Relationship between HIV Status of Pregnant Women andLBW of Newborn

Ai-hui WU; Hong-chun SU; Ye WANG; Le LI; Hai-yan MA; Xian-jing HE

doi:10.12259/j.issn.2095-610X.S20201115

Volume 41 Issue 11

Dec. 2020

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Article Navigation > Journal of Kunming Medical University > 2020 > 41(11): 124-129

Ai-hui WU, Hong-chun SU, Ye WANG, Le LI, Hai-yan MA, Xian-jing HE. Relationship between HIV Status of Pregnant Women andLBW of Newborn[J]. Journal of Kunming Medical University, 2020, 41(11): 124-129. doi: 10.12259/j.issn.2095-610X.S20201115

Citation:

Ai-hui WU, Hong-chun SU, Ye WANG, Le LI, Hai-yan MA, Xian-jing HE. Relationship between HIV Status of Pregnant Women andLBW of Newborn[J]. Journal of Kunming Medical University, 2020, 41(11): 124-129. doi: 10.12259/j.issn.2095-610X.S20201115

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Relationship between HIV Status of Pregnant Women andLBW of Newborn

doi: 10.12259/j.issn.2095-610X.S20201115

Dept. of Obstetrics and Gynecology，The Third People’s Hospital of Kunming，Kunming Yunnan 650041，China

Received Date: 2020-08-08
Available Online: 2020-12-03
Publish Date: 2020-11-25

Abstract

Abstract

Objective To analyze the low birth weight（LBW）situation and related risk factors of newborns born to HIV-positive pregnant women. Methods A total of 194 HIV-positive pregnant women who were hospitalized in Kunming Third People's Hospital for delivery from January 2013 to May 2018 were selected as the research subjects. Information on pregnant women includes demographic characteristics, history of obstetrics and gynecology, history of antiretroviral drugs, HIV transmission route, and HIV disease status（including CD4 count, HIV RNA viral load and hemoglobin at the time of enrollment）. Logistic regression analysis was used to determine the risk factors related to LBW. Results Among 194 infants, 38（19.6%）were LBW（< 2500 g）. There were significant differences between LBW infants and non-LBW infants in entry weight, antiretroviral treatment during pregnancy, entry CD4 count, entry HIV RNA viral load and gestational age at delivery（P < 0.05）. Multivariate logistic regression analysis showed that the body weight was light at entry（OR = 2.14, 95% CI = 0.84～4.05, P = 0.013）, and CD4 count at entry（OR = 6.02, 95% CI = 1.50～24.13, P < 0.001）, HIV RNA viral load at entry（OR = 3.34, 95% CI = 1.70～6.55, P < 0.001）and gestational age at delivery（OR = 12.90, 95% CI = 2.03～81.88, P < 0.001）were independent risk factor for LBW. Conclusions The status of HIV disease in pregnant women is related to neonatal LBW. Prenatal screening and diagnosis of HIV are essential for the early prevention and treatment of mother-to-child transmission of HIV and reducing adverse pregnancy outcomes.
- Low birth weight,
- Pregnancy,
- Risk factors,
- HIV positive,
- Prenatal antiretroviral therapy

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References(15)

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