脂肪组织线粒体功能在肥胖中的作用

钱映; 杨寄镯; 黄娟; 袁科迪; 刘俊仪; 冯月梅; 殷建忠

doi:10.12259/j.issn.2095-610X.S20250701

脂肪组织线粒体功能在肥胖中的作用

doi: 10.12259/j.issn.2095-610X.S20250701

钱映^{1, 2,},
杨寄镯^{1, 2},
黄娟³,
袁科迪^{1, 2},
刘俊仪^{1, 2},
冯月梅^{1, 2},
殷建忠^{1, 2, 4, ,}

1.
云南省公共卫生与生物安全重点实验室，云南昆明　650500
2.
昆明医科大学公共卫生学院，云南昆明　650500
3.
昆明医科大学第一附属医院超声医学科，云南昆明　650032
4.
云南省高校营养与食品安全重点实验室，云南昆明　650500

基金项目: 国家自然科学基金（82260641，81860597）；云南省基础研究专项计划重点项目（202501AS070132）；云南省高校服务重点产业科技项目（博士生服务产业科研创新培育项目，FWCY-BSPY2024079）；昆明医科大学一流学科特色团队（2024XKTDTS15）；云南省赵星专家工作站（202505AF350064）

详细信息

作者简介:
钱映（1997～），女，云南安宁人，博士，在站博士后，主要从事营养流行病学研究工作

杨寄镯与钱映对本文有同等贡献

通讯作者:
殷建忠，E-mail：yinjianzhong2005@sina.com

中图分类号: R151
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出版历程
- 收稿日期: 2025-06-04
- 刊出日期: 2025-07-21

The Role of Mitochondrial Function in Adipose Tissue in Obesity

Ying QIAN^{1, 2
,},
Jizhuo YANG^{1, 2},
Juan HUANG³,
Kedi YUAN^{1, 2},
Junyi LIU^{1, 2},
Yuemei FENG^{1, 2},
Jianzhong YIN^{1, 2, 4
, ,}

1.
Yunnan Provincial Key Laboratory of Public Health and Biosafety，Kunming Yunnan 650500
2.
Schoolof Public Health，Kunming Medical University，Kunming Yunnan 650500
3.
Department of Ultrasound Medicine，the First Affiliated Hospital，Kunming Medical University，Kunming Yunnan 650032
4.
Key Laboratory of Nutrition and Food Safety of Yunnan Provincial Education Department，Kunming Yunnan 650500，China

More Information

Corresponding author: 殷建忠，二级教授，博士生导师，国务院政府特殊津贴专家，云岭教学名师，国家级一流本科课程负责人，教育部首届高校健康教育教指委委员，健康云南发展智库首席专家，云南省高校营养与食品安全重点实验室主任、精准营养与公共健康博士生导师团队带头人，省级专家工作站项目负责人。研究领域：营养流行病学。主持国家重点研发计划课题1项、国家自然科学基金 4 项、云南省科技厅基础研究专项计划重点项目1项。获云南省哲学社会科学优秀成果一等奖1项、科技进步三等奖 4 项、卫生科技成果二等奖1项及三等奖3项。代表性成果发表于The Lancet Regional Health-Western Pacific、JHEP Reports、eLife等期刊，入选ESI高水平论文2篇，在The BMJ发表文章简评（Rapid Response）15篇，论文摘要入选Cell Symposium、The Lancet Summit国际学术会议。主持完成教育部公共卫生与预防医学学术学位研究生课程建设项目，获云南省高等教育教学成果奖二等奖1项。

摘要

摘要: 肥胖已成为全球重大公共卫生问题，我国肥胖形势也日益严峻。脂肪组织分为白色脂肪组织（white adipose tissue，WAT）和棕色脂肪组织（brown adipose tissue，BAT），通过分泌多种脂肪因子调节机体代谢稳态。线粒体作为能量代谢的核心细胞器，其功能障碍与肥胖密切相关。肥胖状态下，线粒体动力学失衡、氧化应激及代谢功能障碍等均可导致代谢紊乱。而线粒体功能障碍不仅影响脂肪组织，还波及肌肉、肝脏等多器官受损，进而加剧肥胖及相关代谢疾病。近年来，靶向线粒体功能障碍治疗策略正被积极探索，但临床转化面临挑战。对脂肪组织线粒体功能障碍与肥胖关联进行综述，分析其机制及现有治疗策略，旨为肥胖诊疗提供新视角。
- 肥胖 /
- 脂肪组织 /
- 线粒体功能障碍 /
- 代谢紊乱
Abstract: Obesity has become a major global public health issue, and the situation in China is also becoming increasingly severe. Adipose tissue is categorized into white adipose tissue （WAT） and brown adipose tissue （BAT）, which regulates metabolic homeostasis by secreting various adipokines. Mitochondria, as the core organelles of energy metabolism, its dysfunction are closely related to obesity. In the state of obesity, mitochondrial dynamics imbalance, oxidative stress, and metabolic dysfunction can all lead to energy metabolism disorders and adipose tissue dysfunction. Moreover, mitochondrial dysfunction not only affects adipose tissue but also extends to multiple organs such as muscles and livers, thereby exacerbating obesity and related metabolic diseases. In recent years, although numerous therapeutic strategies targeting mitochondrial dysfunction have been actively explored, their clinical translation faces challenges. This review explores the association between mitochondrial dysfunction in adipose tissue and obesity, analyses its mechanism and existing treatment strategies, aiming to provide a new perspective for the diagnosis and treatment of obesity.
- Obesity /
- Adipose tissue /
- Mitochondrial dysfunction /
- Metabolic disorders

HTML全文

图 1 脂肪细胞特征比较

Figure 1. Comparison of adipocyte characteristics

下载: 全尺寸图片幻灯片

图 2 线粒体动力学失衡与氧化应激恶性循环机制示意图

Figure 2. Schematic diagram of the vicious cycle between mitochondrial dynamics imbalance and oxidative stress

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图 3 线粒体代谢障碍的多因素机制示意图

Figure 3. Schematic illustration of the multifactorial mechanisms of mitochondrial metabolic dysfunction

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图 4 mtDNA突变对线粒体ETC及ATP合成影响的机制示意图

Figure 4. Schematic diagram of the Mechanism of mtDNA Mutations on Mitochondrial ETC and ATP Synthesis

下载: 全尺寸图片幻灯片

图 5 靶向线粒体功能障碍治疗机制示意图

Figure 5. Schematic diagram of the mechanism of therapeutic strategies targeting mitochondrial dysfunction

下载: 全尺寸图片幻灯片

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脂肪组织线粒体功能在肥胖中的作用

doi: 10.12259/j.issn.2095-610X.S20250701

作者简介:
钱映（1997～），女，云南安宁人，博士，在站博士后，主要从事营养流行病学研究工作

杨寄镯与钱映对本文有同等贡献

通讯作者:
殷建忠，E-mail：yinjianzhong2005@sina.com

计量

The Role of Mitochondrial Function in Adipose Tissue in Obesity

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目录

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脂肪组织线粒体功能在肥胖中的作用

doi: 10.12259/j.issn.2095-610X.S20250701

作者简介: 钱映（1997～），女，云南安宁人，博士，在站博士后，主要从事营养流行病学研究工作 杨寄镯与钱映对本文有同等贡献

通讯作者: 殷建忠，E-mail：yinjianzhong2005@sina.com

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The Role of Mitochondrial Function in Adipose Tissue in Obesity

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作者简介:
钱映（1997～），女，云南安宁人，博士，在站博士后，主要从事营养流行病学研究工作

杨寄镯与钱映对本文有同等贡献

通讯作者:
殷建忠，E-mail：yinjianzhong2005@sina.com