Clinical Study on Characteristics of Kawasaki Disease in Yunnan Province

Hui-bo YANG; Qin MIAO; De-liang LIU; Si-si LI

doi:10.12259/j.issn.2095-610X.S20201121

Volume 41 Issue 11

Dec. 2020

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Hui-bo YANG, Qin MIAO, De-liang LIU, Si-si LI. Clinical Study on Characteristics of Kawasaki Disease in Yunnan Province[J]. Journal of Kunming Medical University, 2020, 41(11): 103-108. doi: 10.12259/j.issn.2095-610X.S20201121

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Hui-bo YANG, Qin MIAO, De-liang LIU, Si-si LI. Clinical Study on Characteristics of Kawasaki Disease in Yunnan Province[J]. Journal of Kunming Medical University, 2020, 41(11): 103-108. doi: 10.12259/j.issn.2095-610X.S20201121

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Clinical Study on Characteristics of Kawasaki Disease in Yunnan Province

doi: 10.12259/j.issn.2095-610X.S20201121

1.
Dept. of Pediatrics，The Third People’s Hospital of Yunnan Province，Kunming Yunnan 650011
2.
The first Clinical Medical College of Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2020-08-11
Available Online: 2020-12-03
Publish Date: 2020-11-25

Abstract

Abstract

Objective To investigate the incidence and clinical features of Kawasaki disease（KD）among children in Yunnan province. Methods A total of 163 patients with Kawasaki disease were studied retrospectively. All of them were treated in the Third People's Hospital of Yunnan Province in Kunming from January 2013 to December 2018. The clinical features and lymphocyte subpopulations in the patients with Kawasaki disease were analyzed. Results 59.51% of the patients were 0～2 years old. Patients had conjunctival congestion, chapped lips, rash, abnormal erythrocyte sedimentation rate（ESR）, elevated C-reactive protein（CRP）, platelet count greater than 500, and white blood cell（WBC）greater than 10 000. In addition, extremity changes, cervical lymphadenopathy, perianal skin flushing, kappa disease, anemia, neutrophil abnormalities, and WBC less than 4000 were also detected in patients with Kawasaki disease. The results of color Doppler ultrasound showed that the intima of Kawasaki patients was not smooth and the left and right coronary arteries were dilated. CD19⁺ was increased in 93.66% of Kawasaki disease patients, and other lymphocyte subsets were also changed. CD3⁺CD8⁺ and CD3⁺CD4⁺ were significantly correlated with age（Pearson Correlation Coefficicient > 0.2）. Conclusion Children under 2 years old are susceptible groups, and there are significant immunologic disorders in acute phase in the patients with Kawasaki disease. It is more scientific and reasonable to diagnose Kawasaki disease by combining the characteristics of Kawasaki disease, blood parameters, cardiac color Doppler ultrasound and lymphocyte subsets.
- Kawasaki disease,
- Clinical features,
- Lymphocyte subsets,
- Age relation

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References(21)

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