糖尿病肾小管病研究进展

熊煜欣; 杨莹

doi:10.12259/j.issn.2095-610X.S20230920

糖尿病肾小管病研究进展

doi: 10.12259/j.issn.2095-610X.S20230920

熊煜欣,
杨莹^,

云南大学附属医院内分泌科，云南昆明　650021

基金项目: 国家自然科学基金资助项目（82160159）；云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目（202001AY70001-091）

详细信息

作者简介:
熊煜欣（1979～），男，云南昆明人，在读博士研究生，主要从事糖尿病肾病及糖尿病创面修复科研工作

通讯作者:
杨莹，E-mail：yangying2072@126.com

中图分类号: R587.2
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- 文章访问数: 1088
- HTML全文浏览量: 608
- PDF下载量: 30
- 被引次数: 0
出版历程
- 收稿日期: 2023-04-01
- 网络出版日期: 2023-09-28
- 刊出日期: 2023-09-30

Research Progress of Diabetic Tubulopathy

Yuxin XIONG,
Ying YANG^,

Dept. of Endocrinology，The Affiliated Hospital of Yunnan University， Kunming Yunnan 650021，China

摘要

摘要: 糖尿病肾病已成为慢性肾脏疾病和终末期肾病的主要原因。更好地了解糖尿病肾病早期变化的特征和分子机制，有助于开发预防该慢性病变的新策略。早期糖尿病肾病损伤机制和治疗靶点的研究已由以肾小球损伤为中心转移到糖尿病肾小管病（diabetic tubulopathy，DT）。就血糖、补体、生物标志物和线粒体在糖尿病肾小管病的作用机制研究和相关治疗靶点进行综述，以期为早期糖尿病肾病的诊断和治疗提供新的方向。
- 糖尿病肾病 /
- 糖尿病肾小管病 /
- 补体 /
- 生物标志物 /
- 线粒体
Abstract: Diabetic kidney disease（DKD） has become a major cause of chronic kidney disease and end-stage renal disease. A better understanding of the characteristics and molecular mechanisms of the early changes in DKD will contribute to the development of new strategies to prevent this chronic disease. The research on the damage mechanism and therapeutic targets of early DKD has shifted from glomerular damage to diabetic tubulopathy（DT）. This article summarizes the mechanism and therapeutic targets of blood glucose, complement, biomarkers and mitochondria in DT, with the purpose to provide a new direction for the diagnosis and treatment of early DKD.
- Diabetic kidney disease /
- Diabetic tubulopathy /
- Complement /
- Biomarker /
- Mitochondria

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参考文献(71)

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糖尿病肾小管病研究进展

doi: 10.12259/j.issn.2095-610X.S20230920

作者简介:
熊煜欣（1979～），男，云南昆明人，在读博士研究生，主要从事糖尿病肾病及糖尿病创面修复科研工作

通讯作者:
杨莹，E-mail：yangying2072@126.com

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Research Progress of Diabetic Tubulopathy

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目录

[1]	杨曼, 赵兴安, 葛芸娜, 秦娟, 王玺雅, 陶四明. 基于综合生物信息分析鉴定心房颤动相关炎症基因及其与免疫细胞浸润的关联, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240303
[2]	周静, 李麟玲, 汪海红, 杨玉琼. 糖尿病肾病开展Triangle分层分级管理+LEARNS模式的效果及心理状态的观察, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240429
[3]	赵玲, 钟洪玲, 高歆茹, 李妹, 毛婷婷, 李荣勇, 柯亭羽. SGLT-2抑制剂延缓糖尿病肾病进展的临床疗效, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230527
[4]	薛国强, 卫欣欣, 姚娜, 赵文化. 二甲双胍通过调控PARP-1活性对2型糖尿病肾脏的保护作用, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20210632
[5]	曾怡, 廖云娟, 李颖, 何振坤. 达格列净治疗早期糖尿病肾病的疗效及对血清MCP-1、IL-6水平的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20211218
[6]	张尊月, 李坪, 唐莉, 王昆华, 龙艳喜, 王华伟. 线粒体和胚胎发育关系的研究进展, 昆明医科大学学报.
[7]	向茜. 维生素D受体基因FokI位点单核苷酸多态性与糖尿病肾病的相关性, 昆明医科大学学报.
[8]	杨丹. 间充质干细胞的旁分泌作用对糖尿病肾病的影响, 昆明医科大学学报.
[9]	张席军. 中期因子及CTGF与糖尿病肾病患者纤维化相关因子关系探讨, 昆明医科大学学报.
[10]	向茜. 25羟维生素D与2型糖尿病肾病的关系, 昆明医科大学学报.
[11]	安新焕. ACE和eNOS 2个基因多态性并存与糖尿病肾病的相关性, 昆明医科大学学报.
[12]	李会芳. 糖尿病肾病易感基因位点多态性的交互作用, 昆明医科大学学报.
[13]	王兴宁. 尿微量白蛋白与肌酐比值在2型糖尿病早期肾损伤中的应用, 昆明医科大学学报.
[14]	毛文文. 布美他尼治疗老年2型糖尿病中晚期肾病的临床疗效观察, 昆明医科大学学报.
[15]	杜兴华. 血清胱抑素C和血清肌酐、尿素在糖尿病肾病早期诊断中的应用价值, 昆明医科大学学报.
[16]	卢房利. β-catenin与视黄醇结合蛋白对糖尿病肾病的诊断价值, 昆明医科大学学报.
[17]	唐丽丽. GLP-1与2型糖尿病及糖尿病肾病的相关性研究, 昆明医科大学学报.
[18]	陈关芬. 缬沙坦联合胰激肽原酶治疗早期糖尿病肾病的临床评价, 昆明医科大学学报.
[19]	. α-硫辛酸对2型糖尿病早期肾病保护作用的探讨, 昆明医科大学学报.
[20]	李梅蕊. PC-1基因多态性与2型糖尿病及糖尿病肾病的相关性研究, 昆明医科大学学报.

留言板

糖尿病肾小管病研究进展

doi: 10.12259/j.issn.2095-610X.S20230920

作者简介: 熊煜欣（1979～），男，云南昆明人，在读博士研究生，主要从事糖尿病肾病及糖尿病创面修复科研工作

通讯作者: 杨莹，E-mail：yangying2072@126.com

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Research Progress of Diabetic Tubulopathy

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作者简介:
熊煜欣（1979～），男，云南昆明人，在读博士研究生，主要从事糖尿病肾病及糖尿病创面修复科研工作

通讯作者:
杨莹，E-mail：yangying2072@126.com