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头颈4D- CTA 结合SDF-1a/CXCR4 信号通路评估颅内后交通动脉瘤破裂风险的价值

徐艺铭 钟剑锋 李斌 周欣颜 朱红丽 梁靖 廖承德

徐艺铭, 钟剑锋, 李斌, 周欣颜, 朱红丽, 梁靖, 廖承德. 头颈4D- CTA 结合SDF-1a/CXCR4 信号通路评估颅内后交通动脉瘤破裂风险的价值[J]. 昆明医科大学学报, 2024, 45(3): 59-64. doi: 10.12259/j.issn.2095-610X.S20240309
引用本文: 徐艺铭, 钟剑锋, 李斌, 周欣颜, 朱红丽, 梁靖, 廖承德. 头颈4D- CTA 结合SDF-1a/CXCR4 信号通路评估颅内后交通动脉瘤破裂风险的价值[J]. 昆明医科大学学报, 2024, 45(3): 59-64. doi: 10.12259/j.issn.2095-610X.S20240309
Yiming XU, Jianfeng ZHONG, Bin LI, Xinyan ZHOU, Hongli ZHU, Jing LIANG, Chengde LIAO. Value of Head and Neck 4D-CTA Combined with SDF-1a/CXCR4 Signaling Pathway in Assessing the Risk of Ruptured Intracranial Posterior Communicating Aneurysms[J]. Journal of Kunming Medical University, 2024, 45(3): 59-64. doi: 10.12259/j.issn.2095-610X.S20240309
Citation: Yiming XU, Jianfeng ZHONG, Bin LI, Xinyan ZHOU, Hongli ZHU, Jing LIANG, Chengde LIAO. Value of Head and Neck 4D-CTA Combined with SDF-1a/CXCR4 Signaling Pathway in Assessing the Risk of Ruptured Intracranial Posterior Communicating Aneurysms[J]. Journal of Kunming Medical University, 2024, 45(3): 59-64. doi: 10.12259/j.issn.2095-610X.S20240309

头颈4D- CTA 结合SDF-1a/CXCR4 信号通路评估颅内后交通动脉瘤破裂风险的价值

doi: 10.12259/j.issn.2095-610X.S20240309
基金项目: 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(202401AY0700-358);云南省教育厅科学研究基金资助项目(2024J0399);昆明市心血管影像技术中心(2023-SW(技术)-04);昆明市“十百千”工程(2021-SW(后背)-09)。
详细信息
    作者简介:

    徐艺铭(1983~),男,辽宁大连人,医学硕士,副主任医师,主要从事头颈血管研究工作

    通讯作者:

    梁靖,E-mail:845628673@qq.com

    廖承德,E-mail:1114052293@qq.com

  • 中图分类号: R445.3

Value of Head and Neck 4D-CTA Combined with SDF-1a/CXCR4 Signaling Pathway in Assessing the Risk of Ruptured Intracranial Posterior Communicating Aneurysms

  • 摘要:   目的  探讨利用4D-CTA结合SDF-1a/CXCR4 信号通路评估颅内后交通动脉瘤破裂风险的价值。  方法  将 50 名未破裂颅内前交通动脉瘤患者和 50 名破裂颅内前交通动脉瘤患者分为未破裂组 1 和破裂组 1。所有患者均接受 4D-CTA 检查并检测血清SDF-1a水平。非破裂组 1 接受了 12 个月的随访后把后脉瘤破裂的患者被纳入破裂组 2,动脉瘤未破裂的患者被纳入非破裂组 2。  结果  诊断颅内后交通动脉瘤破裂的 Wn、AR、L、SR、SDF-1a 及其组合的 AUC 值均大于 0.70。破裂组 2 Wn、AR、L、SR和SDF-1a及其组合预测颅内后交通动脉瘤破裂的AUC值均大于0.70。  结论  4D-CTA 联合SDF-1a能有效区分破裂的颅内后交通动脉瘤并预测破裂风险。
  • 图  1  AR、SR 及 VOR 测量简图

    Figure  1.  AR, SR,and VOR measurement diagrams

    图  2  4D-CTA 搏动点示意图

    Figure  2.  Schematic diagram of 4D-CTA pulsatile points

    图  3  AR、SR 及 VOR 数值 测量图示并动脉瘤基底部见异常搏动点(黄箭头所示)

    Figure  3.  Diagram of 4D measurement of AR,SR,and VOR values(shown by yellow arrow)

    图  4  4D-CTA成像 后交通动脉异常搏动点(绿箭头)

    Figure  4.  Abnormal pulse points of Traffic artery after 4D-CTA (green arrow)

    图  5  4D-CTA联合SDF-1对颅内后交通动脉瘤破裂的诊断价值

    Figure  5.  Diagnostic value of 4D-CTA combined with SDF-1 in the rupture of intracranial posterior communicating aneurysms

    图  6  4D-CTA联合SDF-1对颅内后交通动脉瘤破裂的预测价值

    Figure  6.  Predictive value of 4D-CTA combined with SDF-1 for ruptured intracranial aneurysms

    表  1  破裂组1和非破裂组1 SDF-1对比[μg/L,($\bar x \pm s $)]

    Table  1.   Comparison of SDF-1 between unruptured group 1 and ruptured group 1 [μg/L,($\bar x \pm s $)]

    组别SDF-1
    破裂组 1 (n=50) 135.03±11.01
    非破裂 1 (n=50) 149.48±13.22
    T 5.900
    P <0.001*
      *P<0.05。
    下载: 导出CSV

    表  2  4D-CTA联合SDF-1对颅内后交通动脉瘤破裂的诊断价值

    Table  2.   Diagnostic value of 4D-CTA combined with SDF-1 in the rupture of intracranial posterior communicating aneurysms.

    因素AUC临界值95%CIP特性异敏感性
    Wn0.8442.9900.765~0.923<0.001*0.7600.860
    AR0.8881.1150.818~0.958<0.001*0.8400.900
    L0.8344.5850.758~0.909<0.001*0.6600.820
    SR0.7711.2550.679~0.863<0.001*0.6800.740
    SDF-10.800141.1550.712~0.887<0.001*0.7600.760
    Combination0.9760.953~0.999<0.001*0.8800.960
      *P<0.05。
    下载: 导出CSV

    表  3  破裂组2和非破裂组2 SDF-1对比[μg/L,($\bar x \pm s $)]

    Table  3.   Comparison of SDF-1 between unruptured group 2 and ruptured group 2 [μg/L,($\bar x \pm s $)]

    组别SDF-1
    破裂组2 (n=19) 142.38±11.22
    非破裂2 (n=31) 128.13±10.22
    t 4.660
    P <0.001*
      *P<0.05。
    下载: 导出CSV

    表  4  联合SDF-1对颅内后交通动脉瘤破裂的预测价值

    Table  4.   Predictive value of combined SDF-1 for rupture of intracranial posterior communicating aneurysms

    因素AUC临界值95%CIP特性异敏感性
    Wn0.9262.7100.856~0.996<0.001*0.8710.842
    AR0.7051.0650.546~0.8630.0160.7100.632
    L0.7444.2150.579~0.9100.0040.7420.737
    SR0.7921.1150.652~0.9320.0010.6450.789
    SDF-10.847133.5100.742~0.952<0.001*0.7100.789
    Combination0.9730.928~1.000<0.001*0.9030.947
      *P<0.05。
    下载: 导出CSV
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出版历程
  • 收稿日期:  2023-12-15
  • 网络出版日期:  2024-03-12
  • 刊出日期:  2024-03-30

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