沙库巴曲缬沙坦治疗糖尿病合并心血管并发症的研究进展

陈琳; 念馨; 蔡红雁

doi:10.12259/j.issn.2095-610X.S20241101

沙库巴曲缬沙坦治疗糖尿病合并心血管并发症的研究进展

doi: 10.12259/j.issn.2095-610X.S20241101

陈琳¹,
念馨^1, ,,
蔡红雁²

1.
昆明医科大学第一附属医院内分泌一科
2.
心脏内二科，云南昆明　650032

基金项目: 国家自然科学基金资助项目（82270372）；云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目（202201AY070001-066）；云南省“兴滇英才支持计划”名医专项基金资助项目（RLMY20220005）；云南省重大疑难疾病中西医临床协作试点基金资助项目（300073）；昆明医科大学科技创新团队基金资助项目（CXTD202209）

详细信息

作者简介:
陈琳（2000～），女，云南曲靖人，在读硕士研究生，主要从事内分泌与代谢性疾病研究及临床工作

通讯作者:
念馨，E-mail：nianxinkm@hotmail.com

中图分类号: R587.1
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- 被引次数: 0
出版历程
- 收稿日期: 2024-10-22
- 网络出版日期: 2024-11-18

Research Progress in the Treatment of Diabetes Mellitus with Cardiovascular Complications with Sacubitril Valsartan

Lin CHEN¹,
Xin NIAN^{1
, ,},
Hongyan CAI²

1.
Dept. of Endocrinology
2.
Dept 2. of Cardiology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

More Information

Corresponding author: 念馨，女，主任医师，博士研究生导师，于昆明医科大学第一附属医院从事内分泌与代谢病学临床、教学和科研工作20余年。2011年在泰国玛海多大学培训，2015年完成云南省高等学校青年骨干教师培养项目，2016—2017年在美国宾夕法尼亚大学医学院访学。现为中国内分泌代谢医师分会青年委员，中国微循环学会糖尿病与微循环专业委员会青年委员，中华医学会内分泌学分会脂代谢学组委员，云南省医师协会内分泌代谢科医师分会委员，云南省医学会糖尿病学分会副主委，云南省医学会罕见病学分会副主委，云南省康复医学会减重与代谢性疾病专委会副主委，云南省内分泌代谢病质控中心专家。主持完成国家自然科学基金地区基金1项，国家重点研发计划重大慢性非传染性疾病防控研究重点专项子课题1项，云南省科技厅-昆明医科大学联合基金2项。云南省医学学科带头人，云南省“兴滇英才”名医，2023年获云南省重大疑难疾病中西医临床协作试点项目支持。以第一完成人获省科技进步奖1项，厅级科技成果奖2项。发表论文30余篇，SCI收录7篇，北大中文核心5篇。获得荣誉：云南省高等教育学会2013—2015年科学研究优秀成果三等奖。2013年云南省多媒体教学比赛三等奖。云南省科技厅科技进步奖三等奖及云南省云南省卫生厅科研成果三等奖各1项。多次荣获先进个人，职业道德先进个人，优秀教师，进修医师优秀导师，优秀党员等称号。

摘要

摘要: 糖尿病由于多种因素常并发心血管并发症，心血管并发症也是糖尿病患者死亡的常见因素，因此，在改善糖尿病患者糖代谢同时也需控制心血管并发症。沙库巴曲缬沙坦是一种新型复合物，有着抑制脑啡肽酶和血管紧张素受体的双重作用，目前在临床上常作为心力衰竭患者的常用药物。近期的研究提示，沙库巴曲缬沙坦可能还存在着潜在的代谢益处，在改善糖尿病患者心功能的同时能改善血糖控制，有望成为糖尿病可常规使用的药物，带来心血管及代谢方面的益处。综述沙库巴曲缬沙坦在治疗糖尿病患者合并心血管疾病时的临床疗效及代谢益处。
- 沙库巴曲缬沙坦 /
- 脑啡肽酶 /
- 肾素血管紧张素系统 /
- 利钠肽 /
- 血糖
Abstract: Diabetes often coexists with cardiovascular complications, which are also a common cause of death in diabetes patients. Therefore, in addition to improving glucose metabolism, it is also necessary to control cardiovascular complications in diabetes patients. Sacubitril valsartan is a novel compound with dual actions of inhibiting neprilysin and angiotensin receptor, and it is commonly used as a heart failure drug in clinical practice. Recent studies suggest that sacubitril valsartan may also have potential metabolic benefits, improving cardiac function while improving glycemic control in diabetes patients, and it is expected to become a drug that can be used routinely in diabetes, bringing cardiovascular and metabolic benefits. This review focuses on the clinical efficacy and metabolic benefits of sacubitril valsartan in the treatment of diabetes patients with cardiovascular diseases.
- Sacubitril valsartan /
- Neprilysin /
- Renin angiotensin system /
- Natriuretic peptide /
- Blood sugar

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