Chaojie ZOU, Yikai TANG, Shuwen DU, Yuqi CHENG. Effects of Modulation of CDC42 Activity in Hippocampal Neurons on Memory and Anxiety Behaviors of Mice[J]. Journal of Kunming Medical University, 2022, 43(11): 1-8. doi: 10.12259/j.issn.2095-610X.S20221105
Citation: Xu XU, Li-yong WU, Ming-li ZHOU, Guo-fu ZHU. Relationship between microRNA-146a and the Plaque Stability in Coronary Heart Disease Patients[J]. Journal of Kunming Medical University, 2020, 41(11): 56-61. doi: 10.12259/j.issn.2095-610X.S20201119

Relationship between microRNA-146a and the Plaque Stability in Coronary Heart Disease Patients

doi: 10.12259/j.issn.2095-610X.S20201119
  • Received Date: 2020-10-12
    Available Online: 2020-12-03
  • Publish Date: 2020-11-25
  •   Objectives  To investigate the association between microRNA-146a(miR-146a)and the plaque stability in patients with coronary heart disease.  Methods  Real-time PCR was used to measure miR-146a expression in 324 patients. ELISA was used to measure the level of hs-CRP, IL-6 and IL-8. Coronary angiography was used to evaluate the degree of coronary artery stenosis. Intravascular ultrasound(IVUS)was used to evaluate the plaque stability of coronary stenotic lesions.  Results  (1)The levels of hs-CRP, IL-6 and IL-8 were significantly increased in the UAP and AMI groups compared with the CPS groups(P < 0.01).(2)The miR-146a expression in peripheral blood mononuclear cells(PBMCs)and plasma was significantly higher in CAD patients than those in non-CAD group(P < 0.05, P < 0.001).(3)The miR-146a expression in PBMCs was higher in SAP, UAP and AMI group than CPS group(P < 0.01, P < 0.001, P < 0.001). The expression patterns of miR-146a in plasma was consistent with that of PBMCs.(4)The expression of miR-146a in PBMCs and plasma were significantly higher in vulnerable plaque group than those in stable plaque group(P < 0.05).(5)The level of miR-146a in PBMCs and plasma was significantly higher in soft plaque group than those in fibrous plaque group and calcified plaque group(P < 0.05).  Conclusions  The expression of miR-146a is associated with the plaque stability of coronary stenotic lesions.
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