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根尖牙乳头干细胞成骨分化的研究进展

钱石兵,  史会萍,  李艳秋,  杨镕羽,  段开文

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文章导航 > 昆明医科大学学报  > 2024 >  45(9): 168-173
蔡斌, 宋海, 王振, 韩雪, 于建云. TDP-43与神经退行性疾病及脑损伤的相关性研究进展[J]. 昆明医科大学学报, 2018, 39(05): 124-127.
引用本文: 钱石兵, 史会萍, 李艳秋, 杨镕羽, 段开文. 根尖牙乳头干细胞成骨分化的研究进展[J]. 昆明医科大学学报, 2024, 45(9): 168-173. doi: 10.12259/j.issn.2095-610X.S20240926
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Cai Bin , Song Hai , Wang Zhen , Han Xue , Yu Jian Yun . Research Progress of the Relationship of the Expression of TAR DNA/RNA-binding Domain Protein 43 in Neurodegenerative Disease and Brain Injury[J]. Journal of Kunming Medical University, 2018, 39(05): 124-127.
Citation: Shibing QIAN, Huiping SHI, Yanqiu LI, Rongyu YANG, Kaiwen DUAN. Research Progress on Osteogenic Differentiation of Apical Papilla Stem Cells[J]. Journal of Kunming Medical University, 2024, 45(9): 168-173. doi: 10.12259/j.issn.2095-610X.S20240926
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根尖牙乳头干细胞成骨分化的研究进展

doi: 10.12259/j.issn.2095-610X.S20240926
  • 1.

    曲靖医学高等专科学校口腔学院，云南 曲靖　655100

  • 2.

    昆明市延安医院口腔科，云南 昆明　650051

  • 3.

    大理大学口腔学院，云南 大理　671003

基金项目: 国家自然科学基金资助项目（81160135）；云南省生物医药重大科技专项基金（202102AA100007）；云南省教育厅科学研究基金教师类项目（2024J1609）
详细信息
    作者简介:

    钱石兵（1996～），男，云南曲靖人，医学硕士，助教，主要从事牙周病和口腔黏膜疾病的防治工作

    通讯作者:

    段开文，E-mail：kwduan@aliyun.com

  • 中图分类号: R78

Research Progress on Osteogenic Differentiation of Apical Papilla Stem Cells

  • 1.

    School of Stomatology，Qujing Medical College，Qujing Yunnan 655100

  • 2.

    Dept. of Stomatology，The Affiliated Yan’an Hospital，Kunming Yunnan 650051

  • 3.

    School of Stomatology，Dali University，Dali Yunnan 671003，China

摘要

    摘要
  • 摘要: 根尖牙乳头干细胞（stem cells from apical papilla，SCAP）具有很强的多系分化潜能，其中成骨分化可以应用于骨组织再生，为口腔颌骨缺损治疗提供新思路。成骨分化是个复杂的网络调控过程，诸如各种细胞因子、表观遗传物质、各种信号分子和信号通路等内源性物质均可产生不同程度的影响。这些因素相互作用可以促进SCAP的增殖、迁移和成骨分化，但其在SCAP成骨分化的不同进程中的具体机制和内在联系各不相同。对近年来有关促进SCAP成骨分化的各种因素及其可能的调控机制研究文献进行综述，以期为其进一步的应用研究提供新信息。
    Abstract: Stem cells from apical papilla （SCAP） have a strong multi-line differentiation potential, in which osteogenic differentiation can be applied to bone tissue regeneration, providing a new idea for the treatment of oral jaw defects. Osteogenic differentiation is a complex network regulation process, and endogenous substances such as various cytokines, epigenetic material, various signaling molecules and signaling pathways can have different degrees of influence. The interaction of these factors can promote the proliferation, migration and osteogenic differentiation of SCAP, but the specific mechanisms and internal links in different processes of osteogenic differentiation of SCAP are different. In this paper, the factors that promote osteogenic differentiation of SCAP and their possible regulatory mechanisms were reviewed to provide new information for further application research.
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  • 收稿日期:  2023-12-05
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