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RSS2011 Vol. 32, No. 11
2011, 32(11)
Abstract:
Objective To establish a two-dimensional quantitative structure-activity relationship(2D-QSAR)model for predicting the inhibitory activities of flavonoids on recombinant human protein kinase CK2 holoenzyme.Method 2D-QSAR study was performed in a series of flavonoids with inhibitory activities on recombinant human protein kinase CK2 holoenzyme by combination of density functional theory,molecular mechanics and statistics.Result The established 2D-QSAR model(Eq.1)showed a reasonable regressive performance(R2 ...
Objective To establish a two-dimensional quantitative structure-activity relationship(2D-QSAR)model for predicting the inhibitory activities of flavonoids on recombinant human protein kinase CK2 holoenzyme.Method 2D-QSAR study was performed in a series of flavonoids with inhibitory activities on recombinant human protein kinase CK2 holoenzyme by combination of density functional theory,molecular mechanics and statistics.Result The established 2D-QSAR model(Eq.1)showed a reasonable regressive performance(R2 ...
2011, 32(11)
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Objective To synthesize the derivatives of panaxatriol and Protopanaxatriol from Panax notoginseng.Method Protopanaxatriol was oxidated with Jones and obtained with NaBH4 and Panaxatriol was oxidated with PCC and obtained with NaBH4.Result Ten derivatives were obtained and four of them were new compounds.Conclusion Four new compounds are easy to get and make the foundation for activity screening of a large number of derivatives.
Objective To synthesize the derivatives of panaxatriol and Protopanaxatriol from Panax notoginseng.Method Protopanaxatriol was oxidated with Jones and obtained with NaBH4 and Panaxatriol was oxidated with PCC and obtained with NaBH4.Result Ten derivatives were obtained and four of them were new compounds.Conclusion Four new compounds are easy to get and make the foundation for activity screening of a large number of derivatives.
2011, 32(11)
Abstract:
Objective To learn the sub-health status and influencing factors of Kunming bus drivers.Methods Epidemiological Cross-sectional study method combined with questionnaire survey were used in this study.The qualified questionnaires were put into a database and then the data were statistically analyzed by using SPSS13.0.The qualified questionnaires' number was 398,the prevalence of subheath was 22.4%.We used subheath as the dependent variable,and used working time,sleep time,physic practice as the independent v...
Objective To learn the sub-health status and influencing factors of Kunming bus drivers.Methods Epidemiological Cross-sectional study method combined with questionnaire survey were used in this study.The qualified questionnaires were put into a database and then the data were statistically analyzed by using SPSS13.0.The qualified questionnaires' number was 398,the prevalence of subheath was 22.4%.We used subheath as the dependent variable,and used working time,sleep time,physic practice as the independent v...
2011, 32(11)
Abstract:
Objective To compare the difference between electrospinning and air-assisted electrospinning in preparation of sub-micron and Nano silk-fibroin fibers.Method The silk-fibroin fibers were prepared with electrospinning and air-assisted electrospinning.Result The thinner fibers could be obtained by air-assisted electrospinning,when air flow rate was increased to 4 L/min.Conclusion With the air-assisted electrospinning,the thinner fibers can be prepared,compared with electrospinning.
Objective To compare the difference between electrospinning and air-assisted electrospinning in preparation of sub-micron and Nano silk-fibroin fibers.Method The silk-fibroin fibers were prepared with electrospinning and air-assisted electrospinning.Result The thinner fibers could be obtained by air-assisted electrospinning,when air flow rate was increased to 4 L/min.Conclusion With the air-assisted electrospinning,the thinner fibers can be prepared,compared with electrospinning.
2011, 32(11)
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Objective To analyze the effect of microarc oxidation on the surface of polished and sandblasted titanium and its physical and chemical properties.Methods The pure titanium with 15 mm of diameter and 1mm of thickness were divided into 4 groups:G surfaces,SB surfaces,GMAO surfaces and SBMAO surfaces.Scanning electron microscopy(SEM),X-ray diffraction(XRD)and energy spectrum were used to test the physical and chemical properties of titanium surface.Results(1)On the basis of grinding and sandblasting,MAO surfa...
Objective To analyze the effect of microarc oxidation on the surface of polished and sandblasted titanium and its physical and chemical properties.Methods The pure titanium with 15 mm of diameter and 1mm of thickness were divided into 4 groups:G surfaces,SB surfaces,GMAO surfaces and SBMAO surfaces.Scanning electron microscopy(SEM),X-ray diffraction(XRD)and energy spectrum were used to test the physical and chemical properties of titanium surface.Results(1)On the basis of grinding and sandblasting,MAO surfa...
2011, 32(11)
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Objective To establish the rat model of retinal light injury,and observe the effect of Compound Light Capsule on the rat retinal light injury under electron microscope.Methods 30 SD rats(60 eyes)were divided into high dose group,middle dose group,low dose group,sham group,and normal group in random,6 SD rats(12 eyes)in each group.Rats were intragastrically administered with Compound Light Capsule 7 days before modeling,and the administration lasted for 2 weeks.Experimental rats in each group were exposured ...
Objective To establish the rat model of retinal light injury,and observe the effect of Compound Light Capsule on the rat retinal light injury under electron microscope.Methods 30 SD rats(60 eyes)were divided into high dose group,middle dose group,low dose group,sham group,and normal group in random,6 SD rats(12 eyes)in each group.Rats were intragastrically administered with Compound Light Capsule 7 days before modeling,and the administration lasted for 2 weeks.Experimental rats in each group were exposured ...
2011, 32(11)
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Objectives To discuss the feasibility of inducing differentiating BMSC(Bone Mesenchymal Stem Cell)to urothelial epithelia in vitro,and to look for a new source of seed cell for the form of bladder in tissue engineering.Methods We extracted the pig's bone marrow in vitro,then primarily cultured them,and enpanded and identified BMSCs.We obtained the urothelial epithelium tissue by mechanical separation,and primarily cultured,amplified and identified the urothelial epithelium,and collected the culture supernat...
Objectives To discuss the feasibility of inducing differentiating BMSC(Bone Mesenchymal Stem Cell)to urothelial epithelia in vitro,and to look for a new source of seed cell for the form of bladder in tissue engineering.Methods We extracted the pig's bone marrow in vitro,then primarily cultured them,and enpanded and identified BMSCs.We obtained the urothelial epithelium tissue by mechanical separation,and primarily cultured,amplified and identified the urothelial epithelium,and collected the culture supernat...
2011, 32(11)
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Objective To investigate the career planning situation of village-oriented medical students(also named as tuition-free medical students),analyze the existing problems,and provide some reasonable suggestions on village-oriented medical students' education.Method 100 village-oriented medical students were investigated by questionnaires and 20 students were given in-depth individual interview to learn their career planning.Results The primary reasons that contribute to their choice of profession are financial ...
Objective To investigate the career planning situation of village-oriented medical students(also named as tuition-free medical students),analyze the existing problems,and provide some reasonable suggestions on village-oriented medical students' education.Method 100 village-oriented medical students were investigated by questionnaires and 20 students were given in-depth individual interview to learn their career planning.Results The primary reasons that contribute to their choice of profession are financial ...
2011, 32(11)
Abstract:
Objective To compare and analyse the effects of two-port laparoscopic cholecystectomy and three-port laparoscopic cholecystectomy.Methods 102 patients who underwent laparoscopic cholecystectomy in Yui People's Hospital from Dec.2008 to Jan.2011 were randomly selected to receive either the two-port or the three-port technique.All patients were blinded to the type of operation they underwent.The length of the operation,bleeding amount,postoperative pain,postoperative complication,postoperative stay,and satisf...
Objective To compare and analyse the effects of two-port laparoscopic cholecystectomy and three-port laparoscopic cholecystectomy.Methods 102 patients who underwent laparoscopic cholecystectomy in Yui People's Hospital from Dec.2008 to Jan.2011 were randomly selected to receive either the two-port or the three-port technique.All patients were blinded to the type of operation they underwent.The length of the operation,bleeding amount,postoperative pain,postoperative complication,postoperative stay,and satisf...
2011, 32(11)
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Objective To study the changes of triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(H-DLC)and low density lipoprotein cholesterol(L-DLC)in patients with acute myocardial infarction(AMI).Methods We studied he data including blood biochemical indicators and disease history of 206 patients with AMI(AMI group)and 240 patients without AMI(control group)by case history random sampling.Some patients with AMI were followed up.Results(1)The blood levels of TG,TC and LDL-C in AMI group were ...
Objective To study the changes of triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(H-DLC)and low density lipoprotein cholesterol(L-DLC)in patients with acute myocardial infarction(AMI).Methods We studied he data including blood biochemical indicators and disease history of 206 patients with AMI(AMI group)and 240 patients without AMI(control group)by case history random sampling.Some patients with AMI were followed up.Results(1)The blood levels of TG,TC and LDL-C in AMI group were ...
2011, 32(11)
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Objective To investigate the changes of plasma levels of TFPI in different type of CHD patients and the association with coronary heart disease.Methods This study was conducted in 66 CHD patients and 22 healthy adults.The blood specimens were collected before using LMWH in AMI patients;and the blood specimens of SAP patients and healthy adults were collected on the second morning.After centrifugal treatment,the plasma was saved in a ultra-low temperature refrigerator.Coronary angiography was carried out on ...
Objective To investigate the changes of plasma levels of TFPI in different type of CHD patients and the association with coronary heart disease.Methods This study was conducted in 66 CHD patients and 22 healthy adults.The blood specimens were collected before using LMWH in AMI patients;and the blood specimens of SAP patients and healthy adults were collected on the second morning.After centrifugal treatment,the plasma was saved in a ultra-low temperature refrigerator.Coronary angiography was carried out on ...
2011, 32(11)
Abstract:
Objective To investigate the association between serum homocyteine(Hcy)and coronary arteriosclerosis.Methods 340 patients in our hospital who had cronary anginography were divided into 4groups: stable angina(SA)group,unatable angina(UA)group,acute myocardial infarction(AMI) group and control group.Gensine score and the level of serum Hcy were determinated in all cases.Results(1)Compared with control group,the serum Hcy levels were significantly higher in all groups with coronary heart desease(P< 0.01),incre...
Objective To investigate the association between serum homocyteine(Hcy)and coronary arteriosclerosis.Methods 340 patients in our hospital who had cronary anginography were divided into 4groups: stable angina(SA)group,unatable angina(UA)group,acute myocardial infarction(AMI) group and control group.Gensine score and the level of serum Hcy were determinated in all cases.Results(1)Compared with control group,the serum Hcy levels were significantly higher in all groups with coronary heart desease(P< 0.01),incre...
2011, 32(11)
Abstract:
Objective To explore the diagnostic value of Vibration Response Imaging System assisting bedside chest radiography in differentiating thoracic mass shadows.Methods Patients in RICU(respiratory intensive care unit)with thoracic mass shadows inspected by bedside chest radiography were further diagnosed with Vibration Response Imaging System.When the pathogenetic condition of patients were slightly stable,they were performed computed tomography.The consistency between different diagnostic methods and computed ...
Objective To explore the diagnostic value of Vibration Response Imaging System assisting bedside chest radiography in differentiating thoracic mass shadows.Methods Patients in RICU(respiratory intensive care unit)with thoracic mass shadows inspected by bedside chest radiography were further diagnosed with Vibration Response Imaging System.When the pathogenetic condition of patients were slightly stable,they were performed computed tomography.The consistency between different diagnostic methods and computed ...
2011, 32(11)
Abstract:
Objective To explore the value of high frequency ultrasound in diagnosis of small breast lesions and pre-operation guide-wire localizationby combining with pathology results,evaluate the diagnosis value of ultrasound in pre-infiltrating lesions of breast and infiltrating small breast cancer.Methods 67 breast lesions from 53 patients were detected with the diameter from 5 mm to 15 mm.35 of them were less than 10 mm in diameter.The sonographic characters were analyzed,the guide-wires were inserted under the g...
Objective To explore the value of high frequency ultrasound in diagnosis of small breast lesions and pre-operation guide-wire localizationby combining with pathology results,evaluate the diagnosis value of ultrasound in pre-infiltrating lesions of breast and infiltrating small breast cancer.Methods 67 breast lesions from 53 patients were detected with the diameter from 5 mm to 15 mm.35 of them were less than 10 mm in diameter.The sonographic characters were analyzed,the guide-wires were inserted under the g...
2011, 32(11)
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Objective To explore the application of damage control operation(DCO)in ultrasound interventional treatment of bile duct injury.Methods Clinical data of 19 cases with severe bile duct injury from December 2003 to December 2009 were selected as the object of this study,which Ultrasound interventional method was used in the damage control operation.DCO was performed in all 19 patients.PTCD was performed in 13 patients.Abdominal paracentesis drainage and/or hepatophyma and biloma drainage was performed in 6 pa...
Objective To explore the application of damage control operation(DCO)in ultrasound interventional treatment of bile duct injury.Methods Clinical data of 19 cases with severe bile duct injury from December 2003 to December 2009 were selected as the object of this study,which Ultrasound interventional method was used in the damage control operation.DCO was performed in all 19 patients.PTCD was performed in 13 patients.Abdominal paracentesis drainage and/or hepatophyma and biloma drainage was performed in 6 pa...
2011, 32(11)
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Objective To learn the current clinical status of neurological complications after spinal anesthesia and put forward feasible prevention programs.Methods We recorded detailedly the patients' characteristics and anesthesia operation,and reviewing the incidence of neurological complications in patients undertook spinal anesthesia.Multivariate regression analysis was used to analyze the risk factors of neurological complications.Results The major neurological complication of 600 patients who received spinal an...
Objective To learn the current clinical status of neurological complications after spinal anesthesia and put forward feasible prevention programs.Methods We recorded detailedly the patients' characteristics and anesthesia operation,and reviewing the incidence of neurological complications in patients undertook spinal anesthesia.Multivariate regression analysis was used to analyze the risk factors of neurological complications.Results The major neurological complication of 600 patients who received spinal an...
2011, 32(11)
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Objective To investigate the diagnosis and treatment of small bowel obstruction induced by phytobezoar.Method The clinical data of 21 patients with small bowel obstruction induced by phytobezoar in our hospital from February 2005 to February 2011 were analysed retrospectively.Results The 21 cases of small bowel obstruction induced by phytobezoar were diagnosed by medical history,clinical symptoms and physical sign,abdominal anteroposterior erect view,B-ultrasonic tomography,computerized tomography.15 patien...
Objective To investigate the diagnosis and treatment of small bowel obstruction induced by phytobezoar.Method The clinical data of 21 patients with small bowel obstruction induced by phytobezoar in our hospital from February 2005 to February 2011 were analysed retrospectively.Results The 21 cases of small bowel obstruction induced by phytobezoar were diagnosed by medical history,clinical symptoms and physical sign,abdominal anteroposterior erect view,B-ultrasonic tomography,computerized tomography.15 patien...
2011, 32(11)
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Objective To evaluate the curative effects of integrating pantoprazole and Mosapride on gastroesophageal reflux disease after esophagectomy.Methods 92 patients with gastroesophageal reflux after esophagectomy between 2007 and 2010 were analyzed retrospectively in our hospital.The difference of curative effects was compared between pantoprazole group(control group)and integrating Pantoprazole and Mosapride group(treatment group).Results The effective rate on reflux symptom of control group and treatment grou...
Objective To evaluate the curative effects of integrating pantoprazole and Mosapride on gastroesophageal reflux disease after esophagectomy.Methods 92 patients with gastroesophageal reflux after esophagectomy between 2007 and 2010 were analyzed retrospectively in our hospital.The difference of curative effects was compared between pantoprazole group(control group)and integrating Pantoprazole and Mosapride group(treatment group).Results The effective rate on reflux symptom of control group and treatment grou...
2011, 32(11)
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Objective To investigate the characteristics of changes of ambulatory blood pressure and heart rate variability(HRV)in patients with chronic kidney disease with hypertension(HCKD).Methods 56 patients with HCKD,44 patients with essential hypertension(EH)and 43 normal subjects were selected randomly,and their ambulatory blood pressure and dynamic electrocardiogram were simultaneously monitored to compare and analyze their ambulatory blood pressure parameter and the varied characteristics of HRV.Results Compar...
Objective To investigate the characteristics of changes of ambulatory blood pressure and heart rate variability(HRV)in patients with chronic kidney disease with hypertension(HCKD).Methods 56 patients with HCKD,44 patients with essential hypertension(EH)and 43 normal subjects were selected randomly,and their ambulatory blood pressure and dynamic electrocardiogram were simultaneously monitored to compare and analyze their ambulatory blood pressure parameter and the varied characteristics of HRV.Results Compar...
2011, 32(11)
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Objective To investigate pathogenic factor and therapy of acute left heart failure in gestation period.Method We retrospectively analyzed the clinical profile of 52 cases with acute left heart failure in gestational period.Results All Patients were peasants with bad medical condition,and they never received the prenatal examination.The incidence rate of pre-eclampsia with acute left heart failure was 73.07%,and that of hyperthyroidism was 13.46%.All parturient and fetus had remedied by the therapy of heart ...
Objective To investigate pathogenic factor and therapy of acute left heart failure in gestation period.Method We retrospectively analyzed the clinical profile of 52 cases with acute left heart failure in gestational period.Results All Patients were peasants with bad medical condition,and they never received the prenatal examination.The incidence rate of pre-eclampsia with acute left heart failure was 73.07%,and that of hyperthyroidism was 13.46%.All parturient and fetus had remedied by the therapy of heart ...
2011, 32(11)
Abstract:
Objective To give sedation analgesia treatment to chronic obstructive pulmonary disease(COPD)patients with invasive ventilation and observe the efficacy of mechanical ventilation.Methods 265 COPD patients in acute exacerbation who were treated with invasive ventilation were randomly divided into two groups: Conventional therapy plus midazolam group(126 cases)and midazolam combined with morphine group(139 cases).The efficacy of mechanical ventilation and the usage amount of midazolam were compared between tw...
Objective To give sedation analgesia treatment to chronic obstructive pulmonary disease(COPD)patients with invasive ventilation and observe the efficacy of mechanical ventilation.Methods 265 COPD patients in acute exacerbation who were treated with invasive ventilation were randomly divided into two groups: Conventional therapy plus midazolam group(126 cases)and midazolam combined with morphine group(139 cases).The efficacy of mechanical ventilation and the usage amount of midazolam were compared between tw...
2011, 32(11)
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Objective To compare the physiologic effects and the clinical efficacy of CPAP and standard oxygen therapy in patients with Type I Respiratory Insufficiency.Methods One unit,randomized,and unblinded trial of 119 elderly patients who were admitted to intensive care unit from September 2003 to December 2009 with a PaO2/FIO2 ratio of 300 mm Hg or less due to bilateral pulmonary edema.Patients were randomly assigned to receive oxygen therapy alone(n=58)or oxygen therapy plus CPAP(n=61).Main outcome measures of ...
Objective To compare the physiologic effects and the clinical efficacy of CPAP and standard oxygen therapy in patients with Type I Respiratory Insufficiency.Methods One unit,randomized,and unblinded trial of 119 elderly patients who were admitted to intensive care unit from September 2003 to December 2009 with a PaO2/FIO2 ratio of 300 mm Hg or less due to bilateral pulmonary edema.Patients were randomly assigned to receive oxygen therapy alone(n=58)or oxygen therapy plus CPAP(n=61).Main outcome measures of ...
2011, 32(11)
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Objective To study the clinical characteristics of far lateral lumbar disc herniation(FLLDH) and the appropriate operation way.Methods Thirteen patients with far lateral disc herniation were divided into two types by the place of herniated disc,that was foraminal disc herniation and extraforaminal disc herniation.The patients with foraminal disc herniation were treated with posterior lumbar interbody fusion(PLIF)while the patients with extraforaminal disc herniation were treated with intertransverse approac...
Objective To study the clinical characteristics of far lateral lumbar disc herniation(FLLDH) and the appropriate operation way.Methods Thirteen patients with far lateral disc herniation were divided into two types by the place of herniated disc,that was foraminal disc herniation and extraforaminal disc herniation.The patients with foraminal disc herniation were treated with posterior lumbar interbody fusion(PLIF)while the patients with extraforaminal disc herniation were treated with intertransverse approac...
2011, 32(11)
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Objective To explore the most appropriate treatment method for cervical erosion.Methods From May 2010 to June 2011,126 patients with cervical erosion in our hospital were randomly divided into two groups:cervical microwave treatment group and cervical microwave and EaLeSu treatment group.The therapeutic effects and side effects were compared between two groups.Results The therapeutic effects of the two methods had significant difference(P < 0.01).The therapeutic effects of cervical microwave and EaLeSu trea...
Objective To explore the most appropriate treatment method for cervical erosion.Methods From May 2010 to June 2011,126 patients with cervical erosion in our hospital were randomly divided into two groups:cervical microwave treatment group and cervical microwave and EaLeSu treatment group.The therapeutic effects and side effects were compared between two groups.Results The therapeutic effects of the two methods had significant difference(P < 0.01).The therapeutic effects of cervical microwave and EaLeSu trea...
2011, 32(11)
Abstract:
Objective To investigate the misdiagnosis causes and preventive measures of senile right colon cancer with acute appendicitis.Method Retrospective study was used to analyze the experience of 18 cases of senile right colon cancer with acute appendicitis in Kunming Yan'an Hospital from January 2008 to January 2010.Result 18 patients with right colon cancer were misdiagnosed as acute and chronic appendicitis or appendix abscess on admission,and were confirmed as colon cancer with acute simple appendicitis by p...
Objective To investigate the misdiagnosis causes and preventive measures of senile right colon cancer with acute appendicitis.Method Retrospective study was used to analyze the experience of 18 cases of senile right colon cancer with acute appendicitis in Kunming Yan'an Hospital from January 2008 to January 2010.Result 18 patients with right colon cancer were misdiagnosed as acute and chronic appendicitis or appendix abscess on admission,and were confirmed as colon cancer with acute simple appendicitis by p...
2011, 32(11)
Abstract:
Objective To evaluate the reliability of of academic record in final examination of Medical Statistics by using the methods of generalizability theory and to give advice on how to modify examination paper and the way of checking examination papers.Methods Estimation value of variance component from different variations were calculated by applying the principle of generalizability theory and using statistical software SPSS.Furthermore,relative error,absolute error,generalizability coefficient,index of depend...
Objective To evaluate the reliability of of academic record in final examination of Medical Statistics by using the methods of generalizability theory and to give advice on how to modify examination paper and the way of checking examination papers.Methods Estimation value of variance component from different variations were calculated by applying the principle of generalizability theory and using statistical software SPSS.Furthermore,relative error,absolute error,generalizability coefficient,index of depend...
