DNA甲基化与精神分裂症的研究进展

尹文卅; 卢玉梅; 佟金莲; 聂胜洁; 阮冶

doi:10.12259/j.issn.2095-610X.S20230811

DNA甲基化与精神分裂症的研究进展

doi: 10.12259/j.issn.2095-610X.S20230811

尹文卅^{1, 2, 3},
卢玉梅⁴,
佟金莲^{1, 2, 3, ,},
聂胜洁⁵,
阮冶^{1, 2, 3}

1.
云南省精神病医院医务部
2.
云南省精神卫生防治中心
3.
昆明医科大学附属精神卫生中心，云南昆明　650224
4.
昆明医科大学法医学院，云南昆明　650500
5.
昆明医科大学研究生院，云南昆明　650500

基金项目: 国家自然科学基金资助项目（31860300）；昆明市卫生健康委员会卫生科研课题项目（2022-03-09-002）

详细信息

作者简介:
尹文卅（1987～），男，云南昆明人，医学硕士，主治医师，主要从事精神疾病的诊断、治疗与研究工作

通讯作者:
佟金莲，E-mail：bbyhyx@126.com

中图分类号: R749.3
计量
- 文章访问数: 1229
- HTML全文浏览量: 810
- PDF下载量: 6
- 被引次数: 0
出版历程
- 收稿日期: 2023-06-11
- 网络出版日期: 2023-09-09
- 刊出日期: 2023-08-30

Research Progress of DNA Methylation and Schizophrenia

Wensa YIN^{1, 2, 3},
Yumei LU⁴,
Jinlian TONG^{1, 2, 3
, ,},
shengjie NIE⁵,
Ye RUAN^{1, 2, 3}

1.
Dept. of Medical Administration，The Psychiatric Hospital of Yunnan Province
2.
The Mental Health Prevention and Treatment Center of Yunnan Province
3.
The Mental Health Center Affiliated to Kunming Medical University，Kunming Yunnan 650224
4.
School of Forensic Medicine，Kunming Medical University，Kunming Yunnan 650500
5.
Dept. of Postgraduate，Kunming Medical University，Kunming Yunnan 650500，China

摘要

摘要: 精神分裂症是一种以认知、思维、情感、行为等多方面显著异常为特征的精神疾病，是最常见的重性精神疾病之一，给个人、家庭以及社会带来严重困扰。近年来针对精神分裂症患者的表观遗传学研究，DNA甲基化是主要的研究方向之一。综述近年来DNA甲基化与精神分裂症的研究进展，以期为精神分裂症症的进一步研究提供新的思路及参考价值。
- 精神分裂症 /
- DNA甲基化 /
- MAOA基因 /
- COMT基因 /
- GAD1基因
Abstract: Schizophrenia is a mental disorder characterized by significant abnormalities in cognition, thinking, emotion, and behavior. It is one of the most common severe mental disorders and causes serious distress to individuals, families, and society. In recent years, epigenetic studies focusing on DNA methylation have been conducted to understand schizophrenia. This review summarizes the research progress on DNA methylation and schizophrenia in recent years, aiming to provide new insights and reference value for further research on schizophrenia.
- Schizophrenia /
- DNA methylation /
- MAOA gene /
- COMT gene /
- GAD1 gene

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