2024 Vol. 45, No. 1

Expert Forum
Research Progress of miRNA in Non-alcoholic Fatty Liver Disease
Hang CHEN, Qi CUI, Minshan HUANG, Jianjun LIU, Lanqing MA
2024, 45(1): 1-7. doi: 10.12259/j.issn.2095-610X.S20240101
Abstract(1361) HTML PDF(67)
Abstract:
Nonalcoholic fatty liver disease(NAFLD) is the most common chronic liver disease, with a global prevalence of approximately 30.05% to 32.4%. It is closely associated with various other diseases. In recent years, microRNAs(miRNAs) have played a crucia...
Original Articles Basic of Medicine
Correlation Analysis of HLA-DM Gene Polymorphisms with Polio Vaccine-induced Antibody Response
Runan QI, Lei SHI, Shuyuan LIU, Jing LI, Li SHI
2024, 45(1): 8-14. doi: 10.12259/j.issn.2095-610X.S20240102
Abstract(1039) HTML PDF(21)
Abstract:
Objective To investigate the correlation between HLA-DM gene polymorphism and antibody response induced by poliomyelitis vaccine. Methods 355 healthy infants aged 2 to 3 months in Guangxi Zhuang Autonomous Region were selected as the study objects,...
CD147 Mediates Cervical Cancer Cell Pyroptosis and Proliferation through AIM2 Inflammasome
Ling WANG, Xiangchuan QIN, Jinqiu LI, Hasim AXIANGU
2024, 45(1): 15-21. doi: 10.12259/j.issn.2095-610X.S20240103
Abstract(1208) HTML PDF(16)
Abstract:
Objective To investigate the effect of transmembrane protein CD147 expression on AIM2 inflammasome-mediated pyroptosis and proliferation of cervical cancer cells. Methods Western Blot was used to detect the expression of CD147 in cervical cancer cell...
Metabolomics of Siha Supernatant in Cervical Cancer Cells with Down-regulated HPV16 E6/E7 Expression
Jinbao XIAO, Junda ZHAO, Junqi MA
2024, 45(1): 22-27. doi: 10.12259/j.issn.2095-610X.S20240104
Abstract(1770) HTML PDF(13)
Abstract:
Objective To detecte the differential metabolites and related pathways in Siha cells of cervical cancer by screening the inhibition of HPV16 E6/E7 expression based on 1H NMR metabolomics so as to identify the key metabolic markers involved in the dev...
Culture of Malignant Pleural Mesothelioma Cells and the Effects of CDKN2B on Cancer Cell
Xiaochuan YIN, Ruiyang YIN, Ranhua LI, Fangqi CAI, Yue CUI, Tao BI, Xinghe TONG
2024, 45(1): 28-34. doi: 10.12259/j.issn.2095-610X.S20240105
Abstract(1188) HTML PDF(15)
Abstract:
Objective To investigate the effects of different culture conditions(RPMI-1640, DMEM and DMEM/F12 medium) on the passage of MPM cells isolated from the tissues of Malignant pleural mesothelioma(MPM), and to study the effects of CDKN2B on the prolifer...
Comparison of Methods for Generating Thrombotic Models after the Endothelial Injury
Jingqiu ZHANG, Yongping LU, Linkun TA, Yue SUN, Qi CHEN
2024, 45(1): 35-40. doi: 10.12259/j.issn.2095-610X.S20240112
Abstract(1144) HTML PDF(7)
Abstract:
Objective Endothelial injury plays a crucial role in forming deep vein thrombosis. This study aims to compare the effectiveness of various methods for creating rabbit femoral vein thrombotic models after the endothelial injuryso as to provide a solid...
The Prevalance of Depression and Anxiety among Elderly People in Dai Rural Areas of Jinggu County Yunnan Province and Its Relationship with Socio-economic Status
Qin LI, Lan LIU, Yi ZHAO, Chenghuan SUN, Mei ZUO, You HUANG, Guohui LI, Le CAI
2024, 45(1): 41-47. doi: 10.12259/j.issn.2095-610X.S20240107
Abstract(1480) HTML PDF(17)
Abstract:
Objective The aim of this study is to analyze the prevalence of depression and anxiety symptoms and its relationship with the socio-economic position(SEP) among the elderly people in Dai rural areas of Jinggu County, Yunnan province. Methods A mult...
The Investigation and Analysis of the Situation of COVID-19 Vaccination and Vaccination Willingness in HIV/AIDS Population in Yunnan Province
Songqin LYU, Shan HUANG, Litang MA, Xiu WANG, Hongtao ZHANG, Qin LI, Chunping WAN, Zhengchao LYU
2024, 45(1): 48-54. doi: 10.12259/j.issn.2095-610X.S20240108
Abstract(1468) HTML PDF(12)
Abstract:
Objective To investigate the vaccination status and vaccination willingness of novel coronavirus in HIV/AIDS population in Yunnan. Methods From October 2021 to June 2022, a questionnaire survey was conducted among 2180 HIV/AIDS patients in Kunming, Q...
Studies on the Intention Use of Diabetes Personal Management Application and Related Factors
Aiping CHENG, Cong ZHANG
2024, 45(1): 55-60. doi: 10.12259/j.issn.2095-610X.S20240109
Abstract(950) HTML PDF(14)
Abstract:
Objective To understand the intention of the community diabetes management application and analyze the related factors. Methods Diabetes patients in the community were selected as the research objects, and the diabetes management application intenti...
Clinical Research
Correlation Analysis between the Common Clinical Indexes and Diabetic Foot Ulcer
Shujie ZHOU, Ling ZHAO, Tingyu KE
2024, 45(1): 61-66. doi: 10.12259/j.issn.2095-610X.S20240110
Abstract(1404) HTML PDF(23)
Abstract:
Objective To analyze the relationship between the common clinical indicators and diabetic foot ulcer(DFU) in type 2 diabetes mellitus(T2DM) patients by using the cross-sectional study and to provide the reference indicators for clinical DFU monitorin...
Clinical Studies on Thyroid Dysfunction Caused by Immune Checkpoint Inhibitors in Tumor Patients
Meng LI, Ben NIU, Jin HU, Yanlin MA
2024, 45(1): 67-72. doi: 10.12259/j.issn.2095-610X.S20240111
Abstract(1175) HTML PDF(17)
Abstract:
Objective To investigate the clinical characteristics and risk factors of thyroid dysfunction(TD) in malignant tumor patients treated with immune checkpoint inhibitors(ICIs). Methods A total of 157 cancer patients who were hospitalized and received ...
Changes of Sex Hormone Levels in Infertile Population with Polycystic Ovary Syndrome after the Assisted Reproductive Technology Treatment
Limei HE, Xuemin FENG, Linjun LI, Ying CHEN, Zexing YANG
2024, 45(1): 73-77. doi: 10.12259/j.issn.2095-610X.S20240106
Abstract(1960) HTML PDF(12)
Abstract:
Objective To investigate the changes of sex hormone levels in polycystic ovary syndrome(PCOS) in infertile population after the assisted reproductive technology treatment, and to provide an evidence for the choice of the treatment. Methods The medi...
Risk Factors of Recurrence in Patients with Ischemic Stroke Treated with Aspirin Single Drug Antiplatelet Therapy
Qian LI, Puqiong FENG, Qin YAO, Hanmei CHEN, Ting ZHAO, Hui WU
2024, 45(1): 78-82. doi: 10.12259/j.issn.2095-610X.S20240113
Abstract(1060) HTML PDF(16)
Abstract:
Objective To investigate the risk factors of relapse in patients with ischemic stroke using aspirin for single drug antiplatelet therapy. Methods A retrospective analysis was conducted on 200 patients with mild and medium ischemic stroke after 12 mon...
Investigation and Analysis of Vitamin K Level Distribution in 1177 Infants of Different Age Groups
Jinyan ZHOU, Kerong LI, Yan MA, Jiqiang WANG, Zhengming ZHANG, Wang LI
2024, 45(1): 83-86. doi: 10.12259/j.issn.2095-610X.S20240114
Abstract(1186) HTML PDF(17)
Abstract:
Objective T o investigate the distributions of vitamin K1 and K2 in infants of different age groups by comparing the serum levels of vitamin K1 and K2 in them. Methods 1177 infants from 0 to 3 months were divided into 6 age groups. Those born/treate...
Analysis of Surgical Treatment of 20 Cases of Ebstein’ s Anomaly Combined with Atrial Septal Defect
Xiong JIN, Runwei MA, Chunjie MU
2024, 45(1): 87-92. doi: 10.12259/j.issn.2095-610X.S20240115
Abstract(1005) HTML PDF(9)
Abstract:
Objective To analyze the treatment strategy of the atrial septal defect in the surgical treatment of Ebstein’ s anomaly combined with the atrial septal defect and the short-term follow-up results of the treatment of Ebstein’ s anomaly. Methods A ret...
Changes and Significance of D-D,F1+2 and P-selectin in Patients with Acute Deep Venous Thrombosis of Lower Extremities before and after Catheter-thrombolysis
Bin LIN, Kai ZHANG, Jie WANG, Xinmin CHEN
2024, 45(1): 93-99. doi: 10.12259/j.issn.2095-610X.S20240116
Abstract(1024) HTML PDF(13)
Abstract:
Objective To explore the changes and clinical significance of D-dimer(D-D), prothrombin fragment 1+2(F1+2) and P-selectin in patients with acute deep venous thrombosis of lower extremities(DVT) before and after catheterization and thrombolysis. Meth...
Clinical and Pathological Characteristics of Extrapleural Solitary Fibrous Tumor
Ying LIU, Shujie SONG, Lin WU
2024, 45(1): 100-106. doi: 10.12259/j.issn.2095-610X.S20240117
Abstract(914) HTML PDF(8)
Abstract:
Objective To investigate the clinical and pathological characteristics of the extrapleural solitary fibrous tumor and the relevant differential diagnosis. Methods HE and immunohistochemical staining were performed on 26 samples of isolated fibrous t...
The Effects of Bronchoalveolar Lavage Combined with Microbiological Rapid on-site Evaluation in the Maintenance of Potential Donor Lung
Liming GONG, Jianghua RAN, Yinjia WANG, Zhiwei LI, Qian YANG, Qing WANG, Dongkun WANG, Zhengneng TANG
2024, 45(1): 107-115. doi: 10.12259/j.issn.2095-610X.S20240118
Abstract(1506) HTML PDF(6)
Abstract:
Objective To explore the effects of bronchoalveolar lavage combined with microbiological rapid on-site evaluation in potential donor lung maintenance. Methods Brain death patients who met the inclusion criteria and were admitted to the Intensive Car...
The Predictive Value of MMP-9 the and NLR Values for Bleeding Transformation after the Revascularization in Acute Ischemic Stroke
Baogang HUANG, Kang DU, Fengming XU, Haohao WU, Shaoyong GUAN, Qianjun FAN, Junsu YANG, Fang QIAN
2024, 45(1): 116-121. doi: 10.12259/j.issn.2095-610X.S20240119
Abstract(1689) HTML PDF(16)
Abstract:
Objective To study the correlation between the changes of matrix metalloproteinase-9(MMP-9) and neutrophil/lymphocyte ratio(NLR) before and after the revascularization of acute ischemic stroke(AIS), so as to find biomarkers to predict the bleeding tr...
Early Efficacies of Drainage in Arthroscopic Reconstruction with Anterior Cruciate Ligament Reconstruction
Yuping DUAN, Hualei ZHAO, Xueliang FEI, Yongxin TANG, Yongsheng XU
2024, 45(1): 122-126. doi: 10.12259/j.issn.2095-610X.S20240120
Abstract(922) HTML PDF(9)
Abstract:
Objective To investigate the impact of not using drainage on clinical outcomes after arthroscopic autologous semitendinosus tendon reconstruction with anterior cruciate ligament reconstruction. Methods From March 2022 to June 2023, 59 patients under...
The Relationship between Urinary NGAL and Flow-mediated Vasodilation in Prehypertension
Da PENG, Aijun ZHANG
2024, 45(1): 127-132. doi: 10.12259/j.issn.2095-610X.S20240121
Abstract(970) HTML PDF(24)
Abstract:
Objective To explore the correlation between the urinary neutrophil gelatinase-associated lipid carrier protein(NGAL) and Brachial artery flow-mediated vasodilation(FMD) in Prehypertension. Methods 156 patients with Prehypertension found to have th...
Analysis of Vitamin D in Children with Henoch-Schonlein Purpura
Sixiang LIU, Yongkun HUANG, Shulan SHI, Jingjing SUN, Lisi LUO, Li WANG, Yu LING
2024, 45(1): 133-135. doi: 10.12259/j.issn.2095-610X.S20240122
Abstract(1119) HTML PDF(14)
Abstract:
Objective To analyze the changes of vitamin D in children with Henoch-Schonlein purpura(HSP). Methods 130 children with HSP from Kunming Children’ s Hospital between July 2022-July 2023 were selected as the study subjects and 100 healthy children wer...
Effect of Photo-activated Disinfection as An Adjunctive Therapy in the Treatment of Chronic Periodontitis
Weimin QIAN, Liangju CAO, Yu JIANG, Dan PU, Fengting MU, Yongsheng PAN
2024, 45(1): 136-142. doi: 10.12259/j.issn.2095-610X.S20240123
Abstract(1147) HTML PDF(10)
Abstract:
Objective To evaluate the effect of photo-activated disinfection(PAD) as a kind of adjuvant treatment on moderate to severe chronic periodontitis. Methods 21 patients with the chronic periodontitis(totally 218 selected sites) were randomly enrolled ...
The Effects of the Laparoscopic and Open Surgery on the Postoperative Intestinal Function Recovery Time in Elderly Patients with Colorectal Cancer
Bo LIU, Qiaolian WU, Quanchang ZHANG
2024, 45(1): 143-148. doi: 10.12259/j.issn.2095-610X.S20240124
Abstract(1728) HTML PDF(8)
Abstract:
Objective To investigate the effects of the laparoscopic surgery and open surgery on the postoperative intestinal function recovery time in elderly patients with colorectal cancer(CRC). Methods 66 elderly patients with CRC and treated in the 2nd Peo...
The Distribution and Drug Resistance of Pathogenic Bacteria in Respiratory Tract Infections in Children from 2019 to 2022
Xuelin ZHANG, Lu LIU, Yanzhi CHEN, Caijun ZHA, Yanli LI
2024, 45(1): 149-155. doi: 10.12259/j.issn.2095-610X.S20240125
Abstract(1213) HTML PDF(22)
Abstract:
Objective To analyze the clinical characteristics and the antimicrobial resistance of respiratory tract infection in children in Baoshan City, guide clinicians to rationally apply antibiotics, and improve the success rate of treatment. Methods Retros...
Effect Evaluation of Multidisciplinary Collaborative Diagnosis and Treatment Model for Children with Brain Injury
Xiongwu YU, Yunli ZHOU, Zhiyong DING, Chaohong WANG, Zeyi XIE, Hongna LU, Hua JIN
2024, 45(1): 156-162. doi: 10.12259/j.issn.2095-610X.S20240126
Abstract(1021) HTML PDF(7)
Abstract:
Objective To summarize the experience of multi-disciplinary team(MDT) in the pediatric department of Qujing Maternal and Child Health Hospital, and to evaluate the effectiveness of MDT on neonatal brain injury. Methods The clinical data of children ...
The Effect of Smoking on the Semen Quality in Male Infertile
Yingjie YAO, Jinfeng CAI, Jianghou HOU, Yunyan CHEN, Ming XIA, Haiyun YANG, Pengying XIAO, Lijun WANG
2024, 45(1): 163-167. doi: 10.12259/j.issn.2095-610X.S20240127
Abstract(1546) HTML PDF(17)
Abstract:
Objective To investigate the effect of smoking on the semen quality in infertile men. Methods A total of 360 male infertility patients were enrolled and divided into the smoking group(\begin{document}$n $\end{document}=190) and non-smoking group(\be...
Reviews
Applications of Biologically Oriented Preparation Technique in Prosthodontics
Hao HUANG, Xuelin LI, Fei SONG, Xiuling JI, Yingying XIANG
2024, 45(1): 168-171. doi: 10.12259/j.issn.2095-610X.S20240128
Abstract(1669) HTML PDF(36)
Abstract:
The preparation edge of the tooth in oral restoration has always been the hot concern for dentists, and the improper preparation edge may lead to such diseases as caries and periodontitis, and ultimately lead to the restoration failure. The applicati...
Advances in Epigenetic Regulatory Mechanisms in HSV1 Infection
Changjing WU, Yufang ZOU, Xinwei HUANG
2024, 45(1): 172-178. doi: 10.12259/j.issn.2095-610X.S20240129
Abstract(1590) HTML PDF(33)
Abstract:
Herpes simplex viruses type 1(HSV1) is among the most ubiquitous human pathogens that cause a wide variety of disease states. The latent infection of the central nervous system and sporadically reactivation is the central part of HSV1 pathogenesis, w...
Nursing Forum
Latent Class Analysis and Influencing Factors of Cognitive Ability Level of Hospice Care Nursing Students
Yong DONG, Jiao YANG, Shuaizhong CAI, Yan SU, Haiyin YANG, Shiyao YANG, Yuexi ZHU, Qiongyao GUAN
2024, 45(1): 179-186. doi: 10.12259/j.issn.2095-610X.S20240130
Abstract(1590) HTML PDF(34)
Abstract:
Objective To explore the different latent class and characteristics of the cognitive ability level of undergraduate nursing students in hospice care based on the individual-centered perspective, and analyze its influencing factors to provide the refe...
Studies on the Influence of Three-level Assistance Model Based on Narrative Nursing Theory on the Mental Health of Medical Staff
Zhijun REN, Shuping GAO, Yumei ZHOU, Yu XI, Ping HE
2024, 45(1): 187-192. doi: 10.12259/j.issn.2095-610X.S20240131
Abstract(1713) HTML PDF(15)
Abstract:
Objective To explore the impact of the three-level assistance model based on the narrative nursing theory on the mental health status of medical staff. Methods 140 medical staff working in a third class hospital in Xiangyang City were selected as th...