DRD1在神经系统疾病和功能中的研究进展

李瑾瑜; 冯良升; 高扬; 李钰; 吴帮旭; 邹英鹰

doi:10.12259/j.issn.2095-610X.S20240501

DRD1在神经系统疾病和功能中的研究进展

doi: 10.12259/j.issn.2095-610X.S20240501

1.
昆明医科大学第一临床医学院，云南昆明　650032
2.
昆明医科大学基础医学院，云南昆明　650500

基金项目: 国家自然科学基金资助项目（32060184）；昆明医科大学大学生创新创业训练基金资助项目（2023CXD267）

详细信息

作者简介:
李瑾瑜（2004～），女，云南昆明人，昆明医科大学在读本科生

通讯作者:
邹英鹰，E-mail：zouyingyingzyy@126.com

中图分类号: R741.02
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出版历程
- 收稿日期: 2024-01-11
- 网络出版日期: 2024-04-29
- 刊出日期: 2024-05-31

Research Progress of DRD1 in Neurological Disorders and Functions

1.
The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
School of Basic Medicine of Kunming Medical University，Kunming Yunnan 650500，China

More Information

Corresponding author: 邹英鹰，教授，博士生/硕士生导师, 云南省“兴滇英才支持计划” 教学名师、享受云南省特殊津贴专家、云南省中青年学术和技术带头人、云南省卓越青年教师，从事病理学教学科研工作24 a。现任昆明医科大学基础医学院副院长。长期致力于糖尿病性中枢神经损伤及保护的研究，并取得一定的相关成果。包括发现糖尿病长期病变可导致视网膜、海马、嗅球、小脑等多部位损伤及其功能障碍，提出这些部位损伤的部分分子机制，并积极开展云南特色药物天麻素修复糖尿病性中枢神经系统损伤的机制研究。先后主持各级科研项目8项，其中国家自然科学基金项目4项、省级重点项目1项等。目前以通讯、第一作者发表高水平外文论文15篇。此外，主持各级病理学课程及教学改革项目10项，其中包括国家级一流本科课程2门、省部级教学项目3项、校级质量工程项目5项等。担任第二届中国研究型医院学会超微与分子病理学专业委员会委员、中华医学会病理学分会第十二届委员会病理学教学工作委员会委员、云南省医师协会病理医师分会第三届委员会常委等。

摘要

摘要: 多巴胺D1受体（dopamine D1 receptor ，DRD1）是目前已知神经系统表达最广泛的多巴胺受体亚型。DRD1能通过多种信号通路发挥运动、情感、认知、学习记忆以及神经内分泌等功能。这些功能可能与帕金森综合征、精神分裂症、抑郁症等精神疾病以及免疫有关。而DRD1的表达变化通常提示了神经系统功能的改变。因此DRD1可以作为神经系统疾病和功能变化的潜在指标和神经系统疾病治疗的潜在靶点。综述DRD1在神经系统中的分布和功能，重点强调DRD1与神经系统相关的信号通路。
- 多巴胺受体 /
- 神经系统 /
- DRD1 /
- 多巴胺
Abstract: Dopamine D1 receptor （DRD1） is currently known as the dopamine receptor subtype with the most widespread expression in the nervous system. DRD1 plays a role in various signaling pathways to perform many functions such as movement, emotion, cognition, learning and memory, as well as neuroendocrine activities. These functions may be associated with conditions like Parkinson's syndrome, schizophrenia, depression, and immune responses. Changes in the expression of DRD1 often indicate alterations in neurological functions. Therefore, DRD1 has the potential to serve as an indicator of neurological disorders and functional changes, as well as a potential target for the treatment of neurological diseases. This article reviews the distribution and functions of DRD1 in the nervous system, with a particular emphasis on DRD1's involvement in signaling pathways related to the nervous system.
- Dopamine receptor /
- Nervous system /
- DRD1 /
- DA

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DRD1在神经系统疾病和功能中的研究进展

doi: 10.12259/j.issn.2095-610X.S20240501

作者简介:
李瑾瑜（2004～），女，云南昆明人，昆明医科大学在读本科生

通讯作者:
邹英鹰，E-mail：zouyingyingzyy@126.com

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Research Progress of DRD1 in Neurological Disorders and Functions

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目录

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DRD1在神经系统疾病和功能中的研究进展

doi: 10.12259/j.issn.2095-610X.S20240501

作者简介: 李瑾瑜（2004～），女，云南昆明人，昆明医科大学在读本科生

通讯作者: 邹英鹰，E-mail：zouyingyingzyy@126.com

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Research Progress of DRD1 in Neurological Disorders and Functions

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作者简介:
李瑾瑜（2004～），女，云南昆明人，昆明医科大学在读本科生

通讯作者:
邹英鹰，E-mail：zouyingyingzyy@126.com