肠道菌群与儿童非酒精性脂肪性肝病的研究进展

李露; 田云粉

doi:10.12259/j.issn.2095-610X.S20230708

肠道菌群与儿童非酒精性脂肪性肝病的研究进展

doi: 10.12259/j.issn.2095-610X.S20230708

李露,
田云粉^,

昆明理工大学附属医院/云南省第一人民医院儿科，云南昆明　650032

基金项目: 国家自然科学基金资助项目（81760110）；云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目（202201AY070001-253）

详细信息

作者简介:
李露（1995～），女，四川资阳人，在读硕士研究生，主要从事儿科消化临床工作

通讯作者:
田云粉，E-mail：136506595@qq.com

中图分类号: R725.7
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出版历程
- 收稿日期: 2022-02-24
- 网络出版日期: 2023-07-18
- 刊出日期: 2023-07-25

Research Progress on Intestinal Microflora and Non-alcoholic Fatty Liver Disease in Children

Lu LI,
Yunfen TIAN^,

Dept. of Pediatrics，The Affiliated Hospital of Kunming University of Science and Technology/ Dept. of Pediatrics，The 1st People’s Hospital of Yunnan Province， Kunming Yunnan 650032，China

摘要

摘要: 儿童非酒精性脂肪性肝病（NAFLD）是全球儿童最常见慢性肝脏疾病，其发病率随着全球肥胖的流行而逐步上升，但缺乏规范、有效的治疗方案。目前其发病机制尚未完全阐明，在众多致病因素中，肠道菌群失调是目前的研究热点，为NAFLD的诊断、预防和治疗开辟了新的方向，但目前对儿童NAFLD的治疗仍在探索中。对近年来肠道菌群及其代谢产物介导儿童NAFLD 的可能机制以及以肠道菌群为干预靶点的诊治方法进行综述，为儿童NAFLD的治疗提供一些新的思路及方法。
- 非酒精性脂肪性肝病 /
- 儿童 /
- 肠道菌群 /
- 肝肠轴 /
- 靶向治疗
Abstract: Pediatric non-alcoholic fatty liver disease （NAFLD） is the most common cause of pediatric chronic liver disease worldwide, and its incidence is gradually increasing with the global epidemic of obesity, but there is no standardized and effective treatment plan. At present, the pathogenesis of NAFLD has not been fully elucidated, Among many pathogenic factors, intestinal microflora disorder is the current research hotspot, which opens up a new direction for the diagnosis, prevention, and treatment of NAFLD. However, the treatment of NAFLD in children is still being explored. In this paper, the possible mechanism of intestinal flora and its metabolites mediating NAFLD in children in recent years was reviewed, as well as the diagnosis and treatment methods using intestinal flora as an intervention target, hoping to provide some new ideas and methods for the treatment of NAFLD in children.
- Non-alcoholic fatty liver disease /
- Children /
- Gut microbiota /
- Gut-liver axis /
- Targeted therapy

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参考文献(72)

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肠道菌群与儿童非酒精性脂肪性肝病的研究进展

doi: 10.12259/j.issn.2095-610X.S20230708

作者简介:
李露（1995～），女，四川资阳人，在读硕士研究生，主要从事儿科消化临床工作

通讯作者:
田云粉，E-mail：136506595@qq.com

计量

Research Progress on Intestinal Microflora and Non-alcoholic Fatty Liver Disease in Children

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目录

[1]	李波, 孙杨, 缪应雷. 炎症性肠病的肠道微生态变化及对策, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240401
[2]	胡伟, 李金男, 杨伟, 苏黎, 喻卓, 陈志松. 儿童肌部室间隔缺损的介入治疗研究, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240307
[3]	陈杭, 崔琦, 黄敏杉, 刘建军, 马岚青. miRNA在非酒精性脂肪性肝病中的研究进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240101
[4]	牛俊杰, 姬文娟, 于拽拽. 肠道菌群、血清ET、PCT水平与脓毒症病情程度、预后的相关性, 昆明医科大学学报.
[5]	李媛媛, 宋亚贤, 徐玉善, 曾晓甫, 袁惠, 徐兆, 江艳. 肠道菌群代谢物TMAO与非酒精性脂肪性肝病的关系, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240210
[6]	李抒瑾, 杨艳飞, 苏敏, 凌昱, 饶艳琼, 崔继华. 儿童注意缺陷多动障碍共病情绪问题的单核苷酸多态性研究, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230420
[7]	李丹, 万绪莲, 李律宇, 云宇, 罗光云, 刘韦兵, 林公府, 李宁, 黎勇坤, 段为钢. 尿酸酶缺失大鼠肠道菌群的变化, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230205
[8]	张学敏, 田云粉. 胆汁酸代谢异常在非酒精性脂肪性肝病发展中的作用, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20231125
[9]	陆小华, 袁洪新. BTLA、CTLA-4基因多态性与肝癌TACE联合靶向治疗疗效及预后相关性, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230927
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肠道菌群与儿童非酒精性脂肪性肝病的研究进展

doi: 10.12259/j.issn.2095-610X.S20230708

作者简介: 李露（1995～），女，四川资阳人，在读硕士研究生，主要从事儿科消化临床工作

通讯作者: 田云粉，E-mail：136506595@qq.com

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出版历程

Research Progress on Intestinal Microflora and Non-alcoholic Fatty Liver Disease in Children

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出版历程

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作者简介:
李露（1995～），女，四川资阳人，在读硕士研究生，主要从事儿科消化临床工作

通讯作者:
田云粉，E-mail：136506595@qq.com