Effect of Ulinastatin Combined with Continuous Renal Replacement Therapy in Treatment of Severe Burn Patients and Its Influence on Inflammatory Factors and 28-day all-cause Mortality

Bin HUANG; Rui-hua ZHAO; Qi-hua FEI; Jian-wei LI; Yan ZHI; Wen-jun LIU; Xiao-qing LI

doi:10.12259/j.issn.2095-610X.S20201102

Volume 41 Issue 11

Dec. 2020

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Article Navigation > Journal of Kunming Medical University > 2020 > 41(11): 109-113

Bin HUANG, Rui-hua ZHAO, Qi-hua FEI, Jian-wei LI, Yan ZHI, Wen-jun LIU, Xiao-qing LI. Effect of Ulinastatin Combined with Continuous Renal Replacement Therapy in Treatment of Severe Burn Patients and Its Influence on Inflammatory Factors and 28-day all-cause Mortality[J]. Journal of Kunming Medical University, 2020, 41(11): 109-113. doi: 10.12259/j.issn.2095-610X.S20201102

Citation:

Bin HUANG, Rui-hua ZHAO, Qi-hua FEI, Jian-wei LI, Yan ZHI, Wen-jun LIU, Xiao-qing LI. Effect of Ulinastatin Combined with Continuous Renal Replacement Therapy in Treatment of Severe Burn Patients and Its Influence on Inflammatory Factors and 28-day all-cause Mortality[J]. Journal of Kunming Medical University, 2020, 41(11): 109-113. doi: 10.12259/j.issn.2095-610X.S20201102

Citation:

Bin HUANG, Rui-hua ZHAO, Qi-hua FEI, Jian-wei LI, Yan ZHI, Wen-jun LIU, Xiao-qing LI. Effect of Ulinastatin Combined with Continuous Renal Replacement Therapy in Treatment of Severe Burn Patients and Its Influence on Inflammatory Factors and 28-day all-cause Mortality[J]. Journal of Kunming Medical University, 2020, 41(11): 109-113. doi: 10.12259/j.issn.2095-610X.S20201102

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Effect of Ulinastatin Combined with Continuous Renal Replacement Therapy in Treatment of Severe Burn Patients and Its Influence on Inflammatory Factors and 28-day all-cause Mortality

doi: 10.12259/j.issn.2095-610X.S20201102

Dept. of Burns，The 2nd Affiliated Hospital of Kunming Medical University， Kunming Yunnan 650101，China

Received Date: 2020-10-12
Available Online: 2020-12-03
Publish Date: 2020-11-25

Abstract

Abstract

Objective To explore the effect of ulinastatin combined with continuous renal replacement therapy（CRRT）on inflammatory factors and 28-day all-cause mortality in severe burns. Methods A selection of 86 patients with severe burns admitted to the Second Affiliated Hospital of Kunming Medical University from January 2017 to August 2019 were divided into CRRT group and Ulinastatin combined CRRT group according to the random number table, with 43 cases in each group. CRRT group: conventional treatment + CRRT, ulinastatin combined with CRRT group: combined with ulinastatin on the basis of CRRT group for 7 consecutive days. Compare the critical scores（APACHEⅡ score, SOFA score, Marshall score）, serum inflammatory factors（TNF-α, IL-6, IL-8）, antibiotics and vasoactive drugs before treatment and 7 days after treatment between the two groups. The duration of mechanical ventilation and 28-day all-cause mortality. The Kaplan-Meier survival curve was drawn to analyze the 28-day survival of the two groups of patients. Results Before treatment, there was no significant difference in APACHEⅡ, SOFA, and Marshall scores between the two groups of patients（P > 0.05）. The scores of the two groups of patients after 7 days of treatment were significantly lower than those before treatment（P < 0.05）. The APACHEⅡ, SOFA, and Marshall scores of the patients in the Ulinastatin combined CRRT group were significantly lower than those in the CRRT group after 7 days of treatment（P < 0.05）. Before treatment, the differences in serum TNF-α, IL-6 and IL-8 between the two groups were not statistically significant（P > 0.05）. After 7 days of treatment, serum TNF-α, IL-6 and IL-8 of the two groups were lower than before treatment（P < 0.05）. The serum TNF-α, IL-6 and IL-8 of patients in the ulinastatin combined CRRT group were significantly lower than those in the CRRT group after 7 days of treatment（P < 0.05）. There was a statistically significant difference in 28-day all-cause mortality between the ulinastatin combined CRRT group and the CRRT group（23.26% vs 44.19%, P < 0.05）. Conclusion Ulinastatin combined with CRRT in the treatment of severe burn patients can reduce APACHEⅡ, SOFA and Marshall scores, serum TNF-α, IL-6, IL-8 levels and 28-day all-cause mortality, shorten the treatment time, and have better efficacy and high safety.
- Severe burns,
- Ulinastatin,
- Continuous renal replacement therapy,
- All-cause death,
- Inflammatory factors

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