Relationship between microRNA-146a and the Plaque Stability in Coronary Heart Disease Patients

Xu XU; Li-yong WU; Ming-li ZHOU; Guo-fu ZHU

doi:10.12259/j.issn.2095-610X.S20201119

Volume 41 Issue 11

Dec. 2020

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Xu XU, Li-yong WU, Ming-li ZHOU, Guo-fu ZHU. Relationship between microRNA-146a and the Plaque Stability in Coronary Heart Disease Patients[J]. Journal of Kunming Medical University, 2020, 41(11): 56-61. doi: 10.12259/j.issn.2095-610X.S20201119

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Relationship between microRNA-146a and the Plaque Stability in Coronary Heart Disease Patients

doi: 10.12259/j.issn.2095-610X.S20201119

1.
Dept. of Geriatrics，Ganmei Hospital，Kunming First People’s Hospital，Kunming Yunnan 650011
2.
Dept. of Cardiology，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2020-10-12
Available Online: 2020-12-03
Publish Date: 2020-11-25

Abstract

Abstract

Objectives To investigate the association between microRNA-146a（miR-146a）and the plaque stability in patients with coronary heart disease. Methods Real-time PCR was used to measure miR-146a expression in 324 patients. ELISA was used to measure the level of hs-CRP, IL-6 and IL-8. Coronary angiography was used to evaluate the degree of coronary artery stenosis. Intravascular ultrasound（IVUS）was used to evaluate the plaque stability of coronary stenotic lesions. Results （1）The levels of hs-CRP, IL-6 and IL-8 were significantly increased in the UAP and AMI groups compared with the CPS groups（P < 0.01）.（2）The miR-146a expression in peripheral blood mononuclear cells（PBMCs）and plasma was significantly higher in CAD patients than those in non-CAD group（P < 0.05, P < 0.001）.（3）The miR-146a expression in PBMCs was higher in SAP, UAP and AMI group than CPS group（P < 0.01, P < 0.001, P < 0.001）. The expression patterns of miR-146a in plasma was consistent with that of PBMCs.（4）The expression of miR-146a in PBMCs and plasma were significantly higher in vulnerable plaque group than those in stable plaque group（P < 0.05）.（5）The level of miR-146a in PBMCs and plasma was significantly higher in soft plaque group than those in fibrous plaque group and calcified plaque group（P < 0.05）. Conclusions The expression of miR-146a is associated with the plaque stability of coronary stenotic lesions.
- miR-146a,
- Coronary artery disease,
- IVUS,
- Plaque stability

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References(20)

References

[1]	胡盛寿,高润霖,刘力生,等. 《中国心血管病报告2018》概要[J].中国循环杂志,2019,34(3):209-220. doi: 10.3969/j.issn.1000-3614.2019.03.001
[2]	Geovanini G R,Libby P. Atherosclerosis and inflammation:overview and updates[J]. Clin Sci(Lond),2018,132(12):1243-1252. doi: 10.1042/CS20180306
[3]	Zhong L,Simard M J,Huot J. Endothelial microRNAs regulating the NF-κB pathway and cell adhesion molecules during inflammation[J]. FASEB J,2018,32(8):4070-4084. doi: 10.1096/fj.201701536R
[4]	Churov A,Summerhill V,Grechko A,et al. MicroRNAs as potential biomarkers in atherosclerosis[J]. Int J Mol Sci,2019,20(22):5547. doi: 10.3390/ijms20225547
[5]	Bostjancic E,Glavac D. Importance of microRNAs in skin morphogenesis and diseases[J]. Acta Dermatovenerol Alp Panonica Adriat,2008,17(3):95-102.
[6]	Stanczyk J,Pedrioli D M,Brentano F,et al. Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis[J]. Arthritis Rheum,2008,58(4):1001-1009. doi: 10.1002/art.23386
[7]	Chen X,Gao Q,Zhou L,et al. MiR-146a alleviates inflammation of acute gouty arthritis rats through TLR4/MyD88 signal transduction pathway[J]. Eur Rev Med Pharmacol Sci,2019,23(21):9230-9237.
[8]	Yao R,Ma Y,Du Y,et al. The altered expression of inflammation-related microRNAs with microRNA-155 expression correlates with Th17 differentiation in patients with acute coronary syndrome[J]. Cell Mol Immunol,2011,8(6):486-495. doi: 10.1038/cmi.2011.22
[9]	Zhu G F,Yang L X,Guo R W,et al. microRNA-155 is inversely associated with severity of coronary stenotic lesions calculated by the Gensini score[J]. Coron Artery Dis,2014,25(4):304-310. doi: 10.1097/MCA.0000000000000088
[10]	Mintz G S,Nissen S E,Anderson W D,et al. American college of cardiology clinical expert consensus document on standards for acquisition,measurement and reporting of Intravascular Ultrasound Studies(IVUS). A report of the American college of cardiology task force on clinical expert consensus documents[J]. J Am Coll Cardiol,2001,37(5):1478-1492. doi: 10.1016/S0735-1097(01)01175-5
[11]	Endo M,Hibi K,Shimizu T,et al. Impact of ultrasound attenuation and plaque rupture as detected by intravascular ultrasound on the incidence of no-reflow phenomenon after percutaneous coronary intervention in ST-segment elevation myocardial infarction[J]. J Am Coll Cardiol Intv,2010,3(5):540-549. doi: 10.1016/j.jcin.2010.01.015
[12]	Livak K J,Schmittgen T D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T))Method[J]. Methods,2001,25(4):402-408. doi: 10.1006/meth.2001.1262
[13]	Tayefi M,Tajfard M,Saffar S,et al. hs-CRP is strongly associated with coronary heart disease(CHD):A data mining approach using decision tree algorithm[J]. Comput Methods Programs Biomed,2017,141:105-109. doi: 10.1016/j.cmpb.2017.02.001
[14]	Tajfard M,Latiff L A,Rahimi H R,et al. Serum concentrations of MCP-1 and IL-6 in combination predict the presence of coronary artery disease and mortality in subjects undergoing coronary angiography[J]. Mol Cell Biochem,2017,435(1-2):37-45. doi: 10.1007/s11010-017-3054-5
[15]	Glaser R,Selzer F,Faxon D P,et al. Clinical progression of incidental,asymptomatic lesions discovered during culprit vessel coronary intervention[J]. Circulation,2005,111(2):143-149. doi: 10.1161/01.CIR.0000150335.01285.12
[16]	Taganov K D,Boldin M P,Chang K J,et al. NF-kappaB-dependent induction of microRNA miR-146,an inhibitor targeted to signaling proteins of innate immune responses[J]. Proc Natl Acad Sci USA,2006,103(33):12481-12486. doi: 10.1073/pnas.0605298103
[17]	Zeng Z,Gong H,Li Y,et al. Upregulation of miR-146a contributes to the suppression of inflammatory responses in LPS-induced acute lung injury[J]. Exp Lung Res,2013,39(7):275-282. doi: 10.3109/01902148.2013.808285
[18]	Gao M,Wang X,Zhang X,et al. Attenuation of cardiac dysfunction in polymicrobial sepsis by microRNA-146a is mediated via targeting of IRAK1 and TRAF6 expression[J]. J Immunol,2015,195(2):672-682. doi: 10.4049/jimmunol.1403155
[19]	Pundziute G,Schuijf J D,van Velzen J E,et al. Assessment with multi-slice computed tomography and gray-scale and virtual histology intravascular ultrasound of gender-specific differences in extent and composition of coronary atherosclerotic plaques in relation to age[J]. Am J Cardiol,2010,105(4):480-486. doi: 10.1016/j.amjcard.2009.09.054
[20]	Blaha M J,Nasir K,Rivera J J,et al. Gender differences in coronary plaque composition by coronary computed tomography angiography[J]. Coron Artery Dis,2009,20(8):506-512. doi: 10.1097/MCA.0b013e328331368d

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