2024 Vol. 45, No. 11

Expert Forum
Research Progress on Detection Techniques of Common Foodborne Pathogens
Xuejuan HUANG, Yandong GUO, Ran LIU, Yanjiao WANG, Shaoxiong WU, Wei CHANG, Fei MI, Jianzhong YIN
2024, 45(11): 1-8. doi: 10.12259/j.issn.2095-610X.S20241122
Abstract(425) HTML PDF(47)
Abstract:
Food safety is a major public health problem in the world. Foodborne pathogens are the main factors threatening human health and food safety. Rapid and accurate detection of foodborne pathogens is of great significance to ensure food safety and preve...
Original Articles Basic of Medicine
Expression Analysis of WDR36 and WRN Genes of Borrelia Burgdorferi in HMC3 Cell Line Infection Model
Zhen LI, Senyuan DONG, Bishu MA, Shuya FU, Fukai BAO, Aihua LIU
2024, 45(11): 9-15. doi: 10.12259/j.issn.2095-610X.S20241102
Abstract(477) HTML PDF(13)
Abstract:
Objective The aim is to explore the molecular mechanism of neurological Lyme disease, particularly by identifying two differentially expressed genes WDR36 and WRN associated with Burkholderia infection through transcriptome analysis. Secondly, to ver...
The Association of HOXD-AS2 and MIR3142HG Gene Polymorphisms with Cervical Intraepithelial Neoplasia
Xueya CHEN, Jinmei XU, Zhi LI, Yan LIANG, Yufeng YAO, Fengquan HE, Zhiling YAN
2024, 45(11): 16-21. doi: 10.12259/j.issn.2095-610X.S20241103
Abstract(356) HTML PDF(16)
Abstract:
Objective To explore the association of HOXD-AS2 and MIR3142HG gene polymorphism with cervical intraepithelial neoplasia (CIN). Methods Two single nucleotide polymorphisms (SNPs) located in HOXD-AS2 (rs1348808) and located in MIR3142HG (rs2431099) w...
miR-212-3p Targeted Regulation of NAP1L1 Inhibits Glioma Cell Proliferation,Migration and EMT
Xiaobing GUO, Xiaowen LI, Hengxi LI, Yan CAO, Ping LI
2024, 45(11): 22-30. doi: 10.12259/j.issn.2095-610X.S20241104
Abstract(249) HTML PDF(7)
Abstract:
Objective To explore the molecular mechanism of miR-212-3p in glioma cell proliferation, invasion and epithelial-mesenchymal transition (EMT). Methods The expression of miR-212-3p and NAP1L1 were detected by RT-qPCR in glioma cells. NC mimic, miR-21...
Protective Effects of Xiyanping Injection on Lipopolysaccharide-induced Acute Lung Injury in Mice
Shaoyan NIE, Susu FAN, Yushan ZHU, Xuerong PENG, Yang WANG, Xuan ZHANG
2024, 45(11): 31-37. doi: 10.12259/j.issn.2095-610X.S20241105
Abstract(627) HTML PDF(17)
Abstract:
Objective To explore the protective effects of Xiyanping injection against lipopolysaccharide (lipopolysaccharide, LPS)-induced acute lung injury (acute lung injury, ALI)in mice, and preliminarily investigate its mechanism. Methods The mice were ran...
Observation and Analysis of Coronary Microcirculation by Establishing Rat Myocardial Ischemia and in Vitro CMECs Hypoxia Model
Zheng JIA, Zhengjiang XING, Qian LIU, Yibin DU, Bing LI, Ying XIE, Yi ZHAO
2024, 45(11): 38-45. doi: 10.12259/j.issn.2095-610X.S20241106
Abstract(502) HTML PDF(17)
Abstract:
Objective To establish in vivo rat ischemic myocardial injury and in vitro cardiac microvascular endothelial cell (CMEC) hypoxia models so as to investigate the structural and biological changes and probe the angiogenesis basis of coronary microcircu...
Regulatory Mechanisms of TLR4/NF-κB/ MUC5B in Allergic Rhinitis
Aheng WANG, Zhen SONG, Guanghua YANG, Haiyan HE
2024, 45(11): 46-51. doi: 10.12259/j.issn.2095-610X.S20241107
Abstract(482) HTML PDF(27)
Abstract:
Objective To explore the regulatory mechanism of TLR4/NF-κB/MUC5B in allergic rhinitis. Methods A mouse model of allergic rhinitis was established to observe the changes in pathological characteristics of the model and to detect the expression of TLR...
The Analysis of Exposure and Influencing Factors of Pyrethroid Pesticides in Rural Women during Different Pregnancy Stages in Xuanwei,Yunnan Province
Siwei YANG, Yan LI, Xia XIAO, Xiaoxiao SONG, Lin SUN, Rui MA
2024, 45(11): 52-58. doi: 10.12259/j.issn.2095-610X.S20241108
Abstract(251) HTML PDF(13)
Abstract:
Objective The purpose of the study is to understand the exposure of rural women to pyrethroid pesticides during each pregnancy stage. Methods From December 2014 to December 2016, 216 pregnant and postpartum women with the average age between 24.81±5...
Visual Analysis of Symptom Clusters of Hepatocarcinoma Patients Based on Citespace
Qiong WU, Na LI, Yujuan XU
2024, 45(11): 59-66. doi: 10.12259/j.issn.2095-610X.S20241109
Abstract(301) HTML PDF(12)
Abstract:
Objective To analyze the research hotspots and frontiers of symptom clusters of hepatocarcinoma patients. Methods The relevant literatures on liver cancer symptom cluster research collected by CNKI since 1987 were searched, and a total of 100 releva...
Multi-level Model Analysis of Factors Influencing Physicians' Job Burnout
Rui WANG, Cilin HAN, Yuanqing CAO, Xiaoyan YANG
2024, 45(11): 67-72. doi: 10.12259/j.issn.2095-610X.S20241110
Abstract(528) HTML PDF(10)
Abstract:
Objective To analyze the factors influencing physician job burnout. Methods A multistage stratified random sampling method was adopted to select a total of 1190 physicians from 10 public general hospitals above the second level in 5 regions of Yunna...
The Influence of Medical Cooperation on the Work Engagement of Dental Specialist Nurses
Jinyu YANG, Yingmei LI, Lan YAO
2024, 45(11): 73-80. doi: 10.12259/j.issn.2095-610X.S20241111
Abstract(352) HTML PDF(10)
Abstract:
Objective To investigate the current situation of medical cooperation and nurses' work engagement of dental specialty nurses in Yunnan province, and to explore the impact of medical cooperation on the work engagement of dental specialty nurses. Meth...
A Two Sample Mendelian Randomization Study on Nut Intake and Chronic Obstructive Pulmonary Disease
Su ZHANG, Zheng HUANG, Na LI, Jing XU, Yiting TAO
2024, 45(11): 81-86. doi: 10.12259/j.issn.2095-610X.S20241112
Abstract(354) HTML PDF(11)
Abstract:
Objective To explore the causal relationship between nut intake and chronic obstructive pulmonary disease by two-sample Mendelian randomization method. Methods SNP loci closely related to nut intake was extracted from the summarized large sample ope...
Clinical Research
Analysis of Risk Factors for Co-Infection of Ulcerative Colitis with Epstein-barr Virus and Cytomegalovirus
Meizi RAO, Xinyi JIANG, Jiarong MIAO
2024, 45(11): 87-94. doi: 10.12259/j.issn.2095-610X.S20241113
Abstract(565) HTML PDF(11)
Abstract:
Objective To analyze the risk factors of EB virus (EBV) and cytomegalovirus (CMV) infections in patients with ulcerative colitis (UC) and their relationship with drug efficacy. Methods A retrospective analysis was conducted on clinical data from 280 ...
Effect of Dapagliflozin on Cardiac Structure and Function in Patients with Heart Failure Due to Mildly Reduced Ejection Fraction
Mengdan XU, Hong XIANG, Xiaolong GAO, Jin ZHANG, Haiyan WU, Lilin WANG
2024, 45(11): 95-102. doi: 10.12259/j.issn.2095-610X.S20241114
Abstract(307) HTML PDF(19)
Abstract:
Objective To investigate the effects of dapagliflozin on cardiac structure and function in patients with heart failure due to mildly reduced ejection fraction. Methods Patients diagnosed with heart failure due to mildly reduced ejection fraction in ...
Diagnosis and Treatment of 11 Cases of Primary Hepatic Neuroendocrine Tumors
Jiong LUO, Jifeng SU, Lin WANG
2024, 45(11): 103-109. doi: 10.12259/j.issn.2095-610X.S20241128
Abstract(2089) HTML PDF(12)
Abstract:
Objective To summarize the case data of patients with primary liver neuroendocrine tumors (PHNET) and analyze their clinical characteristics, imaging manifestations, pathological characteristics, and diagnosis and treatment status so as to improve th...
The Correlation of Iron Metabolism Indexes,Cytokines,and Liver Function in Patients with Hemophagocytic Syndrome
Fen LI, Jie ZHAO, Haixi ZHANG, Lin ZHANG, Xuezhong GU
2024, 45(11): 110-116. doi: 10.12259/j.issn.2095-610X.S20241115
Abstract(339) HTML PDF(11)
Abstract:
Objective To investigate preliminarily the causes of elevated ferritin in patients with hemophagocytic syndrome by analyzing the iron metabolism indexes, liver function and cytokine levels. Methods 41 patients with the hemophagocytic syndrome and an...
ORM1 Effect on Sphingolipid Metabolism in Dry Eye via SPTLC1
Yunyun LI, Ning CHANG, Yuru ZHAI
2024, 45(11): 117-124. doi: 10.12259/j.issn.2095-610X.S20241116
Abstract(228) HTML PDF(13)
Abstract:
Objective To study the effect of ORM1 on sphingolipid metabolism in dry eye via SPTLC1 so as to provide a new research direction for the pathogenesis of dry eye. Methods By the subcutaneous injection of scopolamine hydrobromide (SCOP), a dry eye mod...
The Effects of NLR,PLR,and FRA in Peripheral Blood on Normal Bone Mass and Bone Loss after Fractures
Jingyu YAO, Rui WEI, Lin ZHANG, Shengliu SHI, Peng BAI
2024, 45(11): 125-129. doi: 10.12259/j.issn.2095-610X.S20241117
Abstract(270) HTML PDF(6)
Abstract:
Objective To investigate the effects of neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and fibrin/albumin ratio in systemic inflammatory markers on bone loss and normal bone function after fractures. Methods A retrospective study was conduc...
The Analysis of Biochemical Indexes of Bone Metabolism and Influencing Factors in 6462 Adult Population in Kunming Area
Wenping SHAO, Ying ZHAO, Xin LI, Ruizhu TANG
2024, 45(11): 130-136. doi: 10.12259/j.issn.2095-610X.S20241118
Abstract(317) HTML PDF(7)
Abstract:
Objective To investigate the relationship between the biochemical indexes of bone metabolism and gender, age and season in adult residents. Methods The data of 6462 cases of physical examination in the physical examination center of the First Affili...
The Clinical Features and Antibiotic Selection in Children with Acute Leukemia Complicated by Bloodstream Infections from Multidrug-Resistant Bacteria
Jianming SUN, Yuan LI, Qin SU
2024, 45(11): 137-143. doi: 10.12259/j.issn.2095-610X.S20241119
Abstract(363) HTML PDF(17)
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Objective To investigate the clinical features, independent risk factors, and antibiotic selection in children with acute leukemia complicated by multidrug-resistant (multiple resistant bacteria, MDR) bloodstream infections. Methods A retrospective ...
The Clinical Effect of Compound Multi-point Optical Defocusing Lens on Myopia Progression in Children
Jiarui LIANG, Xiaofan ZHANG, Li CHEN, Jieying ZHANG, Liping XUE, Min HU, Yuan ZHOU
2024, 45(11): 144-148. doi: 10.12259/j.issn.2095-610X.S20241120
Abstract(748) HTML PDF(27)
Abstract:
Objective To observe the effect of the delay of myopia in children wearing composite multi-point optical defocusing lens. Methods A total of 52 cases (n = 104) of monocal lens wearers were selected as the control group, and 78 cases (n = 156) of com...
AIDS Research
Analysis of the Current Status and Influencing Factors of Metabolic Syndrome in Patients Undergoing Antiretroviral Therapy for AIDS
Bo TIAN, Yongmei JIN, Haiwen LI, Chongxi LI, Wei ZHANG, Wei GUAN, Haiyun CHEN, Qi XUE, Huirong YANG, Jun LIU
2024, 45(11): 149-154. doi: 10.12259/j.issn.2095-610X.S20241121
Abstract(531) HTML PDF(6)
Abstract:
Objective To investigate the current status of metabolic syndrome (MS) in ART patients and analyze its influencing factors. Methods Data from 1972 ART patients were collected and the prevalence of MS was determined according to the diagnostic guidel...
Reviews
Research Progress in the Treatment of Diabetes Mellitus with Cardiovascular Complications with Sacubitril Valsartan
Lin CHEN, Xin NIAN, Hongyan CAI
2024, 45(11): 155-160. doi: 10.12259/j.issn.2095-610X.S20241101
Abstract(339) HTML PDF(23)
Abstract:
Diabetes often coexists with cardiovascular complications, which are also a common cause of death in diabetes patients. Therefore, in addition to improving glucose metabolism, it is also necessary to control cardiovascular complications in diabetes p...
The Role of DDX46 in the Occurrence And Development of Malignant Tumors
Yu HUO, Yunhe JU, Yutao WANG, Yalin ZENG, Junfeng LIANG
2024, 45(11): 161-165. doi: 10.12259/j.issn.2095-610X.S20241123
Abstract(268) HTML PDF(18)
Abstract:
With the deepening development of molecular biology, people's understanding of the mechanisms of cancer occurrence is becoming increasingly profound. In recent years, DDX46 has been found to be overexpressed in various cancers such as colorectal canc...
Teaching Research
Interventional Study on the Teaching Effectiveness of Undergraduate Academic Mentors Based on CE Evaluation Index System
Baochun TANG, Xiaoling WEN, Li HUANG, Wei ZOU, Xiaoqing ZHANG
2024, 45(11): 166-173. doi: 10.12259/j.issn.2095-610X.S20241124
Abstract(688) HTML PDF(10)
Abstract:
Objective To explore the intervention effect of an evaluation index system based on the comprehensive evaluation (CE) on undergraduate academic mentorship. Methods Delphi method and Analytic Hierarchy Process were used to determine the evaluation in...
Nursing Forum
The Health Education Based on Cognitive Behavioral Therapy in Patients with Colorectal Cancer during the Chemotherapy Intervals and Its Application in the Virtual Community Nursing
Yiling ZUO, Jiayan SUN, Limei MING, Guilan ZHANG, Yunxia SHEN, Xiaolin ZHANG
2024, 45(11): 174-180. doi: 10.12259/j.issn.2095-610X.S20241125
Abstract(519) HTML PDF(17)
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Objective To investigate the effect of health education under the guidance of cognitive behavioral therapy in the virtual community care of patients with colorectal cancer chemotherapy intermittent. Methods 74 colorectal cancer patients who underwen...
Construction and Application of PBL Combined with Scenario Simulation in GTCS Nursing Emergency Training
Yanbei CHEN, Ping YAO, Xiaoli PAN, Yaodong FAN, Yan DONG, Jinyong LONG, Huatao NIU
2024, 45(11): 181-185. doi: 10.12259/j.issn.2095-610X.S20241126
Abstract(264) HTML PDF(11)
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Objective To study the construction and application effect of PBL teaching model combined with the scenario simulation teaching method in the nursing first aid course for generalized tonic-clonic seizure (GTCS) attacks. Methods A total of 120 nursin...
The Application of Parallel Medical Record Writing in Nursing Practice Teaching
Yun TIAN, Yumei ZHOU, Juanjuan LIN, Limin XING, Linjun ZHANG, Shuping GAO
2024, 45(11): 186-190. doi: 10.12259/j.issn.2095-610X.S20241127
Abstract(330) HTML PDF(7)
Abstract:
Objective To explore the application effect of parallel medical record writing in practice teaching of nursing students. Methods From September 2021 to February 2022, 58 nursing students who practiced in a Grade A hospital in Xiangyang City were sel...