2023 Vol. 44, No. 1

Original Articles Basic of Medicine
Effects of Pin1 on the Proliferation and Apoptosis of Cervical Cancer SiHa Cells by Regulating Key Enzymes of Lipid Metabolism
Yan HAI, Tursun MIKRBAN, Hasim AXIANGU
2023, 44(1): 1-6. doi: 10.12259/j.issn.2095-610X.S20230107
Abstract(4965) HTML PDF(33)
Abstract:
Objective To investigate the effect of down-regulation of Pin1 expression on lipid synthesis, proliferation and apoptosis of cervical cancer SiHa cells. Methods Western Blot was used to detect the expression of Pin1 in Hela, SiHa and H8 cells; Lenti...
Mutation Analysis of OprD Gene in Pseudomonas Aeruginosa with Car-R/ Ceph-S
Xi ZHENG, Jinzhu MA, Qinchun LI, Yu GAO, Ying PAN, Guibo SONG
2023, 44(1): 7-11. doi: 10.12259/j.issn.2095-610X.S20230121
Abstract(3413) HTML PDF(26)
Abstract:
Objective To study the mutation types of OprD gene in Pseudomonas aeruginosa resistant to carbapenems but sensitive to cephalosporins (Car-R/Ceph-S). Methods Ten strains of Pseudomonas aeruginosa which were resistant to carbapenems but sensitive to c...
Identification of Papaveraceae Based on Chloroplast DNA matK+rbcL+ trnH-psbA
Yujie FAN, Lei HUANG, Shida SU, Shaoming SU
2023, 44(1): 12-18. doi: 10.12259/j.issn.2095-610X.S20230104
Abstract(2761) HTML PDF(46)
Abstract:
Objective To explore the identification method of Papaver with the use of DNA barcoding technology and find reliable DNA barcoding sequence for intraspecific and interspecific identification of Papaver. Methods Five different species of Papaver rhoe...
Relationship between Mutations of KRAS,NRAS and BRAF Genes and Colorectal Liver Metastases
Haimei GOU, Li FANG, Xiaowu ZHONG
2023, 44(1): 19-24. doi: 10.12259/j.issn.2095-610X.S20230106
Abstract(4285) HTML PDF(18)
Abstract:
Objective To investigate the relationship between KRAS, NRAS and BRAF gene mutations and liver metastasis in colorectal cancer. Methods A total of 246 colorectal cancer tissue specimens were collected from the Affiliated Hospital of North Sichuan Me...
Pyrotosis Participates in the Pathogenesis of Necrotizing Enterocolitis in Early Offspring Rats
Jing WANG, Hongying MI, Yi ZHANG, Li LI, Jianhua YU, Liqiao LIU, Qingyu LIU, Liwei WANG
2023, 44(1): 25-30. doi: 10.12259/j.issn.2095-610X.S20230124
Abstract(4914) HTML PDF(11)
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Objective To establish a mouse model of necrotizing enterocolitis and detect the key protein molecules in serum of neonatal rats with early NEC, so as to preliminatively determine whether necrotizing enterocolitis is involved in early neonatal necrot...
Screening Analysis of Flat Foot Disease in School-age Children in Kunming City
Yingjie ZHANG, Tong WU, Luyun LIU, Weijun BAO, Jiazheng HUANG, Ying XIONG, Jiayu XIAO
2023, 44(1): 31-34. doi: 10.12259/j.issn.2095-610X.S20230120
Abstract(3042) HTML PDF(32)
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Objective To investigate the incidence probability and epidemiological characteristics of flat foot in school-age children (7~13 years old) in Kunming, and to provide the evidence for the prevention of flat foot. Methods The incidence of flat foot,...
Clinical Research
The Diagnostic Value of Combined Prediction Model for Acute Type A Aortic Dissection Rupture
Zhengmei ZI, Li HAO, Nan WANG, Guobing CHEN
2023, 44(1): 35-40. doi: 10.12259/j.issn.2095-610X.S20230128
Abstract(3363) HTML PDF(8)
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Objective To create a combined model and explore its value in predicting the rupture risk of acute type A aortic dissection (ATAAD). Methods The relevant data and the first cTn-I value of the ATAAD patients admitted and treated in a tertiary hospita...
Expression Levels of TNF-α,sTNFR-55 and sTNFR-75 in Induced Sputum and Serum of AECOPD Patients and Their Clinical Significance
Qingsong MA, Zhihuan ZHAO, Lirong MA, Weijing LI, Ling LIU
2023, 44(1): 41-46. doi: 10.12259/j.issn.2095-610X.S20230112
Abstract(2577) HTML PDF(8)
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Objective To investigate the different expression levels of TNF-α, sTNFR-55 and sTNFR-75 in the induced sputum and serum of AECOPD patients and their clinical significance. Methods Forty AECOPD patients were enrolled and hospitalized during January ...
Correlation Analysis between Pathological Features of IgA Nephropathy and Dyslipidemia
Jingshan CHEN, Li LI, Shili SHANG, Guoyong HE, Wenjing ZHOU, Sha LI, Di ZHANG, Yonglan LIU, Jun LI
2023, 44(1): 47-53. doi: 10.12259/j.issn.2095-610X.S20230111
Abstract(4360) HTML PDF(13)
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Objective To investigate the relationship between dyslipidemia and its clinical features and renal pathological features in patients with IgA nephropathy. Methods 150 patients with lgA nephropathy were divided into dyslipidemia group and normal bloo...
Establishment and Significance of Screening System for Acute Leukemia in Children Based on Detection of TEL-AML1 Fusion Gene in Neonatal Cord Blood
Yaling ZHAO, Kun WU, Rong HUANG, Genya HE, Zhenbo DING, Caiying ZHANG
2023, 44(1): 54-58. doi: 10.12259/j.issn.2095-610X.S20230126
Abstract(3959) HTML PDF(4)
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Objective To establish an early screening system for childhood acute lymphoblastic leukemia based on the detection of TEL-AML1 fusion gene in neonatal umbilical cord blood and to explore its clinical significance. Methods First, the newborn with hig...
Intraoperative Nalmefene Reduces Remifentanil-induced Postoperative Hyperalgesia
Xiaoying YAN, Shimei LI, Haixia JIANG
2023, 44(1): 59-64. doi: 10.12259/j.issn.2095-610X.S20230118
Abstract(2341) HTML PDF(11)
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Objective Intraoperative use of a high-dose remifentanil may induce postoperative hyperalgesia. This paper aims to investigate whether low-dose nalmefene can prevent the postoperative hyperalgesia induced by high-dose remifentanil. Methods Ninety p...
Evaluation of Therapeutic Effect of Transabdominal and Transvaginal Ultrasound on Cesarean Scar Pregnancy
Chunmei MENG, Kefan YE, Yunyu HE, Dongyan REN, Xiaomei WU, Yifeng ZHANG
2023, 44(1): 65-69. doi: 10.12259/j.issn.2095-610X.S20230113
Abstract(3637) HTML PDF(5)
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Objective To investigate the clinical significance of color Doppler ultrasound in the diagnosis and treatment of cesarean scar pregnancy. Methods A total of 82 CSP patients diagnosed and treated in the Department of Gynecology of Yunnan First Peopl...
Correlation between Internal Carotid Artery Stenosis and Cognitive Impairment
Yao HUANG, Xi LI, Bo YAN, Lei LEI, Zegang YIN, Jin FAN, Peng BAI
2023, 44(1): 70-75. doi: 10.12259/j.issn.2095-610X.S20230105
Abstract(3895) HTML PDF(7)
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Objective To investigate the correlation of different degrees and sides of internal carotid artery stenosis with cognitive impairment. Methods From June 2017 to August 2018, patients for cerebrovascular examination with CTA or DSA were selected from...
Imaging Measurement of Intramedullary Nail Design for Proximal Fifth Metatarsal Fracture
Guangxiong HE, Sixue PAN, Juan WU, Junyi XIANG, Yu LU, Chaoyu BAO
2023, 44(1): 76-79. doi: 10.12259/j.issn.2095-610X.S20230108
Abstract(5076) HTML PDF(9)
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Objective To measure the size of the fifth metatarsal bone marrow cavity, the length of the intramedullary nail and the length of the fifth metatarsal bone in normal adults by X-ray, and to provide a basis for the selection of the diameter and length...
Clinical Significance of C Reactive Protein and Procalcitonin Detection in Neonatal ABO Hemolytic Jaundice
Tuan LI, Yu’e ZHOU, Li MA, Gui LIAO
2023, 44(1): 80-84. doi: 10.12259/j.issn.2095-610X.S20230122
Abstract(5289) HTML PDF(11)
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Objective To investigate the clinical significance of c reactive protein and procalcitonin levels in neonatal ABO hemolytic jaundice . Methods A total of 50 ABO hemolytic jaundice neonates admitted to a grade III and class A hospital in Yunnan Provi...
Effect of Different Intestinal Surgical Methods on Prognosis of Patients with Intestinal Invasive Epithelial Ovarian Cancer
Yaping JIANG, Hongying YANG, Haohan WANG, Xianling Ning, Xielan YANG
2023, 44(1): 85-90. doi: 10.12259/j.issn.2095-610X.S20230109
Abstract(3815) HTML PDF(7)
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Objective To investigate the effect of intestinal segment resection and local tumor removal on the prognosis of patients with intestinal metastatic epithelial ovarian cancer. Methods The clinical data of the patients who were admitted to Yunnan Prov...
Effect of Dual-task Training on Mobility Function in Patients with Parkinson’s Disease
Xiaoying LIN, Yan TAN, Lei YANG
2023, 44(1): 91-96. doi: 10.12259/j.issn.2095-610X.S20230110
Abstract(4051) HTML PDF(21)
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Objective To examine the effect of dual-task (DT) training on mobility function in patients with Parkinson’s disease (PD). Methods 56 patients with PD were randomly divided into DT training group or single-task (ST) training group. Each group of pa...
The Efficacy and Safety of Different Antiviral Treatment Regimens in Patients with ALT Elevation and Low Viral Load in the Indeterminate Phase of Chronic Hepatitis B
Ti WU, Kang HUANG, Zhirong ZHAO, Haiwen LI, Xiaofei LI, Yongrui YANG
2023, 44(1): 97-103. doi: 10.12259/j.issn.2095-610X.S20230117
Abstract(3566) HTML PDF(17)
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Objective To observe the clinical efficacy and safety of first-line nucleos (t)ide analogues antiviral therapy in newly diagnosed chronic hepatitis B patients with low viral load and uncertain stage. Methods A total of 96 diagnosed treatment-naive c...
Diagnostic Value of Interleukin-6,Interleukin-10,High-sensitivity C-reactive Protein and Procalcitonin in Children with Acute Lymphoblastic Leukemia Complicated by Infection
Shulan SHI, Lijuan QIU, Liyue KUI, Min SU, Bailing ZHOU, Rongjie LI, Jianming SUN
2023, 44(1): 104-108. doi: 10.12259/j.issn.2095-610X.S20230115
Abstract(3890) HTML PDF(13)
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Objective To explore peripheral blood interleukin-6 ( IL-6), interleukin-10 ( IL-10) hypersensitive C-reactive protein ( hs-CRP) and procalcitonin ( PCT) in children with acute lymphoblastic leukemia ( ALL) co-infection. Methods A total of 141 child...
Analysis of Nutritional Status and Immune Function of Tuberculosis Patients in Yunnan
Lin WANG, Lingjun SHEN, Haiwen LI, Xiaoyan WANG, Jianpeng GAO, Zhiqiang MA
2023, 44(1): 109-115. doi: 10.12259/j.issn.2095-610X.S20230116
Abstract(3993) HTML PDF(13)
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Objective To investigate the characteristics and significance of nutritional status and immune function in patients with pulmonary tuberculosis. Methods 1041 tuberculosis patients admitted to Kunming Third People’s Hospital from March 2021 to March ...
Analysis of Serum High-sensitivity HBV DNA in Patients with Chronic Hepatitis B with Low Viral Load in Kunming Area
Dong PU, Tingting YU, Lihua LI, Runwu ZHANG, Kunli WU, Dongling LI
2023, 44(1): 116-121. doi: 10.12259/j.issn.2095-610X.S20230114
Abstract(4690) HTML PDF(14)
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Objective To investigate the relationship among high-sensitive HBV-DNA load , high-sensitivity HBV-DNA load, HBV genotype distribution, HBV P region drug resistance mutation, HBeAg, HBsAg, ALT and its value of clinical application in patients among t...
Quantitative Analysis of Real-time Ultrasound Elastography in Elderly Patients with Advanced Malignant Obstructive Jaundice and the Assessment of Prognostic Value of PTCD
Hong LI
2023, 44(1): 122-127. doi: 10.12259/j.issn.2095-610X.S20230123
Abstract(3503) HTML PDF(4)
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Objective To explore the relationship between the quantitative analysis of real-time ultrasound elastography and the prognosis of percutaneous transbiliary drainage (PTCD) in elderly patients with advanced malignant obstructive jaundice. Methods A r...
Application of CT Radiomics in the Short-Term Prognosis of Combined Therapy for Hepatocellular Carcinoma
Qianting DUAN, Guanshun WANG, Rong DING, Na WANG, Hongli CUN, Ling YANG
2023, 44(1): 128-134. doi: 10.12259/j.issn.2095-610X.S20220818
Abstract(4286) HTML PDF(114)
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Objective To investigate the value of enhanced CT radiomics model in predicting the short-term efficacy (within 6 months) of TACE combined with sorafenib in hepatocellular carcinoma. Method The clinical, pathological and preoperative CT images of 15...
Reviews
Research Progress of Cytoreductive Treatment for Metastatic Prostate Cancer
Longguo DAI, Yu BAI
2023, 44(1): 135-139. doi: 10.12259/j.issn.2095-610X.S20230103
Abstract(3271) HTML PDF(15)
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Metastatic prostate cancer (mPCa) will progress to castrate-resistant state after a period of androgen-deprivation therapy (ADT) alone. Therefore, increasing focus is being placed on the additional survival benefits that could potentially be achieved...
The Role of Radioactive Iodine-125 Particles in EMT and Clinical Treatment of Lung Adenocarcinoma
Fei SONG, Jiayin CHE, Ming HUANG, Dan XU, Hongyang LI, Dingkun LI, Yingying XIANG
2023, 44(1): 140-143. doi: 10.12259/j.issn.2095-610X.S20230101
Abstract(3831) HTML PDF(10)
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Lung cancer is one of the most common tumors, and Yunnan has the highest incidence of lung cancer in China. Many patients are diagnosed with advanced lung cancer and are treated with a combination of chemotherapy, radiotherapy, targeted therapy, immu...
Research Progress on the Pathogenesis of Pterygium
Huawei JIANG, Xia LIU, Yan WANG, Minhui ZHANG, Weidan YIN, Liwei ZHANG
2023, 44(1): 144-150. doi: 10.12259/j.issn.2095-610X.S20230125
Abstract(3662) HTML PDF(38)
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Pterygium is a common ocular surface disease in the population and its risk factors are mainly ultraviolet radiation. The pathogenesis mainly includes oxidative stress, phototoxicity, cell proliferation and apoptosis, extracellular matrix remodeling,...
Teaching Research
Application of Oral Digital Positioning System Combined with CBL in The Teaching of Orthodontic Bracket Bonding and Positioning
Jing ZHOU, Liqiong CHEN, Wenjuan FENG, Changyun WU, Su SUN, Changquan LI, Quan WANG
2023, 44(1): 151-155. doi: 10.12259/j.issn.2095-610X.S20230127
Abstract(3789) HTML PDF(19)
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Objective To explore the feasibility and effectiveness of the oral digital positioning system combined with the CBL teaching method in the teaching of orthodontic bracket bonding and positioning. Methods 56 students were divided into group A (28 stu...
An Analysis of Key Factors for Improving the Teaching Quality of Pediatric Pharmacy Based on Kano Model
Huiying LI, Caixia TU, Danyang REN, Aihua YAN, Qibing XIE
2023, 44(1): 156-162. doi: 10.12259/j.issn.2095-610X.S20230102
Abstract(3513) HTML PDF(14)
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Objective To explore the key factors for improving the teaching quality of pediatric pharmacy with the use of Kano model. Method The students who practiced in the pharmacy department of Kunming Children’s Hospital from October 2021 to June 2022 were...
Nursing Forum
Effects of Red Light Irradiation Combined with Lower Extremity Muscle Strength Training on Lower Extremity Motor Function,TCSS Score and SOD Level in Patients with Diabetic Peripheral Neuropathy
Fenghua LU, Zhaolin DU, Rong ZHANG
2023, 44(1): 163-167. doi: 10.12259/j.issn.2095-610X.S20230129
Abstract(3784) HTML PDF(7)
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Objective To analyze the effect of red light irradiation combined with lower extremity muscle strength training on lower extremity motor function, Toronto Clinical Scoring System (TCSS) score and superoxide dismutase (SOD) level in patients with diab...
Studies on the Effect of Fasting or Feeding on Intestinal Oxygenation in Neonates during Blood Transfusion
Yuan YUAN, Lijuan YIN, Yonglin QI
2023, 44(1): 168-172. doi: 10.12259/j.issn.2095-610X.S20230119
Abstract(3831) HTML PDF(23)
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Objective To investigate the effect of fasting or feeding on intestinal oxygenation in neonates during the blood transfusion. Methods From June 2021 to July 2022, a total of 59 eligible neonates who received the red blood cell infusion treatment in ...