环状RNA在系统性红斑狼疮中的潜在应用研究进展

李力; 张瑞仙

doi:10.12259/j.issn.2095-610X.S20240622

环状RNA在系统性红斑狼疮中的潜在应用研究进展

doi: 10.12259/j.issn.2095-610X.S20240622

李力¹,
张瑞仙^2, ,

1.
大理大学公共卫生学院，云南大理　671013
2.
云南省第一人民医院疾病预防控制科，云南昆明　650034

基金项目: 国家自然科学基金资助项目（82060305）

详细信息

作者简介:
李力（1998～），女，云南西双版纳人，在读硕士研究生，主要从事系统性红斑狼疮发病机制研究工作

通讯作者:
张瑞仙，E-mail：zhangrx2005@163.com

中图分类号: R593.2
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出版历程
- 收稿日期: 2023-09-22
- 网络出版日期: 2024-05-23
- 刊出日期: 2024-06-25

Research Progress on The Potential Application of Circular RNA in Systemic Lupus Erythematosus

Li LI¹,
Ruixian ZHANG^{2
, ,}

1.
School of Public Health，Dali University，Dali Yunnan 671013
2.
Dept. of Disease Control and Prevention，The 1st People’s Hospital of Yunnan Province，Kunming Yunnan 650034，China

摘要

摘要: 环状RNA（circular RNA，circRNA）是由pre-mRNA反向剪接形成的1种闭合环状结构的RNA，其在分子特征、生物学功能和调控机制等方面均具有多样性。近年来，人们越来越认识到circRNA在多种人类疾病中发挥作用、并可能作为分子标志物用于预测疾病的诊断及预后，这其中包括经典的自身免疫性疾病——系统性红斑狼疮（systemic lupus erythematosus，SLE）。目前，已发现的部分circRNAs在SLE中表达失调，且可通过不同机制（如“分子海绵”作用、调节信号通路、抑制蛋白激酶激活和诱导细胞凋亡等）促进SLE的发生发展，另外一部分可作为SLE的潜在临床生物标志物，具有应用转化的潜能。就近年来有关circRNA在SLE中的研究展开综述，以期为circRNA在SLE中的后续研究提供科学依据和参考。
- 环状RNA /
- 系统性红斑狼疮 /
- 生物标志物 /
- 分子机制
Abstract: Circular RNA （circRNA）, formed by reverse splicing of pre-mRNA, constitutes a closed-loop RNA structure with diversity in molecular characteristics, biological functions, and regulatory mechanisms. In recent years, there has been growing recognition of the roles of circRNA in various human diseases, serving potentially as molecular biomarkers for disease diagnosis and prognosis prediction, including the classical autoimmune disease systemic lupus erythematosus （SLE）. Currently, dysregulated expression of some circRNAs has been observed in SLE, which can promote the occurrence and development of SLE through different mechanisms such as "molecular sponge" effects, modulation of signaling pathways, inhibition of protein kinase activation, and induction of cell apoptosis. Another part may serve as potential clinical biomarkers for SLE, holding translational potential. This paper reviews the research on circRNA in SLE over the past years, aiming to provide scientific evidence and references for subsequent studies on circRNA in SLE.
- Circular RNA /
- Systemic lupus erythematosus /
- Biomarkers /
- Molecular mechanisms

HTML全文

图 1 环状RNA的形成及类型（本图通过Figdraw自绘）

Figure 1. Formation and types of circRNA（This figure is self-drawn via Figdraw）

下载: 全尺寸图片幻灯片

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