Relationship between microRNA-146a and the Plaque Stability in Coronary Heart Disease Patients

Xu XU; Li-yong WU; Ming-li ZHOU; Guo-fu ZHU

doi:10.12259/j.issn.2095-610X.S20201119

Volume 41 Issue 11

Dec. 2020

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Xu XU, Li-yong WU, Ming-li ZHOU, Guo-fu ZHU. Relationship between microRNA-146a and the Plaque Stability in Coronary Heart Disease Patients[J]. Journal of Kunming Medical University, 2020, 41(11): 56-61. doi: 10.12259/j.issn.2095-610X.S20201119

Citation:

Xu XU, Li-yong WU, Ming-li ZHOU, Guo-fu ZHU. Relationship between microRNA-146a and the Plaque Stability in Coronary Heart Disease Patients[J]. Journal of Kunming Medical University, 2020, 41(11): 56-61. doi: 10.12259/j.issn.2095-610X.S20201119

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Relationship between microRNA-146a and the Plaque Stability in Coronary Heart Disease Patients

doi: 10.12259/j.issn.2095-610X.S20201119

1.
Dept. of Geriatrics，Ganmei Hospital，Kunming First People’s Hospital，Kunming Yunnan 650011
2.
Dept. of Cardiology，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2020-10-12
Available Online: 2020-12-03
Publish Date: 2020-11-25

Abstract

Abstract

Objectives To investigate the association between microRNA-146a（miR-146a）and the plaque stability in patients with coronary heart disease. Methods Real-time PCR was used to measure miR-146a expression in 324 patients. ELISA was used to measure the level of hs-CRP, IL-6 and IL-8. Coronary angiography was used to evaluate the degree of coronary artery stenosis. Intravascular ultrasound（IVUS）was used to evaluate the plaque stability of coronary stenotic lesions. Results （1）The levels of hs-CRP, IL-6 and IL-8 were significantly increased in the UAP and AMI groups compared with the CPS groups（P < 0.01）.（2）The miR-146a expression in peripheral blood mononuclear cells（PBMCs）and plasma was significantly higher in CAD patients than those in non-CAD group（P < 0.05, P < 0.001）.（3）The miR-146a expression in PBMCs was higher in SAP, UAP and AMI group than CPS group（P < 0.01, P < 0.001, P < 0.001）. The expression patterns of miR-146a in plasma was consistent with that of PBMCs.（4）The expression of miR-146a in PBMCs and plasma were significantly higher in vulnerable plaque group than those in stable plaque group（P < 0.05）.（5）The level of miR-146a in PBMCs and plasma was significantly higher in soft plaque group than those in fibrous plaque group and calcified plaque group（P < 0.05）. Conclusions The expression of miR-146a is associated with the plaque stability of coronary stenotic lesions.
- miR-146a,
- Coronary artery disease,
- IVUS,
- Plaque stability

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References(20)

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