长链非编码RNA在软骨发育及骨关节炎中作用机制的研究进展

谢飞飞; 辛隐子; 徐敏; 李景涵; 王伟

doi:10.12259/j.issn.2095-610X.S20241001

长链非编码RNA在软骨发育及骨关节炎中作用机制的研究进展

doi: 10.12259/j.issn.2095-610X.S20241001

谢飞飞^{1, 2},
辛隐子^{1, 2},
徐敏¹,
李景涵^{1, 2},
王伟^1, ,

1.
昆明医科大学口腔医学院/医院正畸科
2.
云南省口腔医学重点实验室，云南昆明　650106

基金项目: 国家自然科学基金资助项目（82060196）；云南省“兴滇英才支持计划” 资助项目（XDYC-QNRC-2022-0313）；云南省科技厅-昆明医科大学基础研究联合专项资助项目（202401AY070001-332）；昆明医科大学错颌畸形多阶段多学科联合防治科技创新团队项目（CXTD202213）；昆明医科大学复杂颅颌牙面畸形诊治技术团队基金项目（2024XKTDTS08）

详细信息

作者简介:
谢飞飞（1998～），女，云南昆明人，在读硕士研究生，主要从事骨关节炎炎症研究工作

通讯作者:
王伟，E-mail：wangwei8@kmmu.edu.cn

中图分类号: R684.3
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出版历程
- 收稿日期: 2024-05-16
- 网络出版日期: 2024-10-12
- 刊出日期: 2024-10-31

Mechanisms of Long Non-Coding RNAs in Cartilage Development and Related Diseases

Feifei XIE^{1, 2},
Yinzi XIN^{1, 2},
Min XU¹,
Jinghan LI^{1, 2},
Wei WANG^{1
, ,}

1.
Dept. of Orthodontics，School / Hospital of Stomatology Kunming Medical University，Kunming Yunnan 650106
2.
Yunnan Key Laboratory of Stomatology，Kunming Yunnan 650106，China

More Information

Corresponding author: 王伟，博士，主治医师，硕士研究生导师。担任云南省口腔正畸学专业住院医师规范化培训指导教师，口腔执业医师资格实践技能考试考官；中华口腔医学会第八届、第九届口腔正畸专业委员会青年委员，云南省口腔医学会第三届口腔正畸专业委员会委员兼秘书；世界正畸医师联盟（WFO）会员，国际牙科研究学会（IADR）会员。入选云南省“兴滇英才支持计划”青年人才。获云南省科技进步三等奖1项，授权专利1项。主持包括国家自然科学基金在内的3项国家及省厅级科研项目，第一作者发表SCI论文3篇。

摘要

摘要: 软骨的生长发育及骨关节炎进程十分复杂，同时受到多种生长因子、细胞因子、内外环境等因素影响，并由多条生物信号分子通路交叉调控，因此，其分子作用机制对于软骨发育和骨关节炎的诊治至关重要。长链非编码RNA（Long non-coding RNAs，LncRNAs）是一类转录本长度超过200个核苷酸的非编码RNA，在生物发育、基因表达以及表观遗传中发挥着复杂精确的调控作用，与人类疾病的发生、发展和防治具有密切关系。近年来，许多与软骨生长发育和炎症相关的lncRNAs被相继发现。通过对lncRNAs的分类、功能及其在软骨发育和炎症中的作用进行系统综述，发现多种lncRNAs参与了软骨生长发育和骨关节炎的发生与发展，调控相关lncRNAs的表达可减轻软骨炎症，减缓疾病进展。旨在为lncRNAs与软骨生长发育及骨关节炎的基础研究及临床应用提供科学的参考依据。
- 骨关节炎 /
- 长链非编码RNA /
- 基因调控 /
- 软骨生长发育 /
- 软骨疾病
Abstract: The growth and disease progression of cartilage are highly complex, influenced by various growth factors, cytokines, and both internal and external environmental factors. This process is regulated by multiple intersecting biological signaling pathways. Consequently, the study of its molecular mechanisms is crucial for the development and treatment of cartilage-related diseases. Long non-coding RNAs （lncRNAs） are a class of regulatory non-coding RNAs with transcript lengths exceeding 200 nucleotides. They play a complex and precise role in biological development, gene expression and epigenetics, and are closely associated with the onset, progression and prevention of human diseases. In recent years, numerous lncRNAs related to cartilage growth and disease have been discovered. This article systematically reviews the classification, function and mechanisms of action of lncRNAs in cartilage development and disease. It reveals that various lncRNAs are involved in the onset and progression of cartilage growth and diseases. Regulating the expression of relevant lncRNAs can alleviate cartilage inflammation and slow disease progression. This paper aims to provide a scientific basis for basic research and clinical application of lncRNAs in cartilage growth and disease.
- Osteoarthritis /
- Long non-coding RNA /
- Regulation of genes /
- Cartilage growth and development /
- Cartilage diseases

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参考文献(45)

[1]	徐文飞,梅其杰,明春玉,等. 基于单细胞转录组测序分析骨关节炎软骨细胞分化的分子机制[J]. 生物骨科材料与临床研究,2024,21(1):1-6+13. doi: 10.3969/j.issn.1672-5972.2024.01.001
[2]	Guilak F. Biomechanical factors in osteoarthritis[J]. Best Practice & Research Clinical Rheumatology,2011,25(6):815-823.
[3]	Tong L,Yu H,Huang X,et al. Current understanding of osteoarthritis pathogenesis and relevant new approaches[J]. Bone Research,2022,10(1):60. doi: 10.1038/s41413-022-00226-9
[4]	Bai J,Zhang Y,Zheng X,et al. LncRNA MM2P-induced,exosome-mediated transfer of Sox9 from monocyte-derived cells modulates primary chondrocytes[J]. Cell Death & Disease,2020,11(9):763.
[5]	Hoolwerff M,Metselaar P I,Tuerlings M,et al. Elucidating epigenetic regulation by identifying functional cis-acting long noncoding RNAs and their targets in osteoarthritic articular cartilage[J]. Arthritis & Rheumatology,2020,72(11):1845-1854.
[6]	Okuyan H M,Begen M A. LncRNAs in osteoarthritis[J]. Clinica Chimica Acta,2022,532:145-163. doi: 10.1016/j.cca.2022.05.030
[7]	The ENCODE Project Consortium. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project[J]. Nature,2007,447(7146):799-816. doi: 10.1038/nature05874
[8]	Della Bella E,Koch J,Baerenfaller K. Translation and emerging functions of non-coding RNAs in inflammation and immunity[J]. Allergy,2022,77(7):2025-2037. doi: 10.1111/all.15234
[9]	Guo C J,Ma X K,Xing Y H,et al. Distinct Processing of lncRNAs contributes to non-conserved functions in stem cells[J]. Cell,2020,181(3): 621-636. e22.
[10]	Statello L,Guo C J,Chen L L,et al. Gene regulation by long non-coding RNAs and its biological functions[J]. Nature Reviews Molecular Cell Biology,2021,22(2):96-118. doi: 10.1038/s41580-020-00315-9
[11]	Gupta S C,Awasthee N,Rai V,et al. Long non-coding RNAs and nuclear factor-κB crosstalk in cancer and other human diseases[J]. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,2020,1873(1):188316. doi: 10.1016/j.bbcan.2019.188316
[12]	Kretz M,Webster D E,Flockhart R J,et al. Suppression of progenitor differentiation requires the long noncoding RNA ANCR[J]. Genes & Development,2012,26(4):338-343.
[13]	Frankish A,Diekhans M,Ferreira A M,et al. GENCODE reference annotation for the human and mouse genomes[J]. Nucleic Acids Research,2019,47(D1):D766-D773. doi: 10.1093/nar/gky955
[14]	Yan L,Liu G,Wu X. The umbilical cord mesenchymal stem cell‐derived exosomal lncRNA H19 improves osteochondral activity through miR‐29b‐3p/FoxO3 axis[J]. Clinical and Translational Medicine,2021,11(1):e255. doi: 10.1002/ctm2.255
[15]	Zhang Y,Liu Q,Liao Q. Long noncoding RNA: A dazzling dancer in tumor immune microenvironment[J]. Journal of Experimental & Clinical Cancer Research,2020,39(1):231.
[16]	Ye X,Wang S,Zhao X,et al. Role of lncRNAs in cis- and trans-regulatory responses to salt in Populus trichocarpa.[J]. The Plant Journal,2022,110(4):978-993. doi: 10.1111/tpj.15714
[17]	Wang F,Tang Z,Shao H,et al. Long noncoding RNA HOTTIP cooperates with CCCTC-binding factor to coordinate HOXA gene expression[J]. Biochemical and Biophysical Research Communications,2018,500(4):852-859. doi: 10.1016/j.bbrc.2018.04.173
[18]	Ma Z,Li M,Roy S,et al. Chromatin boundary elements organize genomic architecture and developmental gene regulation in Drosophila Hox clusters[J]. World Journal of Biological Chemistry,2016,7(3):223. doi: 10.4331/wjbc.v7.i3.223
[19]	Chu C,Quinn J,Chang H Y. Chromatin Isolation by RNA Purification (ChIRP)[J]. Journal of Visualized Experiments,2012,61:3912.
[20]	Niehrs C,Luke B. Regulatory R-loops as facilitators of gene expression and genome stability[J]. Nature Reviews Molecular Cell Biology,2020,21(3):167-178. doi: 10.1038/s41580-019-0206-3
[21]	Pan H,Wang H,Zhang X,et al. Chromosomal instability-associated MAT1 lncRNA insulates MLL1-guided histone methylation and accelerates tumorigenesis[J]. Cell Reports,2022,41(11):111829. doi: 10.1016/j.celrep.2022.111829
[22]	Ghafouri-Fard S,Abak A,Fattahi F,et al. The interaction between miRNAs/lncRNAs and nuclear factor-κB (NF-κB) in human disorders[J]. Biomedicine & Pharmacotherapy,2021,138:111519.
[23]	Herman A B,Tsitsipatis D,Gorospe M. Integrated lncRNA function upon genomic and epigenomic regulation[J]. Molecular Cell,2022,82(12):2252-2266. doi: 10.1016/j.molcel.2022.05.027
[24]	Schmidt K,Weidmann C A,Hilimire T A,et al. Targeting the oncogenic long non-coding RNA SLNCR1 by blocking its sequence-specific binding to the androgen receptor[J]. Cell Reports,2020,30(2): 541-554. e5.
[25]	Carlevaro-Fita J,Johnson R. Global positioning system: Understanding long noncoding RNAs through subcellular localization[J]. Molecular Cell,2019,73(5):869-883. doi: 10.1016/j.molcel.2019.02.008
[26]	Aznaourova M,Janga H,Sefried S,et al. Noncoding RNA MaIL1 is an integral component of the TLR4–TRIF pathway[J]. Proceedings of the National Academy of Sciences,2020,117(16):9042-9053. doi: 10.1073/pnas.1920393117
[27]	Gong C,Maquat L E. lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3′ UTRs via Alu elements[J]. Nature,2011,470(7333):284-288. doi: 10.1038/nature09701
[28]	王为,汤翔宇,易智谦,等. 骨关节炎诱导软骨细胞凋亡和细胞外基质降解的机制[J]. 中国组织工程研究,2022,26(20):3133-3140. doi: 10.12307/2022.610
[29]	Yang Q,Guo J,Ren Z,et al. LncRNA NONHSAT030515 promotes the chondrogenic differentiation of human adipose-derived stem cells via regulating the miR-490-5p/BMPR2 axis[J]. Journal of Orthopaedic Surgery and Research,2021,16(1):658. doi: 10.1186/s13018-021-02757-z
[30]	Shen P,Wang B,Zheng C,et al. LRRC75A-AS1 inhibits chondrogenic differentiation of bmscs via targeting the Mir-140-3p/Wnt/Β-Catenin pathway.[J]. Current Stem Cell Research & Therapy,2023,18(8):1142-1149.
[31]	Wang W,Ding Y,Xu Y,et al. Comprehensive analysis of long noncoding RNAs and mRNAs expression profiles and functional networks during chondrogenic differentiation of murine ATDC5 cells[J]. Acta Biochimica et Biophysica Sinica,2019,51(8):778-790. doi: 10.1093/abbs/gmz064
[32]	Liu F,Song D Y,Huang J,et al. Long non-coding RNA CIR inhibits chondrogenic differentiation of mesenchymal stem cells by epigenetically suppressing ATOH8 via methyltransferase EZH2[J]. Molecular Medicine,2021,27(1):12. doi: 10.1186/s10020-021-00272-9
[33]	Li X,Yang Y,Liang L,et al. Effect of XBP1 deficiency in cartilage on the regulatory network of lncRNA/circRNA-miRNA-mRNA[J]. International Journal of Biological Sciences,2022,18:315-330. doi: 10.7150/ijbs.64054
[34]	Goldring M B. Articular cartilage degradation in osteoarthritis[J]. HSS Journal,2012,8(1):7-9. doi: 10.1007/s11420-011-9250-z
[35]	Zhang X,Liu X,Ni X,et al. Long non-coding RNA H19 modulates proliferation and apoptosis in osteoarthritis via regulating miR-106a-5p[J]. Journal of Biosciences,2019,44(6):128. doi: 10.1007/s12038-019-9943-x
[36]	Yang B,Xu L,Wang S. Regulation of lncRNA-H19/miR-140-5p in cartilage matrix degradation and calcification in osteoarthritis[J]. Annals of Palliative Medicine,2020,9(4):1896-1904. doi: 10.21037/apm-20-929
[37]	Zhang C,Wang P,Jiang P,et al. Upregulation of lncRNA HOTAIR contributes to IL-1β-induced MMP overexpression and chondrocytes apoptosis in temporomandibular joint osteoarthritis[J]. Gene,2016,586(2):248-253. doi: 10.1016/j.gene.2016.04.016
[38]	Wang J,Luo X,Cai S,et al. Blocking HOTAIR protects human chondrocytes against IL-1β-induced cell apoptosis,ECM degradation,inflammatory response and oxidative stress via regulating miR-222-3p/ADAM10 axis[J]. International Immunopharmacology,2021,98:107903. doi: 10.1016/j.intimp.2021.107903
[39]	Wang B,Sun Y,Liu N,et al. LncRNA HOTAIR modulates chondrocyte apoptosis and inflammation in osteoarthritis via regulating miR ‐1277‐5p/ SGTB axis[J]. Wound Repair and Regeneration,2021,29(3):495-504. doi: 10.1111/wrr.12908
[40]	Zhang H,Chen C,Cui Y,et al. lnc-SAMD14-4 can regulate expression of the COL1A1 and COL1A2 in human chondrocytes[J]. PeerJ,2019,7:e7491. doi: 10.7717/peerj.7491
[41]	Li H,Xie S,Li H,et al. LncRNA MALAT1 mediates proliferation of LPS treated-articular chondrocytes by targeting the miR-146a-PI3K/Akt/mTOR axis[J]. Life Sciences,2020,254:116801. doi: 10.1016/j.lfs.2019.116801
[42]	Liu C,Ren S,Zhao S,et al. LncRNA MALAT1/MiR-145 adjusts IL-1β-induced chondrocytes viability and cartilage matrix degradation by regulating ADAMTS5 in human osteoarthritis[J]. Yonsei Medical Journal,2019,60(11):1081. doi: 10.3349/ymj.2019.60.11.1081
[43]	Gao S T,Yu Y M,Wan L P,et al. LncRNA GAS5 induces chondrocyte apoptosis by down-regulating miR-137[J]. European Review for Medical and Pharmacological Sciences,2020,24(21):10984-10991.
[44]	Meng Y,Qiu S,Sun L,et al. Knockdown of exosome‑mediated lnc‑PVT1 alleviates lipopolysaccharide‑induced osteoarthritis progression by mediating the HMGB1/TLR4/NF‑κB pathway via miR‑93‑5p[J]. Molecular Medicine Reports,2020,22(6):5313-5325. doi: 10.3892/mmr.2020.11594
[45]	Lu X,Yu Y,Yin F,et al. Knockdown of PVT1 inhibits IL-1β-induced injury in chondrocytes by regulating miR-27b-3p/TRAF3 axis[J]. International Immunopharmacology,2020,79:106052. doi: 10.1016/j.intimp.2019.106052

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长链非编码RNA在软骨发育及骨关节炎中作用机制的研究进展

doi: 10.12259/j.issn.2095-610X.S20241001

作者简介:
谢飞飞（1998～），女，云南昆明人，在读硕士研究生，主要从事骨关节炎炎症研究工作

通讯作者:
王伟，E-mail：wangwei8@kmmu.edu.cn

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Mechanisms of Long Non-Coding RNAs in Cartilage Development and Related Diseases

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目录

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[4]	皇甫文丽, 黄瑶, 刘波, 吕长海, 刘娟, 代自超. 建立大鼠颞下颌关节骨关节炎动物模型的2种方法比较, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20230308
[5]	张丽菊, 姜晓明, 陈昌贤, 吴喜, 张振勇, 刘为军. 长链非编码RNA-p21调控微小RNA-9/去乙酰化酶1信号通路逆转结直肠癌细胞奥沙利铂耐药性, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220519
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[8]	顾君, 何泽喜, 栾婷, 王海峰, 王剑松, 丁明霞. 外泌体长链非编码RNA在膀胱癌中的研究进展, 昆明医科大学学报. doi: 10.12259/j.issn.2095-610X.S20220110
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长链非编码RNA在软骨发育及骨关节炎中作用机制的研究进展

doi: 10.12259/j.issn.2095-610X.S20241001

作者简介: 谢飞飞（1998～），女，云南昆明人，在读硕士研究生，主要从事骨关节炎炎症研究工作

通讯作者: 王伟，E-mail：wangwei8@kmmu.edu.cn

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出版历程

Mechanisms of Long Non-Coding RNAs in Cartilage Development and Related Diseases

计量

出版历程

目录

作者简介:
谢飞飞（1998～），女，云南昆明人，在读硕士研究生，主要从事骨关节炎炎症研究工作

通讯作者:
王伟，E-mail：wangwei8@kmmu.edu.cn