Research Progress of Glycolytic Reprogramming in Oral Squamous Cell Carcinoma
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摘要: 口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)是口腔颌面部最常见的恶性肿瘤,发病率高且预后不佳。癌细胞通过糖酵解代谢重编程改变代谢方式,以支持其对ATP需求的增加。糖酵解重编程介导了包括口腔鳞状细胞癌在内的多系统肿瘤的发生发展,其中涉及多个信号通路和关键因子。总结OSCC中发生的糖酵解代谢改变、关键因子及临床诊治潜能,综述其在口腔鳞状细胞癌中的作用,以期为研究者提供新的研究方向和思路。Abstract: Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the oral and maxillofacial region with high incidence and poor prognosis. Cancer cells change their metabolism through glycolytic metabolic reprogramming to support their increased demand for ATP. Glycolytic reprogramming mediates the development of multisystem tumors, including oral squamous cell carcinoma, involving multiple signaling pathways and key factors. In this paper, the changes of glycolytic metabolism, key factors and potential clinical diagnostic and theraputic approches of OSCC are summarized, and the role of OSCC in oral squamous cell carcinoma is reviewed in order to provide new research directions and ideas.
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