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吲哚在生物材料表面大肠杆菌生物膜中的研究进展

苏丹燕,  唐文甜,  杨谨旭,  刘华,  李邦胜,  赵应鼎,  黄云超

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文章导航 > 昆明医科大学学报  > 2023 >  44(12): 184-190
苏丹燕, 唐文甜, 杨谨旭, 刘华, 李邦胜, 赵应鼎, 黄云超. 吲哚在生物材料表面大肠杆菌生物膜中的研究进展[J]. 昆明医科大学学报, 2023, 44(12): 184-190. doi: 10.12259/j.issn.2095-610X.S20231229
引用本文: 苏丹燕, 唐文甜, 杨谨旭, 刘华, 李邦胜, 赵应鼎, 黄云超. 吲哚在生物材料表面大肠杆菌生物膜中的研究进展[J]. 昆明医科大学学报, 2023, 44(12): 184-190. doi: 10.12259/j.issn.2095-610X.S20231229
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Danyan SU, Wentian TANG, Jinxu YANG, Hua LIU, Bangsheng LI, Yingding ZHAO, Yunchao HUANG. Research Progress of Indole in E. coli Biofilms on the Surface of Biomaterials[J]. Journal of Kunming Medical University, 2023, 44(12): 184-190. doi: 10.12259/j.issn.2095-610X.S20231229
Citation: Danyan SU, Wentian TANG, Jinxu YANG, Hua LIU, Bangsheng LI, Yingding ZHAO, Yunchao HUANG. Research Progress of Indole in E. coli Biofilms on the Surface of Biomaterials[J]. Journal of Kunming Medical University, 2023, 44(12): 184-190. doi: 10.12259/j.issn.2095-610X.S20231229
shu

吲哚在生物材料表面大肠杆菌生物膜中的研究进展

doi: 10.12259/j.issn.2095-610X.S20231229

  • 昆明医科大学第三附属医院/云南省肿瘤医院胸外一科，云南 昆明　650118

基金项目: 国家自然科学基金资助项目（81960335）；云南省卫生健康委临床医学中心建设项目（ZX2019-05-01）
详细信息
    作者简介:

    苏丹燕（1996～），女，广西平南人，在读硕士研究生，主要从事胸部肿瘤及生物材料感染相关研究工作

    通讯作者:

    黄云超，E-mail：huangych2001@aliyun.com

  • 中图分类号: R318.08

Research Progress of Indole in E. coli Biofilms on the Surface of Biomaterials

  • Dept. of Thoracic Surgery，The 3rd Affilated Hospital of Kunming Medical University/Yunnan Cancer Hospital，Kunming Yunnan 650118，China

    摘要
  • 摘要: 大肠杆菌是一种适应性很强的条件致病菌，可以在植入物表面形成生物膜并产生持久细胞，导致危及生命的感染，抗生素难以治疗。因此，急需1种有效的大肠杆菌生物膜抑制剂来应对公共健康威胁。吲哚是近年发现的大肠杆菌新型群体感应信号分子，在调控细菌生长及生物膜形成方面具有重要意义，是未来研究新型抗生物膜制剂的潜在靶标。综述大肠杆菌生物膜的形成、吲哚的微生物代谢及其调控大肠杆菌生物膜形成研究进展，以期为临床治疗及药物研发提供帮助。
    Abstract: Escherichia coli is a highly adaptable opportunistic pathogen bacterium that can form biofilms on the surface of implants and generates persistent cells, leading to life-threatening infections that are difficult to treat with antibiotics alone. Therefore, there is a need for an effective E.coli biofilm inhibitor to combat this public health threat.Indole is a novel quorum-sensing signaling molecule of E. coli discovered in recent years, which is of great significance in regulating bacterial growth and biofilm formation, and is a potential target for future research on new anti-biofilm preparations. This article reviews the research progress on the formation of Escherichia coli biofilms, the microbial metabolism of indole and its regulation of Escherichia coli biofilm formation, in order to provide information for clinical treatment and drug development.
    • HTML全文

  • 图  1  生物膜形成模式图

    Figure  1.  Diagram of bioflm formation

    下载: 全尺寸图片 幻灯片

    图  2  参与大肠杆菌界间通讯过程的吲哚系统示意图

    Figure  2.  Schematic representation of the indole system that participates in inter-kingdom communication processes in E. coli

    下载: 全尺寸图片 幻灯片
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出版历程
  • 收稿日期:  2023-06-13
  • 网络出版日期:  2023-12-19
  • 刊出日期:  2023-12-25

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