2024 Vol. 45, No. 6

Expert Forum
Advances in Research on the Effects of Liver Cirrhosis on Cardiovascular System and Related Mechanisms
Lu ZHANG, Ye LI, Qingqing WANG, Shenghao LI
2024, 45(6): 1-6. doi: 10.12259/j.issn.2095-610X.S20240601
Abstract(2273) HTML PDF(149)
Abstract:
Cirrhosis has a high global incidence rate and serious harm. Numerous studies have shown that liver cirrhosis may cause cardiovascular abnormalities in patients, which are closely related to the severity of the condition and may have adverse effects ...
Original Articles Basic of Medicine
Domestication and Biological Characteristics of a Vero Cell Line in Suspension Culture
Lanbo FU, Chaolie RUAN, Changxu CHEN, Yu GAO, Xiaolin BAO, Bochuan LIU, Jian ZHOU, Weidong LI
2024, 45(6): 7-14. doi: 10.12259/j.issn.2095-610X.S20240602
Abstract(1992) HTML PDF(225)
Abstract:
Objective To domesticate adherently cultured Vero cells into suspension-cultured cells and investigate their biological characteristics. Methods Cell culture was optimized using serum-free media and the "shaker adaptation method." Additionally, tumo...
Exploring the Effect of TRPC1 and BK-α expression on Diabetic Nephropathy
Hongming LIU, Zhisong CHEN, Lifang ZOU, Zhixiong YANG, Zhuo YU, Wei HU
2024, 45(6): 15-21. doi: 10.12259/j.issn.2095-610X.S20240603
Abstract(1163) HTML PDF(277)
Abstract:
Objective To explore the effect of transient receptor potential channel 1 (TRPC1) protein and large conductivity Ca2+ activated K+ channel α subunit (BK-α) protein on diabetic nephropathy (DKD). Methods SD rats were randomly divided into a control g...
The Molecular Mechanism of miR-205-5p Targeting ERBB3 to Regulate PI3K/AKT/mTOR Pathway and Inhibit Angiogenesis in Hemorrhoids
Zhixiao LI, Xia ZHENG, Chunling LI, Qingsheng LIU, Heng ZHANG
2024, 45(6): 22-35. doi: 10.12259/j.issn.2095-610X.S20240604
Abstract(953) HTML PDF(21)
Abstract:
Objective To explore the molecular mechanism of miR-205-5p targeting ERBB3 to regulate PI3K/AKT/mTOR pathway and inhibit angiogenesis in hemorrhoids. Methods The hemorrhoidal nucleus and normal perianal tissues of 12 patients from July 2021 to June 2...
Effect of Sleeve Gastrectomy on Glucose Metabolism and Autophagy in Obese Mice
Jun XIA, Weisi LI, Wenjie ZHANG, Zongze QI
2024, 45(6): 36-43. doi: 10.12259/j.issn.2095-610X.S20240605
Abstract(903) HTML PDF(33)
Abstract:
Objective To investigate the changes in liver autophagy factor activity in obese mice before and after sleeve gastrectomy(SG). Methods Male obese mice aged 6-8 weeks were randomly divided into a sham surgery group (Sham group, n=6) and a sleeve gast...
A Two-sample Mendelian Randomization Study of Oily Nut Intake and Primary Lung Cancer
Xueyun GUO, Na LI, Guozhong TAO, Zheng HUANG
2024, 45(6): 44-50. doi: 10.12259/j.issn.2095-610X.S20240606
Abstract(952) HTML PDF(14)
Abstract:
Objective To investigate the potential causal relationship between oily nut consumption and primary lung cancer by two-sample Mendelian randomization method. Methods Single nucleotide polymorp hisms (P < 5×10-7) associated with oily nut intake we...
Chemical Compositions of Brassica rapa L.
Zhengde WANG, CUO Raoji PING, Huan BAO, Chunbo QIAN, Junju XU, Meirong HAI
2024, 45(6): 51-56. doi: 10.12259/j.issn.2095-610X.S20240607
Abstract(2236) HTML PDF(10)
Abstract:
Objective To study the chemical constituents of Brassica rapa L. and find its active components. Methods The chemical constituents of Brassica rapa L. were extracted by methanol reflux, separated and purified by silica gel column chromatography, thi...
Pan-Cancer Analysis for the Effects of ANGPT1 and TEK on Human Tumor Progression
Guoqing DU, Zhiqin LIU, Yao LI, Yonghua SHI
2024, 45(6): 57-68. doi: 10.12259/j.issn.2095-610X.S20240608
Abstract(1652) HTML PDF(9)
Abstract:
Objective To probe the expression level, prognostic value, and immune invasion of angipoietin-1 (ANGPT1)and its receptor tyrosine kinase (TEK)in pan-cancer. Methods TIMER2.0、Kaplan-Meier plotter and UALCAN etc. databases were used to analyze the exp...
Preparation and in Vitro-in Vivo Evaluation of Aspirin Enteric-coated Tablets
Liping DUAN, Xiaoxue CHEN, Zhi YANG, Yinshuang WU, Junyu LIU, Di JIN
2024, 45(6): 69-74. doi: 10.12259/j.issn.2095-610X.S20240609
Abstract(2585) HTML PDF(38)
Abstract:
Objective To prepare aspirin enteric-coated tablets and investigate its in vitro - in vivo release characteristics. Methods The powder was directly pressed into tablets, and a coating solution with a solid content of 20% was prepared with the aqueou...
Clinical Research
A Meta-analysis of the Efficacy and Safety of Camrelizumab Combined with Chemotherapy in the Treatment of Non-small Cell Lung Cancer
Caini ZHANG, Ya LI
2024, 45(6): 75-84. doi: 10.12259/j.issn.2095-610X.S20240610
Abstract(648) HTML PDF(17)
Abstract:
Objective To discuss the difference in efficacy and safety of immune checkpoint inhibitor camrelizumab alone and combined chemotherapy in the treatment of non-small cell lung cancer. Aggregate analysis of multiple clinical trial data was conducted to...
Association between Lifestyle Behaviors and Depressive Symptoms of middle school students in rural area of Miao nationality in Pingbian, Yunnan Province
Xiaoxiao LI, Yang LI, Mengdie HU, Shubing CHEN, Xu HONG, Honglv XU
2024, 45(6): 85-93. doi: 10.12259/j.issn.2095-610X.S20240611
Abstract(1823) HTML PDF(13)
Abstract:
Objective To explore the association between lifestyle behaviors and depressive symptoms of middle school students in rural area of Miao nationality in Pingbian, Yunnan Province, and to provide a data reference for changing unhealthy lifestyle behavi...
Study on Influencing Factors of Cognitive Impairment in Late-life Depression Patients
Yuanjia TAO, Yuqi CHENG, Hezhi YAN, Xiangyu SU, Xianyu CHEN, Hongyan JIANG
2024, 45(6): 94-99. doi: 10.12259/j.issn.2095-610X.S20240612
Abstract(608) HTML PDF(8)
Abstract:
Objective To explore the influencing factors of cognitive impairment in elderly patients with depressive disorder. Methods 119 elderly patients with depression were recruited in the 1st Affiliated Hospital of Kunming Medical University. MoCA was use...
Individualized Numerical Simulation of Blood Flow in Stanford Type A Aortic Dissection
Zhenkun YU, Kang LIU, Hua LIN, Beibei WANG, Hongming ZHANG, Jianming XIA
2024, 45(6): 100-105. doi: 10.12259/j.issn.2095-610X.S20240613
Abstract(1253) HTML PDF(36)
Abstract:
Objective To investigate the hemodynamic changes after the occurrence of Stanford type A aortic dissection. Methods Computed tomography angiography(CTA) images of the aorta were collected from 4 Stanford A type aortic dissection patients and 2 healt...
Analysis of PTH and ER Gene Polymorphisms in Patients with Type 2 Diabetes Mellitus Complicated with Osteoporosis
Ling NIU, Rong MA, Cheng ZHANG, Cuijuan MIAO, Yan TANG, Fang LIU, Boyi LI
2024, 45(6): 106-112. doi: 10.12259/j.issn.2095-610X.S20240614
Abstract(1365) HTML PDF(6)
Abstract:
Objective To investigate the characteristics of parathyroid hormone (PTH) and estrogen receptor (ER) gene polymorphisms in patients with type 2 diabetes mellitus (T2DM) complicated with osteoporosis (OP). Methods 110 patients with T2DM from Kunming ...
Study on the Efficacy of Acetylcysteine in Severe Pneumonia in Children under Electronic Bronchoscopy
Ji WANG, Songtao BIN, Li TAN
2024, 45(6): 113-119. doi: 10.12259/j.issn.2095-610X.S20240615
Abstract(583) HTML PDF(10)
Abstract:
Objective To explore the clinical efficacy of acetylcysteine solution retained perfusion inhalation treatment under electronic bronchoscopy in children with severe bacterial pneumonia. Methods From January 1, 2021 to December 31, 2022, 86 children w...
The Diagnostic Value Vectorcardiogram the Early Stage Hypertensive Heart Target Organ Damage Analysis Influencing Factors
Youling LONG, Tianzhen XIONG, Zutao SHENG, Zhixian ZHOU, Rui YIN, Yong SU
2024, 45(6): 120-125. doi: 10.12259/j.issn.2095-610X.S20240616
Abstract(1470) HTML PDF(10)
Abstract:
Objective To investigate the value of vectorcardiography in the diagnosis of abnormal cardiac electrical activity in hypertension, and to analyze the influencing factors of early cardiac target organ damage. Methods 80 cases in the Department of Car...
Application Analysis of Ultrasonic Evaluation in the Determination of Endometrial Receptivity
Fang WEI, Rui TONG, Xingyuan ZHAO, Lijuan LU
2024, 45(6): 126-131. doi: 10.12259/j.issn.2095-610X.S20240617
Abstract(1646) HTML PDF(19)
Abstract:
Objective To investigate the application value of transvaginal three-dimensional ultrasound in the determination of endometrial receptivity. Methods A retrospective study was conducted on 106 patients who were scheduled to undergo assisted reproduct...
Investigation on Nutritional Status of the Elderly in Some Community in Kunming and Analysis of Its Influencing Factors
Lifen WEN, Zhiqin GONG, Ping ZHANG, Manlu MEI, Zhihe TIAN, Yujuan DU
2024, 45(6): 132-139. doi: 10.12259/j.issn.2095-610X.S20240618
Abstract(1349) HTML PDF(12)
Abstract:
Objective To investigate the nutritional status and its influencing factors among the elderly in some communities of Kunming, in order to provide more targeted suggestions for preventing malnutrition among the elderly in the above communities, thereb...
Analysis of the Efficacy and Safety of GM1 Injection Combined with Batroxobin in the Treatment of Sudden Deafness Patients
Liyuan YUN, Junfeng WANG, Ning GUO, Ruimei DING, Haipeng LI, Xueping ZHANG
2024, 45(6): 140-144. doi: 10.12259/j.issn.2095-610X.S20240619
Abstract(903) HTML PDF(8)
Abstract:
Objective To investigate the therapeutic efficacy and safety of the combination of monosialotetrahexosylganglioside (GM1) injection and Batroxobin in treating sudden deafness. Methods The clinical data of 162 patients with sudden deafness in Affilia...
Analysis of Blood Cells and Establishment of Reference Interval of Elderly Derivative Index in Anning Area of Yunnan Province
Hong ZHU, Qiong DU, Zhengwei ZHAO, Liping CHEN, Muli XU, Yungui TU
2024, 45(6): 145-153. doi: 10.12259/j.issn.2095-610X.S20240620
Abstract(1936) HTML PDF(13)
Abstract:
Objective To establish the derived indicators from blood cell analysis of the elderly in Anning region of Yunnan province, lymphocyte to monocyte ratio (LMR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) reference interval...
Effectiveness and Safety Analysis of Cyclopol Combined with Remifentanil in Anesthesia for Endoscopic Gastric Cancer Radical Surgery
Keyan WANG, Bingting LIN, Xiaolin WENG, Bin HUANG, Lie WANG
2024, 45(6): 154-160. doi: 10.12259/j.issn.2095-610X.S20240621
Abstract(1826) HTML PDF(12)
Abstract:
Objective To investigate the effectiveness and safety of cyclophenol combined with remifentanil in anesthesia for laparoscopic radical gastrectomy for gastric cancer. Methods A total of 100 patients who underwent laparoscopic radical gastrectomy for...
Reviews
Research Progress on The Potential Application of Circular RNA in Systemic Lupus Erythematosus
Li LI, Ruixian ZHANG
2024, 45(6): 161-165. doi: 10.12259/j.issn.2095-610X.S20240622
Abstract(800) HTML PDF(15)
Abstract:
Circular RNA (circRNA), formed by reverse splicing of pre-mRNA, constitutes a closed-loop RNA structure with diversity in molecular characteristics, biological functions, and regulatory mechanisms. In recent years, there has been growing recognition ...
Research Progress on Nursing-sensitive Quality Indicators in Anesthesia Nursing Units
Xiaoqing YANG, Chunmei YANG, Huimin YAN, Peixian DONG, Kun YANG
2024, 45(6): 166-170. doi: 10.12259/j.issn.2095-610X.S20240623
Abstract(1286) HTML PDF(20)
Abstract:
The current situation of anesthesia nursing unit construction is described, along with the theoretical basis and methodology for the construction of its nursing-sensitive quality indicators. A review is presented on the construction and application o...
Teaching Research
Comparative Study on Post Competence of Resident Standardization Training Students with Different Learning Styles
Jiangming WANG, Wenxing FAN, Jing YANG
2024, 45(6): 171-174. doi: 10.12259/j.issn.2095-610X.S20240624
Abstract(1969) HTML PDF(17)
Abstract:
Objective To compare the differences in the competency of the students in the standardized training of residents with different learning styles, and explore more effective clinical teaching strategies. Methods Kolb learning style and clinician post ...
Nursing Forum
The Mediating Effect of Hospital Unit Safety Climate between the Nursing Work Environment and Job Satisfaction
Cui WANG, Lu YANG, Dongmei WU, Simin YANG, Qunsong KANG
2024, 45(6): 175-181. doi: 10.12259/j.issn.2095-610X.S20240625
Abstract(1336) HTML PDF(16)
Abstract:
Objective To explore the relationship and influence path between nurses’ perceived work environment, hospital safety climate and nurses’ satisfaction. Methods Using convenience sampling method, 444 in-service nurses in a third-class A hospital in Ch...
Latent Profile Analysis and Influencing Factors of Clinical Nurses' Psychological Resilience in Oncology Hospitals
Yong DONG, Shuaizhong CAI, Jiao YANG, Yan SU, Haiyin YANG, Shiyao YANG, Yuexi ZHU, Qiongyao GUAN
2024, 45(6): 182-189. doi: 10.12259/j.issn.2095-610X.S20240626
Abstract(1640) HTML PDF(21)
Abstract:
Objective To investigate the current status of psychological resilience of clinical nurses in a cancer hospital, identify the potential profile categories of psychological resilience of nurses, and explore its subgroup characteristics and influencing...
The Effect of Active Circulatory Breathing Training in Patients undergoing Lung Cancer Surgery under 5A Mode
Qun HUANG, Lili HOU, Degui WANG, Zhaojun WANG, Siyuan WU, Yingying SANG
2024, 45(6): 190-196. doi: 10.12259/j.issn.2095-610X.S20240627
Abstract(1366) HTML PDF(13)
Abstract:
Objective To analyze the application effect of active circulatory breathing training in patients undergoing thoracoscopic lung cancer surgery based on 5A (Ask, Asses, Advice, Assist, Arrange) mode. Methods 100 patients with lung cancer, treated by t...