Changes of Intestinal Flora in Non-alcoholic Fatty Liver Disease

Ping-yan XUE; Yan JIANG; Yu-shan XU; Hui YUAN; Xuan LI; Ya-xian SONG; Hua LIU

doi:10.12259/j.issn.2095-610X.S20201120

Volume 41 Issue 11

Dec. 2020

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Ping-yan XUE, Yan JIANG, Yu-shan XU, Hui YUAN, Xuan LI, Ya-xian SONG, Hua LIU. Changes of Intestinal Flora in Non-alcoholic Fatty Liver Disease[J]. Journal of Kunming Medical University, 2020, 41(11): 62-67. doi: 10.12259/j.issn.2095-610X.S20201120

Citation:

Ping-yan XUE, Yan JIANG, Yu-shan XU, Hui YUAN, Xuan LI, Ya-xian SONG, Hua LIU. Changes of Intestinal Flora in Non-alcoholic Fatty Liver Disease[J]. Journal of Kunming Medical University, 2020, 41(11): 62-67. doi: 10.12259/j.issn.2095-610X.S20201120

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Changes of Intestinal Flora in Non-alcoholic Fatty Liver Disease

doi: 10.12259/j.issn.2095-610X.S20201120

Ping-yan XUE^{1, 2},
Yan JIANG¹,
Yu-shan XU^{1
,
,},
Hui YUAN³,
Xuan LI⁴,
Ya-xian SONG¹,
Hua LIU⁵

1.
Dept. of Endocrinology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Dept. of Endocrinology，The 2nd People’s Hospital of Qujing City，Qujing Yunnan 655000
3.
Dept. of Ultrasound Medicine
4.
Dept. of Neurosurgery
5.
The Medical Laboratory Department，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2020-09-21
Available Online: 2020-12-03
Publish Date: 2020-11-25

Abstract

Abstract

Objective To observe the changes of intestinal flora in patients with non-alcoholic fatty liver disease （NAFLD） and the role in occurrence and development of the disease. Methods One hundred and fifty patients who were diagnosed as NAFLD and 60 healthy controls were randomly selected. Used the relative quantification of Real Time PCR to detecte the expression level of DNA of target bacteria. Results Compared to the control group, the quantity of Lactobacillus and Eubacterium rectale in NAFLD patients were significant increased, Bifidobacterium and Bacteroides thetaiotaomicron were decreased. Conclusion The quantity of Lactobacillus, Eubacterium rectale, Bifidobacterium, Bacteroides thetaiotaomicron in patients with NAFLD may exist structural imbalance of intestinal flora, gut microbiome probably participate in the occurrence and development of NAFLD, improve the intestinal flora imbalance has a certain treatment value in NAFLD.
- Intestinal flora,
- Non-alcoholic fatty liver disease,
- Phylum firmicutes,
- Bacteroidetes

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References(23)

References

[1]	Chalasani N,Younossi Z,Lavine J E,et al. The diagnosis and management of nonalcoholic fatty liver disease:practice guidance from the American Association for the Study of Liver Diseases[J]. Hepatology,2018,67(1):328-357. doi: 10.1002/hep.29367
[2]	Marshall J C. The gut as a potential trigger of exercise-induced inflammatory responses[J]. Can J Physiol Pharmacol,1998,76(5):479-484. doi: 10.1139/y98-049
[3]	Tilg H,Moschen A R. Evolution of inflammation in nonalcoholic fatty liver disease:the multiple parallel hits hypothesis[J]. Hepatology,2010,52(5):1836-1846. doi: 10.1002/hep.24001
[4]	Polyzos S A,Kountouras J,Mantzoros C S,et al. Obesity and nonalcoholic fatty liver disease:From pathophysiology to therapeutics[J]. Metabolism,2019,92(3):82-97.
[5]	Yufang Ding,Karin Yanagi,Clint Cheng,et al. Interactions between gut microbiota and non-alcoholic liver disease:The role of microbiota-derived metabolites[J]. Pharmacol Res,2019,141(5):521-529.
[6]	Jasirwan C O M,Lesmana C R A,Hasan I,et al. The role of gut microbiota in non-alcoholic fatty liver disease:pathways of mechanisms[J]. Biosci Microbiota Food Health,2019,38(3):81-88. doi: 10.12938/bmfh.18-032
[7]	Akhmedov V A,Gaus O V. Role of intestinal microbiota in the formation of non-alcoholic fatty liver disease[J]. Terapevticheskii Arkhiv,2019,91(2):143-148.
[8]	易艳容,曾亚,何佳,等. 非酒精性脂肪性肝病患者肠道菌群变化及双歧杆菌三联活菌胶囊对肠道菌群、肝功能、血脂及胰岛素抵抗的影响[J].中国肝脏病杂志(电子版),2016,8(3):87-92. doi: 10.3969/j.issn.1674-7380.2016.03.019
[9]	中华医学会肝病学分会脂肪肝和酒精性肝病学组. 非酒精性脂肪性肝病诊疗指南(2010年修订版)[J].中华肝脏病杂志,2010,18(3):163-166. doi: 10.3760/cma.j.issn.1007-3418.2010.03.002
[10]	Jayakumar S,Loomba R. Review article:emerging role of the gut microbiome in the progression of nonalcoholic fatty liver disease and potential therapeutic implications[J]. Aliment Pharmacol Ther,2019,50(2):144-158. doi: 10.1111/apt.15314
[11]	Alexander W,Lukas J G,Frank T. Microbiome & NASH-partners in crime driving progression of fatty liver disease[J]. Z Gastroenterol,2019,57(7):871-882. doi: 10.1055/a-0755-2595
[12]	Aleksandra A K,Danping Zheng,Oren S H,et al. The role of the microbiome in NAFLD and NASH[J]. EMBO Mol Med,2019,11(2):e9302.
[13]	Woodhouse C A,Patel V C,Singanayagam A,et al. Review article:the gut microbiome as a therapeutic target in the pathogenesis and treatment of chronic liver disease[J]. Aliment Pharmacol Ther,2018,47(2):192-202. doi: 10.1111/apt.14397
[14]	Lau L H S,Wong S H. Microbiota,obesity and NAFLD[J]. Adv Exp Med Biol,2018,1061(6):111-125.
[15]	Mouzaki M,Comelli E M,Arendt B M,et al. Intestinal microbiota in patients with nonalcoholic fatty liver disease[J]. Hepatology,2013,58(1):120-127. doi: 10.1002/hep.26319
[16]	Wong V W,Tse C H,Lam T T,et al. Molecular characterization of the fecal microbiota in patients with nonalcoholic steatohepatitis-A longitudinal study[J]. PLoS One,2013,8(4):e62885. doi: 10.1371/journal.pone.0062885
[17]	Wang B,Jiang X,Cao M,et al. Altered fecal microbiota correlates with liver biochemistry in nonobese patients with non-alcoholic fatty liver disease[J]. Sci Rep,2016,8(6):32002.
[18]	Da Silva H E,Teterina A,Comelli E M,et al. Nonalcoholic fatty liver disease is associated with dysbiosis independent of body mass index and insulin resistance[J]. Sci Rep,2018,8(1):1466. doi: 10.1038/s41598-018-19753-9
[19]	Sobhonslidsuk A,Chanprasertyothin S,Pongrujikorn T,et al. The association of gut microbiota with nonalcoholic steatohepatitis in Thais[J]. Bio Med Res Int,2018,8(16):9340316.
[20]	Boursier J,Mueller O,Barret M,et al. The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota[J]. Hepatology,2016,63(3):764-775. doi: 10.1002/hep.28356
[21]	Ge H,Li X,Weiszmann J,et al. Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids[J]. Endocrinology,2008,149(9):4519-4526. doi: 10.1210/en.2008-0059
[22]	Fetissov S O. Role of the gut microbiota in host appetite control:bacterial growth to animal feeding behaviour[J]. Nat Rev Endocrinol,2017,13(1):11-25. doi: 10.1038/nrendo.2016.150
[23]	Torres-Fuentes C,Schellekens H,Dinan T G,et al. The microbiota-gut-brain axis in obesity[J]. Lancet Gastroenterol Hepatol,2017,2(10):747-756. doi: 10.1016/S2468-1253(17)30147-4

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