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2025 Vol. 46, No. 2
2025, 46(2): 1-8.
doi: 10.12259/j.issn.2095-610X.S20250201
Abstract:
Acquired immune deficiency syndrome （AIDS） is a systemic disease caused by the Human Immunodeficiency Virus （HIV）. Chemokine （C-C motif） ligand 3 （CCL3）, as a vital member of the chemokine family, plays an indispensable role in the pathogenesis of AI...
Acquired immune deficiency syndrome （AIDS） is a systemic disease caused by the Human Immunodeficiency Virus （HIV）. Chemokine （C-C motif） ligand 3 （CCL3）, as a vital member of the chemokine family, plays an indispensable role in the pathogenesis of AI...
2025, 46(2): 9-16.
doi: 10.12259/j.issn.2095-610X.S20250202
Abstract:
Objective To explore the the detection of MMP-2, -7, -9, and -12 enzymatic activity using the CEACAM1-derived fluorescent peptide substrate Site 84, investigating the application of substrate Site 84 to distinguishing between MMP-2 and MMP-9 in the g...
2025, 46(2): 17-22.
doi: 10.12259/j.issn.2095-610X.S20250203
Abstract:
Objective To explore the enzymatic reaction kinetics of metoprolol tartrate in an in vitro human liver microsome incubation experiment and to explore the effect of famotidine on the metabolism of metoprolol tartrate. Methods An LC-MS/MS method was d...
2025, 46(2): 23-29.
doi: 10.12259/j.issn.2095-610X.S20250204
Abstract:
Objective To analyze the whole-genome characteristics of a coxsackievirus A10 （CVA10） isolate obtained from fecal samples of children with hand, foot, and mouth disease in 2022. Methods The isolate was obtained from human rhabdomyosarcoma （RD） cells...
2025, 46(2): 30-36.
doi: 10.12259/j.issn.2095-610X.S20250205
Abstract:
Objective To develop a method capable of real-time, rapid, and visual detection of MEs , providing a powerful tool for early diagnosis and assessment of diseases. Methods In this study, flake graphene oxide （2D GO） with excellent peroxidase-like act...
The Effect of 1800 MHz Electromagnetic Radiation on Learning and Cognitive Functions in 3xTg-AD Mice
2025, 46(2): 37-43.
doi: 10.12259/j.issn.2095-610X.S20250206
Abstract:
Objective To explore the effects of 1800 MHz electromagnetic radiation （EMR） on cognitive function of 3xTg-AD and 57C mice, providing a theoretical basis for the potential impacts of electromagnetic radiation on the human body. Methods A total of 12 ...
2025, 46(2): 44-50.
doi: 10.12259/j.issn.2095-610X.S20250207
Abstract:
Objective To investigate the association between single nucleotide polymorphisms （SNP） rs57095329 and rs6864584 of miR-146a gene and cervical intraepithelial neoplasia （CIN） . Methods A total of 96 patients diagnosed with CIN were randomly collected...
2025, 46(2): 51-58.
doi: 10.12259/j.issn.2095-610X.S20250208
Abstract:
Objective To explore the correlation between serum vitamin D （VD3） level differences and immune inflammatory markers in elderly sepsis patients. Methods A total of 103 elderly patients with sepsis（aged 65-99 years） in the ICU of the First Affiliated...
2025, 46(2): 59-66.
doi: 10.12259/j.issn.2095-610X.S20250209
Abstract:
Obejective Based on the Citespace software, this study aims to comb the research hotspots and core contents of the development process of the TMD field in China, and carefully understand the research evolution process of the Temporo-mandibular Disord...
2025, 46(2): 67-73.
doi: 10.12259/j.issn.2095-610X.S20250210
Abstract:
Objective To study the pathogenic bacteria infection in hospitalized diabetic foot patients in the Third People's Hospital of Yunnan Province and its correlation with different Wagner grades, to understand the the characteristics of pathogenic bacter...
2025, 46(2): 74-79.
doi: 10.12259/j.issn.2095-610X.S20250211
Abstract:
Objective To investigate the predictive value of the preoperative fasting Triglyceride-Glucose index （TyG） for contralateral new silence ischemic brain lesions （CNSIBL） following carotid artery stenting （CAS）. Methods A retrospective study was condu...
2025, 46(2): 80-87.
doi: 10.12259/j.issn.2095-610X.S20250212
Abstract:
Objective To investigate the correlation between physical activity duration, sleep quality, weight control, and PRO（patient- reported outcomes） in individuals with hypertension, providing effective information for enhancing patient-reported outcomes ...
2025, 46(2): 88-94.
doi: 10.12259/j.issn.2095-610X.S20250213
Abstract:
Objective To explore the correlation between blood biochemical indexes and blood pressure levels among college students in Kunming City. Methods In November 2021, a cluster sampling method was used to survey 4,781 college students at a university in...
2025, 46(2): 95-102.
doi: 10.12259/j.issn.2095-610X.S20250214
Abstract:
Objective To investigate the predictive value of serum uric acid （UA）, homocysteine （Hcy） and the product index of UA and Hcy in patients with stable coronary artery disease （SCAD）. Methods A total of 783 patients with suspected coronary heart disea...
2025, 46(2): 103-109.
doi: 10.12259/j.issn.2095-610X.S20250215
Abstract:
Objective To investigate the factors influencing the development of extra-pulmonary tuberculosis （EPTB） in patients with viral hepatitis complicated by pulmonary tuberculosis（PTB）. Methods A retrospective analysis was conducted on 427 patients with ...
2025, 46(2): 110-117.
doi: 10.12259/j.issn.2095-610X.S20250216
Abstract:
Objective To construct and evaluate the prediction model of maternal mortality in Yunnan Province, and predict the maternal mortality rate in Yunnan Province from 2024 to 2030. Methods Based on the maternal mortality rates in Yunnan Province from 19...
2025, 46(2): 118-125.
doi: 10.12259/j.issn.2095-610X.S20250217
Abstract:
Objective To explore the risk signals of niraparib and provide references for rational and safe clinical medication. Methods Niraparib-related adverse drug events （ADEs） reports from Q1 2017 to Q2 2023 were extracted from the US FDA Adverse Event Re...
2025, 46(2): 126-133.
doi: 10.12259/j.issn.2095-610X.S20250218
Abstract:
Objective To investigate the current status of frailty in lung cancer patients undergoing radiotherapy and analyze its influencing factors. Methods The convenience sampling method was used to select 241 lung cancer patients admitted to the radiation...
2025, 46(2): 134-140.
doi: 10.12259/j.issn.2095-610X.S20250219
Abstract:
Objective To observe the effect of the GLP-1 receptor agonist liraglutide on β-cell function in patients newly diagnosed with type 2 diabetes patients. Methods Type 2 diabetes patients diagnosed between March 2020 and March 2021 in the Endocrinology...
2025, 46(2): 141-150.
doi: 10.12259/j.issn.2095-610X.S20250220
Abstract:
Objective To explore common target genes related to aging and osteoporosis using data from public databases and to screen for small molecule compounds with potential therapeutic effects. Methods Osteoporosis datasets GSE56814 and GSE56815 were downl...
2025, 46(2): 151-157.
doi: 10.12259/j.issn.2095-610X.S20250221
Abstract:
Objective To investigate the efficacy of combined prediction of postpartum hypertension using 24-h urinary protein quantification （24-hUP）, hematocrit and plasma albumin difference （HCT-ALB）, and brain natriuretic peptide （BNP） in patients with sever...
2025, 46(2): 158-163.
doi: 10.12259/j.issn.2095-610X.S20250222
Abstract:
Malignant melanoma is an extremely aggressive tumor that can be surgically treated in its early stage. In advanced stages, the invasive and proliferative capabilities of melanoma cells continue to increase, and traditional treatment methods such as r...
Malignant melanoma is an extremely aggressive tumor that can be surgically treated in its early stage. In advanced stages, the invasive and proliferative capabilities of melanoma cells continue to increase, and traditional treatment methods such as r...
2025, 46(2): 164-170.
doi: 10.12259/j.issn.2095-610X.S20250223
Abstract:
Objective To investigate the impact of scenario class teaching on language expression, communication skills, and final exam performance of non-clinical majors students in the course of Medical Parasitology. Method Undergraduate students of non-clinic...
2025, 46(2): 171-176.
doi: 10.12259/j.issn.2095-610X.S20250224
Abstract:
Objective To observe the effects of tactile/motor stimulation massage on feeding outcomes and neuromotor development levels of preterm infants. Methods A total of 136 preterm hospitalized infants in the neonatal intensive care unit of a tertiary hos...
