Changes of Intestinal Flora in Non-alcoholic Fatty Liver Disease

Ping-yan XUE; Yan JIANG; Yu-shan XU; Hui YUAN; Xuan LI; Ya-xian SONG; Hua LIU

doi:10.12259/j.issn.2095-610X.S20201120

Volume 41 Issue 11

Dec. 2020

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Ping-yan XUE, Yan JIANG, Yu-shan XU, Hui YUAN, Xuan LI, Ya-xian SONG, Hua LIU. Changes of Intestinal Flora in Non-alcoholic Fatty Liver Disease[J]. Journal of Kunming Medical University, 2020, 41(11): 62-67. doi: 10.12259/j.issn.2095-610X.S20201120

Citation:

Ping-yan XUE, Yan JIANG, Yu-shan XU, Hui YUAN, Xuan LI, Ya-xian SONG, Hua LIU. Changes of Intestinal Flora in Non-alcoholic Fatty Liver Disease[J]. Journal of Kunming Medical University, 2020, 41(11): 62-67. doi: 10.12259/j.issn.2095-610X.S20201120

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Changes of Intestinal Flora in Non-alcoholic Fatty Liver Disease

doi: 10.12259/j.issn.2095-610X.S20201120

Ping-yan XUE^{1, 2},
Yan JIANG¹,
Yu-shan XU^{1
,
,},
Hui YUAN³,
Xuan LI⁴,
Ya-xian SONG¹,
Hua LIU⁵

1.
Dept. of Endocrinology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Dept. of Endocrinology，The 2nd People’s Hospital of Qujing City，Qujing Yunnan 655000
3.
Dept. of Ultrasound Medicine
4.
Dept. of Neurosurgery
5.
The Medical Laboratory Department，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2020-09-21
Available Online: 2020-12-03
Publish Date: 2020-11-25

Abstract

Abstract

Objective To observe the changes of intestinal flora in patients with non-alcoholic fatty liver disease （NAFLD） and the role in occurrence and development of the disease. Methods One hundred and fifty patients who were diagnosed as NAFLD and 60 healthy controls were randomly selected. Used the relative quantification of Real Time PCR to detecte the expression level of DNA of target bacteria. Results Compared to the control group, the quantity of Lactobacillus and Eubacterium rectale in NAFLD patients were significant increased, Bifidobacterium and Bacteroides thetaiotaomicron were decreased. Conclusion The quantity of Lactobacillus, Eubacterium rectale, Bifidobacterium, Bacteroides thetaiotaomicron in patients with NAFLD may exist structural imbalance of intestinal flora, gut microbiome probably participate in the occurrence and development of NAFLD, improve the intestinal flora imbalance has a certain treatment value in NAFLD.
- Intestinal flora,
- Non-alcoholic fatty liver disease,
- Phylum firmicutes,
- Bacteroidetes

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References(23)

References

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