血浆proBDNF水平与原发性干燥综合征伴抑郁症状的相关性研究

冯大莺; 陈华英; 潘虹英; 杨芝兰; 晏姗; 周莉

doi:10.12259/j.issn.2095-610X.S20230605

血浆proBDNF水平与原发性干燥综合征伴抑郁症状的相关性研究

doi: 10.12259/j.issn.2095-610X.S20230605

1.
昆明医科大学第一附属医院风湿免疫科，云南昆明　650032
2.
昆明医科大学附属精神卫生中心，云南昆明　650224
3.
昆明医科大学生物医学工程研究院，云南昆明　650500

基金项目: 国家自然科学基金资助项目（81960806）；云南省科技厅-昆明医科大学应用基础研究联合专项基金重点项目[2019FE001（-001）]；云南省教育厅科学研究基金资助项目（2022J0253）

详细信息

作者简介:
冯大莺（1977～），女，云南昆明人，医学硕士，副主任医师，主要从事风湿免疫科临床工作

通讯作者:
周莉，E-mail：lilyzhou2008km@163.com

中图分类号: R593.2
计量
- 文章访问数: 2833
- HTML全文浏览量: 1827
- PDF下载量: 11
- 被引次数: 0
出版历程
- 收稿日期: 2023-04-14
- 网络出版日期: 2023-06-16
- 刊出日期: 2023-06-25

Correlation between Plasma proBDNF Level and Primary Sjögren’s Syndrome with Depressive Symptoms

1.
Dept. of Rheumatology and Immunology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
The Mental Health Center Affiliated to Kunming Medical University，Kunming Yunnan 650224
3.
Institute of Biomedical Engineering，Kunming Medical University，Kunming Yunnan 650500，China

摘要

摘要: 目的了解血浆proBDNF水平在原发性干燥综合征（pSS）患者伴抑郁症状中的作用，并对相关因素进行探讨，为早期干预提供参考。方法采用自制一般情况调查表及PHQ-9量表对42例pSS患者及81例健康对照进行调查，并对42例pSS患者采用应对方式问卷（SCSQ）、社会支持评定量表（SSRS）进行调查和评分，欧洲抗风湿病联盟pSS病情活动度量表（ESSDAI）评估pSS疾病活动度。取得知情同意后抽取外周血3～5 mL，检测血浆中proBDNF的水平。结果 pSS伴随抑郁症状患者血浆proBDNF水平升高最为明显（P < 0.05），较少的社会支持是pSS伴随抑郁症状的危险因子。结论 proBDNF可能参与了pSS伴随抑郁症状的发病机制，pSS患者合并抑郁症状时需要更多的社会支持。
- 原发性干燥综合征 /
- 脑源性神经营养因子前体 /
- 心理社会因素
Abstract: Objective To study the role of plasma proBDNF level in patients with primary Sjogren's syndrome （pSS） with depressive symptoms, and to explore related factors, so as to provide evidence for early intervention. Methods A total of 42 pSS patients and 81 healthy controls were investigated with self-made general information questionnaire and PHQ-9 scale, and 42 pSS patients were investigated and scored with Coping style questionnaire （SCSQ） and social support rating scale （SSRS）. European Antirheumatic Association pSS Disease Activity Scale （ESSDAI） was used to evaluate the disease activity of pSS. After informed consent was obtained, 3-5 ml peripheral blood was collected to detect the level of proBDNF. Results The increase of plasma proBDNF level in patients with pSS complicated with depressive symptoms was the most significant （P < 0.05）, and less social support was a risk factor. Conclusion ProBDNF may be involved in the pathogenesis of pSS with depressive symptoms, and these patients need more social support.
- Primary Sjögren’s syndrome /
- Precursor of brain derived neurotropin /
- Psychosocial factors

HTML全文

图 1 对照组、pSS组和pSS-D组之间血浆proBDNF水平的比较

Figure 1. Comparison of plasma proBDNF levels among control，pSS and pSS-D groups

^*P < 0.05。

下载: 全尺寸图片幻灯片

表 1 对照组、pSS组和pSS-D组一般人口学资料的比较[n（%）/M（P25，P75）/（$ \bar x \pm s$）]

Table 1. Comparison of the demographic data among control group，pSS group and pSS-D group [n（%），M（P25，P75），（$ \bar x \pm s$）]

项目	对照组	pSS组	pSS-D组	χ²/t/F	P
项目	（n = 81）	（n = 12）	（n = 30）	χ²/t/F	P
性别　男　女	3（3.7） 78（96.3）	0（0） 12（100）	2（6.7） 28（93.3）	0.868	0.769
年龄	43.72 ± 9.26	45.50 ± 10.05	47.57 ± 10.51	1.776	0.174
PHQ-9	2.30 ± 0.84	3.08 ± 1.08	7.90 ± 2.06^a	216.047	0.001^*
病程（月）	−	42（2.25，60.00）	24（10.50，72.00）	185.500	0.878
ESDAI评分	−	2（2.00，3.00）	2（2.00，3.00）	144.500	0.271
pSS-D组与对照组及pSS组PHQ-9得分差异均有统计学意义，^*P < 0.05。

下载: 导出CSV

表 2 pSS组和pSS-D组实验室指标的比较[（$\bar x \pm s $），g/L]

Table 2. Comparison of laboratory indicators between pSS and pSS-D groups [（$\bar x \pm s $），g/L]

项目	pSS组	pSS-D组	t	P
球蛋白	36.54 ± 2.82	36.86 ± 1.54	−0.107	0.916
IgG	19.60 ± 1.94	19.72 ± 1.04	−0.060	0.952
IgA	2.55 ± 0.36	2.64 ± 0.35	−0.161	0.873
IgM	1.37 ± 0.24	1.44 ± 0.16	−0.239	0.812
C3	1.01 ± 0.06	1.05 ± 0.04	−0.499	0.621
C4	0.19 ± 0.02	0.23 ± 0.02	−1.169	0.250
ESR（mmH₂O/h）	26.08 ± 6.70	32.07 ± 4.90	−0.677	0.503
CRP（mg/L）	4.27 ± 1.44	3.00 ± 0.55	1.010	0.319

下载: 导出CSV

表 3 pSS组和pSS-D组在SCSQ 、SSRS总分及SSRS3个维度得分间的比较（$\bar x \pm s $）

Table 3. Comparison of SCSQ，SSRS total score and SSRS scores between pSS and pSS-D groups （$\bar x \pm s $）

项目	pSS组（n = 12）	pSS-D组（n = 30）	t	P
SCSQ	10.916 ± 5.248	9.067 ± 4.989	1.070	0.291
SSRS总分	45.09 ± 9.137	37.39 ± 8.135	2.614	0.013^*
主观支持	10.45 ± 4.156	9.29 ± 3.133	0.971	0.338
客观支持	25.82 ± 3.816	21.45 ± 6.115	2.745	0.010^*
对社会支持利用度	7.73 ± 2.970	7.68 ± 2.286	0.057	0.995
^*P < 0.05。

下载: 导出CSV

参考文献(20)

[1]	韩晓蕾,石磊,任夏瑾,等. 原发性干燥综合征患者睡眠质量情况及其对病情影响分析[J]. 中华风湿病学杂志,2022,26(3):179-184. doi: 10.3760/cma.j.cn141217-20210604-00227
[2]	Goulabchand R,Castille E,Navucet S,et al. The interplay between cognition,depression,anxiety,and sleep in primary Sjogren’s syndrome patients[J]. Scientific Reports,2022,12(1):13176. doi: 10.1038/s41598-022-17354-1
[3]	Cui Y,Xia L,Li L,et al. Anxiety and depression in primary Sjögren’s syndrome:A cross-sectional study[J]. BMC Psychiatry,2018,18(1):131. doi: 10.1186/s12888-018-1715-x
[4]	Milic V,Grujic M,Barisic J,et al. Personality,depression and anxiety in primary Sjögren’s syndrome-Association with sociodemographic factors and comorbidity[J]. PLoS One,2019,14(1):e0210466.
[5]	Grygiel-Górniak B,Limphaibool N,Puszczewicz M. Cytokine secretion and the risk of depression development in patients with connective tissue diseases[J]. Psychiatry Clin Neurosci,2019,73(6):302-316. doi: 10.1111/pcn.12826
[6]	Fauchais A,Lalloué F,Lise M,et al. Role of endogenous brain-derived neurotrophic factor and sortilin in B cell survival[J]. J Immunol,2008,181(5):3027-3038. doi: 10.4049/jimmunol.181.5.3027
[7]	Schuhmann B,Dietrich A,Sel S,et al. A role for brain-derived neurotrophic factor in B cell development[J]. J Neuroimmunol,2005,163(1-2):15-23. doi: 10.1016/j.jneuroim.2005.01.023
[8]	Wang Z,Wu J,Zhong F,et al. Upregulation of proBDNF in the mesenteric lymph nodes in septic mice[J]. Neurotox Res,2019,36(3):540-550. doi: 10.1007/s12640-019-00081-3
[9]	Luo R,Luo C,Zhong F,et al. ProBDNF promotes sepsis-associated encephalopathy in mice by dampening the immune activity of meningeal CD4 T cells[J]. J Neuroinflammation,2020,17(1):169. doi: 10.1186/s12974-020-01850-0
[10]	Zhou L,Xiong J,Lim Y,et al. Upregulation of blood proBDNF and its receptors in major depression[J]. J Affect Disord,2013,150(3):776-784. doi: 10.1016/j.jad.2013.03.002
[11]	Shiboski C H,Shiboski S C,Seror R,et al. 2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren’s Syndrome:A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts[J]. Arthritis Rheumatol,2017,69(1):35-45.
[12]	Aloe L,Bracci-Laudiero L,Bonini S,et al. The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases[J]. Allergy,1997,52(9):883-894. doi: 10.1111/j.1398-9995.1997.tb01247.x
[13]	Strom T,Evrin P E,Karlsson A. Serum beta-2-microglobulin in Sjögren’s syndrome[J]. Scand J Rheumatol,1978,7(2):97-100. doi: 10.3109/03009747809098844
[14]	Lapchak P A,Araujo D M,Hefti F. Systemic interleukin-1 beta decreases brain-derived neurotrophic factor messenger RNA expression in the rat hippocampal formation[J]. Neuroscience,1993,53(2):297-301. doi: 10.1016/0306-4522(93)90196-M
[15]	Hu Z L,Luo C,Hurtado P R,et al. Brain-derived neurotrophic factor precursor in the immune system is a novel target for treating multiple sclerosis[J]. Theranostics,2021,11(2):715-730. doi: 10.7150/thno.51390
[16]	Fauchais A L,Ahmed Boumédiène,Fabrice Lalloué,et al. Brain-derived neurotrophic factor and nerve growth factor correlate with T-cell activation in primary Sjogren's syndrome[J]. Scand J Rheumatol,2009,38(1):50-57. doi: 10.1080/03009740802378832
[17]	Pertovaara M,Silvennoinen O,Isomäki P. Cytokine-induced STAT1 activation is increased in patients with primary Sjögren’s syndrome[J]. Clin Immunol,2016,165:60-67. doi: 10.1016/j.clim.2016.03.010
[18]	Hou R,Garner M,Holmes C,et al. Peripheral inflammatory cytokines and immune balance in generalised anxiety disorder: case-controlled study[J]. Brain,Behavior,and Immunity,2017,62:212-218.
[19]	Liu H T,Lin Y N,Tsai M C,et al. Baicalein exerts therapeutic effects against endotoxin-induced depression-like behavior in mice by decreasing inflammatory cytokines and increasing brain-derived neurotrophic factor levels[J]. Antioxidants (Basel),2022,11(5):947. doi: 10.3390/antiox11050947
[20]	杨敏,刘荣,周润华,等. 原发性干燥综合征患者抑郁症患病率调查及相关因素分析[J]. 中华风湿病学杂志,2013,17(6):387-391.

相关文章(20)

[1]	陈智镖, 黄秋香, 毛丽华, 陈国勇, 刘芸, 王志红. 胚胎植入前遗传学检测在Turner综合征患者中的临床应用, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20231216
[2]	王虹, 杨德兴, 王强, 周维钰, 唐杰夫, 王振方, 付凯, 刘圣哲, 刘荣. ICU脓毒症患者发生再喂养综合征的危险因素分析及预测模型建立, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20221102
[3]	苑晓微, 秦茂华, 王丽君, 杨廷仙, 金晶. 炎症因子在青春期多囊卵巢综合征中的表达特点, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220517
[4]	唐嘉黛, 谢琳, 宋红莉, 陈娇娇. 代谢综合征与胃癌发生发展的相关性研究, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20211130
[5]	董正娇, 张文悫, 杨琳娜, 黄学惠, 张镱严, 张文阳, 张京晶. 汉族多囊卵巢综合征（PCOS）患者生命质量状况及影响因素, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210508
[6]	李孔龙, 陈晶, 赵玲, 舒筠然, 柯亭羽. 阻塞性睡眠呼吸暂停低通气综合征与亚临床甲减的相关性, 昆明医科大学学报.
[7]	何芸, 李文宏, 陈浩, 袁扬, 李慧, 罗洁, 王晓丹. 缓慢连续超滤对抗利尿性心肾综合征的疗效评价, 昆明医科大学学报.
[8]	袁海凤, 苏学文, 李田昌. 急性冠脉综合征首发年龄与既往疾病相关性分析, 昆明医科大学学报.
[9]	胡月新. 两种不同神经电生理检查法对桡管综合征的鉴别诊断, 昆明医科大学学报.
[10]	蒋婷婷. 脂肪因子Vaspin、Apelin及瘦素与多囊卵巢综合征的相关性, 昆明医科大学学报.
[11]	刘娟. 干燥综合征蛋白组学的研究, 昆明医科大学学报.
[12]	刘瑜. 肾小管标记物对原发性肾病综合征诊断价值, 昆明医科大学学报.
[13]	柯亭羽. 阻塞性睡眠呼吸暂停低通气综合征患者骨密度改变, 昆明医科大学学报.
[14]	毛文文. 老年原发性空泡蝶鞍综合征143例临床诊疗, 昆明医科大学学报.
[15]	杨宇舟. 核素显像评价类风湿性关节炎继发干燥综合征的大涎腺功能损害, 昆明医科大学学报.
[16]	梁志明. MRI对后循环可逆性脑病综合征的诊断价值, 昆明医科大学学报.
[17]	陈学平. 自身免疫性肝炎-原发性胆汁性肝硬化重叠综合征36例临床与病理分析, 昆明医科大学学报.
[18]	李力燕. 神经营养因子前体的研究, 昆明医科大学学报.
[19]	丘红梅. 代谢综合征患者胰岛素抵抗与血浆醛固酮相关性研究, 昆明医科大学学报.
[20]	伏忠阳. 青年人早期复极综合征心电图特点及其影响因素, 昆明医科大学学报.