Advances in Epigenetic Regulatory Mechanisms in HSV1 Infection
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摘要: 1型单纯疱疹病毒（HSV1）是一类最为常见的人类传染病原体，感染后可导致一系列程度不同的疾病。HSV1在中枢神经系统的潜伏感染及偶发重激活是其病理发生的关键，也为抗病毒治疗带来了巨大的挑战。目前，关于HSV1感染的建立、维持和重激活的机制并未完全阐明，但普遍认为表观遗传调控可能在其中扮演重要作用。越来越多研究表明，病毒裂解期和潜伏感染期的基因组呈现不同的染色质结构，其富含的多种翻译后修饰组蛋白赋予病毒基因转录激活或抑制特征。此外，病毒潜伏相关转录本LATs也可能参与基因组表观遗传修饰调控。Abstract: Herpes simplex viruses type 1（HSV1） is among the most ubiquitous human pathogens that cause a wide variety of disease states. The latent infection of the central nervous system and sporadically reactivation is the central part of HSV1 pathogenesis, which also brings challenges to antiviral therapies. At present, the mechanism of establishing, maintaining and reactivation of HSV1 has not been fully clarified, whereas it has been generally accepted that the epigenetic regulation may play an important role. Accumulating researches have also indicated that the lytic and latent viral genomes exhibit the different chromatin structures, and the accumulation of diverse post-translational modifies the histones endow viral genes with transcriptional activation or repression features. In addition, the latency-associate transcripts of virus may also participate in the genome epigenetic modification. In this review, we summarize the research progress of epigenetic regulation of HSV1 and highlight the critical role of chromatin remodeling in HSV1 lytic proliferation and establishment of latent infection.
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图 1 HSV1基因的级联表达和表观修饰
VP16：病毒蛋白16；IE：即早期基因；E：早期基因；L：晚期基因UL：基因组长片段区；US：基因组短片段区；RL：长片段重复区；RS：短片段重复区；图片来源于Figdraw[2] 。
Figure 1. Cascade expression and epigenetic modification of HSV1 gene
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