自噬在膀胱癌发展和治疗中的研究进展

陈诗; 付什; 谭智勇; 王剑松; 王海峰

doi:10.12259/j.issn.2095-610X.S20230503

自噬在膀胱癌发展和治疗中的研究进展

doi: 10.12259/j.issn.2095-610X.S20230503

昆明医科大学第二附属医院泌尿外科/云南省泌尿系统疾病临床医学中心，云南昆明　650101

基金项目: 国家自然科学基金资助项目（81660422，81860452）

详细信息

作者简介:
陈诗（1992～），男，湖北宜昌人，在读硕士研究生，住院医师，主要从事膀胱癌基础研究工作

通讯作者:
王海峰，E-mail：wanghaifeng@kmmu.edu.cn

中图分类号: R737.14
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- 被引次数: 0
出版历程
- 收稿日期: 2023-01-01
- 网络出版日期: 2023-05-12
- 刊出日期: 2023-05-25

Research Progress of Autophagy in the Development and Treatment of Bladder Cancer

Dept. of Urology，The 2nd Affiliated Hospital of Kunming Medical University，Yunnan Urinary System Disease Clinical Medical Center，Kunming Yunnan 650101，China

摘要

摘要: 自噬是细胞通过溶酶体降解细胞内物质的一种自我消化过程，被认为是肿瘤在应激条件下维持生存的重要保护机制。大量证据表明，自噬是一把双刃剑，通过不同的信号通路，既可抑制肿瘤的发生，又可促进肿瘤的存活与生长。因此，越来越多的学者认为自噬有望成为肿瘤治疗的新策略。通过总结自噬调控膀胱癌侵袭、转移等生物学行为，以及在膀胱癌治疗的最新进展，以期为靶向自噬抗肿瘤药物的研发和治疗提供新的思路。
- 膀胱癌 /
- 自噬 /
- 肿瘤治疗 /
- 耐药
Abstract: Autophagy is a self-digestive process of cells degrading intracellular substances through lysosomes and is considered to be an important protection mechanism for tumors to maintain survival under stress conditions. A large number of evidence shows that autophagy is a double-edged sword, which can suppress the occurrence of tumors and promote the survival and growth of tumors by different signaling pathways. Therefore, more and more scholars believe that autophagy is expected to become a new strategy for tumor treatment. This paper summarizes the biological behavior of autophagy regulation of bladder cancer invasion, metastasis, and the latest progress in the treatment of bladder cancer and provides new ideas for the development and treatment of autophagy-targeted antitumor drugs.
- Bladder cancer /
- Autophagy /
- Tumor therapy /
- Drug resistance

HTML全文

表 1 自噬与膀胱癌发展

Table 1. Autophagy and the development of bladder cancer

靶标	信号通路	自噬状态	肿瘤调控
砷	不确定	自噬缺陷	肿瘤发生
Rab14	MAPK/ERK	抑制	肿瘤发生
MIR-516A	PHLPP2/BECN1	抑制	肿瘤发生
低营养	TGF-β1/Smad3	激活	上皮间质转化
MIR-21	不确定	抑制	上皮间质转化
缺氧	不确定	激活	血管生成
肿瘤微环境	PI3K/AKT	激活	血管生成
顺铂	BECN1	激活	化疗耐药
吡柔比星	p70S6K/4E-BP1	激活	化疗耐药
IFN-γ	JAK2/STAT3	激活	干性维持
ATG7	USP28/CD44	激活	干性维持
NBR1	Not determined	激活	免疫逃逸
ATG7	FOXO3a/miR-145/PD-L1	激活	免疫逃逸

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表 2 膀胱癌中的靶向自噬治疗

Table 2. Targeted autophagy therapy in bladder cancer

类型	治疗物质	自噬状态	调控作用	测试细胞系
天然活性物质	没食子酸酯	激活	凋亡	T24.5637
	桦木酸	激活	凋亡	T24.EJ
	灵菌红素	抑制	化疗敏感	RT-112
小分子化合药	罗帕洛酸	激活	凋亡	T24.J82
	甲磺酸	抑制	化疗敏感	5637.HT1197
	厄达替尼	激活	凋亡	T24.UMUC-3
非编码RNA	MIR-24-3p	激活	肿瘤发展	T24.BIU-87
	MIR-222	抑制	化疗敏感	T24.5637
	ADAMTS9-AS2	激活	凋亡	5637.UM-UC-3
其他	重组腺病毒	激活	凋亡	T24.5637.EJ
	重组精氨酸酶	激活	凋亡	T24.5637.J82

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