Application of Bone Marrow Mesenchymal Stem Cells in Stomatology
-
摘要: 在颌面部,由肿瘤、创伤、先天或后天性的急性引起的组织缺损使患者的容貌、正常生理功能及心理健康受到严重伤害,使患者的整体生活质量下降。寻找适当的治疗方法来恢复这些缺损的组织是至关重要的。近年来,随着组织工程的飞速发展,人们对于口腔组织再生技术十分重视。骨髓来源的间充质干细胞( bone marrow mesenchymal stem cells ,BMSCs)由于其具有向其他细胞分化的潜力,最常被应用于再生医学。近年来,研究人员开发了许多基于BMSCs的生物支架材料,利用其卓越的性能以满足口腔颌面组织工程的需求。综述BMSCs在口腔医学的研究进展及应用,探讨其在口腔医学中的应用前景。Abstract: In the maxillofacial region, tissue defects caused by tumors, trauma, congenital or acquired acute can cause serious damage to the patient’s appearance, normal physiological function and mental health, and overall quality of life of the patient. It is very important to find an appropriate treatment method to restore these defective tissues. In recent years, with the rapid development of tissue engineering, people attach great importance to oral tissue regeneration technology. Bone marrow mesenchymal stem cells (BMSCs)are most often used in regenerative medicine because of their potential to differentiate into other cells. In recent years, researchers have developed many biological scaffolds based on BMSCs to meet the needs of oral and maxillofacial tissue engineering with their excellent performance. This review introduces the research progress and application of BMSCs in stomatology, and discusses its application prospect in stomatology.
-
Key words:
- Bone marrow mesenchymal stem cells /
- Tissue engineering /
- Cell therapy
-
[1] Fiedler T,Rabe M,Mundkowski R G,et al. Adipose-derived mesenchymal stem cells release microvesicles with procoagulant activity[J]. Int J Biochem Cell Biol,2018,100(1):49-53. [2] Kishimoto N,Honda Y,Momota Y,et al. Dedifferentiated Fat (DFAT) cells: a cell source for oral and maxillofacial tissue engineering[J]. Oral Dis,2018,24(7):1161-1167. doi: 10.1111/odi.12832 [3] Buduru Smaranda Dana,Gulei Diana,Zimta Alina-Andreea,et al. The potential of different origin stem cells in modulating oral bone regeneration processes[J]. Cells,2019,8(1):29. doi: 10.3390/cells8010029 [4] Ansari Sahar,Seagroves Jackson T,Chen Chider,et al. Dental and orofacial mesenchymal stem cells in craniofacial regeneration: The prosthodontist’s point of view[J]. Journal of Prosthetic Dentistry,2017,118(4):455-461. doi: 10.1016/j.prosdent.2016.11.021 [5] Hu Lifang,Yin Chong,Zhao Fan,et al. Mesenchymal stem cells:Cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment[J]. International Journal of Molecular Sciences,2018,19(2):360. [6] Nemeth K,Mezey E. Bone marrow stromal cells as immunomodulators. A primer for dermatologists[J]. J Dermatol Sci,2015,77(1):11-20. doi: 10.1016/j.jdermsci.2014.10.004 [7] Deak E,Seifried E,Henschler R. Homing pathways of mesenchymal stromal cells (MSCs) and their role in clinical applications[J]. International Reviews of Immunology,2010,29(5):514-529. doi: 10.3109/08830185.2010.498931 [8] Blanc K L,Rasmusson I,Sundberg B,et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells[J]. Lancet,2004,363(9419):1439-1441. doi: 10.1016/S0140-6736(04)16104-7 [9] Ciccocioppo Rachele,Bernardo Maria Ester,Sgarella Adele,et al. Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn’s disease[J]. GUT,2011,60(6):788-798. doi: 10.1136/gut.2010.214841 [10] Tan Jianming,Wu Weizhen,Xu Xiumin,et al. Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants:A randomized controlled trial[J]. Jama-Journal of The American Medical Association,2012,307(11):1169-1177. doi: 10.1001/jama.2012.316 [11] Oh Eun Jung,Lee Ho Won,Kalimuthu Senthilkumar,et al. In vivo migration of mesenchymal stem cells to burn injury sites and their therapeutic effects in a living mouse model[J]. Journal of Controlled Releaser,2018,279(1):79-88. [12] Kakabadze Mariam Z,Paresishvili Teona,Mardaleishvili Konstantine,et al. Local drug delivery system for the treatment of tongue squamous cell carcinoma in rats[J]. Oncology Letters.,2022,23(1):13. [13] Xiao Quan,Zhao Zhe,Teng Yun,et al. BMSC-derived exosomes alleviate intervertebral disc degeneration by modulating AKT/mTOR-mediated autophagy of nucleus pulposus cells[J]. Stem Cells International,2022,7(9):9896444. [14] Zhou Yan,Wen Lulu,Li Yanfei,et al. Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis[J]. Neural Regeneration Research,2022,17(1):194-202. doi: 10.4103/1673-5374.314323 [15] Kinane D F,Stathopoulou P G,Papapanou P N. Periodontal diseases[J]. Nat Rev Dis Primers.,2017,3(2):17038. [16] Xu Xinyue,Li Xuan,Wang Jia,et al. Concise review:Periodontal tissue regeneration using stem cells:Strategies and translational considerations[J]. Stem Cells Translational Medicine,2019,8(4):392-403. doi: 10.1002/sctm.18-0181 [17] Sanz A R,Carrión F S,Chaparro A P. Mesenchymal stem cells from the oral cavity and their potential value in tissue engineering[J]. Periodontol,2015,67(1):251-267. doi: 10.1111/prd.12070 [18] Baba Shunsuke,Yamada Yoichi,Komuro Akira,et al. Phase I/II trial of autologous bone marrow stem cell transplantation with a three-dimensional woven-fabric scaffold for periodontitis[J]. Stem Cells International.,2016,10(17):6205910. [19] Xu Mengting,Wei Xing,Fang Jie,et al. Combination of SDF-1 and bFGF promotes bone marrow stem cell-mediated periodontal ligament regeneration[J]. Bioscience Reports,2019,39(12):BSR20190785. doi: 10.1042/BSR20190785 [20] Liu Li,Guo Shujuan,Shi Weiwei,et al. Bone marrow mesenchymal stem cell-derived small extracellular vesicles promote periodontal regeneration[J]. Tissue Engineering Part A,2021,27(13-14):962-976. doi: 10.1089/ten.tea.2020.0141 [21] Kaku Masaru,Akiba Yosuke,Akiyama Kentaro,et al. Cell-based bone regeneration for alveolar ridge augmentation-cell source,endogenous cell recruitment and immunomodulatory function[J]. Journal of Prosthodontic Research,2015,59(2):96-112. doi: 10.1016/j.jpor.2015.02.001 [22] Grassi Felice Roberto,Grassi Roberta,Rapone Biagio,et al. Dimensional changes of buccal bone plate in immediate implants inserted through open flap,open flap and bone grafting and flapless techniques: A cone-beam computed tomography randomized controlled clinical trial[J]. Clinical Oral Implants Research,2019,30(12):1155-1164. doi: 10.1111/clr.13528 [23] Su Peihong,Tian Ye,Yang Chaofei,et al. Mesenchymal stem cell migration during bone formation and bone diseases therapy[J]. International Journal of Molecular Sciences,2018,19(8):2343. doi: 10.3390/ijms19082343 [24] Jiang Yinhua,Shang Yu,Zou Duohong,et al. Effect of rat allogeneic BMSCs-Bio-Oss-bFGF compound on tooth extraction healing: a micro-CT study[J]. Shanghai Journal of Stomatology,2022,31(1):38-43. [25] Niu Qiannan,He Jiaojiao,Wu Minke,et al. Transplantation of bone marrow mesenchymal stem cells and fibrin glue into extraction socket in maxilla promoted bone regeneration in osteoporosis rat[J]. Life Sciencess,2022,290:119480. doi: 10.1016/j.lfs.2021.119480 [26] Ma Dong,Wang Yuanyin,Chen Yongxiang,et al. Promoting osseointegration of dental implants in dog maxillary sinus floor augmentation using dentin matrix protein 1-transduced bone marrow stem cells[J]. Tissue Engineering and Regenerative Medicine,2020,17(5):705-715. doi: 10.1007/s13770-020-00277-1 [27] Xu Ling,Zhang Wenjie,Lv Kaige,et al. Peri-implant bone regeneration using rhPDGF-BB,BMSCs,and β-TCP in a canine model[J]. Clinical Implant Dentistry and Related Research,2016,18(2):241-252. doi: 10.1111/cid.12259 [28] El-Zekrid Mona H,Mahmoud Salah H,Ali Fawzy A,et al. Healing capacity of autologous bone marrow- derived mesenchymal stem cells on partially pulpotomized dogs’ teeth[J]. Journal of Endodontics,2019,45(3):287-294. doi: 10.1016/j.joen.2018.11.013 [29] Zhang Lixia,Shen Lili,Ge Shaohua,et al. Systemic BMSC homing in the regeneration of pulp-like tissue and the enhancing effect of stromal cell-derived factor-1 on BMSC homing[J]. International Journal of Clinical and Experimental Pathology,2015,8(9):10261-10271. [30] Davies O G,Cooper P R,Shelton R M,et al. A comparison of the in vitro mineralisation and dentinogenic potential of mesenchymal stem cells derived from adipose tissue,bone marrow and dental pulp[J]. Journal of Bone And Mineral Metabolism,2015,33(4):371-382. doi: 10.1007/s00774-014-0601-y [31] Wang Sainan,Huang Guibin,Dong Yanmei. Directional migration and odontogenic differentiation of bone marrow stem cells induced by dentin coated with nanobioactive glass[J]. Journal of Endodontics,2020,46(2):216-223. doi: 10.1016/j.joen.2019.11.004
点击查看大图
计量
- 文章访问数: 3371
- HTML全文浏览量: 2001
- PDF下载量: 16
- 被引次数: 0