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RSS2024 Vol. 45, No. 5
2024, 45(5): 1-7.
doi: 10.12259/j.issn.2095-610X.S20240501
Abstract:
Dopamine D1 receptor （DRD1） is currently known as the dopamine receptor subtype with the most widespread expression in the nervous system. DRD1 plays a role in various signaling pathways to perform many functions such as movement, emotion, cognition,...
Dopamine D1 receptor （DRD1） is currently known as the dopamine receptor subtype with the most widespread expression in the nervous system. DRD1 plays a role in various signaling pathways to perform many functions such as movement, emotion, cognition,...
2024, 45(5): 8-15.
doi: 10.12259/j.issn.2095-610X.S20240502
Abstract:
Objective NRAS and MAPK1 genes are important regulators of the Ras/Raf/MEK/ERK signaling pathway, and their functions and expression levels have been associated with a variety of human tumors. This study aims to investigate the correlation between th...
2024, 45(5): 16-22.
doi: 10.12259/j.issn.2095-610X.S20240503
Abstract:
Objective To construct and evaluate the specific CTL cell response induced by HPV16 E6 and E7 multi epitope DNA vaccines and their intervention effects on tumor growth so as to reveal their potential as candidate HPV therapeutic vaccines. Methods The...
2024, 45(5): 23-28.
doi: 10.12259/j.issn.2095-610X.S20240504
Abstract:
Objective To explore the histological and ultrastructural changes in lung tissues of piglets with the early onset scoliosis （EOS） with the combination of thoracic insufficiency syndrome （TIS） before and after the treatment with the growth-friendly te...
2024, 45(5): 29-36.
doi: 10.12259/j.issn.2095-610X.S20240505
Abstract:
Objective To investigate the impact of TRIM48 overexpression on glioma and explore the underlying mechanism. Methods Twelve nude mice were randomly assigned into two groups: one inoculated with U87 glioma cells stably overexpressing TRIM48 （oeTRIM48...
2024, 45(5): 37-43.
doi: 10.12259/j.issn.2095-610X.S20240506
Abstract:
Objective To explore the effect of probiotics interventionon of the expression of Aβ in rats with cerebral ischemia-reperfusion and the protective effect of neurons. Methods Male SD rats were selected as the experimental animals and randomly divided...
2024, 45(5): 44-48.
doi: 10.12259/j.issn.2095-610X.S20240507
Abstract:
Objective To explore the effect of HIF-1α on the migration and invasion of gallbladder cancer cells and its related regulatory mechanism. Methods GBC-SD cells were constructed and transfected with lentivirus, and the experimental group （HIF-1α shRNA...
2024, 45(5): 49-59.
doi: 10.12259/j.issn.2095-610X.S20240508
Abstract:
Objective To identify key HUB genes involved in lung development through transcriptomic sequencing and bioinformatics analysis using tissue samples collected from an established piglet model of early-onset scoliosis with thoracic insufficiency syndro...
2024, 45(5): 60-65.
doi: 10.12259/j.issn.2095-610X.S20240509
Abstract:
Objective To investigate the expression of receptor tyrosine kinase-like orphan rectetpor 1 （ROR1） in invasive lung adenocarcinoma with different histological grades, and to analyze its relationship with histopathological grade of lung adenocarcinoma...
2024, 45(5): 66-72.
doi: 10.12259/j.issn.2095-610X.S20240510
Abstract:
Objective To explore the feasibility of applying the prognosis model based on lysosomal related genes（LRGs） in patients with bladder cancer （BC）. Methods Bladder cancer data were downloaded from The Cancer Genome Atlas （TCGA） program and dataset of ...
2024, 45(5): 73-81.
doi: 10.12259/j.issn.2095-610X.S20240511
Abstract:
Objective To explore the related factors of cognitive impairment after the acute ischemic stroke and develop a clinical nomogram model. Methods 175 patients with the acute ischemic stroke were selected as the study objects, and the cognitive functio...
2024, 45(5): 82-87.
doi: 10.12259/j.issn.2095-610X.S20240513
Abstract:
Objective To investigate the predictive value of systemic inflammatory response index （SIRI） for acute ischemic stroke-associated pneumonia of the brain. Methods The baseline data of patients diagnosed with acute ischemic stroke in the First Affilia...
2024, 45(5): 88-93.
doi: 10.12259/j.issn.2095-610X.S20240514
Abstract:
Objective To evaluate the clinical effect of ultrasound-guided intercostal nerve pulsed radiofrequency on the treatment of postherpetic neuralgia in the upper thoracic segment after herpes zoster infection. Methods A total of 67 patients with posthe...
2024, 45(5): 94-102.
doi: 10.12259/j.issn.2095-610X.S20240515
Abstract:
Objective To evaluate the efficiency of posterolateral approach in the treatment of single-segment nonspecific lumbar spondylodiscitis by observation of the clinical results of posterior lateral percutaneous transforaminal endoscopic debridement （PTE...
2024, 45(5): 103-108.
doi: 10.12259/j.issn.2095-610X.S20240516
Abstract:
Objective To analyze the clinical effects of rapid rehabilitation technology combined with injury control in the rehabilitation of patients with multiple injuries and the occurrence of complications, and to explore the factors affecting the occurrenc...
2024, 45(5): 109-115.
doi: 10.12259/j.issn.2095-610X.S20240517
Abstract:
Objective To investigate the value of Adler grading with color Doppler ultrasound in the diagnosis of cervical cancer, and to analyze its correlation with pathological indexes. Methods 136 patients with cervical cancer in the hospital from January 2...
2024, 45(5): 116-122.
doi: 10.12259/j.issn.2095-610X.S20240518
Abstract:
Objective To analyze the relationship between the level of peripheral blood T lymphocyte subsets and the pathological characteristics of patients with acute myeloid leukemia （AML）, as well as its prognostic value for chemotherapy. Methods A total of...
2024, 45(5): 123-129.
doi: 10.12259/j.issn.2095-610X.S20240519
Abstract:
Objective To explore the clinical epidemiological characteristics and risk factors of systemic inflammatory response syndrome （SIRS） in children with burns, so as to provide a reference for the early diagnosis and prevention of SIRS. Methods A retros...
2024, 45(5): 130-135.
doi: 10.12259/j.issn.2095-610X.S20240520
Abstract:
Objective To analyze the morbidity rate and severity of retinopathy of prematurity （ROP） so as to provide a basis for the clinical prevention and treatment and reduce the severity of ROP. Methods 648 premature infants, including 371 males and 277 fem...
2024, 45(5): 136-143.
doi: 10.12259/j.issn.2095-610X.S20240521
Abstract:
Objective To investigate the clinical characteristics of 53 cases of congenital hyperbilirubinemia （Gilbert syndrome, Crigler-Najjar syndrome） caused by UGT1A1 gene mutation in Yunnan Province and the characteristics of UGT1A1 gene mutation. Methods ...
2024, 45(5): 144-150.
doi: 10.12259/j.issn.2095-610X.S20240522
Abstract:
Objective To investigate the correlation and clinical significance of peripheral blood serum amyloid A （SAA） to C-reactive protein （CRP） ratio （SAA/CRP）, neutrophils lymphocytes ratio （NLR） and HBV-DNA levels and disease severity in patients with chr...
2024, 45(5): 151-156.
doi: 10.12259/j.issn.2095-610X.S20240523
Abstract:
Objective To analyze the effect of bronchoalveolar lavage combined with low molecular weight heparin on the prognosis with prone ventilation due severe pneumonia. Methods 102 patients with the severe pneumonia from hospitals from January 2021 to Jan...
2024, 45(5): 157-163.
doi: 10.12259/j.issn.2095-610X.S20240524
Abstract:
Objective To explore the efficacy of combination therapy of Ginkgo biloba injection and donepezil in the treatment of Alzheimer's disease （AD） based on cerebral hemodynamics and inflammatory factors. Methods A total of 90 patients with AD in Zhangjia...
2024, 45(5): 164-169.
doi: 10.12259/j.issn.2095-610X.S20240525
Abstract:
Objective To explore the clinical efficacy of intrathoracic injection of thrombin combined with drainage tube suspension in the treatment of refractory pneumothorax, and to observe the effect of this treatment scheme on the closure time of leakage an...
2024, 45(5): 170-177.
doi: 10.12259/j.issn.2095-610X.S20240526
Abstract:
Objective To study the effect of alcohol on endogenous GHB content in human blood. Methods LC-MS/MS inspection method was established in the blood for γ- Hydroxybutyric acid （GHB）, γ- butyrolactone （GBL） and 1,4-butanediol （1,4-BD）. 22 healthy subjec...
2024, 45(5): 178-183.
doi: 10.12259/j.issn.2095-610X.S20240527
Abstract:
Functional near-infrared spectroscopy （fNIRS） is widely used in neurology and epilepsy is one of them. Combined with the electroencephalogram （EEG）, fNIRS could record the whole state of seizure, which is beneficial to the understanding of the pathop...
Functional near-infrared spectroscopy （fNIRS） is widely used in neurology and epilepsy is one of them. Combined with the electroencephalogram （EEG）, fNIRS could record the whole state of seizure, which is beneficial to the understanding of the pathop...
2024, 45(5): 184-189.
doi: 10.12259/j.issn.2095-610X.S20240528
Abstract:
Quality-adjusted life years （QALYs）, as a kind of multi-dimensional health utility index, has been widely used in the health economics evaluation and disease burden evaluation. At present, there are no detailed reports on the calculation methods of Q...
Quality-adjusted life years （QALYs）, as a kind of multi-dimensional health utility index, has been widely used in the health economics evaluation and disease burden evaluation. At present, there are no detailed reports on the calculation methods of Q...
2024, 45(5): 190-194.
doi: 10.12259/j.issn.2095-610X.S20240529
Abstract:
Objective To investigate and evaluate the humanistic care ability of the nursing interns before and after the intervention of narrative education, and comprehensively understand the practical status and application value of the narrative teaching met...
2024, 45(5): 195-200.
doi: 10.12259/j.issn.2095-610X.S20240530
Abstract:
Objective To explore the relationship between the self-management, hospital discharge readiness and the quality of life in patients with type B aortic dissection. Methods A total of 143 patients with type B aortic dissection in a tertiary hospital i...
