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RSS2017 Vol. 38, No. 04
2017, 38(04): 5-9.
Abstract:
Objective To explore the role of EP2 receptor in pathological changes of brain injury by investigating the positive expression and changes of EP2 in rat hippocampus brain regions after pure cerebral concussion( PCC). Methods The PCC rats models were established by using a self-made metal pendulum-striker concussive device. To observe the postive expression of EP2 receptor with optical density and cell count changes in CA1-4, up and down the dentate gyrus brain regins,the rats were randomly divided into 3 h, 12 h, 1 d, 2 d, 3 d and 7 d six groups(n=5) after PCC and one normal group(n=5) was used as the control.The immunohistochemistry(SP method) was used with anti-EP2 rabbit polyclonal antibody. Results The results showed that EP2 receptor immunoreactivity was lightly observed in normal group. The expression of EP2 receptor showed a significant upward trend at 3 h after PCC, peak expression appeared in 3 d group(P<0.05)and showed a downward trend in 7 d group. Conclusion The EP2 receptor induced by PCC is closely related to the pathological changes after PCC injury.
Objective To explore the role of EP2 receptor in pathological changes of brain injury by investigating the positive expression and changes of EP2 in rat hippocampus brain regions after pure cerebral concussion( PCC). Methods The PCC rats models were established by using a self-made metal pendulum-striker concussive device. To observe the postive expression of EP2 receptor with optical density and cell count changes in CA1-4, up and down the dentate gyrus brain regins,the rats were randomly divided into 3 h, 12 h, 1 d, 2 d, 3 d and 7 d six groups(n=5) after PCC and one normal group(n=5) was used as the control.The immunohistochemistry(SP method) was used with anti-EP2 rabbit polyclonal antibody. Results The results showed that EP2 receptor immunoreactivity was lightly observed in normal group. The expression of EP2 receptor showed a significant upward trend at 3 h after PCC, peak expression appeared in 3 d group(P<0.05)and showed a downward trend in 7 d group. Conclusion The EP2 receptor induced by PCC is closely related to the pathological changes after PCC injury.
2017, 38(04): 10-13.
Abstract:
Objective To explore the effects of paclitaxel on gene and protein expression of wnt/β-catenin signaling pathway in cholangiocarcinoma cell line QBC939. Methods Western blot was used to detectβ-cateninprotein expression level in 0.1, 1, 10 nmol/L paclitaxel groups and control group for 24 h. q-PCR was used to detect c-jun and p53 mRNA expression level in 10nmol/L paclitaxel group and control group for 24 h.Results Compared with control group, the expression levels of β-catenin protein in paclitaxel groups were decreased, the expression levels of β-catenin protein were significantly reduced when paclitaxel concentration at10 nmol/L(P<0.05). Compared with control group,the expression levels of p53 mRNA were up-regulated and c-jun mRNA were down-regulated in10nmol/L paclitaxel group(P <0.05). Conclusions Paclitaxel may Down-regulate the expression of β-catenin and up-regulate the p53 mRNA, then block the wnt/β-catenin signaling pathway and down-regulate c-jun mRNA in cholangiocarcinoma cell line QBC939.
Objective To explore the effects of paclitaxel on gene and protein expression of wnt/β-catenin signaling pathway in cholangiocarcinoma cell line QBC939. Methods Western blot was used to detectβ-cateninprotein expression level in 0.1, 1, 10 nmol/L paclitaxel groups and control group for 24 h. q-PCR was used to detect c-jun and p53 mRNA expression level in 10nmol/L paclitaxel group and control group for 24 h.Results Compared with control group, the expression levels of β-catenin protein in paclitaxel groups were decreased, the expression levels of β-catenin protein were significantly reduced when paclitaxel concentration at10 nmol/L(P<0.05). Compared with control group,the expression levels of p53 mRNA were up-regulated and c-jun mRNA were down-regulated in10nmol/L paclitaxel group(P <0.05). Conclusions Paclitaxel may Down-regulate the expression of β-catenin and up-regulate the p53 mRNA, then block the wnt/β-catenin signaling pathway and down-regulate c-jun mRNA in cholangiocarcinoma cell line QBC939.
2017, 38(04): 14-17.
Abstract:
Objective To investigate the expression of PAR4 and mechanism of esophageal cancer cells.Methods(1) We used PCR and western blot to detect the expression of PAR4 in human esophageal epithelial cells(HEEpiC), human esophageal cancer cells(TE-10, TE-11,Eca-109).(2) The BSP method was used to test the methylation of PAR4 gene promoter region in four cells.Results(1) The expression level of PAR4 mRNA in TE-10,TE-11,Eca-109 cells was lower than that of HEEpiC cells.(2) In HEEpiC,TE-10,TE-11 and Eca-109,the frequency of methoylation occurred at the 19 CpG loci of PAR4 was 35.4%,83.8%,87.6% and94.3%, respectively. Conclusion The expression of PAR4 in esophageal cancer cells is increased, the hypermethylation at promoter of PAR4 gene may contribute to less expression of PAR4 in esophageal cancer cells.
Objective To investigate the expression of PAR4 and mechanism of esophageal cancer cells.Methods(1) We used PCR and western blot to detect the expression of PAR4 in human esophageal epithelial cells(HEEpiC), human esophageal cancer cells(TE-10, TE-11,Eca-109).(2) The BSP method was used to test the methylation of PAR4 gene promoter region in four cells.Results(1) The expression level of PAR4 mRNA in TE-10,TE-11,Eca-109 cells was lower than that of HEEpiC cells.(2) In HEEpiC,TE-10,TE-11 and Eca-109,the frequency of methoylation occurred at the 19 CpG loci of PAR4 was 35.4%,83.8%,87.6% and94.3%, respectively. Conclusion The expression of PAR4 in esophageal cancer cells is increased, the hypermethylation at promoter of PAR4 gene may contribute to less expression of PAR4 in esophageal cancer cells.
2017, 38(04): 18-21.
Abstract:
Objective To explore the changes of serum IL-2 and IL-6 of rats with insulin resistance after swimming training intervention,so as to provide scientific basis for further reducing and preventing the occurrence and development of diabetes. Methods Eight weeks male SD rats were induced to insulin resistance model by abdominal injection of 0.75 mg/kg of bovine Fetuin-A(purity of 95%). The insulin resistance index(HOMA IR) 8hours after injection was detected to confirm the success of modeling. The model rats were randomly divided into control group(RR) and exercise group(RE),and normal rats were selected as the blank control group(group C), 6 rats in each group. Rats in the RE group were given swimming training without weight loading,60 min/d for8 weeks, rats in group C and group RR were removed from the swimming pool immediately after flooding.Immunohistochemistry and western blot method were used respectively to detect the serum Fetuin-A and the indexes of insulin resistance(HOMA IR). ELISA was used to detect serum IL-2, IL-2R and IL-6 levels. Results The HOMA-IR of rats in RE group was significantly lower than that in RR group. Compared with the RR group,the serum IL-2 levels of rats in RE group were increased significantly(P < 0.05). Compared with the C group,the serum IL-6 levels in RR group were increased significantly. Compared with the RR group,the serum IL-6levels in RE group were decreased significantly(P < 0.01). Conclusions Swimming training can significantly improve the IL-2 levels and the diastolic function of heart at the same time of reducing insulin resistance index. And the down-regulation of IL-6 expression suggests that IL-6 may also be used as a reference to test insulin resistance index.
Objective To explore the changes of serum IL-2 and IL-6 of rats with insulin resistance after swimming training intervention,so as to provide scientific basis for further reducing and preventing the occurrence and development of diabetes. Methods Eight weeks male SD rats were induced to insulin resistance model by abdominal injection of 0.75 mg/kg of bovine Fetuin-A(purity of 95%). The insulin resistance index(HOMA IR) 8hours after injection was detected to confirm the success of modeling. The model rats were randomly divided into control group(RR) and exercise group(RE),and normal rats were selected as the blank control group(group C), 6 rats in each group. Rats in the RE group were given swimming training without weight loading,60 min/d for8 weeks, rats in group C and group RR were removed from the swimming pool immediately after flooding.Immunohistochemistry and western blot method were used respectively to detect the serum Fetuin-A and the indexes of insulin resistance(HOMA IR). ELISA was used to detect serum IL-2, IL-2R and IL-6 levels. Results The HOMA-IR of rats in RE group was significantly lower than that in RR group. Compared with the RR group,the serum IL-2 levels of rats in RE group were increased significantly(P < 0.05). Compared with the C group,the serum IL-6 levels in RR group were increased significantly. Compared with the RR group,the serum IL-6levels in RE group were decreased significantly(P < 0.01). Conclusions Swimming training can significantly improve the IL-2 levels and the diastolic function of heart at the same time of reducing insulin resistance index. And the down-regulation of IL-6 expression suggests that IL-6 may also be used as a reference to test insulin resistance index.
2017, 38(04): 22-27.
Abstract:
Objective To explore the immunoregulatory mechanisms of glial cells in retina after optic nerve injury in rats by using rats with traumatic optic nerve injury as TON model to detect the activation of microglia,astrocyte,and observe the temporal and spatial expression of inflammatory mediators and neurotrophic factors in retina at different time points after TON. Methods We established an animal model of rat optic nerve traumatic and draw materials from the rats at 1d, 3d, 5d and 7d after injury.Western-blot was used to dectect the expression levels of IL-1β, TNF-α and iNOS at all time points after injury. Immunofluorescence staining was used to detect microglia, astrocytes and the specific lesions expression and distribution of IL-1β,TNF-α,iNOS,Nestin inthe retina. Results Compared with the control group, the expression of IL-1β protein was peaked at 3 days after injury, and the difference was statistically significant(P <0.05), the expression declined at 5 days, the difference was not statistically significant(P>0.05). The expression of TNF-α increased at all time points after injury(P<0.05), and the expression level of TNF-α reached the peak at 3 days after injury. Compared with the control group, the difference was a statistical significant(P <0.01). The level of iNOS was significantly up-regulated at 1 day after injury, and the expression level of iNOS was significantly higher than the control group,and the difference was statistically significant(P<0.05), the expression declined at 3 days, the difference was not statistically significant(P>0.05). Immunohistochemical staining showed that after the injury,we can observe the activation of microglia and astrocytes. IL-1β and iNOS were expressed in activated microglia and astrocytes.But we were unable to observe the expression of TNF-α in astrocytes at all time points. Nestin expression was observed in astrocytes at 7 days after injury. Conclusions The activated astrocytes and microglia in retina are the main sources of IL-1β and iNOS after traumatic optic nerve injury. The activated astrocytes may have neuroprotective effects in the model.
Objective To explore the immunoregulatory mechanisms of glial cells in retina after optic nerve injury in rats by using rats with traumatic optic nerve injury as TON model to detect the activation of microglia,astrocyte,and observe the temporal and spatial expression of inflammatory mediators and neurotrophic factors in retina at different time points after TON. Methods We established an animal model of rat optic nerve traumatic and draw materials from the rats at 1d, 3d, 5d and 7d after injury.Western-blot was used to dectect the expression levels of IL-1β, TNF-α and iNOS at all time points after injury. Immunofluorescence staining was used to detect microglia, astrocytes and the specific lesions expression and distribution of IL-1β,TNF-α,iNOS,Nestin inthe retina. Results Compared with the control group, the expression of IL-1β protein was peaked at 3 days after injury, and the difference was statistically significant(P <0.05), the expression declined at 5 days, the difference was not statistically significant(P>0.05). The expression of TNF-α increased at all time points after injury(P<0.05), and the expression level of TNF-α reached the peak at 3 days after injury. Compared with the control group, the difference was a statistical significant(P <0.01). The level of iNOS was significantly up-regulated at 1 day after injury, and the expression level of iNOS was significantly higher than the control group,and the difference was statistically significant(P<0.05), the expression declined at 3 days, the difference was not statistically significant(P>0.05). Immunohistochemical staining showed that after the injury,we can observe the activation of microglia and astrocytes. IL-1β and iNOS were expressed in activated microglia and astrocytes.But we were unable to observe the expression of TNF-α in astrocytes at all time points. Nestin expression was observed in astrocytes at 7 days after injury. Conclusions The activated astrocytes and microglia in retina are the main sources of IL-1β and iNOS after traumatic optic nerve injury. The activated astrocytes may have neuroprotective effects in the model.
2017, 38(04): 28-31.
Abstract:
Objective To investigate the correlation of 5-HT transporter protein gene(SLC6A4)polymorphism and conduct disorder in children in primary and middle school in Kunming area. Methods Eighty-eight students with conduct disorder were studied. The technique of polytnerase Chain Reaction was used to study the SLC6A4 gene in conduct disorder. Results There was no statistically significant difference between conduct disorder and non-conduct disorder group in genotypes and allele frequencies. There was statistically significant difference in male group(P <0.05) but no in female group(P >0.05).Conclusions The SLC6A4 gene polymorphism may be correlated with conduct disorder in children.
Objective To investigate the correlation of 5-HT transporter protein gene(SLC6A4)polymorphism and conduct disorder in children in primary and middle school in Kunming area. Methods Eighty-eight students with conduct disorder were studied. The technique of polytnerase Chain Reaction was used to study the SLC6A4 gene in conduct disorder. Results There was no statistically significant difference between conduct disorder and non-conduct disorder group in genotypes and allele frequencies. There was statistically significant difference in male group(P <0.05) but no in female group(P >0.05).Conclusions The SLC6A4 gene polymorphism may be correlated with conduct disorder in children.
2017, 38(04): 32-34.
Abstract:
Objective To investigate the practical application of IBS method in the full sibling testing.Methods PowerPlex21 System kit was used to amplify the 19 STR loci(D3S1358, D6S1043,D13S317,Penta E,D16S539,D18S51,D2S1338,CSF1 PO,Penta D,TH01, v WA, D21S11, D7S820, D5S818,TPOX,D8S1179,D12S391,D19S433,FGA) from the 234 pairs of determined full siblings and 200 unrelated individuals of Han population in Yunnan province,and ABI3130 genetic analyzer automatic detection and Gene Mapper ID v3.2 software were used for STR genotyping.The typing results were calculated on the basis of the IBS method(SF/Z JD0105002-2014).Results The rate of full siblings was 82.91%, and it was higher than 75%in the standard. 17.09% of the samples could not give tendentious opinions. The scores from 13 to 22 had 65 pairs of unrelated individuals, and it accounted for 32.50%.There were 135 pairs of less than 13 points that accounted for67.50%. Conclusion The application of IBS method in the identification of full siblings in Yunnan has a high value in forensic medicine.
Objective To investigate the practical application of IBS method in the full sibling testing.Methods PowerPlex21 System kit was used to amplify the 19 STR loci(D3S1358, D6S1043,D13S317,Penta E,D16S539,D18S51,D2S1338,CSF1 PO,Penta D,TH01, v WA, D21S11, D7S820, D5S818,TPOX,D8S1179,D12S391,D19S433,FGA) from the 234 pairs of determined full siblings and 200 unrelated individuals of Han population in Yunnan province,and ABI3130 genetic analyzer automatic detection and Gene Mapper ID v3.2 software were used for STR genotyping.The typing results were calculated on the basis of the IBS method(SF/Z JD0105002-2014).Results The rate of full siblings was 82.91%, and it was higher than 75%in the standard. 17.09% of the samples could not give tendentious opinions. The scores from 13 to 22 had 65 pairs of unrelated individuals, and it accounted for 32.50%.There were 135 pairs of less than 13 points that accounted for67.50%. Conclusion The application of IBS method in the identification of full siblings in Yunnan has a high value in forensic medicine.
2017, 38(04): 35-39.
Abstract:
Objective To establish the diagnosis and prevention programs osteoporosis in line with the reality of Kunming, by learning the developing regularity of bone mineral density of patients in our hospital and the prevalence of osteoporosis in Kunming. Methods We tested the bone mineral density on lumbar vertebra with the application of DEXA among 744 patients screened by the medical files which in the department of Orthopedics and Rehabilitation Medicine inpatient and outpatient on 30 th December, 2013 to 30 th December, 2014, and calculated value of T,recorded the fat percentage for each subject. Refer to the International Osteoporosis Foundation(IOF) Osteoporosis one minute test, made subjective evaluation to 744 patients.Results(1) Male and female peak bone mineral density were 30-34 years of age. With the age increasing, men had no significant changes in bone mineral density, bone mineral density decreased bone density,and the extent of the peak between different age groups(P > 0.05);Bone mineral density in women before the age of 50 changed little,then gradually declined over50, the degree of peak bone mineral density had significant difference between different age groups(P < 0.05).(2) The prevalence of osteoporosis(OP) in men and women was 41.0% and 39.2%, respectively.(3) With the fat percentage(%) increase in bone mineral density, there was a increasing trend in the peak bone mineral density.(4) Men and women with osteoporosis showed that one minute test, the results were similar for men and women,the percentage of the presence of the risk of osteoporosis in men was 51.7%, in women was 62.0%. In the positive population, the prevalence of osteoporosis(OP) was 58.7% and 60.4% in men and women, respectively.Conclusions(1) Kunming osteoporosis prevention and control situation is more serious.(2) We should strengthen publicity and education of osteoporosis knowledge in Kunming residents, advocate reasonable diet,healthy exercise, early screening, especially for high-risk groups aged over 50.(3) We should provide effective and objective basis for establishing perfect diagnosis and prevention programs of osteoporosis.
Objective To establish the diagnosis and prevention programs osteoporosis in line with the reality of Kunming, by learning the developing regularity of bone mineral density of patients in our hospital and the prevalence of osteoporosis in Kunming. Methods We tested the bone mineral density on lumbar vertebra with the application of DEXA among 744 patients screened by the medical files which in the department of Orthopedics and Rehabilitation Medicine inpatient and outpatient on 30 th December, 2013 to 30 th December, 2014, and calculated value of T,recorded the fat percentage for each subject. Refer to the International Osteoporosis Foundation(IOF) Osteoporosis one minute test, made subjective evaluation to 744 patients.Results(1) Male and female peak bone mineral density were 30-34 years of age. With the age increasing, men had no significant changes in bone mineral density, bone mineral density decreased bone density,and the extent of the peak between different age groups(P > 0.05);Bone mineral density in women before the age of 50 changed little,then gradually declined over50, the degree of peak bone mineral density had significant difference between different age groups(P < 0.05).(2) The prevalence of osteoporosis(OP) in men and women was 41.0% and 39.2%, respectively.(3) With the fat percentage(%) increase in bone mineral density, there was a increasing trend in the peak bone mineral density.(4) Men and women with osteoporosis showed that one minute test, the results were similar for men and women,the percentage of the presence of the risk of osteoporosis in men was 51.7%, in women was 62.0%. In the positive population, the prevalence of osteoporosis(OP) was 58.7% and 60.4% in men and women, respectively.Conclusions(1) Kunming osteoporosis prevention and control situation is more serious.(2) We should strengthen publicity and education of osteoporosis knowledge in Kunming residents, advocate reasonable diet,healthy exercise, early screening, especially for high-risk groups aged over 50.(3) We should provide effective and objective basis for establishing perfect diagnosis and prevention programs of osteoporosis.
2017, 38(04): 40-44.
Abstract:
Objective To investigate the expression and significance of CD90 and α-SMA in benign bile duct scar.Methods Immunohistochemical staining of SP was applied to investigate the expression of protein CD90,α-SMA, type Ⅰ collagen, type Ⅲ collagen in 14 cases of benign bile duct scar and 10 cases of normal bile duct group.Finally image analysis was performed. Fibroblasts from the benign bile duct scar were cultivated. The expression of CD90 was measured in fibroblasts by immunofluorescence and flow cytometry. Results The expression of CD90 and α-SMA in benign bile duct scar was higher than that in normal bile duct group(P<0.05), There was positive correlation between the expression of both two in benign bile duct scar and normal bile(r=0.681,P=0.000). The expression of typeⅠcollagen and type Ⅲ collagen in benign bile duct scar was higher than that in normal bile duct group(P<0.05). There was negative correlation between the expression of both two in benign bile duct scar and normal bile(r=-0.413 P=0.011).Fibroblasts from the benign bile duct scar were cultivated and the excessive exprerssion of CD90 was found by immunofluorescence and flow cytometry. The expression of CD90, α-SMA, type Ⅰ collagen and type Ⅲ collagen were higher in benign bile duct scar than normal bile, In benign bile duct scar, the expression of CD90 and α-SMA was positively related,type Ⅰ collagen and type Ⅲ collagen was negatively related.Conclusions CD90 in fibroblasts of human benign bile duct scar is overexpressed. CD90 may be the specific phenotype of abnormal hyperplasia in benign bile duct scar.
Objective To investigate the expression and significance of CD90 and α-SMA in benign bile duct scar.Methods Immunohistochemical staining of SP was applied to investigate the expression of protein CD90,α-SMA, type Ⅰ collagen, type Ⅲ collagen in 14 cases of benign bile duct scar and 10 cases of normal bile duct group.Finally image analysis was performed. Fibroblasts from the benign bile duct scar were cultivated. The expression of CD90 was measured in fibroblasts by immunofluorescence and flow cytometry. Results The expression of CD90 and α-SMA in benign bile duct scar was higher than that in normal bile duct group(P<0.05), There was positive correlation between the expression of both two in benign bile duct scar and normal bile(r=0.681,P=0.000). The expression of typeⅠcollagen and type Ⅲ collagen in benign bile duct scar was higher than that in normal bile duct group(P<0.05). There was negative correlation between the expression of both two in benign bile duct scar and normal bile(r=-0.413 P=0.011).Fibroblasts from the benign bile duct scar were cultivated and the excessive exprerssion of CD90 was found by immunofluorescence and flow cytometry. The expression of CD90, α-SMA, type Ⅰ collagen and type Ⅲ collagen were higher in benign bile duct scar than normal bile, In benign bile duct scar, the expression of CD90 and α-SMA was positively related,type Ⅰ collagen and type Ⅲ collagen was negatively related.Conclusions CD90 in fibroblasts of human benign bile duct scar is overexpressed. CD90 may be the specific phenotype of abnormal hyperplasia in benign bile duct scar.
2017, 38(04): 45-48.
Abstract:
Objective To discuss and summarize the significance of invasive pressure monitoring in low blood pressure of the dominant right coronary artery after STEMI PPCI, in correcting the course of treatment of low blood pressure. Methods According to whether adjusting therapeutic strategies, 82 cases of dominant right coronary patients with low blood pressure after PPCI were divided into two groups. The incidence of acute left heart failure and the time used to correct low blood pressure in patients during the treatment were compared between two groups.Results During treatment process of correcting low blood pressure, in 22 cases without adjusting treatment strategy according to pressure monitoring data,5 cases appeared acute left heart dysfunction,the incidence was 22.7%, the average time to correct low blood pressure was(53±7.2) h. In 60 cases with adjusting treatment strategy according to pressure monitoring data, no acute left heart dysfunction was found, and the average time to correct low blood pressure was(36 ±5.6) h, the difference between the two groups was statistically significant(P <0.05).Conclusion For patients with STEMI induced by acute occlusion of dominant right coronary artery, in treatment course of correcting low blood pressure after PPCI,adjusting the treatment strategy according to invasive pressuremonitoring data can significantly reduce the risks of acute left heart failure and correct low blood pressure faster.
Objective To discuss and summarize the significance of invasive pressure monitoring in low blood pressure of the dominant right coronary artery after STEMI PPCI, in correcting the course of treatment of low blood pressure. Methods According to whether adjusting therapeutic strategies, 82 cases of dominant right coronary patients with low blood pressure after PPCI were divided into two groups. The incidence of acute left heart failure and the time used to correct low blood pressure in patients during the treatment were compared between two groups.Results During treatment process of correcting low blood pressure, in 22 cases without adjusting treatment strategy according to pressure monitoring data,5 cases appeared acute left heart dysfunction,the incidence was 22.7%, the average time to correct low blood pressure was(53±7.2) h. In 60 cases with adjusting treatment strategy according to pressure monitoring data, no acute left heart dysfunction was found, and the average time to correct low blood pressure was(36 ±5.6) h, the difference between the two groups was statistically significant(P <0.05).Conclusion For patients with STEMI induced by acute occlusion of dominant right coronary artery, in treatment course of correcting low blood pressure after PPCI,adjusting the treatment strategy according to invasive pressuremonitoring data can significantly reduce the risks of acute left heart failure and correct low blood pressure faster.
2017, 38(04): 49-51.
Abstract:
Objective To study the low-elongation effects of micro-screw planting resistance with the micro-screw planting resistance.Methods Forty-seven cases of patients with micro-screw planting resistance in our hospital from May 2014 to April 2016 were retrospectively analyzed, and the materials and treatment effects of these patients were investigated and analyzed. Results The vertical distance from the molar to the plane of the palate before and after the treatment were(27.1 ± 6.8) mm and(17.8 ± 3.7) mm respectively,with significant difference(P<0.05). Patients with elongated molars depressed average length of(9.30 ±2.81) mm. 2 of the 47 patients had a loosening of the screw,with an incidence of 4.3%, and got good stability after re-implantation, no screw fracture, periodontitis, or gum infection. 39 were satisfied with the treatment, 4 were satisfied with the treatment, 3 were not satisfied with the treatment, and the satisfaction was 83.0%. Conclusion The low-elongation effects of micro-screw planting resistance with the micro-screw planting resistance are good.
Objective To study the low-elongation effects of micro-screw planting resistance with the micro-screw planting resistance.Methods Forty-seven cases of patients with micro-screw planting resistance in our hospital from May 2014 to April 2016 were retrospectively analyzed, and the materials and treatment effects of these patients were investigated and analyzed. Results The vertical distance from the molar to the plane of the palate before and after the treatment were(27.1 ± 6.8) mm and(17.8 ± 3.7) mm respectively,with significant difference(P<0.05). Patients with elongated molars depressed average length of(9.30 ±2.81) mm. 2 of the 47 patients had a loosening of the screw,with an incidence of 4.3%, and got good stability after re-implantation, no screw fracture, periodontitis, or gum infection. 39 were satisfied with the treatment, 4 were satisfied with the treatment, 3 were not satisfied with the treatment, and the satisfaction was 83.0%. Conclusion The low-elongation effects of micro-screw planting resistance with the micro-screw planting resistance are good.
2017, 38(04): 52-57.
Abstract:
Objective To explore the incidence trends for different pathological types of occupational lung cancer in tin miners in Gejiu city of Yunnan province and analyze the treatment and efficacy of lung squamous cell carcinoma. Methods A retrospective study was carried out to review the pathological data of 210 patients who diagnosed occupational lung cancer in tin miners at the 3rd People's Hospital of Honghe Autonomous from January2005 to December 2012.The treatment patterns, overall survival(OS) and prognostic factors of 97 patients with squamous cell lung carcinoma were assessed from diagnosis until death or last follow-up. The Kaplan-Meier method was used to evaluate the overall survival. Log-rank test(for univariate prognostic analysis) and Cox regression analysis(for multivariate prognostic analysis) were performed in the 97 squamous cell lung carcinoma patients.Results The percentage distribution of pathological categories of all the 210 occupational lung cancer patients of tin miners was as follows: squamous cell lung carcinoma 46.2%, adenocarcinoma(AC) 31%, small cell lung carcinoma 19%, and the other 3.8%. Of the 97 patients of occupational squamous cell lung carcinoma of tin miners,the 1-, 2-, and 3-year OS rates of TMN stage I-II patients were 83.3%, 74.8%, 64.8%, stage Ⅲa-Ⅲb were29.8%,6.8 %,3.4% and stage IV were 9.8%,2.4%,0%(p=0.000). Multivariate analysis showed that KPS score,TNM stage and treatment patterns were the independent prognostic factors of overall survival in patients with occupational squamous cell lung carcinoma. Conclusions In the occupational lung carcinoma of tin miners in Gejiu, Yunnan before 2005, the proportion of squamous cell carcinoma(SCC) decreased and the proportion of adenocarcinoma corresponding increased. In occupational squamous cell lung carcinoma patients, the prognosis of TMN stage I/II was similar to the patients with NSCLC at home and aboard. While for patients of stage III and IV,the prognosis was worse. The KPS scoring, TNM staging and therapy methods are the independent prognostic factors for occupational squamous cell lung carcinoma patients.
Objective To explore the incidence trends for different pathological types of occupational lung cancer in tin miners in Gejiu city of Yunnan province and analyze the treatment and efficacy of lung squamous cell carcinoma. Methods A retrospective study was carried out to review the pathological data of 210 patients who diagnosed occupational lung cancer in tin miners at the 3rd People's Hospital of Honghe Autonomous from January2005 to December 2012.The treatment patterns, overall survival(OS) and prognostic factors of 97 patients with squamous cell lung carcinoma were assessed from diagnosis until death or last follow-up. The Kaplan-Meier method was used to evaluate the overall survival. Log-rank test(for univariate prognostic analysis) and Cox regression analysis(for multivariate prognostic analysis) were performed in the 97 squamous cell lung carcinoma patients.Results The percentage distribution of pathological categories of all the 210 occupational lung cancer patients of tin miners was as follows: squamous cell lung carcinoma 46.2%, adenocarcinoma(AC) 31%, small cell lung carcinoma 19%, and the other 3.8%. Of the 97 patients of occupational squamous cell lung carcinoma of tin miners,the 1-, 2-, and 3-year OS rates of TMN stage I-II patients were 83.3%, 74.8%, 64.8%, stage Ⅲa-Ⅲb were29.8%,6.8 %,3.4% and stage IV were 9.8%,2.4%,0%(p=0.000). Multivariate analysis showed that KPS score,TNM stage and treatment patterns were the independent prognostic factors of overall survival in patients with occupational squamous cell lung carcinoma. Conclusions In the occupational lung carcinoma of tin miners in Gejiu, Yunnan before 2005, the proportion of squamous cell carcinoma(SCC) decreased and the proportion of adenocarcinoma corresponding increased. In occupational squamous cell lung carcinoma patients, the prognosis of TMN stage I/II was similar to the patients with NSCLC at home and aboard. While for patients of stage III and IV,the prognosis was worse. The KPS scoring, TNM staging and therapy methods are the independent prognostic factors for occupational squamous cell lung carcinoma patients.
2017, 38(04): 58-62.
Abstract:
Objective To explore the CT imaging features of Castleman's disease, and improve the awareness of Castleman's disease before surgery. Methods The clinical data and CT imaging data of 13 patients with pathologically proved Castleman's disease were analyzed retrospectively. Results Nine cases were localized with hyaline vascular type in pathological classification, including 4 cases in chest(2 cases in lung, 2 cases in mediastinum), 5 cases in abdomen(1 case in abdominal cavity and 4 case in retroperitoneum). Four cases were multicentric with lesions distributed in the lung, abdominal cavity, axillary and groin, and pathologically classified into hyaline vascular type in 1, plasma cell type in 10, and mixed type in 2.All lesions were of iso-density on plain CT with well-defined margin.After intravenous administration of contrast agent, the markedly and long-lasted enhancement was seen in all localized cases with hyaline vascular type. While multicentric cases showed different enhancement with correspond with different pathological classification, which 2 cases were markedly enhancement,but 2 cases were mild-moderate enhancemeny. Two of localized lesions were found with punctate, branching calcification, and 3 of localized lesions were found with peripheral scattered enlarged lymph nodes which were pathologically confirmed as reactive lymphadenitis. Conclusions The localized Castleman's disease with predominanthyaline vascular type has characteristics on CT images, including soft tissue mass with markedly and long-lasted enhancement, and some of cases with branching calcification and satellite lesions. However,multicentric Castleman's disease has no obvious features for diagnosis.
Objective To explore the CT imaging features of Castleman's disease, and improve the awareness of Castleman's disease before surgery. Methods The clinical data and CT imaging data of 13 patients with pathologically proved Castleman's disease were analyzed retrospectively. Results Nine cases were localized with hyaline vascular type in pathological classification, including 4 cases in chest(2 cases in lung, 2 cases in mediastinum), 5 cases in abdomen(1 case in abdominal cavity and 4 case in retroperitoneum). Four cases were multicentric with lesions distributed in the lung, abdominal cavity, axillary and groin, and pathologically classified into hyaline vascular type in 1, plasma cell type in 10, and mixed type in 2.All lesions were of iso-density on plain CT with well-defined margin.After intravenous administration of contrast agent, the markedly and long-lasted enhancement was seen in all localized cases with hyaline vascular type. While multicentric cases showed different enhancement with correspond with different pathological classification, which 2 cases were markedly enhancement,but 2 cases were mild-moderate enhancemeny. Two of localized lesions were found with punctate, branching calcification, and 3 of localized lesions were found with peripheral scattered enlarged lymph nodes which were pathologically confirmed as reactive lymphadenitis. Conclusions The localized Castleman's disease with predominanthyaline vascular type has characteristics on CT images, including soft tissue mass with markedly and long-lasted enhancement, and some of cases with branching calcification and satellite lesions. However,multicentric Castleman's disease has no obvious features for diagnosis.
2017, 38(04): 63-67.
Abstract:
Objective To review the characteristics of the 9553 cases of lung cancer patients admitted to Yunnan Province from 2005 to 2014, and to provide some reference for the prevention and treatment of lung cancer in Yunnan province. Methods The distribution, age and sex constitution, disease characteristics and dynamic changes of 9553 patients with lung cancer were analyzed statistically and analyzed by chi-square analysis before and after 5 years. Results Among 9553 patients, the number of lung cancer patients in Qujing City(2910 cases,30.5%) and Kunming City(2736 cases, 28.6%) was much higher than that in other 14 counties,only Qujing Xuanwei(county) and Fuyuan(1736 cases) accounted for 59.7% of lung cancer patients in Qujing and 18.2%of lung cancer patients in Yunnan province. The proportion of female lung cancer patients in Xuanwei area was much higher than that of women with lung cancer in Yunnan province(65.5%). In the last 5 years, the number of lung cancer patients(6934 cases) was 2.65 times of the first 5 years of lung cancer patients(2619 cases). The ratio of lung adenocarcinoma in the last 5 years was increased by 12.1% as compared with the first 5 years(38.8% VS26.7%). The number of lung cancer patients(67.46,P<0.05) and lung cancer patients' age was mostly between40-64 years(6257 cases)(26.8%). The number of male patients with squamous cell carcinoma of the lung(2231 cases) was 3.5 times of female(643 cases)(P<0.05). Conclusions Qujing city(especially Xuanwei and Fuyuan area) is still the area with the highest incidence of lung cancer in Yunnan Province. The high incidence of lung cancer in women in Xuanwei area has its unique risk factors. The number of lung cancer in the province is increasing rapidly and the age is increasingly concentrated in the 40 to 64 years old; adenocarcinoma has become the most advanced squamous cell type, more than 90% of patients with squamous cell carcinoma of the lungs are men.
Objective To review the characteristics of the 9553 cases of lung cancer patients admitted to Yunnan Province from 2005 to 2014, and to provide some reference for the prevention and treatment of lung cancer in Yunnan province. Methods The distribution, age and sex constitution, disease characteristics and dynamic changes of 9553 patients with lung cancer were analyzed statistically and analyzed by chi-square analysis before and after 5 years. Results Among 9553 patients, the number of lung cancer patients in Qujing City(2910 cases,30.5%) and Kunming City(2736 cases, 28.6%) was much higher than that in other 14 counties,only Qujing Xuanwei(county) and Fuyuan(1736 cases) accounted for 59.7% of lung cancer patients in Qujing and 18.2%of lung cancer patients in Yunnan province. The proportion of female lung cancer patients in Xuanwei area was much higher than that of women with lung cancer in Yunnan province(65.5%). In the last 5 years, the number of lung cancer patients(6934 cases) was 2.65 times of the first 5 years of lung cancer patients(2619 cases). The ratio of lung adenocarcinoma in the last 5 years was increased by 12.1% as compared with the first 5 years(38.8% VS26.7%). The number of lung cancer patients(67.46,P<0.05) and lung cancer patients' age was mostly between40-64 years(6257 cases)(26.8%). The number of male patients with squamous cell carcinoma of the lung(2231 cases) was 3.5 times of female(643 cases)(P<0.05). Conclusions Qujing city(especially Xuanwei and Fuyuan area) is still the area with the highest incidence of lung cancer in Yunnan Province. The high incidence of lung cancer in women in Xuanwei area has its unique risk factors. The number of lung cancer in the province is increasing rapidly and the age is increasingly concentrated in the 40 to 64 years old; adenocarcinoma has become the most advanced squamous cell type, more than 90% of patients with squamous cell carcinoma of the lungs are men.
2017, 38(04): 68-71.
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Objective To observe the safety and efficacy of concurrent radiotherapy and chemotherapy in the treatment of invasive carcinoma of cervix, and to evaluate its clinical value. Methods We selected 86 patients treated in our hospital in January 2013-2015 year in March according to the diagnostic criteria of invasive cervical cancer in this study, and randomly divided them into two groups, with 43 cases in each group. The simple group was given single radiotherapy before operation, including half amount of radiotherapy in the the cavity, 7Gy each time, 1time/week, total dose of 21 Gy * 3 times. The combined group was given preoperative radiotherapy and chemotherapy, including 21 Gy * 3 times of radiotherapy, and intravenous instillation of 20 mg/m2 of cisplatin for continuous 5 days form the first day of radiotherapy. Patients in both groups were given surgical treatment 2 weeks after single radiotherapy or combined radiotherapy and chemotherapy, then the curative effects of two groups were compared. Results The effective rate of combined group was 90.7%(39 cases) and was higher than that of simple group 72.1%(31 cases)(P<0.05). The parametrial invasion and lymph node positive rate in the combined group was lower than that in the simple group(P<0.05). There was no statistically significant difference in the white blood cell decrease,the incidence of nausea, vomiting, diarrhea and abnormal liver and kidney function between two groups(P>0.05). The hair loss rate in the combined group was 48.8%(21 cases),which was higher than the simple group(0 %)(P<0.05). Conclusion Concurrent chemotherapy in the treatment of cervical cancer infiltration is better, the infiltration and lymph node positive rate is lower, but the incidence of hair loss is higher,so it has important clinical value.
Objective To observe the safety and efficacy of concurrent radiotherapy and chemotherapy in the treatment of invasive carcinoma of cervix, and to evaluate its clinical value. Methods We selected 86 patients treated in our hospital in January 2013-2015 year in March according to the diagnostic criteria of invasive cervical cancer in this study, and randomly divided them into two groups, with 43 cases in each group. The simple group was given single radiotherapy before operation, including half amount of radiotherapy in the the cavity, 7Gy each time, 1time/week, total dose of 21 Gy * 3 times. The combined group was given preoperative radiotherapy and chemotherapy, including 21 Gy * 3 times of radiotherapy, and intravenous instillation of 20 mg/m2 of cisplatin for continuous 5 days form the first day of radiotherapy. Patients in both groups were given surgical treatment 2 weeks after single radiotherapy or combined radiotherapy and chemotherapy, then the curative effects of two groups were compared. Results The effective rate of combined group was 90.7%(39 cases) and was higher than that of simple group 72.1%(31 cases)(P<0.05). The parametrial invasion and lymph node positive rate in the combined group was lower than that in the simple group(P<0.05). There was no statistically significant difference in the white blood cell decrease,the incidence of nausea, vomiting, diarrhea and abnormal liver and kidney function between two groups(P>0.05). The hair loss rate in the combined group was 48.8%(21 cases),which was higher than the simple group(0 %)(P<0.05). Conclusion Concurrent chemotherapy in the treatment of cervical cancer infiltration is better, the infiltration and lymph node positive rate is lower, but the incidence of hair loss is higher,so it has important clinical value.
Clinical Effect of Lansoprazole on Patients with Gastroesophageal Reflux and the Esophageal Dynamics
2017, 38(04): 76-79.
Abstract:
Objective To observe the clinical effect of lansoprazole on the patients with gastroesophageal reflux and the influence on the esophageal dynamics. Methods Seventy-six patients with gastroesophageal reflux in our hospital from October 2015 to August 2016 were set as the study object,and 76 patients were randomly divided into control group(omeprazole group) and observation group(lansoprazole group),38 cases in each group,then the total effective rates,symptoms and signs score and esophageal dynamics indexes of patients in two groups before and after the treatment were respectively analyzed. Results The total effective rate of observation group was significantly higher than the rate of control group(P<0.05),the symptom and sign score and esophageal dynamics indexes of two groups before the treatment had no significantly differences(P>0.05),while the symptom and sign score and esophageal dynamics indexes of observation group after the treatment were all better than those of control group(P<0.05).Conclusion The clinical effect of lansoprazole in the patients with gastroesophageal reflux is better,and it can significantly improve the symptoms and signs and esophageal dynamics state,so its clinical application value is higher.
Objective To observe the clinical effect of lansoprazole on the patients with gastroesophageal reflux and the influence on the esophageal dynamics. Methods Seventy-six patients with gastroesophageal reflux in our hospital from October 2015 to August 2016 were set as the study object,and 76 patients were randomly divided into control group(omeprazole group) and observation group(lansoprazole group),38 cases in each group,then the total effective rates,symptoms and signs score and esophageal dynamics indexes of patients in two groups before and after the treatment were respectively analyzed. Results The total effective rate of observation group was significantly higher than the rate of control group(P<0.05),the symptom and sign score and esophageal dynamics indexes of two groups before the treatment had no significantly differences(P>0.05),while the symptom and sign score and esophageal dynamics indexes of observation group after the treatment were all better than those of control group(P<0.05).Conclusion The clinical effect of lansoprazole in the patients with gastroesophageal reflux is better,and it can significantly improve the symptoms and signs and esophageal dynamics state,so its clinical application value is higher.
2017, 38(04): 80-83.
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Objective To quantitatively analyze the effectiveness and expense of VSD in diabetic foot ulcer and provide the reliable evidence for clinical decision and practice bu using the Evidence-Based Medicine methods.Methods We searched randomized controlled trials that advertised in magazines or journals of china that before December of 2016 in CNKI, CBM, VIP and Wan Fang Database, and selected articles that conformed to inclusion-standard and the references were also retrieved, and then evaluated the quality of the articles by the quality evaluation standard of Cochrane collaboration, meta-analysis was performed by software Revman5.3.Results Four articles were included and the general quality was moderate;meta-analysis showed that the effect and expense of VSD was superior to other interventions in the treatment of diabetic foot ulcer;but the unsymmetrical funnel plot suggested the existence of publication bias. Conclusions In the treatment of diabetic foot ulcer, the effect and expense of VSD is superior to other interventions,deserves to expand and apply in hospitals,but due to the existence of publication bias,the meta-analysis results need more reliable evidences to support in the future.
Objective To quantitatively analyze the effectiveness and expense of VSD in diabetic foot ulcer and provide the reliable evidence for clinical decision and practice bu using the Evidence-Based Medicine methods.Methods We searched randomized controlled trials that advertised in magazines or journals of china that before December of 2016 in CNKI, CBM, VIP and Wan Fang Database, and selected articles that conformed to inclusion-standard and the references were also retrieved, and then evaluated the quality of the articles by the quality evaluation standard of Cochrane collaboration, meta-analysis was performed by software Revman5.3.Results Four articles were included and the general quality was moderate;meta-analysis showed that the effect and expense of VSD was superior to other interventions in the treatment of diabetic foot ulcer;but the unsymmetrical funnel plot suggested the existence of publication bias. Conclusions In the treatment of diabetic foot ulcer, the effect and expense of VSD is superior to other interventions,deserves to expand and apply in hospitals,but due to the existence of publication bias,the meta-analysis results need more reliable evidences to support in the future.
2017, 38(04): 84-87.
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Objective To evaluate the efficacy and safety of ultrasound guided stellate ganglion block for the treatment of insomnia. Methods Forty-eight patients diagnosed as insomnia accepting SGB treatment without contraindication were included and randomly divided into 2 groups, ultrasound guided puncture group(n=24)and conventional puncture group(n=24). Then we evaluated the curative effect, observed the operation time and the incidence of entering blood vessel, Horner syndrome, discomfort during operation, puncture site pain,laryngeal nerve block, brachial plexus block and local anesthetics allergy. Results The effective rate of ultrasound-guided puncture group was 95.83%, the effective rate of the conventional puncture group was 83.33%,there was a statistically significant difference between two groups(P<0.05). The occurring rate of Horner syndrome in ultrasound-guided puncture group was 98.6%,higher than that of conventional puncture group 83.5%(P<0.05). The incidence of entering blood vessel(0%), puncture site pain(1.3%), pneumothorax(0%),brachial plexus block(0%) and laryngeal nerve block were lower than that of conventional puncture group(P<0.05). Conclusion The efficacy of ultrasound-guided stellate ganglion block treatment for insomnia is reliable,and the operation is safer with less adverse reaction compared to conventional blinding puncture.
Objective To evaluate the efficacy and safety of ultrasound guided stellate ganglion block for the treatment of insomnia. Methods Forty-eight patients diagnosed as insomnia accepting SGB treatment without contraindication were included and randomly divided into 2 groups, ultrasound guided puncture group(n=24)and conventional puncture group(n=24). Then we evaluated the curative effect, observed the operation time and the incidence of entering blood vessel, Horner syndrome, discomfort during operation, puncture site pain,laryngeal nerve block, brachial plexus block and local anesthetics allergy. Results The effective rate of ultrasound-guided puncture group was 95.83%, the effective rate of the conventional puncture group was 83.33%,there was a statistically significant difference between two groups(P<0.05). The occurring rate of Horner syndrome in ultrasound-guided puncture group was 98.6%,higher than that of conventional puncture group 83.5%(P<0.05). The incidence of entering blood vessel(0%), puncture site pain(1.3%), pneumothorax(0%),brachial plexus block(0%) and laryngeal nerve block were lower than that of conventional puncture group(P<0.05). Conclusion The efficacy of ultrasound-guided stellate ganglion block treatment for insomnia is reliable,and the operation is safer with less adverse reaction compared to conventional blinding puncture.
2017, 38(04): 88-92.
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Objective To evaluate the effect of retroauricular skin expansion forthe purpose of ear reconstruction. Methods In this technique called three-stage method: 1st soft tissue expander implantation under the skin close to the microtic ear, 2nd the autogenous rib cartilage is harvested, the ear framework is prepared and covered with expanded skin. 3rd the pseudomeatus, tragus and lobule are formed.Results 50 patients out of 55 patients were satisfied with their result and patients were followed up from 6months to 2 years and no complain were received, There were few case with minor complication of(Exposure of expander, Deflation or Infection, Exposure of framework, Steel wire extrusion, Hypertrophic scar, Chest wall deformities) and the complications were treated accurately and carefully and patients were discharged after recoveries.Conclusion The three-stage method is very useful in microtia by using costal autogenous rib cartilage.
Objective To evaluate the effect of retroauricular skin expansion forthe purpose of ear reconstruction. Methods In this technique called three-stage method: 1st soft tissue expander implantation under the skin close to the microtic ear, 2nd the autogenous rib cartilage is harvested, the ear framework is prepared and covered with expanded skin. 3rd the pseudomeatus, tragus and lobule are formed.Results 50 patients out of 55 patients were satisfied with their result and patients were followed up from 6months to 2 years and no complain were received, There were few case with minor complication of(Exposure of expander, Deflation or Infection, Exposure of framework, Steel wire extrusion, Hypertrophic scar, Chest wall deformities) and the complications were treated accurately and carefully and patients were discharged after recoveries.Conclusion The three-stage method is very useful in microtia by using costal autogenous rib cartilage.
2017, 38(04): 93-97.
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Objective To find cytokine index which can make a identification between active tuberculosis infection and latent tuberculosis infection and provide new evidence for tuberculosis diagnosis,we evaluated the levels of IL-2,IL-4,IL-6,IL-10,TNF-α and IFN-γ in people with active tuberculosis,latent tuberculosis infected people and normal people. Methods We detected the serum levels of six cytokines(IL-2, IL-4,IL-6, IL-10, TNF-α and IFN-γ) of 60 tuberculosis cases with T-SPOT.TB(+), 55 cases with latent tuberculosis infection and T-SPOT.TB(+),30 cases of normal people with T-SPOT.TB(-) by cytometric bead array(CBA). Results Compared with other groups, the levels of IL-2, IL-6, TNF-α and IFN-γ of tuberculosis(sputum culture positive) group were significantly increased(P<0.05). About IL-10,there were significant differences between two groups and the levels of IL-10 increased along with the increasing activity of tubercle bacillus and the severity of tuberculosis. TNF-α and IFN-γ of two tuberculosis groups were significantly higher than latent tuberculosis infected group and normal group(P<0.05).The serum levels of IL-4 showed no significant difference between different groups(P >0.05). Conclusions Combined with T-SPOT.TB, the detection of TNF-α and IFN-γ can make a identification between active tuberculosis infection and latent tuberculosis infection at the cytokine level, which is of great importance for the diagnosis and differentiation of latent tuberculosis infection.
Objective To find cytokine index which can make a identification between active tuberculosis infection and latent tuberculosis infection and provide new evidence for tuberculosis diagnosis,we evaluated the levels of IL-2,IL-4,IL-6,IL-10,TNF-α and IFN-γ in people with active tuberculosis,latent tuberculosis infected people and normal people. Methods We detected the serum levels of six cytokines(IL-2, IL-4,IL-6, IL-10, TNF-α and IFN-γ) of 60 tuberculosis cases with T-SPOT.TB(+), 55 cases with latent tuberculosis infection and T-SPOT.TB(+),30 cases of normal people with T-SPOT.TB(-) by cytometric bead array(CBA). Results Compared with other groups, the levels of IL-2, IL-6, TNF-α and IFN-γ of tuberculosis(sputum culture positive) group were significantly increased(P<0.05). About IL-10,there were significant differences between two groups and the levels of IL-10 increased along with the increasing activity of tubercle bacillus and the severity of tuberculosis. TNF-α and IFN-γ of two tuberculosis groups were significantly higher than latent tuberculosis infected group and normal group(P<0.05).The serum levels of IL-4 showed no significant difference between different groups(P >0.05). Conclusions Combined with T-SPOT.TB, the detection of TNF-α and IFN-γ can make a identification between active tuberculosis infection and latent tuberculosis infection at the cytokine level, which is of great importance for the diagnosis and differentiation of latent tuberculosis infection.
2017, 38(04): 98-100.
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Objective To explore the clinical effects of Pantoprazole and Domperidone on larygopharyngeal reflux disease. Methods Eighty patients with initial diagnosis of laryngopharyngeal reflux disease(LPRD) were divided into observation group(40 cases) and control group(40 cases) according to different treatment methods.In the observation group,patients were given pantoprazole 10 mg/times,3 times/day,at 30 minutes before meals,for 8 weeks. The patients in the control group were treated with conventional pharyngeal and pharyngeal laryngeal drugs. The clinical symptoms and signs of the two groups were recorded and compared. Results In the observation group,the significantly effective was in 20 cases,effective in 11 cases, ineffective in 9 cases, the total effective rate was 77.5%;in the control group, the significantly effective was in 3 cases,effective in 5 cases,32 cases were ineffective,the total effective rate was 20%. There was significant difference in total effective rate between the two groups(P<0.05). Conclusion Pantoprazole combined with domperidone is an effective method for the treatment of larypharyngeal reflux disease.
Objective To explore the clinical effects of Pantoprazole and Domperidone on larygopharyngeal reflux disease. Methods Eighty patients with initial diagnosis of laryngopharyngeal reflux disease(LPRD) were divided into observation group(40 cases) and control group(40 cases) according to different treatment methods.In the observation group,patients were given pantoprazole 10 mg/times,3 times/day,at 30 minutes before meals,for 8 weeks. The patients in the control group were treated with conventional pharyngeal and pharyngeal laryngeal drugs. The clinical symptoms and signs of the two groups were recorded and compared. Results In the observation group,the significantly effective was in 20 cases,effective in 11 cases, ineffective in 9 cases, the total effective rate was 77.5%;in the control group, the significantly effective was in 3 cases,effective in 5 cases,32 cases were ineffective,the total effective rate was 20%. There was significant difference in total effective rate between the two groups(P<0.05). Conclusion Pantoprazole combined with domperidone is an effective method for the treatment of larypharyngeal reflux disease.
2017, 38(04): 101-104.
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Objective To explore the diagnosis and treatment of congenital choledochal cyst. Methods The clinical data of 36 cases of congenital choledochal cyst treated in our hospital from 2005 to 2014 were retrospectively analyzed. The diagnosis and surgical methods were analyzed. Results All the patients underwent B and CT examination,19 cases underwent MRCP scan,6 cases diagnosed by ERCP. 36 cases underwent surgical treatment,including 3 cases of emergency external cyst drainage,resection,underwent cyst and Roux-y hepaticojejunostomy in 27 case-s,6 cases of cyst jejunum Roux-y anastomosis. Complications occurred in 6 cases(13.9%),with 1patients died of mult-iple organ failure, 1 case of hepatic arteries were cut off,1 case of incision dehiscence,2cases of bile leakage,1 case of pleural effusion.31 cases were followed up,20 pati-ents symptoms disappeared,7cases of cyst drainage due to the emergency room or internal drainage of cyst,without relieving symptoms underwent cyst resection, hepatic duct jejunum Roux-y anastomosis. 2 cases of occasional bouts of cholangitis,anti-inflammatory treatment the symptoms dis-appeared. 2 cases of left hepatic duct lithiasis underwent left lateral lobectomy of liver, cure. Conclusion B ultrasound is the first choice for the diagnosis of congenital common bile duct cyst, cyst resection and hepatic duct jejunum Roux-y anastomosis is an effective surgical procedure for the treatment of congenital cyst of common bile duct.
Objective To explore the diagnosis and treatment of congenital choledochal cyst. Methods The clinical data of 36 cases of congenital choledochal cyst treated in our hospital from 2005 to 2014 were retrospectively analyzed. The diagnosis and surgical methods were analyzed. Results All the patients underwent B and CT examination,19 cases underwent MRCP scan,6 cases diagnosed by ERCP. 36 cases underwent surgical treatment,including 3 cases of emergency external cyst drainage,resection,underwent cyst and Roux-y hepaticojejunostomy in 27 case-s,6 cases of cyst jejunum Roux-y anastomosis. Complications occurred in 6 cases(13.9%),with 1patients died of mult-iple organ failure, 1 case of hepatic arteries were cut off,1 case of incision dehiscence,2cases of bile leakage,1 case of pleural effusion.31 cases were followed up,20 pati-ents symptoms disappeared,7cases of cyst drainage due to the emergency room or internal drainage of cyst,without relieving symptoms underwent cyst resection, hepatic duct jejunum Roux-y anastomosis. 2 cases of occasional bouts of cholangitis,anti-inflammatory treatment the symptoms dis-appeared. 2 cases of left hepatic duct lithiasis underwent left lateral lobectomy of liver, cure. Conclusion B ultrasound is the first choice for the diagnosis of congenital common bile duct cyst, cyst resection and hepatic duct jejunum Roux-y anastomosis is an effective surgical procedure for the treatment of congenital cyst of common bile duct.
2017, 38(04): 105-108.
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Objective To explore the clinical value of endoscopic minimally invasive treatment for odontogenic maxillary sinus diseases. Methods From March 2010 to April 2016, 43 patients with odontogenic maxillary sinus diseases were randomly divided into A and B groups according to the order of treatment. Group A(n= 22) and group B(n = 21). Group A was treated with endoscopic minimally invasive surgery. Group B was treated with conventional open procedure. The operation time and intra-operative blood loss were compared between the two groups. Postoperative facial swelling subsided time, facial numbness and hospital costs, postoperative satisfaction and other indicators were also compared. Results Compared with Group B, the operation time was shorter(P<0.05), bleeding volume was less(P<0.05), and the time of facial swelling was shorter after operation(P<0.05,) the hospitalization cost was lower(P<0.05), the postoperative satisfaction was higher(P<0.05) in Group A(P<0.05). Conclusions Endoscopic surgery is more effective than traditional open surgery in the treatment of odontogenic maxillary sinus surgery. The former has the advantages of shorter operative time, less blood loss, rapider postoperative recovery, lower incidence of complications and lower hospitalization cost.
Objective To explore the clinical value of endoscopic minimally invasive treatment for odontogenic maxillary sinus diseases. Methods From March 2010 to April 2016, 43 patients with odontogenic maxillary sinus diseases were randomly divided into A and B groups according to the order of treatment. Group A(n= 22) and group B(n = 21). Group A was treated with endoscopic minimally invasive surgery. Group B was treated with conventional open procedure. The operation time and intra-operative blood loss were compared between the two groups. Postoperative facial swelling subsided time, facial numbness and hospital costs, postoperative satisfaction and other indicators were also compared. Results Compared with Group B, the operation time was shorter(P<0.05), bleeding volume was less(P<0.05), and the time of facial swelling was shorter after operation(P<0.05,) the hospitalization cost was lower(P<0.05), the postoperative satisfaction was higher(P<0.05) in Group A(P<0.05). Conclusions Endoscopic surgery is more effective than traditional open surgery in the treatment of odontogenic maxillary sinus surgery. The former has the advantages of shorter operative time, less blood loss, rapider postoperative recovery, lower incidence of complications and lower hospitalization cost.
2017, 38(04): 109-112.
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Objective To predict the incidence of thrombosis through monitoring the post-operation D-dimer level in patients with high risky factors of venous thrombosis,and to reduce the incidence of thrombosis by adopting low molecular weight heparin on patients with an obvious rise of post-operation D-dimer level.Methods62 patients with high risk of VTE factors after gynecological operations from May 2014 to May 2016 were selected and dividedinto 2 groups, 32 patients in study group and 30 patients in comparison group. We monitored the D-dimer levels of both groups at different time points,respectively 1, 2, 3 and 7 days after operations. Any patient in the study group had a D-dimer content ≥ 5 μg/mL within 24-72 hours post-operation,was given hypodermic injection of 4 000 IU enoxaparin sodium once a day for a consecutive 5-7 days to prevent venous thrombosis.In the comparison group, only monitor their D-dimer levels without giving prophylactic injection of enoxaparin sodium.Results Post-operation D-dimer levels in both the study group and the comparison group were higher than those before operations. In the study group, 15 cases of D-dimer level≥5 μg/mL and 2 cases of thrombosis occurred, while in the comparison group 13 cases of D-dimer level≥5ug/ml and 9 cases of thrombosis occurred. The incidence of thrombosis was 13.33% and 69.23%, respectively, the difference had a statistical significance(p <0.05).Conclusions Patients with a significantly higher D-dimer leve land ≥ 5ug/ml after operations are more likely to occur post-operationthrombosis. Monitoring of post-operation D-dimer levelhas a clinical value on predicting thrombosis; prophylactic injection of enoxaparin sodium on patients with a significantly higher D-dimer level and ≥ 5μg/mL is effective to prevent venous thrombosis and thus reduce the incidence of thrombotic disease.
Objective To predict the incidence of thrombosis through monitoring the post-operation D-dimer level in patients with high risky factors of venous thrombosis,and to reduce the incidence of thrombosis by adopting low molecular weight heparin on patients with an obvious rise of post-operation D-dimer level.Methods62 patients with high risk of VTE factors after gynecological operations from May 2014 to May 2016 were selected and dividedinto 2 groups, 32 patients in study group and 30 patients in comparison group. We monitored the D-dimer levels of both groups at different time points,respectively 1, 2, 3 and 7 days after operations. Any patient in the study group had a D-dimer content ≥ 5 μg/mL within 24-72 hours post-operation,was given hypodermic injection of 4 000 IU enoxaparin sodium once a day for a consecutive 5-7 days to prevent venous thrombosis.In the comparison group, only monitor their D-dimer levels without giving prophylactic injection of enoxaparin sodium.Results Post-operation D-dimer levels in both the study group and the comparison group were higher than those before operations. In the study group, 15 cases of D-dimer level≥5 μg/mL and 2 cases of thrombosis occurred, while in the comparison group 13 cases of D-dimer level≥5ug/ml and 9 cases of thrombosis occurred. The incidence of thrombosis was 13.33% and 69.23%, respectively, the difference had a statistical significance(p <0.05).Conclusions Patients with a significantly higher D-dimer leve land ≥ 5ug/ml after operations are more likely to occur post-operationthrombosis. Monitoring of post-operation D-dimer levelhas a clinical value on predicting thrombosis; prophylactic injection of enoxaparin sodium on patients with a significantly higher D-dimer level and ≥ 5μg/mL is effective to prevent venous thrombosis and thus reduce the incidence of thrombotic disease.
2017, 38(04): 113-116.
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Objective To study and analyze the effect of gangliosides in improving the cerebral blood flow and nerve function indexes of newborns with hypoxic ischemic encephalopathy. Methods Sixty-eight newborns with hypoxic ischemic encephalopathy in our hospital from March 2015 to October 2016 were selected as the study object,and they were randomly divided into control group( 34 cases) and observation group(34 cases). The control group was treated with conventional treatment of hypoxic ischemic encephalopathy, the observation group was treated with conventional treatment and gangliosides,then the middle cerebral artery and anterior cerebral artery cerebral blood flow parameters and serum nerve function indexes of two groups before the treatment and at first and second week after the treatment were detected, and the detection results of two groups at different time points were respectively compared. Results The middle cerebral artery and anterior cerebral artery cerebral blood flow parameters and serum nerve function indexes of two groups before the treatment were compared,all P>0.05,and the middle cerebral artery and anterior cerebral artery cerebral blood flow parameters of observation group at first and second week after the treatment were all higher than the results of control group,and serum nerve function indexes were all lower than the results of control group,all P<0.05. Conclusion The gangliosides can significantly improve the cerebral blood flow and nerve function indexes of newborns with hypoxic ischemic encephalopathy, so the application value of gangliosides in these newborns is higher.
Objective To study and analyze the effect of gangliosides in improving the cerebral blood flow and nerve function indexes of newborns with hypoxic ischemic encephalopathy. Methods Sixty-eight newborns with hypoxic ischemic encephalopathy in our hospital from March 2015 to October 2016 were selected as the study object,and they were randomly divided into control group( 34 cases) and observation group(34 cases). The control group was treated with conventional treatment of hypoxic ischemic encephalopathy, the observation group was treated with conventional treatment and gangliosides,then the middle cerebral artery and anterior cerebral artery cerebral blood flow parameters and serum nerve function indexes of two groups before the treatment and at first and second week after the treatment were detected, and the detection results of two groups at different time points were respectively compared. Results The middle cerebral artery and anterior cerebral artery cerebral blood flow parameters and serum nerve function indexes of two groups before the treatment were compared,all P>0.05,and the middle cerebral artery and anterior cerebral artery cerebral blood flow parameters of observation group at first and second week after the treatment were all higher than the results of control group,and serum nerve function indexes were all lower than the results of control group,all P<0.05. Conclusion The gangliosides can significantly improve the cerebral blood flow and nerve function indexes of newborns with hypoxic ischemic encephalopathy, so the application value of gangliosides in these newborns is higher.
2017, 38(04): 117-119.
Abstract:
Objective To evaluate the predictive value of Cr-POSSUM scoring systems in patients with rectal cancer after surgery. Methods 276 patients who underwent surgery with colorectal malignant neoplasms were divided into two groups depending on Cr-POSSUM total scores. Scores 17 points or less were defined as low-risk patients,scores more than 18 points were defined as a high-risk patients. The predicted results were compared with the actual situation by receiver-operating characteristic curve(ROC curve) and the ratio of expected mortality and obseved mortality to evaluate the accuracy. Results In the comparison of patients with high-risk group and low risk group,age, PS score, OS scores, postoperative bleeding and mortality in 30 day after surgery had a statistically significant difference(P<0.05). Conclusion Cr-POSSUM can accurately predict the postoperative mortality of patients with rectal cancer.
Objective To evaluate the predictive value of Cr-POSSUM scoring systems in patients with rectal cancer after surgery. Methods 276 patients who underwent surgery with colorectal malignant neoplasms were divided into two groups depending on Cr-POSSUM total scores. Scores 17 points or less were defined as low-risk patients,scores more than 18 points were defined as a high-risk patients. The predicted results were compared with the actual situation by receiver-operating characteristic curve(ROC curve) and the ratio of expected mortality and obseved mortality to evaluate the accuracy. Results In the comparison of patients with high-risk group and low risk group,age, PS score, OS scores, postoperative bleeding and mortality in 30 day after surgery had a statistically significant difference(P<0.05). Conclusion Cr-POSSUM can accurately predict the postoperative mortality of patients with rectal cancer.
2017, 38(04): 120-122.
Abstract:
Objective To explore the efficacy and safety of laparoscopic presacral fixation in the treatment of female pelvic organ prolapse. Methods Fifty-one women patients with pelvic organ prolapse were given presacral fixation. Among them,32 cases were by laparoscopic operation,and 19 cases were by laparotomy,the average blood loss and the average operation time of all patients would be observed. Results All 51 patients were successfully completed surgery. In the group of laparoscopic operation, the average operation time was(255.48 + 18.15)min, the average blood loss was(50±8.2) mL, the average hospital stay was 5 days. In the laparotomy group,the average operation time was(332.36±11.98) min,the average blood loss was(96±11.67) mL, the average hospital stay was 7 days. Pelvic organ prolapse symptoms were all corrected, pelvic structure returned to normal,all patients were cured,with no relapse after surgery, mesh erosion, leakage, local pain, foreign body sensation,discomfort,and had no obvious effect on sex life. The average operation time and average blood loss of group of laparoscopic operation were significantly lower than the laparotomy group(P<0.05). Conclusion Presacral fixation of uterine or vagina under laparoscope for the treatment of female pelvic organ prolapsed has such advantages as less trauma, clear surgery vision, less bleeding and quick recovery, satisfactory shor-term effect, and is worthy of promotion.
Objective To explore the efficacy and safety of laparoscopic presacral fixation in the treatment of female pelvic organ prolapse. Methods Fifty-one women patients with pelvic organ prolapse were given presacral fixation. Among them,32 cases were by laparoscopic operation,and 19 cases were by laparotomy,the average blood loss and the average operation time of all patients would be observed. Results All 51 patients were successfully completed surgery. In the group of laparoscopic operation, the average operation time was(255.48 + 18.15)min, the average blood loss was(50±8.2) mL, the average hospital stay was 5 days. In the laparotomy group,the average operation time was(332.36±11.98) min,the average blood loss was(96±11.67) mL, the average hospital stay was 7 days. Pelvic organ prolapse symptoms were all corrected, pelvic structure returned to normal,all patients were cured,with no relapse after surgery, mesh erosion, leakage, local pain, foreign body sensation,discomfort,and had no obvious effect on sex life. The average operation time and average blood loss of group of laparoscopic operation were significantly lower than the laparotomy group(P<0.05). Conclusion Presacral fixation of uterine or vagina under laparoscope for the treatment of female pelvic organ prolapsed has such advantages as less trauma, clear surgery vision, less bleeding and quick recovery, satisfactory shor-term effect, and is worthy of promotion.
2017, 38(04): 123-126.
Abstract:
Objective To investigate the clinical effects of internal fixation and joint replacement in the treatment of osteoporosis complicated with intertrochanteric fractures of the elderly and compare the effects of internal fixation and joint replacement. Methods Seventy-eight elderly patients with osteoporotic intertrochanteric fractures treated in our hospital from January 2016 to December 2016 were randomly divided into two groups according to the treatment: the experimental group(hip replacement operation) and the control group(internal fixation Surgery), were treated with joint replacement and internal fixation, the two groups of clinical efficacy, bone mineral density values and complications were compared. Results After treatment, the total effective rate of the experimental group was86.78%, the total effective rate of the control group was 65.87%, the total effective rate of the experimental group was significantly higher than the control group, the difference was statistically significant. After treatment, the BMD values of the two groups were significantly increased, but the experimental group of bone mineral density was significantly higher than the control group(P<0.05), the difference was statistically significant. In addition, the incidence of complications in the experimental group was significantly lower than the control group(P<0.05), the difference was statistically significant. Conclusion Joint replacement of osteoporotic treatment of osteoporosis with intertrochanteric fractures is more excellent than the internal fixation, has significant clinical effect, can effectively improve the quality of life of patients,so it should be widely used in clinical practice.
Objective To investigate the clinical effects of internal fixation and joint replacement in the treatment of osteoporosis complicated with intertrochanteric fractures of the elderly and compare the effects of internal fixation and joint replacement. Methods Seventy-eight elderly patients with osteoporotic intertrochanteric fractures treated in our hospital from January 2016 to December 2016 were randomly divided into two groups according to the treatment: the experimental group(hip replacement operation) and the control group(internal fixation Surgery), were treated with joint replacement and internal fixation, the two groups of clinical efficacy, bone mineral density values and complications were compared. Results After treatment, the total effective rate of the experimental group was86.78%, the total effective rate of the control group was 65.87%, the total effective rate of the experimental group was significantly higher than the control group, the difference was statistically significant. After treatment, the BMD values of the two groups were significantly increased, but the experimental group of bone mineral density was significantly higher than the control group(P<0.05), the difference was statistically significant. In addition, the incidence of complications in the experimental group was significantly lower than the control group(P<0.05), the difference was statistically significant. Conclusion Joint replacement of osteoporotic treatment of osteoporosis with intertrochanteric fractures is more excellent than the internal fixation, has significant clinical effect, can effectively improve the quality of life of patients,so it should be widely used in clinical practice.
2017, 38(04): 127-131.
Abstract:
Objective To investigate the value of the plasma FKN concention in prediction of the severity of coronary heart disease(CHD). Methods In this study, 89 patients who underwent coronary intervention therapy in our hospital between July and December 2015 were sequentially selected. Patients were divide into 3 groups according to the result of Coronary angiography, including group B: 43 patients of acute myocardial infarction(AMI) or Coronary Severe lesions;group B1: 26 patients of single mild Coronary lesions;group N: 20 patients with no Coronary heart disease(CHD),excluded by normal Coronary angiography result. The baseline clinical data of all 89 patients were collected. Enzyme-linked immunosorbent method was used to test the FKN level. SPSS 20.0Statistical software was used for data analysis. Results The FKN levels of patients were decreased in all 3 groups:group B> group B1>group N, with significant differencesbetween the three groups(P <0.000). There was a positive correlation between FKN and Gensini score or hs c Tn T(P<0.05). The area under the curve(AUC) of the receiver operating characteristic(ROC) curves was 0.784, the diagnostic reference value for Coronary heart disease(CHD) acute myocardial infarction was 1.996 in this sudy. Conclusions The plasma FKN levels are positively correlated to the severity of coronary lesion. The specificity and sensitivity of plasma FKN level for coronary heart disease(CHD) diagnosis is similar to CTn T. The plasma FKN levels can provide evidence of lesion severity of Coronary heart disease(CHD).
Objective To investigate the value of the plasma FKN concention in prediction of the severity of coronary heart disease(CHD). Methods In this study, 89 patients who underwent coronary intervention therapy in our hospital between July and December 2015 were sequentially selected. Patients were divide into 3 groups according to the result of Coronary angiography, including group B: 43 patients of acute myocardial infarction(AMI) or Coronary Severe lesions;group B1: 26 patients of single mild Coronary lesions;group N: 20 patients with no Coronary heart disease(CHD),excluded by normal Coronary angiography result. The baseline clinical data of all 89 patients were collected. Enzyme-linked immunosorbent method was used to test the FKN level. SPSS 20.0Statistical software was used for data analysis. Results The FKN levels of patients were decreased in all 3 groups:group B> group B1>group N, with significant differencesbetween the three groups(P <0.000). There was a positive correlation between FKN and Gensini score or hs c Tn T(P<0.05). The area under the curve(AUC) of the receiver operating characteristic(ROC) curves was 0.784, the diagnostic reference value for Coronary heart disease(CHD) acute myocardial infarction was 1.996 in this sudy. Conclusions The plasma FKN levels are positively correlated to the severity of coronary lesion. The specificity and sensitivity of plasma FKN level for coronary heart disease(CHD) diagnosis is similar to CTn T. The plasma FKN levels can provide evidence of lesion severity of Coronary heart disease(CHD).
2017, 38(04): 132-136.
Abstract:
Objective To analyze the results of HIV/AIDs surveillance among the men who have sex with men(MSM) in Guandu District, Kunming City, so as to provide the evidence for the future development of prevention and control strategies. Methods We analyzed the infection of HIV,syphilis and hepatitis C and related behaviors.Results A total of 462 MSM were surveyed in 2013-2015,the total HIV positive rate was 15.8%(73 cases),and the HIV positive rate was 16.2%,15.4%,16.1% in 2013,2014 and 2015,respectively,there was no statistically deference between three years(P >0.05).There were 50 cases(10.8) of syphilis antibody positive,one case(0.2%) of HCV antibody positive. In the last six months, there were 95.7% who had anal sex, among them there were 56.5% who used condom every time,there were 83.5% who used condom in last anal sex;there were 15.2% who had commercial sex with MSM, among them there were 58.2% who used condom every time;there were 21.9% who had sex with women, among them there were 40.6% who used condom every time. Conclusions The awareness rate of HIV/AIDS was high, but the condom use rate was low,there was a discrepancy between their knowledge and their behavior. The HIV positive rate and syphilis antibody positive rate were high,the prevention and control condition is very serious, we should take actions to improve our intervention strategies.
Objective To analyze the results of HIV/AIDs surveillance among the men who have sex with men(MSM) in Guandu District, Kunming City, so as to provide the evidence for the future development of prevention and control strategies. Methods We analyzed the infection of HIV,syphilis and hepatitis C and related behaviors.Results A total of 462 MSM were surveyed in 2013-2015,the total HIV positive rate was 15.8%(73 cases),and the HIV positive rate was 16.2%,15.4%,16.1% in 2013,2014 and 2015,respectively,there was no statistically deference between three years(P >0.05).There were 50 cases(10.8) of syphilis antibody positive,one case(0.2%) of HCV antibody positive. In the last six months, there were 95.7% who had anal sex, among them there were 56.5% who used condom every time,there were 83.5% who used condom in last anal sex;there were 15.2% who had commercial sex with MSM, among them there were 58.2% who used condom every time;there were 21.9% who had sex with women, among them there were 40.6% who used condom every time. Conclusions The awareness rate of HIV/AIDS was high, but the condom use rate was low,there was a discrepancy between their knowledge and their behavior. The HIV positive rate and syphilis antibody positive rate were high,the prevention and control condition is very serious, we should take actions to improve our intervention strategies.
2017, 38(04): 137-141.
Abstract:
Osteoarthritis is the chronic articulatio-synovialis disease which features as cartilage degenerate and secondary osteoproliferation. Current pharmacologic therapy is largely ineffective at altering progression of the disease because the varitious mechanisms for OA remain elusive. The various therapeutic method of OA are not obvious,just relieve symptom or improve the function of joints in short.It is imposbille to stop pathological process of OA, not to mention reverse the degeneration of cartilage.It is a hot study between singal pathway and osteoarthritis,mroe and more researches confirm that the singal pathway of SDF-1/CXCR4,MAPK,Wnt,OPG/RANKL/RANK etc have close association with the generation and progress of OA.However, none of the singgal pathways can completely explan the mechanism of OA,or cure OA by block any singal pathway.So it is hotop to study mechanisms of OA and mew drugs.This rewiew focuses on singal pathway to OA in internation, hope to support theoretical foundation for study and therapy of OA
Osteoarthritis is the chronic articulatio-synovialis disease which features as cartilage degenerate and secondary osteoproliferation. Current pharmacologic therapy is largely ineffective at altering progression of the disease because the varitious mechanisms for OA remain elusive. The various therapeutic method of OA are not obvious,just relieve symptom or improve the function of joints in short.It is imposbille to stop pathological process of OA, not to mention reverse the degeneration of cartilage.It is a hot study between singal pathway and osteoarthritis,mroe and more researches confirm that the singal pathway of SDF-1/CXCR4,MAPK,Wnt,OPG/RANKL/RANK etc have close association with the generation and progress of OA.However, none of the singgal pathways can completely explan the mechanism of OA,or cure OA by block any singal pathway.So it is hotop to study mechanisms of OA and mew drugs.This rewiew focuses on singal pathway to OA in internation, hope to support theoretical foundation for study and therapy of OA
2017, 38(04): 142-146.
Abstract:
The growth and development of condyle is affected by the mechanical stress stimulation, which maintains the balance of condylar chondrocytes and extracellular matrix metabolism, as well as the structure and function of the temporomandibular joint. The adaptive remodeling relies on the mechanical signals response of the chondrocytes. This review aims to discuss about some of the main factors related to the mechanical stress signal transduction of the condylar chondrocytes.
The growth and development of condyle is affected by the mechanical stress stimulation, which maintains the balance of condylar chondrocytes and extracellular matrix metabolism, as well as the structure and function of the temporomandibular joint. The adaptive remodeling relies on the mechanical signals response of the chondrocytes. This review aims to discuss about some of the main factors related to the mechanical stress signal transduction of the condylar chondrocytes.
2017, 38(04): 147-150.
Abstract:
Heart rate variability biofeedback(HRVB) plays a very important role in the treatment of psychosomatic disease and some organic diseases, which supplement the deficiency of the traditional treatment method,guide to the occurrence and outcome of these diseases. In this paper,the mechanism of HRVB and main application in the depression and anxiety disorders are summarized as follows.
Heart rate variability biofeedback(HRVB) plays a very important role in the treatment of psychosomatic disease and some organic diseases, which supplement the deficiency of the traditional treatment method,guide to the occurrence and outcome of these diseases. In this paper,the mechanism of HRVB and main application in the depression and anxiety disorders are summarized as follows.
2017, 38(04): 72-75.
Abstract:
Objective To retrospectively analyze the curative effect of 131I therapy for treating post-operative differentiated thyroid carcinoma( DTC) and the influencing factors. Methods Two hundred and sixteen post-operative DTC patients who had received 131I therapy were involved in this retrospective study. The efficacy was assessed by 131I whole body scan in four days after the therapy every time. Besides,the overall curative effect was observed according to patients' pathological type,location of metastasis and frequency of 131I therapy respectively.Results After high dose 131I treatment, the total effective rate in patients with was 86.57%. The curative effect on cervical lymph node metastasis of DTC was significantly better than that of lung metastasis and bone metastasis.Meanwhile, no obvious side effects were observed during the study.Conclusions Large dose of 131I therapy for DTC metastasis is safe and effective. The location of tumor metastasis may influence the curative effect.
