Ran XU, Enfu FENG, Yuyu XIONG, Jiade ZHU, Gonghao HE. The Effect of Famotidine on the Metabolism of Metoprolol Tartrate in Human Liver Microsomes[J]. Journal of Kunming Medical University, 2025, 46(2): 17-22. doi: 10.12259/j.issn.2095-610X.S20250203
Citation: Huang SUN, Wei LUO, Mi-er MA, Hui-kai MU, Lei ZHONG, Xue-juan MA, Yun-zhu PENG, Rui-jie LI. Value of Fragmented QRS in Predicting Prognosis of Patients after Cardiac Resynchronization Therapy[J]. Journal of Kunming Medical University, 2020, 41(11): 38-43. doi: 10.12259/j.issn.2095-610X.S20201111

Value of Fragmented QRS in Predicting Prognosis of Patients after Cardiac Resynchronization Therapy

doi: 10.12259/j.issn.2095-610X.S20201111
  • Received Date: 2020-08-23
  • Publish Date: 2020-11-25
  •   Objestive   To investigate the association between characteristics of Fragmented QRS(fQRS)before and after CRT implantation and response to CRT.   Methods   Patients with heart failure planned for CRT were enrolled. The 12-lead ECGs before and after CRT were analyzed. The presence of fQRs was confirmed according to the definition in previous studies. Echocardiography imagines were obtained before and 6 months after the CRT implantation.   Results   The study included 108 patients(78 male, 72.2%)with a mean age of 56.5 ± 11.9 years. Totally 75 patients(69.4%)responded to CRT with significantly increased mean LVEF(from 30.71±1.92 to 50.61±2.57, P < 0.001)and decreased LVESV(from 195.26±78.79 to 156.55±84.44, P < 0.001). After CRT implantation, the number of leads with fQRS remained unchanged in responders(6.25±2.68 vs. 6.03±2.54, P= 0.57 before and after CRT respectively)but increased in non-responders(6.18±2.20 vs.7.36±2.61, P = 0.013 before and after CRT respectively). In the multivariate logistic analysis, a decreased number of leads with fQRS and shortened QRS duration immediately after CRT implantation was found to be a predictor of response to CRT.   Conclusions   In patients undergoing CRT, new fQRS as well as an increased number of leads with fQRS in 12-lead ECG immediately after CRT implantation predicts non-response to CRT and may help in the decision making in heart failure patients.
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