阿尔茨海默病与肌少症的孟德尔随机化研究

李瑞; 苏建培; 李瑾; 邓文君; 张亚洲

doi:10.12259/j.issn.2095-610X.S20240804

阿尔茨海默病与肌少症的孟德尔随机化研究

doi: 10.12259/j.issn.2095-610X.S20240804

1.
昆明市第二人民医院老年病科，云南昆明　650204
2.
昆明医科大学第一附属医院老年消化科，云南昆明　650032

基金项目: 昆明市卫生健康委员会卫生科研项目（2022-03-10-004）；昆明市卫生人才培养项目[2022-sw（后备）-52]

详细信息

作者简介:
李瑞（1994～），女，云南昭通人，医学硕士，住院医师，主要从事老年医学临床工作

通讯作者:
张亚洲，E-mail：15887117301@163.com

中图分类号: R493；R685
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- PDF下载量: 27
- 被引次数: 0
出版历程
- 收稿日期: 2024-02-17
- 网络出版日期: 2024-07-06
- 刊出日期: 2024-08-05

A Mendelian Randomization Study on Alzheimer’ s Disease and Sarcopenia

1.
Dept. of Geriatrics，2nd People’s Hospital of Kunming，Kunming Yunnan 650204
2.
Dept. of Geriatric Gastroenterology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

摘要

摘要: 目的探究阿尔茨海默病与肌少症之间的因果关系。方法基于公开的全基因组关联分析（genome-wide association analysis ，GWAS）数据库中阿尔茨海默病与肌少症的3种相关表型：四肢瘦体质量、步行速度、低握力，通过逆方差加权法、中位数加权法、MR-Egger回归等进行两样本孟德尔随机化分析，并进行了异质性检验和多效性分析等敏感性分析。结果两样本孟德尔随机化研究显示，阿尔茨海默病可能会增加四肢瘦体质量的减少的风险（β = 0.010，95%CI：0.001～0.018， P = 0.021）；同时，阿尔茨海默病可能会减慢步行速度（β = 0.009，95%CI：0.003～0.016，P = 0.005）。结论阿尔茨海默病可能导致肌少症发生风险增加。
- 孟德尔随机化 /
- 阿尔茨海默病 /
- 肌少症
Abstract: Objective To explore the causal relationship between Alzheimer’ s disease and sarcopenia. Methods This study is based on three related phenotypes of Alzheimer's disease and sarcopenia in the public genome-wide association analysis （GWAS） database, namely, appendicular lean mass, walking speed, and low grip strength. Two-sample Mendelian randomization analysis was conducted using inverse variance weighting method, median weighting method, MR-Egger regression, etc., and sensitivity analysis was performed, including heterogeneity testing and multiple effect analysis. Results The MR analyses demonstrated that Alzheimer’ s disease may increase the risk of reduced appendicular lean mass （β = 0.010 , 95% confidence interval （CI） = 0.001～0.018, P = 0.021）, while Alzheimer’ s disease was a significantly correlated with low walking speed （β = 0.009, 95% confidence interval （CI） = 0.003～0.016, P = 0.005）. Conclusion Alzheimer’ s disease may increases the risk of sarcopenia.
- Mendelian randomization /
- Alzheimer’ s disease /
- Sarcopenia

HTML全文

图 2 阿尔茨海默病与肌少症的漏斗图

A ：阿尔茨海默病与四肢瘦体质量的漏斗图；B：阿尔茨海默病与步行速度的漏斗图；C：阿尔茨海默病与低握力的漏斗图。

Figure 2. Funnel plots of Alzheimer’ s disease and sarcopenia

下载: 全尺寸图片幻灯片

图 1 阿尔茨海默病与和肌少症的孟德尔随机化分析森林图

Figure 1. MR forest plot for Alzheimer’ s disease and Sarcopenia

下载: 全尺寸图片幻灯片

表 1 阿尔茨海默病与肌少症的3种相关表型 GWAS 数据信息表

Table 1. GWAS data information on Alzheimer’s disease and sarcopenia related traits

表型	ID号	出版年份	SNPs	样本量（n）	研究人群
四肢瘦体质量	ebi-a-GCST90000025	2020	18071518	450243	欧洲人群
步行速度	ukb-b-4711	2018	9851867	459915	欧洲人群
低握力	ebi-a-GCST90007526	2021	9336415	256523	欧洲人群
阿尔茨海默病	ieu-b-2	2019	10528610	63926	欧洲人群

下载: 导出CSV

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