬细胞的极化, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210101
[6]	马丽娅, 饶南荃, 杨禾丰. 间充质干细胞外泌体在口腔组织再生中的研究进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210527
[7]	魏韩笑, 张爱君, 李强, 金培生. 血管内皮祖细胞外泌体调控骨髓间充质干细胞基因表达谱芯片, 昆明医科大学学报.
[8]	王福科, 张红, 杨桂然, 肖渝, 何川, 宋恩, 李彦林. 携载增强型绿色荧光蛋白基因慢病毒转染骨髓间充质干细胞示踪方法, 昆明医科大学学报.
[9]	赵娴, 韩雪松, 周箐竹, 李杉, 刘流, 王松梅. EPCs与BMSCs干细胞联合培养体系修复机体骨缺损, 昆明医科大学学报.
[10]	徐林, 胡敏, 李钟辉, 范建楠. 骨髓间充质干细胞复合人工支架材料治疗骨缺损的研究进展, 昆明医科大学学报.
[11]	杨丹. 间充质干细胞的旁分泌作用对糖尿病肾病的影响, 昆明医科大学学报.
[12]	唐帮丽. 脐带间充质干细胞移植治疗狼疮性肾炎的疗效与机制, 昆明医科大学学报.
[13]	胡正雄. TGF-β2和geneX对BrdU标记骨髓间充质干细胞增殖与成骨分化的作用, 昆明医科大学学报.
[14]	易敏. 兔骨髓间充质干细胞的培养及初步鉴定, 昆明医科大学学报.
[15]	邰文琳. 骨髓间充质干细胞抗肺泡上皮细胞凋亡作用研究, 昆明医科大学学报.
[16]	戚宗泽. 兔骨髓间充质干细胞的分离、体外培养、鉴定及成脂诱导, 昆明医科大学学报.
[17]	王殿华. 骨髓间充质干细胞移植治疗急性肺损伤研究进展, 昆明医科大学学报.
[18]	邰文琳. 小鼠骨髓间充质干细胞体外扩增的实验研究, 昆明医科大学学报.
[19]	. 体外诱导猪骨髓间充质干细胞向尿路上皮细胞分化的实验研究, 昆明医科大学学报.
[20]	杨锋. 两种培养方法在猪自体骨髓间充质干细胞培养的比较研究, 昆明医科大学学报.