沙库巴曲缬沙坦治疗糖尿病合并心血管并发症的研究进展

陈琳; 念馨; 蔡红雁

doi:10.12259/j.issn.2095-610X.S20241101

沙库巴曲缬沙坦治疗糖尿病合并心血管并发症的研究进展

doi: 10.12259/j.issn.2095-610X.S20241101

陈琳¹,
念馨^1, ,,
蔡红雁²

1.
昆明医科大学第一附属医院内分泌一科
2.
心脏内二科，云南昆明　650032

基金项目: 国家自然科学基金资助项目（82270372）；云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目（202201AY070001-066）；云南省“兴滇英才支持计划”名医专项基金资助项目（RLMY20220005）；云南省重大疑难疾病中西医临床协作试点基金资助项目（300073）；昆明医科大学科技创新团队基金资助项目（CXTD202209）

详细信息

作者简介:
陈琳（2000～），女，云南曲靖人，在读硕士研究生，主要从事内分泌与代谢性疾病研究及临床工作

通讯作者:
念馨，E-mail：nianxinkm@hotmail.com

中图分类号: R587.1
计量
- 文章访问数: 142
- HTML全文浏览量: 99
- PDF下载量: 12
- 被引次数: 0
出版历程
- 收稿日期: 2024-10-22
- 网络出版日期: 2024-11-18
- 刊出日期: 2024-11-25

Research Progress in the Treatment of Diabetes Mellitus with Cardiovascular Complications with Sacubitril Valsartan

Lin CHEN¹,
Xin NIAN^{1
, ,},
Hongyan CAI²

1.
Dept. of Endocrinology
2.
Dept 2. of Cardiology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

摘要

摘要: 糖尿病由于多种因素常并发心血管并发症，心血管并发症也是糖尿病患者死亡的常见因素，因此，在改善糖尿病患者糖代谢同时也需控制心血管并发症。沙库巴曲缬沙坦是一种新型复合物，有着抑制脑啡肽酶和血管紧张素受体的双重作用，目前在临床上常作为心力衰竭患者的常用药物。近期的研究提示，沙库巴曲缬沙坦可能还存在着潜在的代谢益处，在改善糖尿病患者心功能的同时能改善血糖控制，有望成为糖尿病可常规使用的药物，带来心血管及代谢方面的益处。综述沙库巴曲缬沙坦在治疗糖尿病患者合并心血管疾病时的临床疗效及代谢益处。
- 沙库巴曲缬沙坦 /
- 脑啡肽酶 /
- 肾素血管紧张素系统 /
- 利钠肽 /
- 血糖
Abstract: Diabetes often coexists with cardiovascular complications, which are also a common cause of death in diabetes patients. Therefore, in addition to improving glucose metabolism, it is also necessary to control cardiovascular complications in diabetes patients. Sacubitril valsartan is a novel compound with dual actions of inhibiting neprilysin and angiotensin receptor, and it is commonly used as a heart failure drug in clinical practice. Recent studies suggest that sacubitril valsartan may also have potential metabolic benefits, improving cardiac function while improving glycemic control in diabetes patients, and it is expected to become a drug that can be used routinely in diabetes, bringing cardiovascular and metabolic benefits. This review focuses on the clinical efficacy and metabolic benefits of sacubitril valsartan in the treatment of diabetes patients with cardiovascular diseases.
- Sacubitril valsartan /
- Neprilysin /
- Renin angiotensin system /
- Natriuretic peptide /
- Blood sugar

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参考文献(33)

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