炎症性肠病的肠道微生态变化及对策

李波; 孙杨; 缪应雷

doi:10.12259/j.issn.2095-610X.S20240401

炎症性肠病的肠道微生态变化及对策

doi: 10.12259/j.issn.2095-610X.S20240401

昆明医科大学第一附属医院消化内科/云南省消化系统疾病研究所/云南省消化系统疾病临床研究中心，云南昆明　650032

基金项目: 国家自然科学基金资助项目（U1802282；82060107）

详细信息

作者简介:
李波（2000～），女，白族，云南大理人，在读硕士研究生，主要从事炎症性肠病与肠道微生态研究工作

通讯作者:
缪应雷，E-mail：myldu@sina.com

中图分类号: R574
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出版历程
- 收稿日期: 2024-04-10
- 网络出版日期: 2024-04-21
- 刊出日期: 2024-04-29

Intestinal Microecological Changes and Therapeutics in Inflammatory Bowel Disease

Dept. of Gastroenterology，The 1st Affiliated Hospital of Kunming Medical University/Yunnan Institute of Digestive Disease/Yunnan Clinical Research Center for Digestive Diseases，Kunming Yunnan 650032，China

More Information

Corresponding author: 缪应雷，昆明医科大学第一附属医院主任医师，博士生导师，博士。国家百千万人才工程人选、国家有突出贡献中青年专家、国务院政府特殊津贴、云岭学者、云南省“名医”、云南省医学会消化病学分会-主任委员、国家临床重点专科负责人。主持国家自然科学基金6项（其中重点项目1项），获云南省政府颁发的省级科技进步一等奖2项，三等奖6项。以第一作者或通讯作者发表SCI论文47篇，其中以通讯作者在《Gastroenterology》（IF= 33.883）发表论著2篇、《Cell Host & Microbe》（IF=31.316）发表论著1篇。

摘要

摘要: 炎症性肠病（inflammatory bowel disease，IBD）是1种慢性疾病，其特征是反复发作的肠道炎症，尽管具体原因尚未完全明确，但普遍认为它是由遗传、免疫系统异常、环境因素和肠道微生物群失衡等多重因素共同作用引起的。这些因素的相互作用可能会导致肠道环境稳态受损，进而影响宿主的免疫，最终触发肠道炎症。综述IBD患者肠道微生物群的变化情况，并探讨相应的治疗对策。
- 炎症性肠病 /
- 肠道微生态 /
- 肠道菌群
Abstract: Inflammatory bowel disease （IBD） is a chronic condition characterised by recurrent inflammation of the intestines. Although the specific causes is not fully understood, it is generally believed to be caused by a combination of genetic factors, immune system abnormalities, environmental factors, and imbalances in the gut microbiota. The interaction of these factors may disrupt the intestinal environment, affecting the host's immune system, and ultimately triggering intestinal inflammation. This review discusses changes in the gut microbiota of IBD patients and explores corresponding treatment strategies.
- Inflammatory bowel disease /
- Intestinal microecological /
- Intestinal flora

HTML全文

图 1 基于肠道微生态的IBD治疗策略

Figure 1. Current microecological‐based therapeutic strategies in IBD

下载: 全尺寸图片幻灯片

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