2024 Vol. 45, No. 4

Expert Forum
Intestinal Microecological Changes and Therapeutics in Inflammatory Bowel Disease
Bo LI, Yang SUN, Yinglei MIAO
2024, 45(4): 1-8. doi: 10.12259/j.issn.2095-610X.S20240401
Abstract(2122) HTML PDF(44)
Abstract:
Inflammatory bowel disease (IBD) is a chronic condition characterised by recurrent inflammation of the intestines. Although the specific causes is not fully understood, it is generally believed to be caused by a combination of genetic factors, immune...
Original Articles Basic of Medicine
Correlation between Epithelial Cell Related Genes and Prognosis of Patients with Ovarian Cancer based on Single Cell Sequencing
Lizhu ZHAO, Ying DONG, Yue DENG, Lihua YANG
2024, 45(4): 9-16. doi: 10.12259/j.issn.2095-610X.S20240402
Abstract(1149) HTML PDF(38)
Abstract:
Objective To construct a polygenic risk score based on the expression of epithelial cell markers to evaluate the prognosis of patients with ovarian cancer. Methods The single cell sequencing data of ovarian cancer were reduced and clustered to ident...
Construction of Lipid Metabolism-Related Gene Prognostic Model and Immunoinfiltration Analysis of Ovarian Cancer
Xingfen WANG, Yue DENG, Lihua YANG
2024, 45(4): 17-25. doi: 10.12259/j.issn.2095-610X.S20240403
Abstract(920) HTML PDF(28)
Abstract:
Objective To construct a lipid metabolism-related prognostic model for ovarian cancer (OC), and to investigate the role of lipid metabolism-related biomarkers and the degree of immune cell infiltration in prognosis prediction of OC. Methods Transcri...
Comparative Study on Transdermal Absorption of Bulleyaconitine A in Four Skin Barrier Models of Rabbits
Peipei ZHANG, Jiali CUI, Hongbin LIU, Dangzhu TANG, Yan YANG, Deguang Li
2024, 45(4): 26-34. doi: 10.12259/j.issn.2095-610X.S20240404
Abstract(779) HTML PDF(9)
Abstract:
Objective To compare the transdermal absorption of Bulleyaconitine A on normal rabbit intact skin, normal rabbit damaged skin, pathological damaged normal skin, and pathological damaged injured skin barrier models in vivo. Methods The rabbit model ...
Overexpression of ZIC1 Gene Inhibits Proliferation of Pleural Mesothelioma Cells by Activating P53 Signaling Pathway
Yongjun DENG, Qian CHEN, Jianbin ZOU, Zheng GONG, Huanpeng LIU
2024, 45(4): 35-40. doi: 10.12259/j.issn.2095-610X.S20240405
Abstract(837) HTML PDF(15)
Abstract:
Objective To investigate the effect of cerebellar zinc finger structure 1 (ZIC1) gene overexpression on the proliferation and apoptosis of pleural mesothelioma cells (SMC-1 cells) and the corresponding molecular mechanism. Methods SMC-1 cells were t...
Evaluation of Patient-Reported Outcome Scale for Chronic Gastritis based on SEM Model
Qiuju MIAO, Yuanling CHEN, Na LUO, Xin SHI, Ruiyu LI, Ting SONG, Ying CHEN
2024, 45(4): 41-48. doi: 10.12259/j.issn.2095-610X.S20240406
Abstract(863) HTML PDF(10)
Abstract:
Objective To test the reliability and validity of the Chronic Gastritis Patient Reported Outcomes(PROISCD-CG) scale, and to provide the scientific basis for evaluating the reported outcomes of chronic gastritis patients. Methods A questionnaire surv...
Screening Myopia Rate among Primary and Secondary School Students in Lijiang and Dali during the COVID-19 Epidemic
Xixi LI, Zixue MA, Jie XIAO, Peiqian LI, Xueni XIE, Jinjiao ZHANG, Xiao LUO, Ying HUANG
2024, 45(4): 49-56. doi: 10.12259/j.issn.2095-610X.S20240407
Abstract(1658) HTML PDF(9)
Abstract:
Objective To analyze the 2-year screening myopia rate in Lijiang City and Dali City during the COVID-19 pandemic and analyze the related influencing factors of myopia. Methods A total of 774 students were randomly selected as the research subjects. ...
Association between Myeloperoxidase-463G/A Gene Polymorphism and Essential Hypertension in Yi Nationality
Chengya MA, Jiang YANG, Xi CHEN, Xi XU, Pixuan YIN, Xin SHU, Hongyu PENG, Zhixiang FAN, Li LONG
2024, 45(4): 57-61. doi: 10.12259/j.issn.2095-610X.S20240408
Abstract(1533) HTML PDF(16)
Abstract:
Objective To study the correlation between the polymorphism of myeloperoxidase-463G/A gene and essential hypertension of Yi nationality in Yunnan Province. Methods The PCR-RFLP technique was used to detect the MPO-463G/A gene polymorphism in 86 Yi h...
An Investigative Study of Depression-Anxiety-Stress Situation and its Influencing Factors among Dental Interns
Linqing TIAN, Wenli ZHANG, Shuhui WANG, Lin DAI, Lin ZENG, Xun SHENG
2024, 45(4): 62-66. doi: 10.12259/j.issn.2095-610X.S20240409
Abstract(1172) HTML PDF(13)
Abstract:
Objective To investigate the occurrence and related factors of depression, anxiety, and stress among oral medicine interns during their internship. Methods Using the DASS-21 scale, a survey was conducted among 120 undergraduate oral medicine student...
Clinical Research
Efficacy and Safety of Bevacizumab Combined with Temozolomide for Recurrent High-Grade Glioma
Dongyan YANG, Hua LIN, Yuxiao ZHANG, Kunying ZHAO, Lirong XIANG, Shuda YANG, Weiyan HU
2024, 45(4): 67-73. doi: 10.12259/j.issn.2095-610X.S20240410
Abstract(859) HTML PDF(23)
Abstract:
Objective To explore the short-term efficacy, safety, and prognostic factors affecting the overall survival (OS) of patients with recurrent high-grade glioma (HGG) treated with bevacizumab (BEV) alone and bevacizumab in combination with temozolomide ...
Real-World Clinical Efficacy and Safety of Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIC/FTC/TAF) Single-Tablet Regimen
Fen TENG, Bo TIAN, Chongxi LI, Yongmei JIN, Haiyun CHEN, Jun LIU
2024, 45(4): 74-80. doi: 10.12259/j.issn.2095-610X.S20240411
Abstract(1782) HTML PDF(17)
Abstract:
Objective To analyze the efficacy and safety of the three-in-one single-tablet regimen of bictegravir/emtricitabine/tenofovir alafenamide(BIC/FTC/TAF) in AIDS patients. Methods Newly treated patients who received a single tablet combination(BIC/FTC/...
Efficacy and Safety of Jingangteng Capsules Combined with Antimicrobial Drugs in the Treatment of Chronic Pelvic Inflammatory Disease: A Meta-analysis
Xing LIU, Weixian LI, Yan WU, Xuejiao WU, Xiaodie YAO, Jie CHEN, Lingjun SHEN, Hao FAN
2024, 45(4): 81-91. doi: 10.12259/j.issn.2095-610X.S20240412
Abstract(953) HTML PDF(8)
Abstract:
Objective To systematically evaluate the efficacy and safety of Jingangteng capsule combined with antibiotics in the treatment of chronic pelvic inflammatory disease. Methods Randomized controlled trials (RCTs) of Jingangteng capsule combined with a...
Cost-Effectiveness Analysis of Nilotinib Versus Dasatinib as Second-Line Treatment of Chronic Myeloid Leukemia
Ling MA, Yanhong ZHAO, Jia LIU, Wenlian TU
2024, 45(4): 92-98. doi: 10.12259/j.issn.2095-610X.S20240413
Abstract(878) HTML PDF(9)
Abstract:
Objective To evaluate the cost-effectiveness of nilotinib versus dasatinib in the second-line treatment of Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase. Methods Establish a Markov model for cost-effectiveness analysis, ...
Analysis of Coagulation Function Indexes in Elderly Patients with Novel Coronavirus Pneumonia
Haiping HE
2024, 45(4): 99-104. doi: 10.12259/j.issn.2095-610X.S20240414
Abstract(779) HTML PDF(10)
Abstract:
Objective To explore the clinical significance of coagulation function indexes in the diagnosis and treatment of elderly patients with novel coronavirus pneumonia. Methods This study retrospectively analyzed 68 elderly patients with novel coronaviru...
Effects of AVAPS-AE Mode of Non-invasive Ventilation on PSG Parameters,ESS Score and Comfort in Patients with AECOPD and OSA
Maoliang TIAN, Boxue HAN, Jiamei WANG, Zheng ZONG, Zhiping DENG
2024, 45(4): 105-112. doi: 10.12259/j.issn.2095-610X.S20240415
Abstract(801) HTML PDF(15)
Abstract:
Objective To investigate the effects of non-invasive ventilation in mean volumetric pressure support and automatic expiratory pressure (AVAPS-AE) mode on multichannel sleep monitoring (PSG) parameters, Epworth sleepiness Scale (ESS) score and comfort...
Application of Endoscope and Microscope in Tympanoplasty for Middle-aged and Young Patients with CSOM
Wei DAI, Chuan HU
2024, 45(4): 113-119. doi: 10.12259/j.issn.2095-610X.S20240416
Abstract(749) HTML PDF(6)
Abstract:
Objective To explore the application of otoscopic and microscopic tympanoplasty in the treatment of chronic suppurative otitis media (CSOM) in young and middle-aged patients, and provide a reference for clinical treatment. Methods A total of 104 yo...
Effect of Precise Hepatic Pedicle Dissection Assisted Laparoscopic Hepatectomy and Its Impact on Inflammatory Immune Stress and Liver Function
Lei CHEN, Tong TANG, Daizhong ZHANG, Fengling LIU, Zhongqiu YANG, Huan YAN
2024, 45(4): 120-127. doi: 10.12259/j.issn.2095-610X.S20240417
Abstract(929) HTML PDF(11)
Abstract:
Objective To explore the effect of precise liver pedicle dissection technique assisted laparoscopic hepatectomy on inflammatory immune stress and liver function. Methods A total of 114 patients with primary liver cancer in Dazhou Central Hospital fr...
Changes of Immunoglobulin in TACE Treatment of Hepatocellular Carcinoma and Its Value in Predicting Curative Effect
Lanzhu YAN, Shunyi QIAO, Yanli ZHANG, Erqiang ZHAO, Hu YANG, Jing LIN, Haiyan FU
2024, 45(4): 128-134. doi: 10.12259/j.issn.2095-610X.S20240418
Abstract(1552) HTML PDF(12)
Abstract:
Objective To analyze the changes of immunoglobulin (Ig) during the process of transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) and predict the value of treatment efficacy. Methods A total of 100 HCC patients in Hebei...
Comparison of Clinical Efficacy of Single-port and Double-port Video-assisted Thoracoscopic Lobectomy in the Treatment of Lung Cancer
Hongbo ZHANG, Zhenlong LI, Ying LV, Yichao ZHANG, Xiangming QIU, Tingting HUANG
2024, 45(4): 135-139. doi: 10.12259/j.issn.2095-610X.S20240419
Abstract(898) HTML PDF(9)
Abstract:
Objective To investigate the clinical efficacy of single-port and double port video-assisted thoracoscopic lobectomy in the treatment of lung cancer. Methods Patients who underwent thoracoscopic lobectomy in Beijing Armed Police Corps Hospital from ...
Correlation between Gut Microbiota,Serum ET,PCT Levels with the Severity and Prognosis of Sepsis
Junjie NIU, Wenjuan JI, Zhuaizhuai YU
2024, 45(4): 140-145. doi: 10.12259/j.issn.2095-610X.S20240420
Abstract(877) HTML PDF(12)
Abstract:
Objective To investigate the correlation between the levels of intestinal flora, serum endotoxin (ET), and procalcitonin (PCT) in patients with sepsis and their disease severity and prognosis. Methods A total of 373 patients with sepsis in Jincheng ...
A Clinical Study of Vonoprazan Fumarate Tablets for the Treatment of Non-erosive Reflux Disease
Xiaoyun LI, Jiahao LIU, Weiwei ZHANG, Rongjian CAO, Yan LIU, Zhenguang QI
2024, 45(4): 146-151. doi: 10.12259/j.issn.2095-610X.S20240421
Abstract(1481) HTML PDF(25)
Abstract:
Objective To study the efficacy and adverse reactions of vonoprazan fumarate tablets and esomeprazole magnesium enteric-coated tablets in the treatment of non-erosive reflux disease(NERD). Methods A total of 124 patients with NERD were selected and ...
Risk Factors of Persistent HPV Infection in Patients with Early Cervical Cancer after Operation
Liyan MENG, Chaoqun WANG, Xinghui CHEN, Junjing HE, Yaru NIU, Lisha MA
2024, 45(4): 152-156. doi: 10.12259/j.issn.2095-610X.S20240422
Abstract(875) HTML PDF(8)
Abstract:
Objective To analyze the risk factors of persistent infection of high-risk human papillomavirus after radical hysterectomy for early cervical cancer. Methods A total of 159 early-stage cervical cancer patients who underwent radical hysterectomy or l...
Correlation Analysis of Immune Function of Tuberculosis Patients Infected with COVID-19
Jihong LIU, Zhiqiang MA, Lin WANG, Xiaoyan WANG, Weiguang TIAN, Baoping LI, Rui DONG, Yujia LV
2024, 45(4): 157-162. doi: 10.12259/j.issn.2095-610X.S20240423
Abstract(1585) HTML PDF(12)
Abstract:
Objective To analyze the immunological indicators of TB patients co-infected with COVID-19, clarify their immune status, and explore the relationship and characteristics of relevant indicators with immune status. Methods The study group consisted of...
Clinical Implications of Serum LDH,CysC,and PWR Level Detection in Lung Cancer Patients
Ying WANG, Cong FU, Ying FU
2024, 45(4): 163-169. doi: 10.12259/j.issn.2095-610X.S20240424
Abstract(979) HTML PDF(11)
Abstract:
Objective To investigate the clinical implications of lung function index, serum lactate dehydrogenase(LDH), cysteine protease inhibitor C(CysC) and platelet/white blood cell ratio(PWR) in patients with lung cancer. Methods From January 2023 to Jun...
Correlation between Blood UA,Smad1 Protein,Urine mALB Levels and the Therapeutic Effect of Dapagliflozin in Patients with Type 2 Diabetes Nephropathy
Mengxue LIU, Jia MIAO, Xuehe SHENG
2024, 45(4): 170-176. doi: 10.12259/j.issn.2095-610X.S20240425
Abstract(819) HTML PDF(10)
Abstract:
Objective To observe the levels of uric acid, Smad1 protein, and urine microalbumin in patients with type 2 diabetic nephropathy, and to analyze the correlation between these three factors and the effectiveness of dapagliflozin in treating type 2 dia...
Reviews
Research Advances on Lung Function in Patients Undergone Surgery for Lung Cancer
Ying LUO, Wenxun DONG, Ying CHEN, Xiangxiu TAN
2024, 45(4): 177-183. doi: 10.12259/j.issn.2095-610X.S20240426
Abstract(2053) HTML PDF(36)
Abstract:
After lung cancer surgery, lung function impairment is an unavoidable issue in clinical practice, with factors such as surgical methods, resection sites, and individual differences leading to variations in the extent of lung function loss and recover...
Advances in Endoscopic Thyroid Surgery
Wei WANG, Ruimei SUN
2024, 45(4): 184-191. doi: 10.12259/j.issn.2095-610X.S20240427
Abstract(2045) HTML PDF(30)
Abstract:
Surgery is the main treatment for thyroid cancer, with features good postoperative prognosis, high survival rate, and long life expectancy. With the development of society and medical level, patients not only seek to cure the disease but also have hi...
Teaching Research
Application of “WeChat + Situational Simulation” Interactive Teaching Mode in Nutrition Undergraduate Practical Teaching
Songmei WANG, Yuemei FENG, Shaoxiong WU, Yanxiang GAO, Hongmei PAN, Zhishuang WU, Xian ZHAO
2024, 45(4): 192-196. doi: 10.12259/j.issn.2095-610X.S20240428
Abstract(1763) HTML PDF(15)
Abstract:
Objective To evaluate the effectiveness of the "WeChat + scenario simulation" interactive teaching mode in the practice of nutrition counseling and education, and to provide reference for the cultivation of undergraduate students' competence in the w...
Nursing Forum
Effect and Psychological State of Triangle Hierarchical Management+LEARNS Model for Diabetes Nephropathy
Jing ZHOU, Linling LI, Haihong WANG, Yuqiong YANG
2024, 45(4): 197-202. doi: 10.12259/j.issn.2095-610X.S20240429
Abstract(1674) HTML PDF(13)
Abstract:
Objective To explore the improvement effect of Triangle hierarchical management+LEARNS model on blood sugar level, renal function level and psychological status of patients with diabetes nephropathy in nursing care. Methods A total of 74 diabetic ne...