2024 Vol. 45, No. 12

Expert Forum
The Effects of Caloric Restriction and Intermittent Fasting on Inflammation and Metabolic Diseases
Xibing Zhang, Ling Niu, Fang Liu, Jianghua Ran
2024, 45(12): 1-9. doi: 10.12259/j.issn.2095-610X.S20241201
Abstract(565) HTML PDF(31)
Abstract:
Caloric restriction (CR) and intermittent fasting (IF) are two dietary intervention strategies that have garnered increasing attention for their potential role in regulating inflammation and metabolic disorders. With the widespread adoption of high-c...
Original Articles Basic of Medicine
Therapeutic Effect and Mechanism of Geraniin on Experimental Osteoporotic Fracture in Rabbits
Ning AN, Guang Liu, AiYun WANG, YangJin PAN, Ming ZHANG, Zhuo YU, Peng Chen
2024, 45(12): 10-18. doi: 10.12259/j.issn.2095-610X.S20241202
Abstract(304) HTML PDF(12)
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Objective To study the therapeutic effect and mechanism of geraniin on experimental osteoporotic fracture (OPF) in rabbits. Methods Rabbits were randomly divided into sham operation group, model group, different doses of geraniin groups ( 20, 10, 5 ...
Inhibitory Effect of Crocin on Pituitary Adenomas via IRF7/NF-κB Signaling Pathway
Zhuohui LIU, Shiyin QIN, Hexiang ZHAO, Fengfeng JIA, Biao RUAN, Ruiqing LONG
2024, 45(12): 19-27. doi: 10.12259/j.issn.2095-610X.S20241203
Abstract(251) HTML PDF(7)
Abstract:
Objective To explore the role and mechanism of crocin in pituitary adenoma (PA) through clinical samples and related molecular biology experiments of HP75 cells. Methods From June 2022 to May 2023, 16 PA samples were collected from the Second Depart...
A Comparative Study on the Establishment of Animal Models of Chronic Renal Failure by Two Methods
Yiting TAO, Ge BAI, Dan YU, Zhu ZHOU, Miao LI
2024, 45(12): 28-34. doi: 10.12259/j.issn.2095-610X.S20241204
Abstract(340) HTML PDF(7)
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Objective To investigate the stability of the two kinds of rat models of chronic renal failure, aiming to provide a basis for establishing a feasible and stable animal model of chronic renal failure. Methods The rat model of chronic renal failure wa...
Uncertainty Evaluation of the Determination of the Content of Ambroxol Hydrochloride Injection by Using TOP-DOWN Method and GUM Method
Yongfei LI, Yunhua ZHANG, Wenfen GAO, Jihua LIU, Anbin LIU, Yuena YANG
2024, 45(12): 35-41. doi: 10.12259/j.issn.2095-610X.S20241205
Abstract(175) HTML PDF(6)
Abstract:
Objective By assessing the uncertainty of the determination results for the concentration of ambroxol hydrochloride injection, the reliability of the concentration measurement results is improved, ensuring the safety and efficacy of high-risk dosage ...
Expression of Zinc Finger Transcription Factor Sall4 In Pancreatic Cancer and Its Impact on Cell Invasion and Migration
Qingbin ZENG, Rong XU, Wenzhi DONG, Zhijian CHEN, Weiran LIAO, Kui LONG
2024, 45(12): 42-48. doi: 10.12259/j.issn.2095-610X.S20241206
Abstract(185) HTML PDF(7)
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Objective To investigate the expression of spalt like transcription factor 4 (Sall4) in pancreatic cancer tissues and its clinical significance, as well as the impact of inhibiting its gene expression on the migration and invasion of pancreatic cance...
Prediction of Psoriasis and Potential Treatment of Traditional Chinese Medicine Based on Reverse Network Pharmacology Analysis
Yanhong YANG, Juan HE, Shan JIN, Piaopiao YE, Xin LI, Li QIAO
2024, 45(12): 49-57. doi: 10.12259/j.issn.2095-610X.S20241207
Abstract(608) HTML PDF(44)
Abstract:
Objective To study the pathogenesis of psoriasisand and to provide new research ideas and directions for the prevention and treatment of psoriasis. Methods Psoriasis-related genes were obtained from genecards and NCBI databases, and intersection gen...
Clinical Research
A Study on the Related Factors of Atrial Fibrillation in Patients with Type 2 Diabetes
Wanshu LIU, Furong DENG, Ping YANG, Xin TIAN, Guangli ZHOU, Lingmin ZHAO, Xueting ZHANG, Keyi ZHANG
2024, 45(12): 58-64. doi: 10.12259/j.issn.2095-610X.S20241208
Abstract(262) HTML PDF(15)
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Objective To investigate the factors associated with atrial fibrillation(AF) in patients with Type 2 Diabetes Mellitus (T2DM). Methods Through a case-control study, We selected 688 patients with T2DM who were hospitalized at the First Affiliated Hos...
Analysis on the Expression of Basement Membrane Protein in Endometrial Carcinoma and Its Relationship with Immune Invasion
Ying ZHANG, Xiangru LUO, Xing WANG, Pan ZHAO, Kun LIAN, Yuanqin LI, Mingkun SHAO
2024, 45(12): 65-74. doi: 10.12259/j.issn.2095-610X.S20241209
Abstract(236) HTML PDF(9)
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Objective Immune infiltration, as well as their implications across various cancers, and to establish a clinical prognostic model based on the findings. Methods The expression profile and clinical information of endometrial cancer tissue and adjacent...
Clinical Analysis of the Spectrum of Upper Gastrointestinal Diseases in 424 Cases of Children in A Tertiary Hospital in Kunming
Yanjuan CHEN, Wanrong LUO, Ruixue MA, Yilin DAI, Guixian LI, Yunfen TIAN
2024, 45(12): 75-80. doi: 10.12259/j.issn.2095-610X.S20241210
Abstract(212) HTML PDF(6)
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Objective To investigate the clinical features of the spectrum of upper gastrointestinal diseases in children and to provide assistance in the prevention, diagnosis and treatment of upper gastrointestinal diseases in children. Methods Clinical data ...
An Analysis of the Efficacy of Geriatric Interdisciplinary Team Services for Elderly Patients with Multimorbidity with Malnutrition
Yuwen LIU, Limei ZHANG, Yongli WANG, Xiaomei XU, Yadan MU, Zhijie YANG, Shuting YANG, Fengyun LUO
2024, 45(12): 81-87. doi: 10.12259/j.issn.2095-610X.S20241211
Abstract(257) HTML PDF(9)
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Objective To explore the efficacy of the geriatric interdisciplinary team (GIT) service for elderly patients with multimorbidity and malnutrition. Methods We selected 109 elderly patients with diabetes mellitus (DM), chronic obstructive pulmonary di...
Analysis of Influencing Factors of Perceived Discrimination in HIV-infected Patients Treated with Antiviral Therapy
Hongrui ZHAO, Xuelin XIANG, Zhongjie WANG, Yu XIA, Huadan WANG, Min MA, Liping HE
2024, 45(12): 88-93. doi: 10.12259/j.issn.2095-610X.S20241212
Abstract(1738) HTML PDF(10)
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Objective To investigate the status of perceived discrimination among HIV-infected people receiving antiviral treatment and analyze its influencing factors, so as to provide reference for reducing discrimination and improving the life quality of HIV-...
The Prognostic Value of Preoperative Peripheral Blood Inflammatory Markers Combined with Tumor Markers in Resectable Colon Cancer Patients
Bowen TAN, Yun LIANG, Huan CHEN, Yi LEI, Yuhan WANG, Yan TIAN
2024, 45(12): 94-98. doi: 10.12259/j.issn.2095-610X.S20241213
Abstract(448) HTML PDF(16)
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Objective To analyze the prognostic value of preoperative peripheral blood inflammatory markers neutrophil to lymphocyte ratio (NLR) combined with tumor markers carcinoembryonic antigen (CEA) and glycoprotein antigen CA19-9 in patients with colon can...
Clinical Study Based on DR Imaging Measurement of Ulnar Coronoid Process
Sixue PAN, Huixian CHEN, Shuai CHEN, Guangxiong HE, Kang ZHU, Chaoyu BAO
2024, 45(12): 99-104. doi: 10.12259/j.issn.2095-610X.S20241214
Abstract(1145) HTML PDF(9)
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Objective To explore the influence of different factors on the safe screw placement of the ulnar coronoid process based on the DR imaging measurement of the ulnar coronoid process. Methods During the period from July 2020 to November 2021, 102 norma...
Bioinformatics-Based Analysis of the Roles of MX1IFI44, and STAT1 in Lupus Nephritis
Daolin CUI, Chunli CHEN, Zhenghong ZHOU, Lei GONG
2024, 45(12): 105-114. doi: 10.12259/j.issn.2095-610X.S20241215
Abstract(261) HTML PDF(8)
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Objective To identify potential biomarkers associated with LN, with the goal of improving early diagnosis, disease monitoring, and the development of more precise treatment strategies. Methods Gene expression data were downloaded from the Gene Expre...
Study on the Correlation Between Multiple Drug Resistance of Acinetobacter baumannii with Efflux Pump and Biofilm Formation
Jia WANG, Lei FENG, Yulei ZHENG, Yong YUAN, Yao YAO, Zidan HU, Ni SHEN, Yan YU, Jiawei DING
2024, 45(12): 115-121. doi: 10.12259/j.issn.2095-610X.S20241216
Abstract(432) HTML PDF(14)
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Objective To investigate the correlation between biofilm gene, efflux pump gene, biofilm forming ability and drug resistance of Acinetobacter baumarmii (AB) isolated from the patients of clinical infectious diseases. Methods A total of 119 non-repea...
The Relationship between Peripheral Blood Immunoglobulin,Erythrocyte Sedimentation Rate,Homocysteine and the Degree of Central Nervous System Vasculitis in Children and Their Influence on Prognosis
Xinyi MEN, Jing ZHAO, Yongchun SHEN, Hui JI, Xiuxia WANG
2024, 45(12): 122-128. doi: 10.12259/j.issn.2095-610X.S20241217
Abstract(574) HTML PDF(7)
Abstract:
Objective To investigate the relationship between peripheral blood immunoglobulin, erythrocyte sedimentation rate (ESR), homocysteine (Hcy) and the severity of central nervous system vasculitis (CNSV) in children, as well as its impact on prognosis. ...
Early Predictive Value of Lymphocyte Subsets for Cognitive Dysfunction in Cerebral Ischemia-reperfusion Injury
Jibo QU, Ling ZHU, Binghui HOU, Song BAI, Anmu XIE
2024, 45(12): 129-134. doi: 10.12259/j.issn.2095-610X.S20241218
Abstract(177) HTML PDF(7)
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Objective To explore the early predictive value of lymphocyte subsets for cognitive impairment in cerebral ischemia-reperfusion injury. Methods A study was conducted on 68 patients with cerebral ischemia admitted to Honghe Hospital affiliated to Kun...
The Predictive Value of sFlt-1,SDC4,and sST2 on the Therapeutic Effect of Children with Purpuric Nephritis
Xiaoling YANG, Zhen LIU, Yu WANG, Jing WANG
2024, 45(12): 135-140. doi: 10.12259/j.issn.2095-610X.S20241219
Abstract(815) HTML PDF(4)
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Objective To investigate the correlation between the levels of soluble vascular endothelial growth factor receptor-1 (sFlt-1), polyligand proteoglycan-4 (SDC4), soluble human stromal lysin 2 (sST2) in serum and renal histopathological grading in chil...
Clinical Application of Single-port Laparoscopic Salpingectomy with Preserved Salpingum Mesothelium and its Influence on Ovarian Reserve Function and Assisted Pregnancy Outcome
Liru QU, Jianping QIU, Ningning ZHANG, Xinxin CHENG, Jiancheng YANG, Xiaoyan ZHANG
2024, 45(12): 141-146. doi: 10.12259/j.issn.2095-610X.S20241220
Abstract(1148) HTML PDF(12)
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Objective To explore the clinical application of salpingectomy with preserving salpingum mesothelium under single-port laparoscopy and its influence on ovarian reserve function and assisted pregnancy outcome. Methods From January 2019 to January 202...
Correlation between Serum Levels of Anti-HBC,CHE,and Apolipoprotein AI and the Development of Viral Hepatitis
Su XU, Yuqing LIU, Xingwang ZHENG
2024, 45(12): 147-152. doi: 10.12259/j.issn.2095-610X.S20241221
Abstract(183) HTML PDF(5)
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Objective To investigate the correlation between serum hepatitis B core anbody (anti-HBC), cholinesterase (CHE) and apolipoprotein AI (ApoAI) and the development of viral hepatitis. Methods 388 patients with viral hepatitis admitted to Nanjing Pukou...
Analysis of the Predictive Effects of Lipid Metabolism and Liver Function Indicators on Prediabetes
Yanfen MA, Sasa LIU, Jian HU, Depei CAI, Yongfeng QIAO, Xiaoqin WANG
2024, 45(12): 153-159. doi: 10.12259/j.issn.2095-610X.S20241222
Abstract(302) HTML PDF(11)
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Objective To study the relationship between lipid metabolism and liver function indexes in prediabetic population, and explore the predictive value of these indexes for prediabetes. Methods 546 patients with prediabetes who underwent physical examin...
Reviews
The Role of Intestinal Flora and Its Metabolites in The Development of Atherosclerosis
Aiyun WANG, Yuting WANG, Jing CAI, Ruoyan NI, Caiying LUO, Zhuo YU, Peng CHEN
2024, 45(12): 160-166. doi: 10.12259/j.issn.2095-610X.S20241223
Abstract(296) HTML PDF(20)
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Intestinal flora and their metabolites play an important role in the occurrence and development of cardiovascular diseases such as atherosclerosis (AS), and have become an important target for the prevention and treatment of AS. In this paper, we foc...
Pruritus in Keloid:Pathogenesis and Treatments
Yichao JIN, Xiaochuan WANG, Chunping AO, Liangheng XU
2024, 45(12): 167-171. doi: 10.12259/j.issn.2095-610X.S20241224
Abstract(331) HTML PDF(19)
Abstract:
Keloids are benign skin lesions that form during the wound healing process due to abnormal proliferation of fibroblasts and excessive extracellular matrix deposition. It is reported that 86% of keloid patients experience pruritus; however, the sympto...
Teaching Research
Application of “Learning by Doing” in the Teaching of Obstetrics and Gynecology Nursing for Undergraduate Nursing Students
Ying ZHU, Nu er da wu lie ti BAI YI LA·, Qingqing NIE, Ha si mu MAI WU LU DAI·, Zhenli WANG
2024, 45(12): 172-177. doi: 10.12259/j.issn.2095-610X.S20241225
Abstract(227) HTML PDF(11)
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Objective To explore the application of the "learning by doing" learning theory and methods in the teaching of Obstetrics and Gynecology Nursing for undergraduate nursing students. Method By setting up an experimental group of 151 students and a con...
Nursing Forum
A Survey on the Current Situation of Demand for Extended Nursing Services for Newborns after Discharge
Ting HU, Luyao WANG, Jing LIANG, Jing ZHANG, Jiao LENG, Xiufang LI
2024, 45(12): 178-184. doi: 10.12259/j.issn.2095-610X.S20241226
Abstract(177) HTML PDF(6)
Abstract:
Objective To investigate the current demand for extended nursing services for newborns after discharge. Methods A survey was conducted on the demand for extended nursing services after discharge of newborns using the "Survey Form for Demand for Exten...