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沙库巴曲缬沙坦在植入埋藏式心律转复除颤器慢性心力衰竭患者中的应用

尚蒙 高晓龙 匡晓晖 张曦 张进 王礼琳

尚蒙, 高晓龙, 匡晓晖, 张曦, 张进, 王礼琳. 沙库巴曲缬沙坦在植入埋藏式心律转复除颤器慢性心力衰竭患者中的应用[J]. 昆明医科大学学报, 2023, 44(11): 63-69. doi: 10.12259/j.issn.2095-610X.S20231109
引用本文: 尚蒙, 高晓龙, 匡晓晖, 张曦, 张进, 王礼琳. 沙库巴曲缬沙坦在植入埋藏式心律转复除颤器慢性心力衰竭患者中的应用[J]. 昆明医科大学学报, 2023, 44(11): 63-69. doi: 10.12259/j.issn.2095-610X.S20231109
Meng SHANG, Xiaolong GAO, Xiaohui KUANG, Xi ZHANG, Jin ZHANG, Lilin WANG. Application of Sacubitril/valsartan in Patients with Chronic Heart Failure Implanted with Implantable Cardioverter Defibrillators[J]. Journal of Kunming Medical University, 2023, 44(11): 63-69. doi: 10.12259/j.issn.2095-610X.S20231109
Citation: Meng SHANG, Xiaolong GAO, Xiaohui KUANG, Xi ZHANG, Jin ZHANG, Lilin WANG. Application of Sacubitril/valsartan in Patients with Chronic Heart Failure Implanted with Implantable Cardioverter Defibrillators[J]. Journal of Kunming Medical University, 2023, 44(11): 63-69. doi: 10.12259/j.issn.2095-610X.S20231109

沙库巴曲缬沙坦在植入埋藏式心律转复除颤器慢性心力衰竭患者中的应用

doi: 10.12259/j.issn.2095-610X.S20231109
基金项目: 国家自然科学基金资助项目(81360039)
详细信息
    作者简介:

    尚蒙(1996~),女,河南镇平人,在读硕士研究生,主要从事心血管疾病临床工作

    通讯作者:

    王礼琳,E-mail:kmwanglin@163.com

  • 中图分类号: R541.6

Application of Sacubitril/valsartan in Patients with Chronic Heart Failure Implanted with Implantable Cardioverter Defibrillators

  • 摘要:   目的  探讨沙库巴曲缬沙坦(S/V)对植入埋藏式心律转复除颤器(ICD)进行心脏性猝死(SCD)一级预防的射血分数下降性的慢性心力衰竭(HFrEF)患者心功能及室性心律失常的影响。  方法  纳入2017年9月至2022年12月期间在云南省第一人民医院心血管内科住院的接受S/V治疗并植入ICD进行SCD一级预防的HFrEF患者。(1)统计患者随访12个月时S/V剂量,治疗3月、6月、12月时心脏彩超指标(LVEF、LVEDD、LAD);(2)ICD记录的室性心律失常事件及治疗情况,动态心电图指标:平均每小时室性早搏次数、全部窦性心搏RR间期的标准差(SDNN)及校正后的平均QT间期(QTc)。  结果  共纳入56例患者。(1)随访1 a时,S/V的平均用药剂量为94.6 mg,bid。(2)随访3月LVEF、LVEDD、LAD均较治疗前改善;随访6月LVEF、LVEDD、LAD较治疗3月时改善;随访12月LVEF、LVEDD、LAD较治疗6月时改善,差异均有统计学意义(P < 0.05)。(3)与随访1~6月相比较,随访7~12月患者室性心动过速/心室颤动(VT/VF)、非持续性室性心动过速(NSVT)、监测室速发作次数均减少,差异有统计学意义(P < 0.05)。(4)与治疗前相比较,随访1 a患者SDNN由(94.38±26.42) ms增加至(102.23±20.36) ms;平均QTc由(441.92±10.64) ms缩短到(411.46±6.00) ms,差异均有统计学意义(P < 0.05)。  结论  (1)植入ICD进行SCD一级预防的HFrEF患者服用S/V治疗的1 a内心脏结构及功能持续改善;(2)随访期间S/V减少了室性心律失常的发生。
  • 表  1  S/V的使用情况[n(%)]

    Table  1.   Usage of S/V[n(%)]

    时间 剂量( mg,bid)
    12.52550100200
    初始 1(1.79) 22(39.29) 26(46.43) 6(10.71) 1(1.79)
    1 a 0(0.00) 2(3.57) 24(42.86) 20(35.71) 10(17.86)
    下载: 导出CSV

    表  2  随访期间LVEF、LVEDD、LAD改善情况表($ \bar x \pm s $

    Table  2.   The improvement of LVEF、LVEDD、LAD during the follow-up period($ \bar x \pm s $

    指标时间数值tP
    LVEF(%) 基线 27.61±5.88
    3月 34.09±7.17 7.666 <0.001*
    6月 38.22±9.46 8.310 <0.001*
    1 a 41.87±10.81 7.408 <0.001*
    LVEDD(cm) 基线 6.91±0.74
    3月 6.38±0.80 −7.838 <0.001*
    6月 6.09±0.81 −5.765 <0.001*
    1 a 5.75±0.83 −9.629 <0.001*
    LAD(cm) 基线 4.36±0.65
    3月 4.15±0.60 −4.630 <0.001*
    6月 3.98±0.59 −4.541 <0.001*
    1 a 3.81±0.57 −5.600 <0.001*
      注:LVEF:左心室射血分数,LVEDD:左心室舒张末期内径,LAD:左房内径,*P < 0.05。
    下载: 导出CSV

    表  3  心律失常事件

    Table  3.   Arrhythmic events

    观察指标1~6月7~12月zP
    VT/VF发作总次数(次/6月) 22 8 −2.325 0.020*
    ≥1次NSVT发作的患者人数(n 21 13 −2.000 0.046*
    NSVT发作总次数(次/6月) 833 168 −3.791 <0.001*
    Monitored VT(>4 beats,次/6月) 115 67 −2.154 0.031*
    PVC(个/h) 13(2,36) 11(0,30) −1.773 0.076
      注:VT/VF:非持续性室性心动过速,VT-Mon:监测室性心动过速,VT/VF: 室性心动过速/心室颤动,PVC:室性期前收缩。*P < 0.05。
    下载: 导出CSV

    表  4  随访1 a与治疗前SDNN与平均QTc比较(ms,$ \bar x \pm s $

    Table  4.   SDNN and mean QTc were compared after 1-year follow-up and before treatment(ms,$ \bar x \pm s $

    时间SDNN平均QTc
    治疗前 94.38±26.42 441.92±10.64
    1 a 102.23±20.36 411.46±6.00
    t 2.328 −3.128
    P 0.031* 0.026*
      注:SDNN:全部窦性心率RR间期的标准差,QTc:校正后的平均QT间期,*P < 0.05。
    下载: 导出CSV
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  • 收稿日期:  2022-08-22
  • 网络出版日期:  2023-11-09
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