Effect of Low-dose Alprostadil on Pulmonary Arterial Pressure and Hemodynamics in Patients undergoing Liver Transplantation

Yun-fei SHU; Yi-xin JIANG; Bing LI

doi:10.12259/j.issn.2095-610X.S20201110

Volume 41 Issue 11

Dec. 2020

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Article Navigation > Journal of Kunming Medical University > 2020 > 41(11): 138-142

Yun-fei SHU, Yi-xin JIANG, Bing LI. Effect of Low-dose Alprostadil on Pulmonary Arterial Pressure and Hemodynamics in Patients undergoing Liver Transplantation[J]. Journal of Kunming Medical University, 2020, 41(11): 138-142. doi: 10.12259/j.issn.2095-610X.S20201110

Citation:

Yun-fei SHU, Yi-xin JIANG, Bing LI. Effect of Low-dose Alprostadil on Pulmonary Arterial Pressure and Hemodynamics in Patients undergoing Liver Transplantation[J]. Journal of Kunming Medical University, 2020, 41(11): 138-142. doi: 10.12259/j.issn.2095-610X.S20201110

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Effect of Low-dose Alprostadil on Pulmonary Arterial Pressure and Hemodynamics in Patients undergoing Liver Transplantation

doi: 10.12259/j.issn.2095-610X.S20201110

Dept.of Anesthesiology，The First People’s Hospital of Kunming，Kunming Yunnan 650011，China

Received Date: 2020-09-21
Available Online: 2020-12-03
Publish Date: 2020-11-25

Abstract

Abstract

Objective To explore the influence of low-dose alprostadil on patients' pulmonary artery pressure（PAP）and hemodynamics in orthotopic liver transplantation. Methods From March 2018 to September 2019, 22 patients undergoing orthotopic liver transplantation in The First People's Hospital of Kunming were selected and then they were randomly assigned into two groups. Experimental group（12 cases）was continuously pumped with alprostadil（1.5 ng/kg·min）through internal jugular vein; control group（10 cases）was continuously pumped with the same amount of saline through internal jugular vein. Finally the mean pulmonary artery pressure（MPAP）and hemodynamics of the two groups at different times of the surgery were compared. Results There was no significant difference between the two groups in basic information（age, gender, height, weight, ASA classification）（P > 0.05）and basic information in liver transplantation（infusion, concentrated red blood cell concentrate infusion, plasma infusion, blood loss, urine, operation time and anhepatic period time）（P > 0.05）, also there was no statistically significant difference in MPAP and hemodynamics between the two groups at different times of the surgery（P > 0.05）. Conclusion Continuous pumping of 1.5ng/kg·min alprostadil during orthotopic liver transplantation has little effect on PAP and hemodynamics.
- Alprostadil,
- Liver transplantation,
- Pulmonary arterial pressure,
- Floating catheter

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References(12)

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