血浆proBDNF水平与原发性干燥综合征伴抑郁症状的相关性研究

冯大莺; 陈华英; 潘虹英; 杨芝兰; 晏姗; 周莉

doi:10.12259/j.issn.2095-610X.S20230605

血浆proBDNF水平与原发性干燥综合征伴抑郁症状的相关性研究

doi: 10.12259/j.issn.2095-610X.S20230605

1.
昆明医科大学第一附属医院风湿免疫科，云南昆明　650032
2.
昆明医科大学附属精神卫生中心，云南昆明　650224
3.
昆明医科大学生物医学工程研究院，云南昆明　650500

基金项目: 国家自然科学基金资助项目（81960806）；云南省科技厅-昆明医科大学应用基础研究联合专项基金重点项目[2019FE001（-001）]；云南省教育厅科学研究基金资助项目（2022J0253）

详细信息

作者简介:
冯大莺（1977～），女，云南昆明人，医学硕士，副主任医师，主要从事风湿免疫科临床工作

通讯作者:
周莉，E-mail：lilyzhou2008km@163.com

中图分类号: R593.2
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出版历程
- 收稿日期: 2023-04-14
- 网络出版日期: 2023-06-16
- 刊出日期: 2023-06-25

Correlation between Plasma proBDNF Level and Primary Sjögren’s Syndrome with Depressive Symptoms

1.
Dept. of Rheumatology and Immunology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
The Mental Health Center Affiliated to Kunming Medical University，Kunming Yunnan 650224
3.
Institute of Biomedical Engineering，Kunming Medical University，Kunming Yunnan 650500，China

摘要

摘要: 目的了解血浆proBDNF水平在原发性干燥综合征（pSS）患者伴抑郁症状中的作用，并对相关因素进行探讨，为早期干预提供参考。方法采用自制一般情况调查表及PHQ-9量表对42例pSS患者及81例健康对照进行调查，并对42例pSS患者采用应对方式问卷（SCSQ）、社会支持评定量表（SSRS）进行调查和评分，欧洲抗风湿病联盟pSS病情活动度量表（ESSDAI）评估pSS疾病活动度。取得知情同意后抽取外周血3～5 mL，检测血浆中proBDNF的水平。结果 pSS伴随抑郁症状患者血浆proBDNF水平升高最为明显（P < 0.05），较少的社会支持是pSS伴随抑郁症状的危险因子。结论 proBDNF可能参与了pSS伴随抑郁症状的发病机制，pSS患者合并抑郁症状时需要更多的社会支持。
- 原发性干燥综合征 /
- 脑源性神经营养因子前体 /
- 心理社会因素
Abstract: Objective To study the role of plasma proBDNF level in patients with primary Sjogren's syndrome （pSS） with depressive symptoms, and to explore related factors, so as to provide evidence for early intervention. Methods A total of 42 pSS patients and 81 healthy controls were investigated with self-made general information questionnaire and PHQ-9 scale, and 42 pSS patients were investigated and scored with Coping style questionnaire （SCSQ） and social support rating scale （SSRS）. European Antirheumatic Association pSS Disease Activity Scale （ESSDAI） was used to evaluate the disease activity of pSS. After informed consent was obtained, 3-5 ml peripheral blood was collected to detect the level of proBDNF. Results The increase of plasma proBDNF level in patients with pSS complicated with depressive symptoms was the most significant （P < 0.05）, and less social support was a risk factor. Conclusion ProBDNF may be involved in the pathogenesis of pSS with depressive symptoms, and these patients need more social support.
- Primary Sjögren’s syndrome /
- Precursor of brain derived neurotropin /
- Psychosocial factors

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图 1 对照组、pSS组和pSS-D组之间血浆proBDNF水平的比较

Figure 1. Comparison of plasma proBDNF levels among control，pSS and pSS-D groups

^*P < 0.05。

下载: 全尺寸图片幻灯片

表 1 对照组、pSS组和pSS-D组一般人口学资料的比较[n（%）/M（P25，P75）/（$ \bar x \pm s$）]

Table 1. Comparison of the demographic data among control group，pSS group and pSS-D group [n（%），M（P25，P75），（$ \bar x \pm s$）]

项目	对照组	pSS组	pSS-D组	χ²/t/F	P
项目	（n = 81）	（n = 12）	（n = 30）	χ²/t/F	P
性别　男　女	3（3.7） 78（96.3）	0（0） 12（100）	2（6.7） 28（93.3）	0.868	0.769
年龄	43.72 ± 9.26	45.50 ± 10.05	47.57 ± 10.51	1.776	0.174
PHQ-9	2.30 ± 0.84	3.08 ± 1.08	7.90 ± 2.06^a	216.047	0.001^*
病程（月）	−	42（2.25，60.00）	24（10.50，72.00）	185.500	0.878
ESDAI评分	−	2（2.00，3.00）	2（2.00，3.00）	144.500	0.271
pSS-D组与对照组及pSS组PHQ-9得分差异均有统计学意义，^*P < 0.05。

下载: 导出CSV

表 2 pSS组和pSS-D组实验室指标的比较[（$\bar x \pm s $），g/L]

Table 2. Comparison of laboratory indicators between pSS and pSS-D groups [（$\bar x \pm s $），g/L]

项目	pSS组	pSS-D组	t	P
球蛋白	36.54 ± 2.82	36.86 ± 1.54	−0.107	0.916
IgG	19.60 ± 1.94	19.72 ± 1.04	−0.060	0.952
IgA	2.55 ± 0.36	2.64 ± 0.35	−0.161	0.873
IgM	1.37 ± 0.24	1.44 ± 0.16	−0.239	0.812
C3	1.01 ± 0.06	1.05 ± 0.04	−0.499	0.621
C4	0.19 ± 0.02	0.23 ± 0.02	−1.169	0.250
ESR（mmH₂O/h）	26.08 ± 6.70	32.07 ± 4.90	−0.677	0.503
CRP（mg/L）	4.27 ± 1.44	3.00 ± 0.55	1.010	0.319

下载: 导出CSV

表 3 pSS组和pSS-D组在SCSQ 、SSRS总分及SSRS3个维度得分间的比较（$\bar x \pm s $）

Table 3. Comparison of SCSQ，SSRS total score and SSRS scores between pSS and pSS-D groups （$\bar x \pm s $）

项目	pSS组（n = 12）	pSS-D组（n = 30）	t	P
SCSQ	10.916 ± 5.248	9.067 ± 4.989	1.070	0.291
SSRS总分	45.09 ± 9.137	37.39 ± 8.135	2.614	0.013^*
主观支持	10.45 ± 4.156	9.29 ± 3.133	0.971	0.338
客观支持	25.82 ± 3.816	21.45 ± 6.115	2.745	0.010^*
对社会支持利用度	7.73 ± 2.970	7.68 ± 2.286	0.057	0.995
^*P < 0.05。

下载: 导出CSV

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