拟除虫菊酯类农药暴露的免疫毒理学研究进展

齐志业; 陈颖; 李燕

doi:10.12259/j.issn.2095-610X.S20240822

拟除虫菊酯类农药暴露的免疫毒理学研究进展

doi: 10.12259/j.issn.2095-610X.S20240822

齐志业^{1, 2, 3},
陈颖⁴,
李燕^3, ,

1.
昆明医科大学第一附属医院儿内科
2.
儿童医学中心，云南昆明　650032
3.
昆明医科大学公共卫生学院，云南昆明　650500
4.
重庆市渝中区疾病预防控制中心，重庆　400010

基金项目: 国家自然科学基金资助项目（82160621）；云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目（202101AY070001-099）

详细信息

作者简介:
齐志业（1980～），男，河南兰考人，医学博士，副主任医师，主要从事新生儿免疫与感染性疾病研究工作

通讯作者:
李燕，E-mail：yanli20021965@21cn.com

中图分类号: R114
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- 文章访问数: 298
- HTML全文浏览量: 292
- PDF下载量: 11
- 被引次数: 0
出版历程
- 收稿日期: 2024-02-20
- 网络出版日期: 2024-07-08
- 刊出日期: 2024-08-25

Research Progress on Immunotoxicology of Pyrethroid Pesticides Exposures

Zhiye QI^{1, 2, 3},
Ying CHEN⁴,
Yan LI^{3
, ,}

1.
Dept. of Pediatrics
2.
Children’s Medical Center，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
3.
School of Public Health，Kunming Medical University，Kunming Yunnan 650500
4.
Chongqing Yuzhong District Center For Disease Control And Prevention，Chongqing 400010，China

摘要

摘要: 免疫功能是人体的重要生理功能，在维持人类健康中起着至关重要的作用。拟除虫菊酯类农药（pyrethroid pesticides， PYRs）及其代谢产物可对机体产生免疫毒性，导致免疫相关疾病的患病风险增加。通过对PYRs暴露对机体免疫器官、免疫细胞和免疫分子的影响及其免疫毒理学机制进行综述，并对生命早期PYRs暴露所致机体免疫毒性进行总结和展望，为人类PYRs暴露的免疫毒理学研究提供新的思路和建议。
- 拟除虫菊酯 /
- 农药 /
- 免疫功能 /
- 免疫毒理学
Abstract: Immune function is an important physiological function in the human body that plays a crucial role in maintaining human health. Pyrethroid pesticides （PYRs） and their metabolites can have immunotoxic effects on the body, increasing the risk of immune-related diseases. This review summarizes the effects of PYRs exposure on the body’ s immune organs, immune cells, and immune molecules, as well as the immunotoxic mechanisms, and provides a summary and outlook on the immunotoxicity caused by early-life PYRs exposure, offering new ideas and recommendations for human studies on the immunotoxicity of PYRs exposure.
- Pyrethrins /
- Pesticides /
- Immune function /
- Immunotoxicity

HTML全文

图 1 PYRs暴露所致机体免疫毒性的机制及信号传导通路示意图

Figure 1. Schematic diagram of the mechanisms and signal transduction pathways of immune toxicity caused by PYRs exposure

下载: 全尺寸图片幻灯片

参考文献(51)

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拟除虫菊酯类农药暴露的免疫毒理学研究进展

doi: 10.12259/j.issn.2095-610X.S20240822

作者简介:
齐志业（1980～），男，河南兰考人，医学博士，副主任医师，主要从事新生儿免疫与感染性疾病研究工作

通讯作者:
李燕，E-mail：yanli20021965@21cn.com

计量

Research Progress on Immunotoxicology of Pyrethroid Pesticides Exposures

计量

目录

[1]	刘记宏, 马志强, 王霖, 王晓燕, 田伟光, 李保萍, 董睿, 吕玉佳. 肺结核患者感染新冠病毒免疫功能的相关性分析, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20240423
[2]	张英, 杨凤霞, 郭敬, 张庆玲. 循S-ABC框架的系统心理干预措施对原发性肝癌患者围术期心理痛苦及免疫功能的影响, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20231126
[3]	王霖, 沈凌筠, 李海雯, 王晓燕, 高建鹏, 马志强. 云南省肺结核病患者营养状况及免疫功能分析, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230116
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[5]	陆霓虹, 刘洪璐, 夏加伟, 陈杨君, 沈凌筠, 杨永锐, 李杰. 免疫功能和SAA、MMP-9、MMP-14在抗结核药物性肝损伤中的临床评估, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220410
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拟除虫菊酯类农药暴露的免疫毒理学研究进展

doi: 10.12259/j.issn.2095-610X.S20240822

作者简介: 齐志业（1980～），男，河南兰考人 ，医学博士，副主任医师，主要从事新生儿免疫与感染性疾病研究工作

通讯作者: 李燕，E-mail：yanli20021965@21cn.com

计量

出版历程

Research Progress on Immunotoxicology of Pyrethroid Pesticides Exposures

计量

出版历程

目录

作者简介:
齐志业（1980～），男，河南兰考人，医学博士，副主任医师，主要从事新生儿免疫与感染性疾病研究工作

通讯作者:
李燕，E-mail：yanli20021965@21cn.com