Effect of Osteoking on Bone Density and Bone Biomechanics of Tree Shrews in a Postmenopausal Osteoporotic Fracture Model

Yu-wei JI; Xin ZHAO; Jiang-li LU; Yi YANG; Wei TANG; Jian-lin JIAO

doi:10.12259/j.issn.2095-610X.S20201103

Volume 41 Issue 11

Dec. 2020

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Yu-wei JI, Xin ZHAO, Jiang-li LU, Yi YANG, Wei TANG, Jian-lin JIAO. Effect of Osteoking on Bone Density and Bone Biomechanics of Tree Shrews in a Postmenopausal Osteoporotic Fracture Model[J]. Journal of Kunming Medical University, 2020, 41(11): 7-11. doi: 10.12259/j.issn.2095-610X.S20201103

Citation:

Yu-wei JI, Xin ZHAO, Jiang-li LU, Yi YANG, Wei TANG, Jian-lin JIAO. Effect of Osteoking on Bone Density and Bone Biomechanics of Tree Shrews in a Postmenopausal Osteoporotic Fracture Model[J]. Journal of Kunming Medical University, 2020, 41(11): 7-11. doi: 10.12259/j.issn.2095-610X.S20201103

Citation:

Yu-wei JI, Xin ZHAO, Jiang-li LU, Yi YANG, Wei TANG, Jian-lin JIAO. Effect of Osteoking on Bone Density and Bone Biomechanics of Tree Shrews in a Postmenopausal Osteoporotic Fracture Model[J]. Journal of Kunming Medical University, 2020, 41(11): 7-11. doi: 10.12259/j.issn.2095-610X.S20201103

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Effect of Osteoking on Bone Density and Bone Biomechanics of Tree Shrews in a Postmenopausal Osteoporotic Fracture Model

doi: 10.12259/j.issn.2095-610X.S20201103

Yu-wei JI^1
,,
Xin ZHAO^1
,,
Jiang-li LU²,
Yi YANG²,
Wei TANG^{1
,
,},
Jian-lin JIAO^{3
,
,}

1.
Dept. of Scientific Research and Education，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Dept. of Laboratory Animal Science
3.
Technology Transferring Center，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2020-08-04
Available Online: 2020-12-03
Publish Date: 2020-11-25

Abstract

Abstract

Objective To observe the effect of osteoking on bone density and bone biomechanics in a postmenopausal osteoporotic fracture（OPF）model tree shrew. Methods Female western Yunnan subspecies tree shrews were subjected to bilateral ovariectomy and hysterectomy to establish an osteoporosis（OP）model, and after 180 days, bone density（BMD）was measured in tree shrews, and 20 OP modeling successes were randomly and equally divided into administration（3 mL/kg）and model groups（equal volume of 0.9% sodium chloride solution）. Ten tree shrews with the same volume of large omentum removed were divided into normal groups（equal volume of 0.9% sodium chloride solution）. The tree shrews in the drug-administered and model groups were subjected to right hindlimb tibial fracture surgery to establish the OPF model. The administration group was given one dose of saline every 2 d for 90 d, and the remaining group was given the same dose of saline. Results Compared with the normal group, the BMD of whole body（including head）, lumbar + pelvic, cervical-caudal, left pelvis, right pelvis, lumbar spine, lumbar + sacral, and whole body（excluding head）were significantly reduced to different degrees in the administered and model groups, and the differences were statistically significant（P < 0.05）. Compared with the model group, the BMD of the whole body（including the head）, lumbar + pelvic, cervical-caudal, left pelvis, lumbar spine, and lumbar + sacral were significantly increased in the administration group, and the differences were statistically significant（P < 0.05）, while the BMD of the right pelvis and whole body（excluding the head）were not statistically different. In terms of bone biomechanics, energy absorption was significantly increased in the administered group compared to the normal group, while maximum load and structural stiffness were not statistically difference; the maximum load, structural stiffness, and energy absorption capacity of the model group were all significantly reduced, and the differences were statistically significant（P < 0.05）. The maximum load, structural stiffness, and energy absorption capacity of the model group were all significantly reduced compared to the drug-administered group, and the differences were statistically significant（P < 0.05）. Conclusion Osteoking can improve both BMD and bone biomechanics in the OPF model of tree shrew.
- Osteoking,
- Tree shrew,
- Osteoporosis,
- Bone density,
- Bone biomechanics

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References(21)

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